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Q9BZH6

- WDR11_HUMAN

UniProt

Q9BZH6 - WDR11_HUMAN

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Protein

WD repeat-containing protein 11

Gene

WDR11

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Enzyme and pathway databases

SignaLinkiQ9BZH6.

Names & Taxonomyi

Protein namesi
Recommended name:
WD repeat-containing protein 11
Alternative name(s):
Bromodomain and WD repeat-containing protein 2
WD repeat-containing protein 15
Gene namesi
Name:WDR11
Synonyms:BRWD2, KIAA1351, WDR15
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 10

Organism-specific databases

HGNCiHGNC:13831. WDR11.

Subcellular locationi

Membrane Curated; Single-pass membrane protein Curated. Cytoplasm 1 Publication. Nucleus 1 Publication
Note: Might be shuttling between the nucleus and the cytoplasm.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei1127 – 114721HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. cilium Source: Ensembl
  2. cytoplasm Source: MGI
  3. integral component of membrane Source: UniProtKB-KW
  4. lysosomal membrane Source: UniProtKB
  5. membrane Source: UniProtKB
  6. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane, Nucleus

Pathology & Biotechi

Involvement in diseasei

A chromosomal aberration involving WDR11 is found in a form of glioblastoma. Translocation t(10;19)(q26;q13.3) with ZNF320.
A chromosomal aberration involving WDR11 is found in a form of Kallmann syndrome. Translocation 46,XY,t(10;12)(q26.12;q13.11).
Hypogonadotropic hypogonadism 14 with or without anosmia (HH14) [MIM:614858]: A disorder characterized by absent or incomplete sexual maturation by the age of 18 years, in conjunction with low levels of circulating gonadotropins and testosterone and no other abnormalities of the hypothalamic-pituitary axis. In some cases, it is associated with non-reproductive phenotypes, such as anosmia, cleft palate, and sensorineural hearing loss. Anosmia or hyposmia is related to the absence or hypoplasia of the olfactory bulbs and tracts. Hypogonadism is due to deficiency in gonadotropin-releasing hormone and probably results from a failure of embryonic migration of gonadotropin-releasing hormone-synthesizing neurons. In the presence of anosmia, idiopathic hypogonadotropic hypogonadism is referred to as Kallmann syndrome, whereas in the presence of a normal sense of smell, it has been termed normosmic idiopathic hypogonadotropic hypogonadism (nIHH).1 Publication
Note: The disease is caused by mutations affecting the gene represented in this entry.
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti395 – 3951R → W in HH14; does not affect the interaction with EMX1; does not affect the subcellular location of the protein. 1 Publication
Corresponds to variant rs201051480 [ dbSNP | Ensembl ].
VAR_069194
Natural varianti435 – 4351A → T in HH14; abolishes the interaction with EMX1; does not affect the subcellular location of the protein. 1 Publication
Corresponds to variant rs318240760 [ dbSNP | Ensembl ].
VAR_069195
Natural varianti448 – 4481R → Q in HH14; reduces the interaction with EMX1; does not affect the subcellular location of the protein. 1 Publication
Corresponds to variant rs144440500 [ dbSNP | Ensembl ].
VAR_069196
Natural varianti690 – 6901H → Q in HH14; abolishes the interaction with EMX1. 1 Publication
Corresponds to variant rs318240761 [ dbSNP | Ensembl ].
VAR_069197
Natural varianti1150 – 11501F → L in HH14; does not affect the subcellular location of the protein. 1 Publication
Corresponds to variant rs139007744 [ dbSNP | Ensembl ].
VAR_069199

Keywords - Diseasei

Disease mutation, Hypogonadotropic hypogonadism, Kallmann syndrome, Proto-oncogene

Organism-specific databases

MIMi614858. phenotype.
Orphaneti478. Kallmann syndrome.
432. Normosmic congenital hypogonadotropic hypogonadism.
PharmGKBiPA37818.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12241224WD repeat-containing protein 11PRO_0000050889Add
BLAST

Proteomic databases

MaxQBiQ9BZH6.
PaxDbiQ9BZH6.
PeptideAtlasiQ9BZH6.
PRIDEiQ9BZH6.

