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Protein

Ras-related protein Rab-34

Gene

RAB34

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Protein transport. Involved in the redistribution of lysosomes to the peri-Golgi region (By similarity). Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. Plays a role in the fusion of phagosomes with lysosomes.By similarity1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi59 – 668GTPBy similarity
Nucleotide bindingi107 – 1115GTPBy similarity
Nucleotide bindingi166 – 1694GTPBy similarity

GO - Molecular functioni

  1. GDP binding Source: GO_Central
  2. GTPase activity Source: GO_Central
  3. GTP binding Source: GO_Central

GO - Biological processi

  1. antigen processing and presentation Source: UniProtKB
  2. Golgi to plasma membrane protein transport Source: UniProtKB
  3. GTP catabolic process Source: GO_Central
  4. lysosome localization Source: UniProtKB
  5. phagosome-lysosome fusion Source: UniProtKB
  6. phagosome maturation Source: UniProtKB
  7. protein localization to plasma membrane Source: UniProtKB
  8. Rab protein signal transduction Source: GO_Central
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-34
Alternative name(s):
Ras-related protein Rab-39
Ras-related protein Rah
Gene namesi
Name:RAB34
Synonyms:RAB39, RAH
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:16519. RAB34.

Subcellular locationi

Cytoplasm By similarity. Golgi apparatus By similarity. Cytoplasmic vesiclephagosome 1 Publication. Cytoplasmic vesiclephagosome membrane By similarity; Lipid-anchor By similarity; Cytoplasmic side By similarity
Note: Recruited to phagosomes containing S.aureus or M.tuberculosis.

GO - Cellular componenti

  1. extracellular vesicular exosome Source: UniProtKB
  2. Golgi apparatus Source: UniProtKB
  3. Golgi cisterna Source: UniProtKB
  4. Golgi stack Source: UniProtKB
  5. perinuclear region of cytoplasm Source: UniProtKB
  6. phagocytic vesicle Source: UniProtKB
  7. phagocytic vesicle membrane Source: UniProtKB-SubCell
  8. vesicle Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA34126.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 259259Ras-related protein Rab-34PRO_0000121243Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine2 Publications
Modified residuei241 – 2411Phosphoserine2 Publications
Modified residuei244 – 2441Phosphoserine1 Publication
Lipidationi257 – 2571S-geranylgeranyl cysteineSequence Analysis
Lipidationi258 – 2581S-geranylgeranyl cysteineSequence Analysis

Keywords - PTMi

Acetylation, Lipoprotein, Phosphoprotein, Prenylation

Proteomic databases

MaxQBiQ9BZG1.
PaxDbiQ9BZG1.
PRIDEiQ9BZG1.

PTM databases

PhosphoSiteiQ9BZG1.

Expressioni

Gene expression databases

BgeeiQ9BZG1.
CleanExiHS_RAB34.
HS_RAB39.
ExpressionAtlasiQ9BZG1. baseline and differential.
GenevestigatoriQ9BZG1.

Organism-specific databases

HPAiHPA021366.

Interactioni

Subunit structurei

Interacts with RILP.1 Publication

Protein-protein interaction databases

BioGridi123784. 5 interactions.
IntActiQ9BZG1. 1 interaction.
MINTiMINT-4538882.
STRINGi9606.ENSP00000410403.

Structurei

3D structure databases

ProteinModelPortaliQ9BZG1.
SMRiQ9BZG1. Positions 54-213.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi81 – 899Effector regionBy similarity

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiCOG1100.
GeneTreeiENSGT00730000110423.
HOGENOMiHOG000233970.
HOVERGENiHBG106693.
InParanoidiQ9BZG1.
KOiK07921.
PhylomeDBiQ9BZG1.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003579. Small_GTPase_Rab_type.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
PRINTSiPR00449. RASTRNSFRMNG.
SMARTiSM00175. RAB. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9BZG1-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNILAPVRRD RVLAELPQCL RKEAALHGHK DFHPRVTCAC QEHRTGTVGF
60 70 80 90 100
KISKVIVVGD LSVGKTCLIN RFCKDTFDKN YKATIGVDFE MERFEVLGIP
110 120 130 140 150
FSLQLWDTAG QERFKCIAST YYRGAQAIII VFNLNDVASL EHTKQWLADA
160 170 180 190 200
LKENDPSSVL LFLVGSKKDL STPAQYALME KDALQVAQEM KAEYWAVSSL
210 220 230 240 250
TGENVREFFF RVAALTFEAN VLAELEKSGA RRIGDVVRIN SDDSNLYLTA

