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Q9BZG2 (PPAT_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 87. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Testicular acid phosphatase

EC=3.1.3.2
Gene names
Name:ACPT
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length426 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Dephosphorylates receptor tyrosine-protein kinase erbB-4 and inhibits the ligand-induced proteolytic cleavage. Ref.2

Catalytic activity

A phosphate monoester + H2O = an alcohol + phosphate.

Subunit structure

Homodimer Probable. Ref.2

Subcellular location

Membrane; Single-pass type I membrane protein Potential.

Tissue specificity

Expressed mainly in the testis. Also expressed in the brain where they are enriched at the postsynaptic sites. Expressed at lower levels in the trachea, prostate, bone marrow, spinal cord, colon, fetal brain, heart, thymus, fetal liver, spleen, leukocytes, ovary, small intestine, pancreas and skeletal muscle. Expression is significantly lower in testicular cancer tissues than in normal testicular tissues. Isoform 3 is expressed in the testis, trachea, prostate and bone marrow. Ref.1

Induction

Up-regulated by mibolerone (a synthetic androgen) and dihydrotestosterone (DHT) and is down-regulated by estrogen and progestin. Ref.1

Post-translational modification

Glycosylated Probable. Ref.2

Sequence similarities

Belongs to the histidine acid phosphatase family.

Ontologies

Keywords
   Cellular componentMembrane
   Coding sequence diversityAlternative splicing
   DomainSignal
Transmembrane
Transmembrane helix
   Molecular functionHydrolase
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionacid phosphatase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9BZG2-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9BZG2-2)

Also known as: Variant 3;

The sequence of this isoform differs from the canonical sequence as follows:
     91-183: Missing.
Isoform 3 (identifier: Q9BZG2-3)

Also known as: Truncated variant 1; Truncated variant 2;

The sequence of this isoform differs from the canonical sequence as follows:
     39-92: FRHGDRAPLA...RFLRSRYEAF → RRPHPGLPLA...PPCGHEAWAS
     93-426: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2626 Potential
Chain27 – 426400Testicular acid phosphatase
PRO_0000259643

Regions

Topological domain27 – 393367Extracellular Potential
Transmembrane394 – 41421Helical; Potential
Topological domain415 – 42612Cytoplasmic Potential

Sites

Active site411Nucleophile By similarity
Active site2891Proton donor By similarity

Amino acid modifications

Glycosylation1911N-linked (GlcNAc...) Potential
Glycosylation2691N-linked (GlcNAc...) Potential
Glycosylation3301N-linked (GlcNAc...) Potential
Glycosylation3391N-linked (GlcNAc...) Potential
Disulfide bond159 ↔ 378 By similarity
Disulfide bond214 ↔ 312 By similarity
Disulfide bond353 ↔ 357 By similarity

Natural variations

Alternative sequence39 – 9254FRHGD…RYEAF → RRPHPGLPLAPPGLALTSPV PRYSAMATGPRWPPTPWTHT RRWPPPCGHEAWAS in isoform 3.
VSP_021493
Alternative sequence91 – 18393Missing in isoform 2.
VSP_021494
Alternative sequence93 – 426334Missing in isoform 3.
VSP_021495

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: BE930398041DB061

FASTA42646,090
        10         20         30         40         50         60 
MAGLGFWGHP AGPLLLLLLL VLPPRALPEG PLVFVALVFR HGDRAPLASY PMDPHKEVAS 

        70         80         90        100        110        120 
TLWPRGLGQL TTEGVRQQLE LGRFLRSRYE AFLSPEYRRE EVYIRSTDFD RTLESAQANL 

       130        140        150        160        170        180 
AGLFPEAAPG SPEARWRPIP VHTVPVAEDK LLRFPMRSCP RYHELLREAT EAAEYQEALE 

       190        200        210        220        230        240 
GWTGFLSRLE NFTGLSLVGE PLRRAWKVLD TLMCQQAHGL PLPAWASPDV LRTLAQISAL 