PTM databases

PhosphoSiteiQ9BZH6.

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiQ9BZH6.
CleanExiHS_BRWD2.
ExpressionAtlasiQ9BZH6. baseline and differential.
GenevestigatoriQ9BZH6.

Organism-specific databases

HPAiHPA038980.

Interactioni

Subunit structurei

Interacts with EMX1 (via the N-terminal and the central portion of the protein. The C-terminus does not.).1 Publication

Protein-protein interaction databases

BioGridi120839. 9 interactions.
IntActiQ9BZH6. 2 interactions.
STRINGi9606.ENSP00000263461.

Structurei

3D structure databases

ProteinModelPortaliQ9BZH6.
SMRiQ9BZH6. Positions 747-778.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati59 – 10850WD 1Add
BLAST
Repeati111 – 15444WD 2Add
BLAST
Repeati354 – 39340WD 3Add
BLAST
Repeati471 – 51040WD 4Add
BLAST
Repeati566 – 60540WD 5Add
BLAST
Repeati708 – 74538WD 6Add
BLAST
Repeati747 – 78741WD 7Add
BLAST
Repeati793 – 83139WD 8Add
BLAST
Repeati893 – 94048WD 9Add
BLAST

Sequence similaritiesi

Contains 9 WD repeats.Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix, WD repeat

Phylogenomic databases

eggNOGiNOG236393.
GeneTreeiENSGT00390000004068.
HOGENOMiHOG000294084.
HOVERGENiHBG060317.
InParanoidiQ9BZH6.
OMAiVHSCEVK.
OrthoDBiEOG7ZSHS5.
PhylomeDBiQ9BZH6.
TreeFamiTF314830.

Family and domain databases

Gene3Di2.130.10.10. 5 hits.
InterProiIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 1 hit.
[Graphical view]
SMARTiSM00320. WD40. 6 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 4 hits.
PROSITEiPS00678. WD_REPEATS_1. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9BZH6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLPYTVNFKV SARTLTGALN AHNKAAVDWG WQGLIAYGCH SLVVVIDSIT
60 70 80 90 100
AQTLQVLEKH KADVVKVKWA RENYHHNIGS PYCLRLASAD VNGKIIVWDV
110 120 130 140 150
AAGVAQCEIQ EHAKPIQDVQ WLWNQDASRD LLLAIHPPNY IVLWNADTGT
160 170 180 190 200
KLWKKSYADN ILSFSFDPFD PSHLTLLTSE GIVFISDFSP SKPPSGPGKK
210 220 230 240 250
VYISSPHSSP AHNKLATATG AKKALNKVKI LITQEKPSAE FITLNDCLQL
260 270 280 290 300
AYLPSKRNHM LLLYPREILI LDLEVNQTVG VIAIERTGVP FLQVIPCFQR
310 320 330 340 350
DGLFCLHENG CITLRVRRSY NNIFTTSNEE PDPDPVQELT YDLRSQCDAI
360 370 380 390 400
RVTKTVRPFS MVCCPVNENA AALVVSDGRV MIWELKSAVC NRNSRNSSSG
410 420 430 440 450
VSPLYSPVSF CGIPVGVLQN KLPDLSLDNM IGQSAIAGEE HPRGSILREV
460 470 480 490 500
HLKFLLTGLL SGLPAPQFAI RMCPPLTTKN IKMYQPLLAV GTSNGSVLVY
510 520 530 540 550
HLTSGLLHKE LSIHSCEVKG IEWTSLTSFL SFATSTPNNM GLVRNELQLV
560 570 580 590 600
DLPTGRSIAF RGERGNDESA IEMIKVSHLK QYLAVVFRDK PLELWDVRTC
610 620 630 640 650
TLLREMSKNF PTITALEWSP SHNLKSLRKK QLATREAMAR QTVVSDTELS
660 670 680 690 700
IVESSVISLL QEAESKSELS QNISAREHFV FTDIDGQVYH LTVEGNSVKD
710 720 730 740 750
SARIPPDGSM GSITCIAWKG DTLVLGDMDG NLNFWDLKGR VSRGIPTHRS
760 770 780 790 800
WVRKIRFAPG KGNQKLIAMY NDGAEVWDTK EVQMVSSLRS GRNVTFRILD
810 820 830 840 850
VDWCTSDKVI LASDDGCIRV LEMSMKSACF RMDEQELTEP VWCPYLLVPR
860 870 880 890 900
ASLALKAFLL HQPWNGQYSL DISHVDYPEN EEIKNLLQEQ LNSLSNDIKK
910 920 930 940 950
LLLDPEFTLL QRCLLVSRLY GDESELHFWT VAAHYLHSLS QEKSASTTAP
960 970 980 990 1000
KEAAPRDKLS NPLDICYDVL CENAYFQKFQ LERVNLQEVK RSTYDHTRKC
1010 1020 1030 1040 1050
TDQLLLLGQT DRAVQLLLET SADNQHYYCD SLKACLVTTV TSSGPSQSTI
1060 1070 1080 1090 1100
KLVATNMIAN GKLAEGVQLL CLIDKAADAC RYLQTYGEWN RAAWLAKVRL
1110 1120 1130 1140 1150
NPEECADVLR RWVDHLCSPQ VNQKSKALLV LLSLGCFFSV AETLHSMRYF
1160 1170 1180 1190 1200
DRAALFVEAC LKYGAFEVTE DTEKLITAIY ADYARSLKNL GFKQGAVLFA
1210 1220
SKAGAAGKDL LNELESPKEE PIEE
Length:1,224
Mass (Da):136,685
Last modified:June 1, 2001 - v1
Checksum:i918221ABEAEFB4ED
GO