SKKKPTCCP
Length:259
Mass (Da):29,044
Last modified:June 1, 2001 - v1
Checksum:i6D38A6F090F9802D
GO
Isoform 2 (identifier: Q9BZG1-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     164-171: Missing.

Show »
Length:251
Mass (Da):28,230
Checksum:i8022E7023BC5137B
GO
Isoform NARR (identifier: P0DI83-1) [UniParc]FASTAAdd to Basket

The sequence of this isoform can be found in the external entry P0DI83.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:198
Mass (Da):21,118
GO
Isoform 4 (identifier: Q9BZG1-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     51-72: Missing.

Note: No experimental confirmation available.

Show »
Length:237
Mass (Da):26,673
Checksum:i8AD7BEDE6338BB85
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti10 – 101D → Y in BAG65412. (PubMed:14702039)Curated
Sequence conflicti55 – 551V → I in BAC11141. (PubMed:14702039)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti197 – 1971V → L.
Corresponds to variant rs12125 [ dbSNP | Ensembl ].
VAR_015097

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei51 – 7222Missing in isoform 4. 1 PublicationVSP_044734Add
BLAST
Alternative sequencei164 – 1718Missing in isoform 2. 2 PublicationsVSP_010142

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF322067 mRNA. Translation: AAK09397.1.
AJ277106 mRNA. Translation: CAC81760.1.
BT006702 mRNA. Translation: AAP35348.1.
AK027312 mRNA. Translation: BAB55034.1.
AK074689 mRNA. Translation: BAC11141.1.
AK304633 mRNA. Translation: BAG65412.1.
AC010761 Genomic DNA. No translation available.
BC016841 mRNA. Translation: AAH16841.1.
BC091510 mRNA. Translation: AAH91510.1.
CCDSiCCDS11240.1. [Q9BZG1-1]
CCDS45636.1. [Q9BZG1-2]
CCDS58536.1. [Q9BZG1-4]
RefSeqiNP_001138414.1. NM_001144942.1. [Q9BZG1-2]
NP_001243205.1. NM_001256276.1. [Q9BZG1-4]
NP_001243206.1. NM_001256277.1. [Q9BZG1-1]
NP_001243207.1. NM_001256278.1.
NP_114140.4. NM_031934.5. [Q9BZG1-1]
UniGeneiHs.301853.

Genome annotation databases

EnsembliENST00000301043; ENSP00000301043; ENSG00000109113. [Q9BZG1-1]
ENST00000395243; ENSP00000378664; ENSG00000109113. [Q9BZG1-2]
ENST00000395245; ENSP00000378666; ENSG00000109113. [Q9BZG1-1]
ENST00000415040; ENSP00000410279; ENSG00000109113. [Q9BZG1-4]
ENST00000436730; ENSP00000404180; ENSG00000109113. [Q9BZG1-1]
ENST00000450529; ENSP00000391048; ENSG00000109113. [Q9BZG1-2]
GeneIDi83871.
KEGGihsa:83871.
UCSCiuc002hce.2. human. [Q9BZG1-1]
uc002hcg.2. human. [Q9BZG1-2]

Polymorphism databases

DMDMi20139693.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF322067 mRNA. Translation: AAK09397.1.
AJ277106 mRNA. Translation: CAC81760.1.
BT006702 mRNA. Translation: AAP35348.1.
AK027312 mRNA. Translation: BAB55034.1.
AK074689 mRNA. Translation: BAC11141.1.
AK304633 mRNA. Translation: BAG65412.1.
AC010761 Genomic DNA. No translation available.
BC016841 mRNA. Translation: AAH16841.1.
BC091510 mRNA. Translation: AAH91510.1.
CCDSiCCDS11240.1. [Q9BZG1-1]
CCDS45636.1. [Q9BZG1-2]
CCDS58536.1. [Q9BZG1-4]
RefSeqiNP_001138414.1. NM_001144942.1. [Q9BZG1-2]
NP_001243205.1. NM_001256276.1. [Q9BZG1-4]
NP_001243206.1. NM_001256277.1. [Q9BZG1-1]
NP_001243207.1. NM_001256278.1.
NP_114140.4. NM_031934.5. [Q9BZG1-1]
UniGeneiHs.301853.

