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Q9BZG2

- PPAT_HUMAN

UniProt

Q9BZG2 - PPAT_HUMAN

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Protein
Testicular acid phosphatase
Gene
ACPT
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Dephosphorylates receptor tyrosine-protein kinase erbB-4 and inhibits the ligand-induced proteolytic cleavage.1 Publication

Catalytic activityi

A phosphate monoester + H2O = an alcohol + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei41 – 411Nucleophile By similarity
Active sitei289 – 2891Proton donor By similarity

GO - Molecular functioni

  1. acid phosphatase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Hydrolase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Testicular acid phosphatase (EC:3.1.3.2)
    Gene namesi
    Name:ACPT
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:14376. ACPT.

    Subcellular locationi

    Topology

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini27 – 393367Extracellular Reviewed prediction
    Add
    BLAST
    Transmembranei394 – 41421Helical; Reviewed prediction
    Add
    BLAST
    Topological domaini415 – 42612Cytoplasmic Reviewed prediction
    Add
    BLAST

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    Complete GO annotation...

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA24450.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2626 Reviewed prediction
    Add
    BLAST
    Chaini27 – 426400Testicular acid phosphatase
    PRO_0000259643Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi159 ↔ 378 By similarity
    Glycosylationi191 – 1911N-linked (GlcNAc...) Reviewed prediction
    Disulfide bondi214 ↔ 312 By similarity
    Glycosylationi269 – 2691N-linked (GlcNAc...) Reviewed prediction
    Glycosylationi330 – 3301N-linked (GlcNAc...) Reviewed prediction
    Glycosylationi339 – 3391N-linked (GlcNAc...) Reviewed prediction
    Disulfide bondi353 ↔ 357 By similarity

    Post-translational modificationi

    Glycosylated Inferred.1 Publication

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ9BZG2.
    PRIDEiQ9BZG2.

    PTM databases

    PhosphoSiteiQ9BZG2.

    Expressioni

    Tissue specificityi

    Expressed mainly in the testis. Also expressed in the brain where they are enriched at the postsynaptic sites. Expressed at lower levels in the trachea, prostate, bone marrow, spinal cord, colon, fetal brain, heart, thymus, fetal liver, spleen, leukocytes, ovary, small intestine, pancreas and skeletal muscle. Expression is significantly lower in testicular cancer tissues than in normal testicular tissues. Isoform 3 is expressed in the testis, trachea, prostate and bone marrow.1 Publication

    Inductioni

    Up-regulated by mibolerone (a synthetic androgen) and dihydrotestosterone (DHT) and is down-regulated by estrogen and progestin.1 Publication

    Gene expression databases

    BgeeiQ9BZG2.
    CleanExiHS_ACPT.
    GenevestigatoriQ9BZG2.

    Interactioni

    Subunit structurei

    Homodimer Inferred.1 Publication

    Protein-protein interaction databases

    STRINGi9606.ENSP00000270593.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9BZG2.
    SMRiQ9BZG2. Positions 32-378.

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG85977.
    HOGENOMiHOG000231439.
    HOVERGENiHBG002203.
    InParanoidiQ9BZG2.
    KOiK14410.
    OMAiISLFYRN.
    OrthoDBiEOG7GXPBJ.
    PhylomeDBiQ9BZG2.
    TreeFamiTF312893.

    Family and domain databases

    Gene3Di3.40.50.1240. 1 hit.
    InterProiIPR000560. His_Pase_superF_clade-2.
    IPR029033. His_PPase_superfam.
    [Graphical view]
    PfamiPF00328. His_Phos_2. 1 hit.
    [Graphical view]
    SUPFAMiSSF53254. SSF53254. 1 hit.
    PROSITEiPS00616. HIS_ACID_PHOSPHAT_1. 1 hit.
    PS00778. HIS_ACID_PHOSPHAT_2. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9BZG2-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAGLGFWGHP AGPLLLLLLL VLPPRALPEG PLVFVALVFR HGDRAPLASY    50
    PMDPHKEVAS TLWPRGLGQL TTEGVRQQLE LGRFLRSRYE AFLSPEYRRE 100
    EVYIRSTDFD RTLESAQANL AGLFPEAAPG SPEARWRPIP VHTVPVAEDK 150
    LLRFPMRSCP RYHELLREAT EAAEYQEALE GWTGFLSRLE NFTGLSLVGE 200
    PLRRAWKVLD TLMCQQAHGL PLPAWASPDV LRTLAQISAL DIGAHVGPPR 250
    AAEKAQLTGG ILLNAILANF SRVQRLGLPL KMVMYSAHDS TLLALQGALG 300
    LYDGHTPPYA ACLGFEFRKH LGNPAKDGGN VTVSLFYRND SAHLPLPLSL 350
    PGCPAPCPLG RFYQLTAPAR PPAHGVSCHG PYEAAIPPAP VVPLLAGAVA 400
    VLVALSLGLG LLAWRPGCLR ALGGPV 426
    Length:426
    Mass (Da):46,090
    Last modified:June 1, 2001 - v1
    Checksum:iBE930398041DB061
    GO
    Isoform 2 (identifier: Q9BZG2-2) [UniParc]FASTAAdd to Basket

    Also known as: Variant 3

    The sequence of this isoform differs from the canonical sequence as follows:
         91-183: Missing.

