Q9BZG1 (RAB34_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ras-related protein Rab-34

Alternative name(s):
Ras-related protein Rab-39
Ras-related protein Rah

Gene names

Name:	RAB34
Synonyms:	RAB39, RAH

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	259 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Protein transport. Involved in the redistribution of lysosomes to the peri-Golgi region By similarity. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. Plays a role in the fusion of phagosomes with lysosomes. Ref.11
Subunit structure	Interacts with RILP. Ref.7
Subcellular location	Cytoplasm By similarity. Golgi apparatus By similarity. Cytoplasmic vesicle › phagosome. Cytoplasmic vesicle › phagosome membrane; Lipid-anchor; Cytoplasmic side By similarity. Note: Recruited to phagosomes containing S.aureus or M.tuberculosis. Ref.11
Sequence similarities	Belongs to the small GTPase superfamily. Rab family.

Ontologies

Keywords
Biological process	Protein transport Transport
Cellular component	Cytoplasm Cytoplasmic vesicle Golgi apparatus Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Ligand	GTP-binding Nucleotide-binding
PTM	Lipoprotein Phosphoprotein Prenylation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	phagosome-lysosome fusion Inferred from mutant phenotype Ref.11. Source: UniProtKB protein transport Inferred from electronic annotation. Source: UniProtKB-KW small GTPase mediated signal transduction Inferred from electronic annotation. Source: InterPro
Cellular_component	Golgi apparatus Inferred from electronic annotation. Source: UniProtKB-SubCell phagocytic vesicle Inferred from direct assay Ref.11. Source: UniProtKB phagocytic vesicle membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9BZG1-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9BZG1-2)

The sequence of this isoform differs from the canonical sequence as follows:
     164-171: Missing.

Isoform NARR (identifier: P0DI83-1)

The sequence of this isoform can be found in the external entry P0DI83.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

Isoform 4 (identifier: Q9BZG1-4)