3D structure databases

ProteinModelPortaliQ9BZG1.
SMRiQ9BZG1. Positions 54-213.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123784. 5 interactions.
IntActiQ9BZG1. 1 interaction.
MINTiMINT-4538882.
STRINGi9606.ENSP00000410403.

PTM databases

PhosphoSiteiQ9BZG1.

Polymorphism databases

DMDMi20139693.

Proteomic databases

MaxQBiQ9BZG1.
PaxDbiQ9BZG1.
PRIDEiQ9BZG1.

Protocols and materials databases

DNASUi83871.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000301043; ENSP00000301043; ENSG00000109113. [Q9BZG1-1]
ENST00000395243; ENSP00000378664; ENSG00000109113. [Q9BZG1-2]
ENST00000395245; ENSP00000378666; ENSG00000109113. [Q9BZG1-1]
ENST00000415040; ENSP00000410279; ENSG00000109113. [Q9BZG1-4]
ENST00000436730; ENSP00000404180; ENSG00000109113. [Q9BZG1-1]
ENST00000450529; ENSP00000391048; ENSG00000109113. [Q9BZG1-2]
GeneIDi83871.
KEGGihsa:83871.
UCSCiuc002hce.2. human. [Q9BZG1-1]
uc002hcg.2. human. [Q9BZG1-2]

Organism-specific databases

CTDi83871.
GeneCardsiGC17M027041.
HGNCiHGNC:16519. RAB34.
HPAiHPA021366.
MIMi610917. gene.
neXtProtiNX_Q9BZG1.
PharmGKBiPA34126.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG1100.
GeneTreeiENSGT00730000110423.
HOGENOMiHOG000233970.
HOVERGENiHBG106693.
InParanoidiQ9BZG1.
KOiK07921.
PhylomeDBiQ9BZG1.

Miscellaneous databases

ChiTaRSiRAB34. human.
GeneWikiiRAB34.
GenomeRNAii83871.
NextBioi72895.
PROiQ9BZG1.
SOURCEiSearch...

Gene expression databases

BgeeiQ9BZG1.
CleanExiHS_RAB34.
HS_RAB39.
ExpressionAtlasiQ9BZG1. baseline and differential.
GenevestigatoriQ9BZG1.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003579. Small_GTPase_Rab_type.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
PRINTSiPR00449. RASTRNSFRMNG.
SMARTiSM00175. RAB. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Human Rab39 coding region (cDNA)."
    Hong W.
    Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Full-length sequencing of 100 cDNA clones from human adult skeletal muscle."
    Stanchi F., Lanfranchi G.
    Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Skeletal muscle.
  3. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 4).
    Tissue: Embryo, Mammary gland and Uterus.
  5. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Brain and Pancreas.
  7. "A unique region of RILP distinguishes it from its related proteins in its regulation of lysosomal morphology and interaction with Rab7 and Rab34."
    Wang T., Wong K.K., Hong W.
    Mol. Biol. Cell 15:815-826(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH RILP.
  8. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-241, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-241 AND SER-244, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. "Rab GTPases regulating phagosome maturation are differentially recruited to mycobacterial phagosomes."
    Seto S., Tsujimura K., Koide Y.
    Traffic 12:407-420(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.
  12. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
    Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
    Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  13. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiRAB34_HUMAN
AccessioniPrimary (citable) accession number: Q9BZG1
Secondary accession number(s): B4E3A0
, E9PEJ9, Q5BJE6, Q8NCJ8, Q96AR4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: June 1, 2001
Last modified: February 4, 2015
This is version 133 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.