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Q9BZF9

- UACA_HUMAN

UniProt

Q9BZF9 - UACA_HUMAN

Protein

Uveal autoantigen with coiled-coil domains and ankyrin repeats

Gene

UACA

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 107 (01 Oct 2014)
      Sequence version 2 (04 Apr 2006)
      Previous versions | rss
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    Functioni

    Regulates APAF1 expression and plays an important role in the regulation of stress-induced apoptosis. Promotes apoptosis by regulating three pathways, apoptosome up-regulation, LGALS3/galectin-3 down-regulation and NF-kappa-B inactivation. Regulates the redistribution of APAF1 into the nucleus after proapoptotic stress. Down-regulates the expression of LGALS3 by inhibiting NFKB1 By similarity.By similarity
    Modulates isoactin dynamics to regulate the morphological alterations required for cell growth and motility. Interaction with ARF6 may modulate cell shape and motility after injury By similarity.By similarity

    GO - Molecular functioni

    1. protein binding Source: UniProtKB

    GO - Biological processi

    1. intrinsic apoptotic signaling pathway in response to DNA damage Source: Ensembl
    2. intrinsic apoptotic signaling pathway in response to oxidative stress Source: Ensembl
    3. negative regulation of inflammatory response Source: Ensembl
    4. negative regulation of NF-kappaB import into nucleus Source: Ensembl
    5. positive regulation of apoptotic process Source: Ensembl
    6. positive regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: Ensembl
    7. positive regulation of protein import into nucleus Source: Ensembl
    8. response to UV Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Uveal autoantigen with coiled-coil domains and ankyrin repeats
    Gene namesi
    Name:UACA
    Synonyms:KIAA1561
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 15

    Organism-specific databases

    HGNCiHGNC:15947. UACA.

    Subcellular locationi

    Nucleus 1 Publication. Cytoplasm 1 Publication. Cytoplasmcytoskeleton 1 Publication
    Note: Expressed diffusely in cytoplasm.

    GO - Cellular componenti

    1. apoptosome Source: Ensembl
    2. cytoplasm Source: HPA
    3. cytoskeleton Source: UniProtKB-SubCell
    4. extracellular region Source: UniProtKB
    5. extracellular vesicular exosome Source: UniProt
    6. membrane Source: Ensembl
    7. mitochondrion Source: HPA
    8. nuclear envelope Source: Ensembl
    9. nucleus Source: HPA
    10. perinuclear region of cytoplasm Source: Ensembl

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton, Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA38062.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 14161416Uveal autoantigen with coiled-coil domains and ankyrin repeatsPRO_0000231650Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionine1 Publication

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiQ9BZF9.
    PaxDbiQ9BZF9.
    PRIDEiQ9BZF9.

    PTM databases

    PhosphoSiteiQ9BZF9.

    Expressioni

    Tissue specificityi

    Highly expressed in skeletal muscle, heart, kidney and pancreas. Expressed in choroid, retina and epidermal melanocytes. Expressed in eye muscles and thyroid follicular cells.2 Publications

    Inductioni

    Up-regulated after TSH stimulation.1 Publication

    Gene expression databases

    ArrayExpressiQ9BZF9.
    BgeeiQ9BZF9.
    CleanExiHS_UACA.
    GenevestigatoriQ9BZF9.

    Organism-specific databases

    HPAiHPA041412.

    Interactioni

    Subunit structurei

    Component of the apoptosome complex, composed of APAF1, pro-caspase-9 and UACA. In the complex, it probably interacts directly with APAF1. Interacts with LGALS3, ARF6 and ACTB By similarity.By similarity

    Protein-protein interaction databases

    BioGridi120392. 12 interactions.
    IntActiQ9BZF9. 6 interactions.
    MINTiMINT-1159571.
    STRINGi9606.ENSP00000314556.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9BZF9.
    SMRiQ9BZF9. Positions 37-313.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati38 – 6629ANK 1Add
    BLAST
    Repeati67 – 9630ANK 2Add
    BLAST
    Repeati100 – 12930ANK 3Add
    BLAST
    Repeati133 – 16230ANK 4Add
    BLAST
    Repeati166 – 19530ANK 5Add
    BLAST
    Repeati199 – 22830ANK 6Add
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili286 – 37489Sequence AnalysisAdd
    BLAST
    Coiled coili438 – 1386949Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi21 – 299Poly-Ala

