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Q9BZF9

- UACA_HUMAN

UniProt

Q9BZF9 - UACA_HUMAN

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Protein

Uveal autoantigen with coiled-coil domains and ankyrin repeats

Gene

UACA

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Regulates APAF1 expression and plays an important role in the regulation of stress-induced apoptosis. Promotes apoptosis by regulating three pathways, apoptosome up-regulation, LGALS3/galectin-3 down-regulation and NF-kappa-B inactivation. Regulates the redistribution of APAF1 into the nucleus after proapoptotic stress. Down-regulates the expression of LGALS3 by inhibiting NFKB1 (By similarity).By similarity
Modulates isoactin dynamics to regulate the morphological alterations required for cell growth and motility. Interaction with ARF6 may modulate cell shape and motility after injury (By similarity).By similarity

GO - Biological processi

  1. intrinsic apoptotic signaling pathway in response to DNA damage Source: Ensembl
  2. intrinsic apoptotic signaling pathway in response to oxidative stress Source: Ensembl
  3. negative regulation of inflammatory response Source: Ensembl
  4. negative regulation of NF-kappaB import into nucleus Source: Ensembl
  5. positive regulation of apoptotic process Source: Ensembl
  6. positive regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: Ensembl
  7. positive regulation of protein import into nucleus Source: Ensembl
  8. response to UV Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Uveal autoantigen with coiled-coil domains and ankyrin repeats
Gene namesi
Name:UACA
Synonyms:KIAA1561
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 15

Organism-specific databases

HGNCiHGNC:15947. UACA.

Subcellular locationi

Nucleus 1 Publication. Cytoplasm 1 Publication. Cytoplasmcytoskeleton 1 Publication
Note: Expressed diffusely in cytoplasm.

GO - Cellular componenti

  1. apoptosome Source: Ensembl
  2. cytoplasm Source: HPA
  3. cytoskeleton Source: UniProtKB-KW
  4. extracellular region Source: UniProtKB
  5. extracellular vesicular exosome Source: UniProt
  6. membrane Source: Ensembl
  7. mitochondrion Source: HPA
  8. nuclear envelope Source: Ensembl
  9. nucleus Source: HPA
  10. perinuclear region of cytoplasm Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38062.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 14161416Uveal autoantigen with coiled-coil domains and ankyrin repeatsPRO_0000231650Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ9BZF9.
PaxDbiQ9BZF9.
PRIDEiQ9BZF9.

PTM databases

PhosphoSiteiQ9BZF9.

Expressioni

Tissue specificityi

Highly expressed in skeletal muscle, heart, kidney and pancreas. Expressed in choroid, retina and epidermal melanocytes. Expressed in eye muscles and thyroid follicular cells.2 Publications

Inductioni

Up-regulated after TSH stimulation.1 Publication

Gene expression databases

BgeeiQ9BZF9.
CleanExiHS_UACA.
ExpressionAtlasiQ9BZF9. baseline and differential.
GenevestigatoriQ9BZF9.

Organism-specific databases

HPAiHPA041412.

Interactioni

Subunit structurei

Component of the apoptosome complex, composed of APAF1, pro-caspase-9 and UACA. In the complex, it probably interacts directly with APAF1. Interacts with LGALS3, ARF6 and ACTB (By similarity).By similarity

Protein-protein interaction databases

BioGridi120392. 15 interactions.
IntActiQ9BZF9. 6 interactions.
MINTiMINT-1159571.
STRINGi9606.ENSP00000314556.