       250        260        270        280        290        300 
DIGAHVGPPR AAEKAQLTGG ILLNAILANF SRVQRLGLPL KMVMYSAHDS TLLALQGALG 

       310        320        330        340        350        360 
LYDGHTPPYA ACLGFEFRKH LGNPAKDGGN VTVSLFYRND SAHLPLPLSL PGCPAPCPLG 

       370        380        390        400        410        420 
RFYQLTAPAR PPAHGVSCHG PYEAAIPPAP VVPLLAGAVA VLVALSLGLG LLAWRPGCLR 


ALGGPV 

« Hide

Isoform 2 (Variant 3) [UniParc].

Checksum: 0C0237096567B30F
Show »

FASTA33335,403
Isoform 3 (Truncated variant 1) (Truncated variant 2) [UniParc].

Checksum: DF4B45C6D2009A31
Show »

FASTA929,912

References

[1]"Molecular cloning of a novel human acid phosphatase gene (ACPT) that is highly expressed in the testis."
Yousef G.M., Diamandis M., Jung K., Diamandis E.P.
Genomics 74:385-395(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS 1; 2 AND 3), INDUCTION, TISSUE SPECIFICITY.
[2]"Regulation of ErbB4 phosphorylation and cleavage by a novel histidine acid phosphatase."
Fleisig H., El-Din El-Husseini A., Vincent S.R.
Neuroscience 127:91-100(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBUNIT, GLYCOSYLATION.
Tissue: Testis.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF321918 Genomic DNA. Translation: AAK09393.1.
AF321918 Genomic DNA. Translation: AAK09394.1.
AF321918 Genomic DNA. Translation: AAK09395.1.
AF321918 Genomic DNA. Translation: AAK09396.1.
CCDSCCDS12802.1. [Q9BZG2-1]
RefSeqNP_149059.1. NM_033068.2. [Q9BZG2-1]
UniGeneHs.293394.

3D structure databases

ProteinModelPortalQ9BZG2.
SMRQ9BZG2. Positions 32-378.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000270593.

PTM databases

PhosphoSiteQ9BZG2.

Polymorphism databases

DMDM74717749.

Proteomic databases

PaxDbQ9BZG2.
PRIDEQ9BZG2.

Protocols and materials databases

DNASU93650.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000270593; ENSP00000270593; ENSG00000142513. [Q9BZG2-1]
ENST00000270594; ENSP00000270594; ENSG00000142513. [Q9BZG2-2]
GeneID93650.
KEGGhsa:93650.
UCSCuc002pta.1. human. [Q9BZG2-1]

Organism-specific databases

CTD93650.
GeneCardsGC19P051293.
HGNCHGNC:14376. ACPT.
MIM606362. gene.
neXtProtNX_Q9BZG2.
PharmGKBPA24450.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG85977.
HOGENOMHOG000231439.
HOVERGENHBG002203.
InParanoidQ9BZG2.
KOK14410.
OMAISLFYRN.
OrthoDBEOG7GXPBJ.
PhylomeDBQ9BZG2.
TreeFamTF312893.

Gene expression databases

BgeeQ9BZG2.
CleanExHS_ACPT.
GenevestigatorQ9BZG2.

Family and domain databases

Gene3D3.40.50.1240. 1 hit.
InterProIPR000560. His_Pase_superF_clade-2.
IPR029033. His_PPase_superfam.
[Graphical view]
PfamPF00328. His_Phos_2. 1 hit.
[Graphical view]
SUPFAMSSF53254. SSF53254. 1 hit.
PROSITEPS00616. HIS_ACID_PHOSPHAT_1. 1 hit.
PS00778. HIS_ACID_PHOSPHAT_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi93650.
NextBio78184.
PROQ9BZG2.
SOURCESearch...

Entry information

Entry namePPAT_HUMAN
AccessionPrimary (citable) accession number: Q9BZG2
Secondary accession number(s): C0H3P7, Q9BZG3, Q9BZG4
Entry history
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: June 1, 2001
Last modified: July 9, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM