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Q9BZG9

- LYNX1_HUMAN

UniProt

Q9BZG9 - LYNX1_HUMAN

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Protein

Ly-6/neurotoxin-like protein 1

Gene
LYNX1, SLURP2
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Acts in different tissues through interaction to nicotinic acetylcholine receptors (nAChRs). In brain, isoform 2 modulates functional properties of nAChRs to prevent excessive excitation, and hence neurodegeneration. Enhances desensitization by increasing both the rate and extent of desensitization of alpha4beta2 nAChRs and slowing recovery from desensitization. Promotes large amplitude ACh-evoked currents through alpha4beta2 nAChRs By similarity. Prevents plasticity in the primary visual cortex late in life By similarity. In keratinocytes, isoform 3 delays differentiation and prevents apoptosis.1 Publication

Protein family/group databases

TCDBi8.A.31.1.1. the ly-6 neurotoxin-like protein1 precursor (lynx1) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Ly-6/neurotoxin-like protein 1
Alternative name(s):
Secreted Ly-6/uPAR domain-containing protein 2
Secreted Ly-6/uPAR-related protein 2
Short name:
SLURP-2
Gene namesi
Name:LYNX1
Synonyms:SLURP2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 8

Organism-specific databases

HGNCiHGNC:29604. LYNX1.

Subcellular locationi

Isoform 1 : Secreted Reviewed prediction 1 Publication
Isoform 2 : Cell membrane; Lipid-anchorGPI-anchor Reviewed prediction. Cell projectiondendrite By similarity
Note: Detected in Purkinje cells soma and proximal dendrites By similarity.1 Publication
Isoform 3 : Secreted 1 Publication

GO - Cellular componenti

  1. anchored component of membrane Source: UniProtKB-KW
  2. dendrite Source: UniProtKB-SubCell
  3. extracellular vesicular exosome Source: UniProt
  4. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cell projection, Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134874147.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020 Reviewed predictionAdd
BLAST
Chaini21 – 131111Ly-6/neurotoxin-like protein 1PRO_0000036154Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi59 ↔ 81 Reviewed prediction
Disulfide bondi62 ↔ 68 Reviewed prediction
Disulfide bondi74 ↔ 102 Reviewed prediction
Disulfide bondi106 ↔ 122 Reviewed prediction
Disulfide bondi123 ↔ 128 Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

MaxQBiQ9BZG9.
PaxDbiQ9BZG9.
PeptideAtlasiQ9BZG9.
PRIDEiQ9BZG9.

Expressioni

Tissue specificityi

Isoform 3 is expressed at highest levels in cervix and esophagus, followed by adult and fetal skin. Expressed at lower levels in brain, lung, stomach, small intestine, colon, rectum, uterus, and thymus. Not detected in spleen nor bone marrow. In the epidermis, predominantly produced by keratinocytes of the suprabasal epidermal compartment (at protein level). In attached gingiva, produced at highest levels by basal cells located in the lowermost epithelial layers (at protein level). Up-regulated 3-fold in psoriatic lesional skin. Detected in serum (at protein level).2 Publications

Gene expression databases

ArrayExpressiQ9BZG9.
BgeeiQ9BZG9.
CleanExiHS_LYNX1.
GenevestigatoriQ9BZG9.

Organism-specific databases

HPAiHPA023711.

Interactioni

Subunit structurei

Isoform 2 interacts with nAChRs, including alpha4beta2 (CHRNA4/CHRNB2) and alpha7 (CHRNA7) By similarity. Competes with alpha-bungarotoxin for nAChR alpha7 binding. Isoform 3 may interact with heteropentameric nAChRs expressed by keratinocytes.1 Publication

Protein-protein interaction databases

BioGridi122450. 2 interactions.
STRINGi9606.ENSP00000337950.

Structurei

Secondary structure

1
131
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi22 – 243
Beta strandi26 – 316
Beta strandi36 – 383
Beta strandi45 – 517
Beta strandi82 – 843
Beta strandi87 – 893
Beta strandi98 – 1047
Beta strandi113 – 1153
Beta strandi118 – 1236
Turni126 – 1294

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1VYEmodel-A1-80[»]
2L03NMR-A21-129[»]
ProteinModelPortaliQ9BZG9.
SMRiQ9BZG9. Positions 21-47.

Miscellaneous databases

EvolutionaryTraceiQ9BZG9.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini59 – 12971UPAR/Ly6Add
BLAST

Sequence similaritiesi

Contains 1 UPAR/Ly6 domain.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG45102.
HOGENOMiHOG000035114.
HOVERGENiHBG052377.
OMAiPYRMKVS.
PhylomeDBiQ9BZG9.