    Show »
    Length:333
    Mass (Da):35,403
    Checksum:i0C0237096567B30F
    GO
    Isoform 3 (identifier: Q9BZG2-3) [UniParc]FASTAAdd to Basket

    Also known as: Truncated variant 1, Truncated variant 2

    The sequence of this isoform differs from the canonical sequence as follows:
         39-92: FRHGDRAPLA...RFLRSRYEAF → RRPHPGLPLA...PPCGHEAWAS
         93-426: Missing.

    Show »
    Length:92
    Mass (Da):9,912
    Checksum:iDF4B45C6D2009A31
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei39 – 9254FRHGD…RYEAF → RRPHPGLPLAPPGLALTSPV PRYSAMATGPRWPPTPWTHT RRWPPPCGHEAWAS in isoform 3.
    VSP_021493Add
    BLAST
    Alternative sequencei91 – 18393Missing in isoform 2.
    VSP_021494Add
    BLAST
    Alternative sequencei93 – 426334Missing in isoform 3.
    VSP_021495Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF321918 Genomic DNA. Translation: AAK09393.1.
    AF321918 Genomic DNA. Translation: AAK09394.1.
    AF321918 Genomic DNA. Translation: AAK09395.1.
    AF321918 Genomic DNA. Translation: AAK09396.1.
    CCDSiCCDS12802.1. [Q9BZG2-1]
    RefSeqiNP_149059.1. NM_033068.2. [Q9BZG2-1]
    UniGeneiHs.293394.

    Genome annotation databases

    EnsembliENST00000270593; ENSP00000270593; ENSG00000142513. [Q9BZG2-1]
    ENST00000270594; ENSP00000270594; ENSG00000142513. [Q9BZG2-2]
    GeneIDi93650.
    KEGGihsa:93650.
    UCSCiuc002pta.1. human. [Q9BZG2-1]

    Polymorphism databases

    DMDMi74717749.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF321918 Genomic DNA. Translation: AAK09393.1 .
    AF321918 Genomic DNA. Translation: AAK09394.1 .
    AF321918 Genomic DNA. Translation: AAK09395.1 .
    AF321918 Genomic DNA. Translation: AAK09396.1 .
    CCDSi CCDS12802.1. [Q9BZG2-1 ]
    RefSeqi NP_149059.1. NM_033068.2. [Q9BZG2-1 ]
    UniGenei Hs.293394.

    3D structure databases

    ProteinModelPortali Q9BZG2.
    SMRi Q9BZG2. Positions 32-378.
    ModBasei Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000270593.

    PTM databases

    PhosphoSitei Q9BZG2.

    Polymorphism databases

    DMDMi 74717749.

    Proteomic databases

    PaxDbi Q9BZG2.
    PRIDEi Q9BZG2.

    Protocols and materials databases

    DNASUi 93650.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000270593 ; ENSP00000270593 ; ENSG00000142513 . [Q9BZG2-1 ]
    ENST00000270594 ; ENSP00000270594 ; ENSG00000142513 . [Q9BZG2-2 ]
    GeneIDi 93650.
    KEGGi hsa:93650.
    UCSCi uc002pta.1. human. [Q9BZG2-1 ]

    Organism-specific databases

    CTDi 93650.
    GeneCardsi GC19P051293.
    HGNCi HGNC:14376. ACPT.
    MIMi 606362. gene.
    neXtProti NX_Q9BZG2.
    PharmGKBi PA24450.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG85977.
    HOGENOMi HOG000231439.
    HOVERGENi HBG002203.
    InParanoidi Q9BZG2.
    KOi K14410.
    OMAi ISLFYRN.
    OrthoDBi EOG7GXPBJ.
    PhylomeDBi Q9BZG2.
    TreeFami TF312893.

    Miscellaneous databases

    GenomeRNAii 93650.
    NextBioi 78184.
    PROi Q9BZG2.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9BZG2.
    CleanExi HS_ACPT.
    Genevestigatori Q9BZG2.

    Family and domain databases

    Gene3Di 3.40.50.1240. 1 hit.
    InterProi IPR000560. His_Pase_superF_clade-2.
    IPR029033. His_PPase_superfam.
    [Graphical view ]
    Pfami PF00328. His_Phos_2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53254. SSF53254. 1 hit.
    PROSITEi PS00616. HIS_ACID_PHOSPHAT_1. 1 hit.
    PS00778. HIS_ACID_PHOSPHAT_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of a novel human acid phosphatase gene (ACPT) that is highly expressed in the testis."
      Yousef G.M., Diamandis M., Jung K., Diamandis E.P.
      Genomics 74:385-395(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS 1; 2 AND 3), INDUCTION, TISSUE SPECIFICITY.
    2. "Regulation of ErbB4 phosphorylation and cleavage by a novel histidine acid phosphatase."
      Fleisig H., El-Din El-Husseini A., Vincent S.R.
      Neuroscience 127:91-100(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBUNIT, GLYCOSYLATION.
      Tissue: Testis.

    Entry informationi

    Entry nameiPPAT_HUMAN
    AccessioniPrimary (citable) accession number: Q9BZG2
    Secondary accession number(s): C0H3P7, Q9BZG3, Q9BZG4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 31, 2006
    Last sequence update: June 1, 2001
    Last modified: July 9, 2014
    This is version 87 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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