Structurei

3D structure databases

ProteinModelPortaliQ9BZF9.
SMRiQ9BZF9. Positions 37-313.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati38 – 6629ANK 1Add
BLAST
Repeati67 – 9630ANK 2Add
BLAST
Repeati100 – 12930ANK 3Add
BLAST
Repeati133 – 16230ANK 4Add
BLAST
Repeati166 – 19530ANK 5Add
BLAST
Repeati199 – 22830ANK 6Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili286 – 37489Sequence AnalysisAdd
BLAST
Coiled coili438 – 1386949Sequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi21 – 299Poly-Ala

Sequence similaritiesi

Contains 6 ANK repeats.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Coiled coil, Repeat

Phylogenomic databases

eggNOGiCOG0666.
GeneTreeiENSGT00530000063369.
HOGENOMiHOG000147885.
HOVERGENiHBG066395.
InParanoidiQ9BZF9.
OMAiLKQGQMY.
OrthoDBiEOG7X9G6C.
PhylomeDBiQ9BZF9.
TreeFamiTF331274.

Family and domain databases

Gene3Di1.25.40.20. 2 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR000727. T_SNARE_dom.
[Graphical view]
PfamiPF12796. Ank_2. 2 hits.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 6 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 5 hits.
PS50192. T_SNARE. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9BZF9-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKSLKSRLRR QDVPGPASSG AAAASAHAAD WNKYDDRLMK AAERGDVEKV
60 70 80 90 100
TSILAKKGVN PGKLDVEGRS VFHVVTSKGN LECLNAILIH GVDITTSDTA
110 120 130 140 150
GRNALHLAAK YGHALCLQKL LQYNCPTEHA DLQGRTALHD AAMADCPSSI
160 170 180 190 200
QLLCDHGASV NAKDVDGRTP LVLATQMSRP TICQLLIDRG ADVNSRDKQN
210 220 230 240 250
RTALMLGCEY GCRDAVEVLI KNGADISLLD ALGHDSSYYA RIGDNLDILT
260 270 280 290 300
LLKTASENTN KGRELWKKGP SLQQRNLTHM QDEVNVKSHQ REHQNIQDLE
310 320 330 340 350
IENEDLKERL RKIQQEQRIL LDKVNGLQLQ LNEEVMVADD LESEREKLKS
360 370 380 390 400
LLAAKEKQHE ESLRTIEALK NRFKYFESDH LGSGSHFSNR KEDMLLKQGQ
410 420 430 440 450
MYMADSQCTS PGIPAHMQSR SMLRPLELSL PSQTSYSENE ILKKELEAMR
460 470 480 490 500
TFCESAKQDR LKLQNELAHK VAECKALALE CERVKEDSDE QIKQLEDALK
510 520 530 540 550
DVQKRMYESE GKVKQMQTHF LALKEHLTSE AASGNHRLTE ELKDQLKDLK
560 570 580 590 600
VKYEGASAEV GKLRNQIKQN EMIVEEFKRD EGKLIEENKR LQKELSMCEM
610 620 630 640 650
EREKKGRKVT EMEGQAKELS AKLALSIPAE KFENMKSSLS NEVNEKAKKL
660 670 680 690 700
VEMEREHEKS LSEIRQLKRE LENVKAKLAQ HVKPEEHEQV KSRLEQKSGE
710 720 730 740 750
LGKKITELTL KNQTLQKEIE KVYLDNKLLK EQAHNLTIEM KNHYVPLKVS
760 770 780 790 800
EDMKKSHDAI IDDLNRKLLD VTQKYTEKKL EMEKLLLEND SLSKDVSRLE
810 820 830 840 850
TVFVPPEKHE KEIIALKSNI VELKKQLSEL KKKCGEDQEK IHALTSENTN
860 870 880 890 900
LKKMMSNQYV PVKTHEEVKM TLNDTLAKTN RELLDVKKKF EDINQEFVKI
910 920 930 940 950
KDKNEILKRN LENTQNQIKA EYISLAEHEA KMSSLSQSMR KVQDSNAEIL
960 970 980 990 1000
ANYRKGQEEI VTLHAEIKAQ KKELDTIQEC IKVKYAPIVS FEECERKFKA
1010 1020 1030 1040 1050
TEKELKDQLS EQTQKYSVSE EEVKKNKQEN DKLKKEIFTL QKDLRDKTVL
1060 1070 1080 1090 1100
IEKSHEMERA LSRKTDELNK QLKDLSQKYT EVKNVKEKLV EENAKQTSEI
1110 1120 1130 1140 1150
LAVQNLLQKQ HVPLEQVEAL KKSLNGTIEN LKEELKSMQR CYEKEQQTVT
1160 1170 1180 1190 1200
KLHQLLENQK NSSVPLAEHL QIKEAFEKEV GIIKASLREK EEESQNKMEE
1210 1220 1230 1240 1250
VSKLQSEVQN TKQALKKLET REVVDLSKYK ATKSDLETQI SSLNEKLANL
1260 1270 1280 1290 1300
NRKYEEVCEE VLHAKKKEIS AKDEKELLHF SIEQEIKDQK ERCDKSLTTI
1310 1320 1330 1340 1350
TELQRRIQES AKQIEAKDNK ITELLNDVER LKQALNGLSQ LTYTSGNPTK
1360 1370 1380 1390 1400
RQSQLIDTLQ HQVKSLEQQL ADADRQHQEV IAIYRTHLLS AAQGHMDEDV
1410
QEALLQIIQM RQGLVC
Length:1,416
Mass (Da):162,505
Last modified:April 4, 2006 - v2
Checksum:i92C1104445FB0009
GO
Isoform 2 (identifier: Q9BZF9-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-26: MKSLKSRLRRQDVPGPASSGAAAASA → MMNCWFSCTPKNR

