Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q9BZG2

- PPAT_HUMAN

UniProt

Q9BZG2 - PPAT_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Testicular acid phosphatase

Gene

ACPT

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Dephosphorylates receptor tyrosine-protein kinase erbB-4 and inhibits the ligand-induced proteolytic cleavage.1 Publication

Catalytic activityi

A phosphate monoester + H2O = an alcohol + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei41 – 411NucleophileBy similarity
Active sitei289 – 2891Proton donorBy similarity

GO - Molecular functioni

  1. acid phosphatase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Names & Taxonomyi

Protein namesi
Recommended name:
Testicular acid phosphatase (EC:3.1.3.2)
Gene namesi
Name:ACPT
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:14376. ACPT.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini27 – 393367ExtracellularSequence AnalysisAdd
BLAST
Transmembranei394 – 41421HelicalSequence AnalysisAdd
BLAST
Topological domaini415 – 42612CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA24450.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626Sequence AnalysisAdd
BLAST
Chaini27 – 426400Testicular acid phosphatasePRO_0000259643Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi159 ↔ 378By similarity
Glycosylationi191 – 1911N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi214 ↔ 312By similarity
Glycosylationi269 – 2691N-linked (GlcNAc...)Sequence Analysis
Glycosylationi330 – 3301N-linked (GlcNAc...)Sequence Analysis
Glycosylationi339 – 3391N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi353 ↔ 357By similarity

Post-translational modificationi

Glycosylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9BZG2.
PRIDEiQ9BZG2.

PTM databases

PhosphoSiteiQ9BZG2.

Expressioni

Tissue specificityi

Expressed mainly in the testis. Also expressed in the brain where they are enriched at the postsynaptic sites. Expressed at lower levels in the trachea, prostate, bone marrow, spinal cord, colon, fetal brain, heart, thymus, fetal liver, spleen, leukocytes, ovary, small intestine, pancreas and skeletal muscle. Expression is significantly lower in testicular cancer tissues than in normal testicular tissues. Isoform 3 is expressed in the testis, trachea, prostate and bone marrow.1 Publication

Inductioni

Up-regulated by mibolerone (a synthetic androgen) and dihydrotestosterone (DHT) and is down-regulated by estrogen and progestin.1 Publication

Gene expression databases

BgeeiQ9BZG2.
CleanExiHS_ACPT.
GenevestigatoriQ9BZG2.

Interactioni

Subunit structurei

Homodimer.1 Publication

Protein-protein interaction databases

STRINGi9606.ENSP00000270593.

Structurei

3D structure databases

ProteinModelPortaliQ9BZG2.
SMRiQ9BZG2. Positions 32-378.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histidine acid phosphatase family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG85977.
GeneTreeiENSGT00530000062956.
HOGENOMiHOG000231439.
HOVERGENiHBG002203.
InParanoidiQ9BZG2.
KOiK14410.
OMAiISLFYRN.
OrthoDBiEOG7GXPBJ.
PhylomeDBiQ9BZG2.
TreeFamiTF312893.

Family and domain databases

Gene3Di3.40.50.1240. 1 hit.
InterProiIPR000560. His_Pase_superF_clade-2.
IPR029033. His_PPase_superfam.
[Graphical view]
PfamiPF00328. His_Phos_2. 1 hit.
[Graphical view]
SUPFAMiSSF53254. SSF53254. 1 hit.
PROSITEiPS00616. HIS_ACID_PHOSPHAT_1. 1 hit.
PS00778. HIS_ACID_PHOSPHAT_2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9BZG2-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAGLGFWGHP AGPLLLLLLL VLPPRALPEG PLVFVALVFR HGDRAPLASY
60 70 80 90 100
PMDPHKEVAS TLWPRGLGQL TTEGVRQQLE LGRFLRSRYE AFLSPEYRRE
110 120 130 140 150
EVYIRSTDFD RTLESAQANL AGLFPEAAPG SPEARWRPIP VHTVPVAEDK
160 170 180 190 200
LLRFPMRSCP RYHELLREAT EAAEYQEALE GWTGFLSRLE NFTGLSLVGE
210 220 230 240 250
PLRRAWKVLD TLMCQQAHGL PLPAWASPDV LRTLAQISAL DIGAHVGPPR
260 270 280 290 300
AAEKAQLTGG ILLNAILANF SRVQRLGLPL KMVMYSAHDS TLLALQGALG
310 320 330 340 350
LYDGHTPPYA ACLGFEFRKH LGNPAKDGGN VTVSLFYRND SAHLPLPLSL
360 370 380 390 400
PGCPAPCPLG RFYQLTAPAR PPAHGVSCHG PYEAAIPPAP VVPLLAGAVA
410 420
VLVALSLGLG LLAWRPGCLR ALGGPV
Length:426
Mass (Da):46,090
Last modified:June 1, 2001 - v1
Checksum:iBE930398041DB061
GO
Isoform 2 (identifier: Q9BZG2-2) [UniParc]FASTAAdd to Basket

Also known as: Variant 3

The sequence of this isoform differs from the canonical sequence as follows:
     91-183: Missing.