Family and domain databases

InterProiIPR001526. LY6_UPAR.
[Graphical view]
PfamiPF00021. UPAR_LY6. 2 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9BZG9-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MTPLLTLILV VLMGLPLAQA LDCHVCAYNG DNCFNPMRCP AMVAYCMTTR    50
TSAAEAIWCH QCTGFGGCSH GSRCLRDSTH CVTTATRVLS NTEDLPLVTK 100
MCHIGCPDIP SLGLGPYVSI ACCQTSLCNH D 131
Length:131
Mass (Da):14,026
Last modified:October 3, 2012 - v3
Checksum:iFAD1259D48A036D7
GO
Isoform 2 (identifier: Q9BZG9-2) [UniParc]FASTAAdd to Basket

Also known as: LYNX1

The sequence of this isoform differs from the canonical sequence as follows:
     52-131: SAAEAIWCHQ...CCQTSLCNHD → YYTPTRMKVS...ILLATLWGLL

Note: Contains a potential GPI-anchor site at Gly-93. The propeptide 94-116 may be cleaved out upon GPI-anchor attachment (Potential).

Show »
Length:116
Mass (Da):12,641
Checksum:iBF5827EB64BFE6F6
GO
Isoform 3 (identifier: Q9BZG9-3) [UniParc]FASTAAdd to Basket

Also known as: SLURP-2

The sequence of this isoform differs from the canonical sequence as follows:
     2-52: TPLLTLILVVLMGLPLAQALDCHVCAYNGDNCFNPMRCPAMVAYCMTTRTS → QLGTGLLLAAVLSLQLA

Show »
Length:97
Mass (Da):10,160
Checksum:i81719A103EC3001A
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei2 – 5251TPLLT…TTRTS → QLGTGLLLAAVLSLQLA in isoform 3. VSP_044157Add
BLAST
Alternative sequencei52 – 13180SAAEA…LCNHD → YYTPTRMKVSKSCVPRCFET VYDGYSKHASTTSCCQYDLC NGTGLATPATLALAPILLAT LWGLL in isoform 2. VSP_044158Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB081838 mRNA. Translation: BAC56859.1.
AY587277 mRNA. Translation: AAT00512.1.
AY358417 mRNA. Translation: AAQ88783.1.
AC083841 Genomic DNA. No translation available.
CH471162 Genomic DNA. Translation: EAW82299.1.
CH471162 Genomic DNA. Translation: EAW82301.1.
CH471162 Genomic DNA. Translation: EAW82302.1.
CH471162 Genomic DNA. Translation: EAW82303.1.
CH471162 Genomic DNA. Translation: EAW82304.1.
CH471162 Genomic DNA. Translation: EAW82306.1.
BC032306 mRNA. No translation available.
BQ685632 mRNA. No translation available.
AF321824 mRNA. Translation: AAK01642.1.
CCDSiCCDS34951.1. [Q9BZG9-1]
CCDS34952.1. [Q9BZG9-3]
CCDS6389.1. [Q9BZG9-2]
RefSeqiNP_076435.1. NM_023946.2. [Q9BZG9-1]
NP_803252.1. NM_177457.3. [Q9BZG9-2]
NP_803253.1. NM_177458.1. [Q9BZG9-3]
NP_803429.1. NM_177476.2. [Q9BZG9-2]
NP_803430.1. NM_177477.2. [Q9BZG9-2]
UniGeneiHs.158665.
Hs.604828.

Genome annotation databases

EnsembliENST00000317543; ENSP00000319846; ENSG00000180155. [Q9BZG9-3]
ENST00000335822; ENSP00000337950; ENSG00000180155. [Q9BZG9-1]
ENST00000345173; ENSP00000332495; ENSG00000180155. [Q9BZG9-2]
ENST00000395192; ENSP00000378618; ENSG00000180155. [Q9BZG9-2]
ENST00000398906; ENSP00000381878; ENSG00000180155. [Q9BZG9-2]
GeneIDi66004.
KEGGihsa:66004.
UCSCiuc003yxa.3. human. [Q9BZG9-3]
uc003yxb.3. human. [Q9BZG9-1]
uc003yxc.1. human. [Q9BZG9-2]