    Sequence similaritiesi

    Contains 6 ANK repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    ANK repeat, Coiled coil, Repeat

    Phylogenomic databases

    eggNOGiCOG0666.
    HOGENOMiHOG000147885.
    HOVERGENiHBG066395.
    InParanoidiQ9BZF9.
    OMAiLKQGQMY.
    OrthoDBiEOG7X9G6C.
    PhylomeDBiQ9BZF9.
    TreeFamiTF331274.

    Family and domain databases

    Gene3Di1.25.40.20. 2 hits.
    InterProiIPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    IPR000727. T_SNARE_dom.
    [Graphical view]
    PfamiPF12796. Ank_2. 2 hits.
    [Graphical view]
    PRINTSiPR01415. ANKYRIN.
    SMARTiSM00248. ANK. 6 hits.
    [Graphical view]
    SUPFAMiSSF48403. SSF48403. 1 hit.
    PROSITEiPS50297. ANK_REP_REGION. 1 hit.
    PS50088. ANK_REPEAT. 5 hits.
    PS50192. T_SNARE. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9BZF9-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MKSLKSRLRR QDVPGPASSG AAAASAHAAD WNKYDDRLMK AAERGDVEKV     50
    TSILAKKGVN PGKLDVEGRS VFHVVTSKGN LECLNAILIH GVDITTSDTA 100
    GRNALHLAAK YGHALCLQKL LQYNCPTEHA DLQGRTALHD AAMADCPSSI 150
    QLLCDHGASV NAKDVDGRTP LVLATQMSRP TICQLLIDRG ADVNSRDKQN 200
    RTALMLGCEY GCRDAVEVLI KNGADISLLD ALGHDSSYYA RIGDNLDILT 250
    LLKTASENTN KGRELWKKGP SLQQRNLTHM QDEVNVKSHQ REHQNIQDLE 300
    IENEDLKERL RKIQQEQRIL LDKVNGLQLQ LNEEVMVADD LESEREKLKS 350
    LLAAKEKQHE ESLRTIEALK NRFKYFESDH LGSGSHFSNR KEDMLLKQGQ 400
    MYMADSQCTS PGIPAHMQSR SMLRPLELSL PSQTSYSENE ILKKELEAMR 450
    TFCESAKQDR LKLQNELAHK VAECKALALE CERVKEDSDE QIKQLEDALK 500
    DVQKRMYESE GKVKQMQTHF LALKEHLTSE AASGNHRLTE ELKDQLKDLK 550
    VKYEGASAEV GKLRNQIKQN EMIVEEFKRD EGKLIEENKR LQKELSMCEM 600
    EREKKGRKVT EMEGQAKELS AKLALSIPAE KFENMKSSLS NEVNEKAKKL 650
    VEMEREHEKS LSEIRQLKRE LENVKAKLAQ HVKPEEHEQV KSRLEQKSGE 700
    LGKKITELTL KNQTLQKEIE KVYLDNKLLK EQAHNLTIEM KNHYVPLKVS 750
    EDMKKSHDAI IDDLNRKLLD VTQKYTEKKL EMEKLLLEND SLSKDVSRLE 800
    TVFVPPEKHE KEIIALKSNI VELKKQLSEL KKKCGEDQEK IHALTSENTN 850
    LKKMMSNQYV PVKTHEEVKM TLNDTLAKTN RELLDVKKKF EDINQEFVKI 900
    KDKNEILKRN LENTQNQIKA EYISLAEHEA KMSSLSQSMR KVQDSNAEIL 950
    ANYRKGQEEI VTLHAEIKAQ KKELDTIQEC IKVKYAPIVS FEECERKFKA 1000
    TEKELKDQLS EQTQKYSVSE EEVKKNKQEN DKLKKEIFTL QKDLRDKTVL 1050
    IEKSHEMERA LSRKTDELNK QLKDLSQKYT EVKNVKEKLV EENAKQTSEI 1100
    LAVQNLLQKQ HVPLEQVEAL KKSLNGTIEN LKEELKSMQR CYEKEQQTVT 1150
    KLHQLLENQK NSSVPLAEHL QIKEAFEKEV GIIKASLREK EEESQNKMEE 1200
    VSKLQSEVQN TKQALKKLET REVVDLSKYK ATKSDLETQI SSLNEKLANL 1250
    NRKYEEVCEE VLHAKKKEIS AKDEKELLHF SIEQEIKDQK ERCDKSLTTI 1300
    TELQRRIQES AKQIEAKDNK ITELLNDVER LKQALNGLSQ LTYTSGNPTK 1350
    RQSQLIDTLQ HQVKSLEQQL ADADRQHQEV IAIYRTHLLS AAQGHMDEDV 1400
    QEALLQIIQM RQGLVC 1416
    Length:1,416
    Mass (Da):162,505
    Last modified:April 4, 2006 - v2
    Checksum:i92C1104445FB0009
    GO
    Isoform 2 (identifier: Q9BZF9-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-26: MKSLKSRLRRQDVPGPASSGAAAASA → MMNCWFSCTPKNR

    Note: No experimental confirmation available.

    Show »
    Length:1,403
    Mass (Da):161,510
    Checksum:i274D35E367DE3B75
    GO

    Sequence cautioni

    The sequence BAA91457.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti139 – 1413HDA → QKK in AAG49577. (PubMed:11162650)Curated
    Sequence conflicti166 – 1661D → K in AAG49577. (PubMed:11162650)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti814 – 8141I → T.
    Corresponds to variant rs3743315 [ dbSNP | Ensembl ].
    VAR_048313

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 2626MKSLK…AAASA → MMNCWFSCTPKNR in isoform 2. 1 PublicationVSP_047199Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF322916 mRNA. Translation: AAG49577.1.
    AB046781 mRNA. Translation: BAB13387.2.
    AC009269 Genomic DNA. No translation available.
    AC087699 Genomic DNA. No translation available.
    CH471082 Genomic DNA. Translation: EAW77855.1.
    BC113407 mRNA. Translation: AAI13408.1.
    BC113409 mRNA. Translation: AAI13410.1.
    AK000990 mRNA. Translation: BAA91457.1. Different initiation.
    AK055435 mRNA. Translation: BAB70922.1.
    AL834464 mRNA. Translation: CAD39123.1.
    CCDSiCCDS10235.1. [Q9BZF9-1]
    CCDS32280.1. [Q9BZF9-2]
    RefSeqiNP_001008225.1. NM_001008224.1. [Q9BZF9-2]
    NP_060473.2. NM_018003.2. [Q9BZF9-1]
    UniGeneiHs.108049.

    Genome annotation databases

    EnsembliENST00000322954; ENSP00000314556; ENSG00000137831. [Q9BZF9-1]
    ENST00000379983; ENSP00000369319; ENSG00000137831. [Q9BZF9-2]
    GeneIDi55075.
    KEGGihsa:55075.
    UCSCiuc002asq.3. human.
    uc002asr.3. human. [Q9BZF9-1]

    Polymorphism databases

    DMDMi91207950.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF322916 mRNA. Translation: AAG49577.1 .
    AB046781 mRNA. Translation: BAB13387.2 .
    AC009269 Genomic DNA. No translation available.
    AC087699 Genomic DNA. No translation available.
    CH471082 Genomic DNA. Translation: EAW77855.1 .
    BC113407 mRNA. Translation: AAI13408.1 .
    BC113409 mRNA. Translation: AAI13410.1 .
    AK000990 mRNA. Translation: BAA91457.1 . Different initiation.
    AK055435 mRNA. Translation: BAB70922.1 .
    AL834464 mRNA. Translation: CAD39123.1 .
    CCDSi CCDS10235.1. [Q9BZF9-1 ]
    CCDS32280.1. [Q9BZF9-2 ]
    RefSeqi NP_001008225.1. NM_001008224.1. [Q9BZF9-2 ]
    NP_060473.2. NM_018003.2. [Q9BZF9-1 ]
    UniGenei Hs.108049.

    3D structure databases

    ProteinModelPortali Q9BZF9.
    SMRi Q9BZF9. Positions 37-313.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 120392. 12 interactions.
    IntActi Q9BZF9. 6 interactions.
    MINTi MINT-1159571.
    STRINGi 9606.ENSP00000314556.

    PTM databases

    PhosphoSitei Q9BZF9.

    Polymorphism databases

    DMDMi 91207950.

    Proteomic databases

    MaxQBi Q9BZF9.
    PaxDbi Q9BZF9.
    PRIDEi Q9BZF9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000322954 ; ENSP00000314556 ; ENSG00000137831 . [Q9BZF9-1 ]
    ENST00000379983 ; ENSP00000369319 ; ENSG00000137831 . [Q9BZF9-2 ]
    GeneIDi 55075.
    KEGGi hsa:55075.
    UCSCi uc002asq.3. human.
    uc002asr.3. human. [Q9BZF9-1 ]

    Organism-specific databases

    CTDi 55075.
    GeneCardsi GC15M070946.
    HGNCi HGNC:15947. UACA.
    HPAi HPA041412.
    MIMi 612516. gene.
    neXtProti NX_Q9BZF9.
    PharmGKBi PA38062.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0666.
    HOGENOMi HOG000147885.
    HOVERGENi HBG066395.
    InParanoidi Q9BZF9.
    OMAi LKQGQMY.
    OrthoDBi EOG7X9G6C.
    PhylomeDBi Q9BZF9.
    TreeFami TF331274.

    Miscellaneous databases

    ChiTaRSi UACA. human.
    GeneWikii UACA.
    GenomeRNAii 55075.
    NextBioi 58608.
    PROi Q9BZF9.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9BZF9.
    Bgeei Q9BZF9.
    CleanExi HS_UACA.
    Genevestigatori Q9BZF9.

    Family and domain databases

    Gene3Di 1.25.40.20. 2 hits.
    InterProi IPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    IPR000727. T_SNARE_dom.
    [Graphical view ]
    Pfami PF12796. Ank_2. 2 hits.
    [Graphical view ]
    PRINTSi PR01415. ANKYRIN.
    SMARTi SM00248. ANK. 6 hits.
    [Graphical view ]
    SUPFAMi SSF48403. SSF48403. 1 hit.
    PROSITEi PS50297. ANK_REP_REGION. 1 hit.
    PS50088. ANK_REPEAT. 5 hits.
    PS50192. T_SNARE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
    2. "Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Kikuno R., Nakayama M., Hirosawa M., Ohara O.
      DNA Res. 7:273-281(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    3. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
      Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
      DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: SEQUENCE REVISION.
    4. "Analysis of the DNA sequence and duplication history of human chromosome 15."
      Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A.
      , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
      Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    7. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 646-1187 (ISOFORM 1/2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-634 (ISOFORM 2).
      Tissue: Brain and Embryo.
    8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1181-1416 (ISOFORM 1/2).
      Tissue: Brain.
    9. Cited for: TISSUE SPECIFICITY, SUBCELLULAR LOCATION, INDUCTION.
    10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    11. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiUACA_HUMAN
    AccessioniPrimary (citable) accession number: Q9BZF9
    Secondary accession number(s): G3XAG2
    , Q14DD3, Q8N3B8, Q96NH6, Q9HCL1, Q9NWC6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 4, 2006
    Last sequence update: April 4, 2006
    Last modified: October 1, 2014
    This is version 107 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    UACA is a possible target autoantigen in Vogt-Koyanagi-Harada (VKH), Behcet disease (BD) and sarcoidosis that cause different types of panuevitis.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 15
      Human chromosome 15: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3