The sequence of this isoform differs from the canonical sequence as follows:
     51-72: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 259	259	Ras-related protein Rab-34		PRO_0000121243
Regions
	Nucleotide binding	59 – 66	8	GTP By similarity
	Nucleotide binding	107 – 111	5	GTP By similarity
	Nucleotide binding	166 – 169	4	GTP By similarity
	Motif	81 – 89	9	Effector region By similarity
Amino acid modifications
	Modified residue	241	1	Phosphoserine Ref.8 Ref.10
	Modified residue	244	1	Phosphoserine Ref.10
	Lipidation	257	1	S-geranylgeranyl cysteine Potential
	Lipidation	258	1	S-geranylgeranyl cysteine Potential
Natural variations
	Alternative sequence	51 – 72	22	Missing in isoform 4.		VSP_044734
	Alternative sequence	164 – 171	8	Missing in isoform 2.		VSP_010142
	Natural variant	197	1	V → L. Corresponds to variant rs12125 [ dbSNP | Ensembl ].		VAR_015097
Experimental info
	Sequence conflict	10	1	D → Y in BAG65412. Ref.4
	Sequence conflict	55	1	V → I in BAC11141. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: 6D38A6F090F9802D	FASTA	259	29,044
	10 20 30 40 50 60 MNILAPVRRD RVLAELPQCL RKEAALHGHK DFHPRVTCAC QEHRTGTVGF KISKVIVVGD 70 80 90 100 110 120 LSVGKTCLIN RFCKDTFDKN YKATIGVDFE MERFEVLGIP FSLQLWDTAG QERFKCIAST 130 140 150 160 170 180 YYRGAQAIII VFNLNDVASL EHTKQWLADA LKENDPSSVL LFLVGSKKDL STPAQYALME 190 200 210 220 230 240 KDALQVAQEM KAEYWAVSSL TGENVREFFF RVAALTFEAN VLAELEKSGA RRIGDVVRIN 250 SDDSNLYLTA SKKKPTCCP
	Isoform 2 [UniParc]. Checksum: 8022E7023BC5137B	FASTA	251	28,230
	10 20 30 40 50 60 MNILAPVRRD RVLAELPQCL RKEAALHGHK DFHPRVTCAC QEHRTGTVGF KISKVIVVGD 70 80 90 100 110 120 LSVGKTCLIN RFCKDTFDKN YKATIGVDFE MERFEVLGIP FSLQLWDTAG QERFKCIAST 130 140 150 160 170 180 YYRGAQAIII VFNLNDVASL EHTKQWLADA LKENDPSSVL LFLTPAQYAL MEKDALQVAQ 190 200 210 220 230 240 EMKAEYWAVS SLTGENVREF FFRVAALTFE ANVLAELEKS GARRIGDVVR INSDDSNLYL 250 TASKKKPTCC P
	Isoform NARR [UniParc]. See P0DI83.		–	–
	Isoform 4 [UniParc]. Checksum: 8AD7BEDE6338BB85	FASTA	237	26,673
	10 20 30 40 50 60 MNILAPVRRD RVLAELPQCL RKEAALHGHK DFHPRVTCAC QEHRTGTVGF CKDTFDKNYK 70 80 90 100 110 120 ATIGVDFEME RFEVLGIPFS LQLWDTAGQE RFKCIASTYY RGAQAIIIVF NLNDVASLEH 130 140 150 160 170 180 TKQWLADALK ENDPSSVLLF LVGSKKDLST PAQYALMEKD ALQVAQEMKA EYWAVSSLTG 190 200 210 220 230 ENVREFFFRV AALTFEANVL AELEKSGARR IGDVVRINSD DSNLYLTASK KKPTCCP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Human Rab39 coding region (cDNA)." Hong W. Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]	"Full-length sequencing of 100 cDNA clones from human adult skeletal muscle." Stanchi F., Lanfranchi G. Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Skeletal muscle.
[3]	"Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 4). Tissue: Embryo, Mammary gland and Uterus.
[5]	"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L. , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C. Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: Brain and Pancreas.
[7]	"A unique region of RILP distinguishes it from its related proteins in its regulation of lysosomal morphology and interaction with Rab7 and Rab34." Wang T., Wong K.K., Hong W. Mol. Biol. Cell 15:815-826(2004) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH RILP.
[8]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-241, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[9]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[10]	"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation." Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B. Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-241 AND SER-244, MASS SPECTROMETRY.
[11]	"Rab GTPases regulating phagosome maturation are differentially recruited to mycobacterial phagosomes." Seto S., Tsujimura K., Koide Y. Traffic 12:407-420(2011) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF322067 mRNA. Translation: AAK09397.1. AJ277106 mRNA. Translation: CAC81760.1. BT006702 mRNA. Translation: AAP35348.1. AK027312 mRNA. Translation: BAB55034.1. AK074689 mRNA. Translation: BAC11141.1. AK304633 mRNA. Translation: BAG65412.1. AC010761 Genomic DNA. No translation available. BC016841 mRNA. Translation: AAH16841.1. BC091510 mRNA. Translation: AAH91510.1.
IPI	IPI00328180. IPI00410673. IPI00908406.
RefSeq	NP_001138414.1. NM_001144942.1. NP_001243205.1. NM_001256276.1. NP_001243206.1. NM_001256277.1. NP_001243207.1. NM_001256278.1. NP_114140.4. NM_031934.5.
UniGene	Hs.301853.
3D structure databases
ProteinModelPortal	Q9BZG1.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9BZG1. 1 interaction.
STRING	9606.ENSP00000410403.
PTM databases
PhosphoSite	Q9BZG1.
Polymorphism databases
DMDM	20139693.
Proteomic databases
PaxDb	Q9BZG1.
PRIDE	Q9BZG1.
Protocols and materials databases
DNASU	83871.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000301043; ENSP00000301043; ENSG00000109113. ENST00000395243; ENSP00000378664; ENSG00000109113. ENST00000395245; ENSP00000378666; ENSG00000109113. ENST00000415040; ENSP00000410279; ENSG00000109113. ENST00000436730; ENSP00000404180; ENSG00000109113. ENST00000450529; ENSP00000391048; ENSG00000109113.
GeneID	83871.
KEGG	hsa:83871.
UCSC	uc002hce.2. human. uc002hcg.2. human.
Organism-specific databases
CTD	83871.
GeneCards	GC17M027041.
HGNC	HGNC:16519. RAB34.
HPA	HPA021366.
MIM	610917. gene.
neXtProt	NX_Q9BZG1.
PharmGKB	PA34126.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG1100.
HOGENOM	HOG000233970.
HOVERGEN	HBG106693.
InParanoid	Q9BZG1.
KO	K07921.
OrthoDB	EOG41NTMP.
PhylomeDB	Q9BZG1.
Gene expression databases
ArrayExpress	Q9BZG1.
Bgee	Q9BZG1.
CleanEx	HS_RAB34. HS_RAB39.
Genevestigator	Q9BZG1.
GermOnline	ENSG00000109113. Homo sapiens.
Family and domain databases
InterPro	IPR005225. Small_GTP-bd_dom. IPR001806. Small_GTPase. IPR003579. Small_GTPase_Rab_type. [Graphical view]
Pfam	PF00071. Ras. 1 hit. [Graphical view]
PRINTS	PR00449. RASTRNSFRMNG.
SMART	SM00175. RAB. 1 hit. [Graphical view]
TIGRFAMs	TIGR00231. small_GTP. 1 hit.
PROSITE	PS51419. RAB. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	RAB34. human.
GenomeRNAi	83871.
NextBio	72895.
SOURCE	Search...

Entry information

Entry name

RAB34_HUMAN

Accession

Primary (citable) accession number: Q9BZG1
Secondary accession number(s): B4E3A0 , E9PEJ9, Q5BJE6, Q8NCJ8, Q96AR4

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 31, 2002
Last sequence update:	June 1, 2001
Last modified:	May 1, 2013
This is version 118 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.