Note: No experimental confirmation available.

Show »
Length:1,403
Mass (Da):161,510
Checksum:i274D35E367DE3B75
GO

Sequence cautioni

The sequence BAA91457.1 differs from that shown. Reason: Erroneous initiation.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti139 – 1413HDA → QKK in AAG49577. (PubMed:11162650)Curated
Sequence conflicti166 – 1661D → K in AAG49577. (PubMed:11162650)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti814 – 8141I → T.
Corresponds to variant rs3743315 [ dbSNP | Ensembl ].
VAR_048313

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 2626MKSLK…AAASA → MMNCWFSCTPKNR in isoform 2. 1 PublicationVSP_047199Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF322916 mRNA. Translation: AAG49577.1.
AB046781 mRNA. Translation: BAB13387.2.
AC009269 Genomic DNA. No translation available.
AC087699 Genomic DNA. No translation available.
CH471082 Genomic DNA. Translation: EAW77855.1.
BC113407 mRNA. Translation: AAI13408.1.
BC113409 mRNA. Translation: AAI13410.1.
AK000990 mRNA. Translation: BAA91457.1. Different initiation.
AK055435 mRNA. Translation: BAB70922.1.
AL834464 mRNA. Translation: CAD39123.1.
CCDSiCCDS10235.1. [Q9BZF9-1]
CCDS32280.1. [Q9BZF9-2]
RefSeqiNP_001008225.1. NM_001008224.1. [Q9BZF9-2]
NP_060473.2. NM_018003.2. [Q9BZF9-1]
UniGeneiHs.108049.

Genome annotation databases

EnsembliENST00000322954; ENSP00000314556; ENSG00000137831. [Q9BZF9-1]
ENST00000379983; ENSP00000369319; ENSG00000137831. [Q9BZF9-2]
GeneIDi55075.
KEGGihsa:55075.
UCSCiuc002asq.3. human.
uc002asr.3. human. [Q9BZF9-1]

Polymorphism databases

DMDMi91207950.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF322916 mRNA. Translation: AAG49577.1 .
AB046781 mRNA. Translation: BAB13387.2 .
AC009269 Genomic DNA. No translation available.
AC087699 Genomic DNA. No translation available.
CH471082 Genomic DNA. Translation: EAW77855.1 .
BC113407 mRNA. Translation: AAI13408.1 .
BC113409 mRNA. Translation: AAI13410.1 .
AK000990 mRNA. Translation: BAA91457.1 . Different initiation.
AK055435 mRNA. Translation: BAB70922.1 .
AL834464 mRNA. Translation: CAD39123.1 .
CCDSi CCDS10235.1. [Q9BZF9-1 ]
CCDS32280.1. [Q9BZF9-2 ]
RefSeqi NP_001008225.1. NM_001008224.1. [Q9BZF9-2 ]
NP_060473.2. NM_018003.2. [Q9BZF9-1 ]
UniGenei Hs.108049.

