Q9BZF3 (OSBL6_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Oxysterol-binding protein-related protein 6
Short name=ORP-6
Short name=OSBP-related protein 6

Gene names

Name:	OSBPL6
Synonyms:	ORP6

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	934 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Tissue specificity	Widely expressed.
Sequence similarities	Belongs to the OSBP family. Contains 1 PH domain.
Sequence caution	The sequence BAB55223.1 differs from that shown. Reason: Erroneous initiation. The sequence BAD92135.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Lipid transport Transport
Coding sequence diversity	Alternative splicing Polymorphism
Ligand	Lipid-binding
PTM	Acetylation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	lipid transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cytosol Inferred from direct assay PubMed 14593528. Source: BHF-UCL nuclear membrane Inferred from direct assay PubMed 14593528. Source: BHF-UCL perinuclear endoplasmic reticulum Inferred from direct assay PubMed 14593528. Source: BHF-UCL plasma membrane Inferred from direct assay PubMed 14593528. Source: BHF-UCL
Molecular_function	phospholipid binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
ORF	Q9Q2G4	3	EBI-2372709,EBI-6248094	From a different organism.

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9BZF3-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9BZF3-2)

The sequence of this isoform differs from the canonical sequence as follows:
     431-466: Missing.

Isoform 3 (identifier: Q9BZF3-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-34: MSSDEKGISPAHKTSTPTHRSASSSTSSQRDSRQ → MHQLSLIRGNRGR
     329-329: Q → QEGPPAKGQFSTTRRRQRLAAAVATT

Isoform 4 (identifier: Q9BZF3-4)

The sequence of this isoform differs from the canonical sequence as follows:
     298-328: Missing.

Isoform 5 (identifier: Q9BZF3-5)

The sequence of this isoform differs from the canonical sequence as follows:
     329-329: Q → QEGPPAKGQFSTTRRRQRLAAAVATT