Sequence cautioni

The sequence BAA92589.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti395 – 3951R → W in HH14; does not affect the interaction with EMX1; does not affect the subcellular location of the protein. 1 Publication
Corresponds to variant rs201051480 [ dbSNP | Ensembl ].
VAR_069194
Natural varianti435 – 4351A → T in HH14; abolishes the interaction with EMX1; does not affect the subcellular location of the protein. 1 Publication
Corresponds to variant rs318240760 [ dbSNP | Ensembl ].
VAR_069195
Natural varianti448 – 4481R → Q in HH14; reduces the interaction with EMX1; does not affect the subcellular location of the protein. 1 Publication
Corresponds to variant rs144440500 [ dbSNP | Ensembl ].
VAR_069196
Natural varianti690 – 6901H → Q in HH14; abolishes the interaction with EMX1. 1 Publication
Corresponds to variant rs318240761 [ dbSNP | Ensembl ].
VAR_069197
Natural varianti978 – 9781K → Q.1 Publication
Corresponds to variant rs144531702 [ dbSNP | Ensembl ].
VAR_069198
Natural varianti1150 – 11501F → L in HH14; does not affect the subcellular location of the protein. 1 Publication
Corresponds to variant rs139007744 [ dbSNP | Ensembl ].
VAR_069199

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF320223 mRNA. Translation: AAK08064.1.
AB037772 mRNA. Translation: BAA92589.2. Different initiation.
AL391425, AC010998 Genomic DNA. Translation: CAH72488.1.
BC040469 mRNA. Translation: AAH40469.1.
BC071564 mRNA. Translation: AAH71564.1.
CCDSiCCDS7619.1.
RefSeqiNP_060587.8. NM_018117.11.
UniGeneiHs.144447.

Genome annotation databases

EnsembliENST00000263461; ENSP00000263461; ENSG00000120008.
GeneIDi55717.
KEGGihsa:55717.
UCSCiuc001lfd.1. human.

Polymorphism databases

DMDMi17368715.

Keywords - Coding sequence diversityi

Chromosomal rearrangement

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF320223 mRNA. Translation: AAK08064.1 .
AB037772 mRNA. Translation: BAA92589.2 . Different initiation.
AL391425 , AC010998 Genomic DNA. Translation: CAH72488.1 .
BC040469 mRNA. Translation: AAH40469.1 .
BC071564 mRNA. Translation: AAH71564.1 .
CCDSi CCDS7619.1.
RefSeqi NP_060587.8. NM_018117.11.
UniGenei Hs.144447.

3D structure databases

ProteinModelPortali Q9BZH6.
SMRi Q9BZH6. Positions 747-778.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 120839. 9 interactions.
IntActi Q9BZH6. 2 interactions.
STRINGi 9606.ENSP00000263461.

PTM databases

PhosphoSitei Q9BZH6.

Polymorphism databases

DMDMi 17368715.

Proteomic databases

MaxQBi Q9BZH6.
PaxDbi Q9BZH6.
PeptideAtlasi Q9BZH6.
PRIDEi Q9BZH6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000263461 ; ENSP00000263461 ; ENSG00000120008 .
GeneIDi 55717.
KEGGi hsa:55717.
UCSCi uc001lfd.1. human.

Organism-specific databases

CTDi 55717.
GeneCardsi GC10P122610.
HGNCi HGNC:13831. WDR11.
HPAi HPA038980.
MIMi 606417. gene.
614858. phenotype.
neXtProti NX_Q9BZH6.
Orphaneti 478. Kallmann syndrome.
432. Normosmic congenital hypogonadotropic hypogonadism.
PharmGKBi PA37818.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG236393.
GeneTreei ENSGT00390000004068.
HOGENOMi HOG000294084.
HOVERGENi HBG060317.
InParanoidi Q9BZH6.
OMAi VHSCEVK.
OrthoDBi EOG7ZSHS5.
PhylomeDBi Q9BZH6.
TreeFami TF314830.

Enzyme and pathway databases

SignaLinki Q9BZH6.

Miscellaneous databases

GeneWikii BRWD2.
GenomeRNAii 55717.
NextBioi 60607.
PROi Q9BZH6.
SOURCEi Search...

Gene expression databases

Bgeei Q9BZH6.
CleanExi HS_BRWD2.
ExpressionAtlasi Q9BZH6. baseline and differential.
Genevestigatori Q9BZH6.

Family and domain databases

Gene3Di 2.130.10.10. 5 hits.
InterProi IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view ]
Pfami PF00400. WD40. 1 hit.
[Graphical view ]
SMARTi SM00320. WD40. 6 hits.
[Graphical view ]
SUPFAMi SSF50978. SSF50978. 4 hits.
PROSITEi PS00678. WD_REPEATS_1. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A novel member of the WD-repeat gene family, WDR11, maps to the 10q26 region and is disrupted by a chromosome translocation in human glioblastoma cells."
    Chernova O.B., Hunyadi A., Malaj E., Pan H., Crooks C., Roe B., Cowell J.K.
    Oncogene 20:5378-5392(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHROMOSOMAL TRANSLOCATION WITH ZNF320.
  2. "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.
    DNA Res. 7:65-73(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  3. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
    Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
    DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: SEQUENCE REVISION.
  4. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.
  6. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. "WDR11, a WD protein that interacts with transcription factor EMX1, is mutated in idiopathic hypogonadotropic hypogonadism and Kallmann syndrome."
    Kim H.G., Ahn J.W., Kurth I., Ullmann R., Kim H.T., Kulharya A., Ha K.S., Itokawa Y., Meliciani I., Wenzel W., Lee D., Rosenberger G., Ozata M., Bick D.P., Sherins R.J., Nagase T., Tekin M., Kim S.H.
    , Kim C.H., Ropers H.H., Gusella J.F., Kalscheuer V., Choi C.Y., Layman L.C.
    Am. J. Hum. Genet. 87:465-479(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, CHROMOSOMAL TRANSLOCATION, INTERACTION WITH EMX1, VARIANTS HH14 TRP-395; THR-435; GLN-448; GLN-690 AND LEU-1150, VARIANT GLN-978, CHARACTERIZATION OF VARIANTS HH14 TRP-395; THR-435; GLN-448; GLN-690 AND LEU-1150.
  9. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiWDR11_HUMAN
AccessioniPrimary (citable) accession number: Q9BZH6
Secondary accession number(s): Q5VWA1, Q9P2J6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: June 1, 2001
Last modified: November 26, 2014
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3