3D structure databases

ProteinModelPortali Q9BZF9.
SMRi Q9BZF9. Positions 37-313.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 120392. 15 interactions.
IntActi Q9BZF9. 6 interactions.
MINTi MINT-1159571.
STRINGi 9606.ENSP00000314556.

PTM databases

PhosphoSitei Q9BZF9.

Polymorphism databases

DMDMi 91207950.

Proteomic databases

MaxQBi Q9BZF9.
PaxDbi Q9BZF9.
PRIDEi Q9BZF9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000322954 ; ENSP00000314556 ; ENSG00000137831 . [Q9BZF9-1 ]
ENST00000379983 ; ENSP00000369319 ; ENSG00000137831 . [Q9BZF9-2 ]
GeneIDi 55075.
KEGGi hsa:55075.
UCSCi uc002asq.3. human.
uc002asr.3. human. [Q9BZF9-1 ]

Organism-specific databases

CTDi 55075.
GeneCardsi GC15M070946.
HGNCi HGNC:15947. UACA.
HPAi HPA041412.
MIMi 612516. gene.
neXtProti NX_Q9BZF9.
PharmGKBi PA38062.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0666.
GeneTreei ENSGT00530000063369.
HOGENOMi HOG000147885.
HOVERGENi HBG066395.
InParanoidi Q9BZF9.
OMAi LKQGQMY.
OrthoDBi EOG7X9G6C.
PhylomeDBi Q9BZF9.
TreeFami TF331274.

Miscellaneous databases

ChiTaRSi UACA. human.
GeneWikii UACA.
GenomeRNAii 55075.
NextBioi 58608.
PROi Q9BZF9.
SOURCEi Search...

Gene expression databases

Bgeei Q9BZF9.
CleanExi HS_UACA.
ExpressionAtlasi Q9BZF9. baseline and differential.
Genevestigatori Q9BZF9.

Family and domain databases

Gene3Di 1.25.40.20. 2 hits.
InterProi IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR000727. T_SNARE_dom.
[Graphical view ]
Pfami PF12796. Ank_2. 2 hits.
[Graphical view ]
PRINTSi PR01415. ANKYRIN.
SMARTi SM00248. ANK. 6 hits.
[Graphical view ]
SUPFAMi SSF48403. SSF48403. 1 hit.
PROSITEi PS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 5 hits.
PS50192. T_SNARE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
  2. "Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Kikuno R., Nakayama M., Hirosawa M., Ohara O.
    DNA Res. 7:273-281(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  3. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
    Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
    DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: SEQUENCE REVISION.
  4. "Analysis of the DNA sequence and duplication history of human chromosome 15."
    Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A.
    , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
    Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  7. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 646-1187 (ISOFORM 1/2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-634 (ISOFORM 2).
    Tissue: Brain and Embryo.
  8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1181-1416 (ISOFORM 1/2).
    Tissue: Brain.
  9. Cited for: TISSUE SPECIFICITY, SUBCELLULAR LOCATION, INDUCTION.
  10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiUACA_HUMAN
AccessioniPrimary (citable) accession number: Q9BZF9
Secondary accession number(s): G3XAG2
, Q14DD3, Q8N3B8, Q96NH6, Q9HCL1, Q9NWC6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: April 4, 2006
Last modified: October 29, 2014
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

UACA is a possible target autoantigen in Vogt-Koyanagi-Harada (VKH), Behcet disease (BD) and sarcoidosis that cause different types of panuevitis.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3