Polymorphism databases

DMDMi408360254.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB081838 mRNA. Translation: BAC56859.1 .
AY587277 mRNA. Translation: AAT00512.1 .
AY358417 mRNA. Translation: AAQ88783.1 .
AC083841 Genomic DNA. No translation available.
CH471162 Genomic DNA. Translation: EAW82299.1 .
CH471162 Genomic DNA. Translation: EAW82301.1 .
CH471162 Genomic DNA. Translation: EAW82302.1 .
CH471162 Genomic DNA. Translation: EAW82303.1 .
CH471162 Genomic DNA. Translation: EAW82304.1 .
CH471162 Genomic DNA. Translation: EAW82306.1 .
BC032306 mRNA. No translation available.
BQ685632 mRNA. No translation available.
AF321824 mRNA. Translation: AAK01642.1 .
CCDSi CCDS34951.1. [Q9BZG9-1 ]
CCDS34952.1. [Q9BZG9-3 ]
CCDS6389.1. [Q9BZG9-2 ]
RefSeqi NP_076435.1. NM_023946.2. [Q9BZG9-1 ]
NP_803252.1. NM_177457.3. [Q9BZG9-2 ]
NP_803253.1. NM_177458.1. [Q9BZG9-3 ]
NP_803429.1. NM_177476.2. [Q9BZG9-2 ]
NP_803430.1. NM_177477.2. [Q9BZG9-2 ]
UniGenei Hs.158665.
Hs.604828.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1VYE model - A 1-80 [» ]
2L03 NMR - A 21-129 [» ]
ProteinModelPortali Q9BZG9.
SMRi Q9BZG9. Positions 21-47.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 122450. 2 interactions.
STRINGi 9606.ENSP00000337950.

Protein family/group databases

TCDBi 8.A.31.1.1. the ly-6 neurotoxin-like protein1 precursor (lynx1) family.

Polymorphism databases

DMDMi 408360254.

Proteomic databases

MaxQBi Q9BZG9.
PaxDbi Q9BZG9.
PeptideAtlasi Q9BZG9.
PRIDEi Q9BZG9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000317543 ; ENSP00000319846 ; ENSG00000180155 . [Q9BZG9-3 ]
ENST00000335822 ; ENSP00000337950 ; ENSG00000180155 . [Q9BZG9-1 ]
ENST00000345173 ; ENSP00000332495 ; ENSG00000180155 . [Q9BZG9-2 ]
ENST00000395192 ; ENSP00000378618 ; ENSG00000180155 . [Q9BZG9-2 ]
ENST00000398906 ; ENSP00000381878 ; ENSG00000180155 . [Q9BZG9-2 ]
GeneIDi 66004.
KEGGi hsa:66004.
UCSCi uc003yxa.3. human. [Q9BZG9-3 ]
uc003yxb.3. human. [Q9BZG9-1 ]
uc003yxc.1. human. [Q9BZG9-2 ]

Organism-specific databases

CTDi 66004.
GeneCardsi GC08M143844.
HGNCi HGNC:29604. LYNX1.
HPAi HPA023711.
MIMi 606110. gene.
neXtProti NX_Q9BZG9.
PharmGKBi PA134874147.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG45102.
HOGENOMi HOG000035114.
HOVERGENi HBG052377.
OMAi PYRMKVS.
PhylomeDBi Q9BZG9.

Miscellaneous databases

EvolutionaryTracei Q9BZG9.
GeneWikii LYNX1.
GenomeRNAii 66004.
NextBioi 67514.
PROi Q9BZG9.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9BZG9.
Bgeei Q9BZG9.
CleanExi HS_LYNX1.
Genevestigatori Q9BZG9.

Family and domain databases

InterProi IPR001526. LY6_UPAR.
[Graphical view ]
Pfami PF00021. UPAR_LY6. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "SLURP-2, a novel member of the human Ly-6 superfamily that is up-regulated in psoriasis vulgaris."
    Tsuji H., Okamoto K., Matsuzaka Y., Iizuka H., Tamiya G., Inoko H.
    Genomics 81:26-33(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), TISSUE SPECIFICITY.
    Tissue: Skin.
  2. "SLURP-2: a novel cholinergic signaling peptide in human mucocutaneous epithelium."
    Arredondo J., Chernyavsky A.I., Jolkovsky D.L., Webber R.J., Grando S.A.
    J. Cell. Physiol. 208:238-245(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), FUNCTION, INTERACTION WITH HETEROPENTAMERIC NACHRS, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
  4. "DNA sequence and analysis of human chromosome 8."
    Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T.
    , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
    Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. The MGC Project Team
    Submitted (AUG-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Pancreas.
  7. Southan C., Simms M., Narjis S.
    Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-80 (ISOFORM 2).
  8. Cited for: STRUCTURE BY NMR OF 21-93 (ISOFORM 2).

Entry informationi

Entry nameiLYNX1_HUMAN
AccessioniPrimary (citable) accession number: Q9BZG9
Secondary accession number(s): D3DWI7, G3XAC2, Q86SR0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: October 3, 2012
Last modified: September 3, 2014
This is version 101 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Isoform 2 is considered to be an endogenous "prototoxin", that shares a N-terminal three-finger structure with snake alpha-neurotoxins.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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