Show »
Length:333
Mass (Da):35,403
Checksum:i0C0237096567B30F
GO
Isoform 3 (identifier: Q9BZG2-3) [UniParc]FASTAAdd to Basket

Also known as: Truncated variant 1, Truncated variant 2

The sequence of this isoform differs from the canonical sequence as follows:
     39-92: FRHGDRAPLA...RFLRSRYEAF → RRPHPGLPLA...PPCGHEAWAS
     93-426: Missing.

Show »
Length:92
Mass (Da):9,912
Checksum:iDF4B45C6D2009A31
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei39 – 9254FRHGD…RYEAF → RRPHPGLPLAPPGLALTSPV PRYSAMATGPRWPPTPWTHT RRWPPPCGHEAWAS in isoform 3. CuratedVSP_021493Add
BLAST
Alternative sequencei91 – 18393Missing in isoform 2. CuratedVSP_021494Add
BLAST
Alternative sequencei93 – 426334Missing in isoform 3. CuratedVSP_021495Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF321918 Genomic DNA. Translation: AAK09393.1.
AF321918 Genomic DNA. Translation: AAK09394.1.
AF321918 Genomic DNA. Translation: AAK09395.1.
AF321918 Genomic DNA. Translation: AAK09396.1.
CCDSiCCDS12802.1. [Q9BZG2-1]
RefSeqiNP_149059.1. NM_033068.2. [Q9BZG2-1]
UniGeneiHs.293394.

Genome annotation databases

EnsembliENST00000270593; ENSP00000270593; ENSG00000142513. [Q9BZG2-1]
GeneIDi93650.
KEGGihsa:93650.
UCSCiuc002pta.1. human. [Q9BZG2-1]

Polymorphism databases

DMDMi74717749.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF321918 Genomic DNA. Translation: AAK09393.1 .
AF321918 Genomic DNA. Translation: AAK09394.1 .
AF321918 Genomic DNA. Translation: AAK09395.1 .
AF321918 Genomic DNA. Translation: AAK09396.1 .
CCDSi CCDS12802.1. [Q9BZG2-1 ]
RefSeqi NP_149059.1. NM_033068.2. [Q9BZG2-1 ]
UniGenei Hs.293394.

3D structure databases

ProteinModelPortali Q9BZG2.
SMRi Q9BZG2. Positions 32-378.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000270593.

PTM databases

PhosphoSitei Q9BZG2.

Polymorphism databases

DMDMi 74717749.

Proteomic databases

PaxDbi Q9BZG2.
PRIDEi Q9BZG2.

Protocols and materials databases

DNASUi 93650.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000270593 ; ENSP00000270593 ; ENSG00000142513 . [Q9BZG2-1 ]
GeneIDi 93650.
KEGGi hsa:93650.
UCSCi uc002pta.1. human. [Q9BZG2-1 ]

Organism-specific databases

CTDi 93650.
GeneCardsi GC19P051293.
HGNCi HGNC:14376. ACPT.
MIMi 606362. gene.
neXtProti NX_Q9BZG2.
PharmGKBi PA24450.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG85977.
GeneTreei ENSGT00530000062956.
HOGENOMi HOG000231439.
HOVERGENi HBG002203.
InParanoidi Q9BZG2.
KOi K14410.
OMAi ISLFYRN.
OrthoDBi EOG7GXPBJ.
PhylomeDBi Q9BZG2.
TreeFami TF312893.

Miscellaneous databases

GenomeRNAii 93650.
NextBioi 78184.
PROi Q9BZG2.
SOURCEi Search...

Gene expression databases

Bgeei Q9BZG2.
CleanExi HS_ACPT.
Genevestigatori Q9BZG2.

Family and domain databases

Gene3Di 3.40.50.1240. 1 hit.
InterProi IPR000560. His_Pase_superF_clade-2.
IPR029033. His_PPase_superfam.
[Graphical view ]
Pfami PF00328. His_Phos_2. 1 hit.
[Graphical view ]
SUPFAMi SSF53254. SSF53254. 1 hit.
PROSITEi PS00616. HIS_ACID_PHOSPHAT_1. 1 hit.
PS00778. HIS_ACID_PHOSPHAT_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning of a novel human acid phosphatase gene (ACPT) that is highly expressed in the testis."
    Yousef G.M., Diamandis M., Jung K., Diamandis E.P.
    Genomics 74:385-395(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS 1; 2 AND 3), INDUCTION, TISSUE SPECIFICITY.
  2. "Regulation of ErbB4 phosphorylation and cleavage by a novel histidine acid phosphatase."
    Fleisig H., El-Din El-Husseini A., Vincent S.R.
    Neuroscience 127:91-100(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBUNIT, GLYCOSYLATION.
    Tissue: Testis.

Entry informationi

Entry nameiPPAT_HUMAN
AccessioniPrimary (citable) accession number: Q9BZG2
Secondary accession number(s): C0H3P7, Q9BZG3, Q9BZG4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: June 1, 2001
Last modified: October 29, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3