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed Ref.10
	Chain	2 – 934	933	Oxysterol-binding protein-related protein 6		PRO_0000100375
Regions
	Domain	86 – 181	96	PH
Amino acid modifications
	Modified residue	2	1	N-acetylserine Ref.10
Natural variations
	Alternative sequence	1 – 34	34	MSSDE…RDSRQ → MHQLSLIRGNRGR in isoform 3.		VSP_036559
	Alternative sequence	298 – 328	31	Missing in isoform 4.		VSP_036560
	Alternative sequence	329	1	Q → QEGPPAKGQFSTTRRRQRLA AAVATT in isoform 3 and isoform 5.		VSP_036561
	Alternative sequence	431 – 466	36	Missing in isoform 2.		VSP_010013
	Natural variant	53	1	R → Q. Corresponds to variant rs35032920 [ dbSNP | Ensembl ].		VAR_057663
	Natural variant	58	1	P → L. Corresponds to variant rs34874235 [ dbSNP | Ensembl ].		VAR_053550
Experimental info
	Sequence conflict	319	1	S → G in BAB55223. Ref.4
	Sequence conflict	350	1	A → V in BAG62123. Ref.4
	Sequence conflict	487	1	S → P in BAC04248. Ref.4
	Sequence conflict	714	1	N → S in BAB55223. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: D20F90EA34C81497	FASTA	934	106,306
	10 20 30 40 50 60 MSSDEKGISP AHKTSTPTHR SASSSTSSQR DSRQSIHILE RTASSSTEPS VSRQLLEPEP 70 80 90 100 110 120 VPLSKEADSW EIIEGLKIGQ TNVQKPDKHE GFMLKKRKWP LKGWHKRFFV LDNGMLKYSK 130 140 150 160 170 180 APLDIQKGKV HGSIDVGLSV MSIKKKARRI DLDTEEHIYH LKVKSQDWFD AWVSKLRHHR 190 200 210 220 230 240 LYRQNEIVRS PRDASFHIFP STSTAESSPA ANVSVMDGKM QPNSFPWQSP LPCSNSLPAT 250 260 270 280 290 300 CTTGQSKVAA WLQDSEEMDR CAEDLAHCQS NLVELSKLLQ NLEILQRTQS APNFTDMQAN 310 320 330 340 350 360 CVDISKKDKR VTRRWRTKSV SKDTKIQLQV PFSATMSPVR LHSSNPNLCA DIEFQTPPSH 370 380 390 400 410 420 LTDPLESSTD YTKLQEEFCL IAQKVHSLLK SAFNSIAIEK EKLKQMVSEQ DHSKGHSTQM 430 440 450 460 470 480 ARLRQSLSQA LNQNAELRSR LNRIHSESII CDQVVSVNII PSPDEAGEQI HVSLPLSQQV 490 500 510 520 530 540 ANESRLSMSE SVSEFFDAQE VLLSASSSEN EASDDESYIS DVSDNISEDN TSVADNISRQ 550 560 570 580 590 600 ILNGELTGGA FRNGRRACLP APCPDTSNIN LWNILRNNIG KDLSKVSMPV ELNEPLNTLQ 610 620 630 640 650 660 HLCEEMEYSE LLDKASETDD PYERMVLVAA FAVSGYCSTY FRAGSKPFNP VLGETYECIR 670 680 690 700 710 720 EDKGFRFFSE QVSHHPPISA CHCESKNFVF WQDIRWKNKF WGKSMEILPV GTLNVMLPKY 730 740 750 760 770 780 GDYYVWNKVT TCIHNILSGR RWIEHYGEVT IRNTKSSVCI CKLTFVKVNY WNSNMNEVQG 790 800 810 820 830 840 VVIDQEGKAV YRLFGKWHEG LYCGVAPSAK CIWRPGSMPT NYELYYGFTR FAIELNELDP 850 860 870 880 890 900 VLKDLLPPTD ARFRPDQRFL EEGNLEAAAS EKQRVEELQR SRRRYMEENN LEHIPKFFKK 910 920 930 VIDANQREAW VSNDTYWELR KDPGFSKVDS PVLW
	Isoform 2 [UniParc]. Checksum: FDCF238AFD0D0B79	FASTA	898	102,293
	10 20 30 40 50 60 MSSDEKGISP AHKTSTPTHR SASSSTSSQR DSRQSIHILE RTASSSTEPS VSRQLLEPEP 70 80 90 100 110 120 VPLSKEADSW EIIEGLKIGQ TNVQKPDKHE GFMLKKRKWP LKGWHKRFFV LDNGMLKYSK 130 140 150 160 170 180 APLDIQKGKV HGSIDVGLSV MSIKKKARRI DLDTEEHIYH LKVKSQDWFD AWVSKLRHHR 190 200 210 220 230 240 LYRQNEIVRS PRDASFHIFP STSTAESSPA ANVSVMDGKM QPNSFPWQSP LPCSNSLPAT 250 260 270 280 290 300 CTTGQSKVAA WLQDSEEMDR CAEDLAHCQS NLVELSKLLQ NLEILQRTQS APNFTDMQAN 310 320 330 340 350 360 CVDISKKDKR VTRRWRTKSV SKDTKIQLQV PFSATMSPVR LHSSNPNLCA DIEFQTPPSH 370 380 390 400 410 420 LTDPLESSTD YTKLQEEFCL IAQKVHSLLK SAFNSIAIEK EKLKQMVSEQ DHSKGHSTQM 430 440 450 460 470 480 ARLRQSLSQA GEQIHVSLPL SQQVANESRL SMSESVSEFF DAQEVLLSAS SSENEASDDE 490 500 510 520 530 540 SYISDVSDNI SEDNTSVADN ISRQILNGEL TGGAFRNGRR ACLPAPCPDT SNINLWNILR 550 560 570 580 590 600 NNIGKDLSKV SMPVELNEPL NTLQHLCEEM EYSELLDKAS ETDDPYERMV LVAAFAVSGY 610 620 630 640 650 660 CSTYFRAGSK PFNPVLGETY ECIREDKGFR FFSEQVSHHP PISACHCESK NFVFWQDIRW 670 680 690 700 710 720 KNKFWGKSME ILPVGTLNVM LPKYGDYYVW NKVTTCIHNI LSGRRWIEHY GEVTIRNTKS 730 740 750 760 770 780 SVCICKLTFV KVNYWNSNMN EVQGVVIDQE GKAVYRLFGK WHEGLYCGVA PSAKCIWRPG 790 800 810 820 830 840 SMPTNYELYY GFTRFAIELN ELDPVLKDLL PPTDARFRPD QRFLEEGNLE AAASEKQRVE 850 860 870 880 890 ELQRSRRRYM EENNLEHIPK FFKKVIDANQ REAWVSNDTY WELRKDPGFS KVDSPVLW
	Isoform 3 [UniParc]. Checksum: 275936D5B48740FF	FASTA	938	106,864
	10 20 30 40 50 60 MHQLSLIRGN RGRSIHILER TASSSTEPSV SRQLLEPEPV PLSKEADSWE IIEGLKIGQT 70 80 90 100 110 120 NVQKPDKHEG FMLKKRKWPL KGWHKRFFVL DNGMLKYSKA PLDIQKGKVH GSIDVGLSVM 130 140 150 160 170 180 SIKKKARRID LDTEEHIYHL KVKSQDWFDA WVSKLRHHRL YRQNEIVRSP RDASFHIFPS 190 200 210 220 230 240 TSTAESSPAA NVSVMDGKMQ PNSFPWQSPL PCSNSLPATC TTGQSKVAAW LQDSEEMDRC 250 260 270 280 290 300 AEDLAHCQSN LVELSKLLQN LEILQRTQSA PNFTDMQANC VDISKKDKRV TRRWRTKSVS 310 320 330 340 350 360 KDTKIQLQEG PPAKGQFSTT RRRQRLAAAV ATTVPFSATM SPVRLHSSNP NLCADIEFQT 370 380 390 400 410 420 PPSHLTDPLE SSTDYTKLQE EFCLIAQKVH SLLKSAFNSI AIEKEKLKQM VSEQDHSKGH 430 440 450 460 470 480 STQMARLRQS LSQALNQNAE LRSRLNRIHS ESIICDQVVS VNIIPSPDEA GEQIHVSLPL 490 500 510 520 530 540 SQQVANESRL SMSESVSEFF DAQEVLLSAS SSENEASDDE SYISDVSDNI SEDNTSVADN 550 560 570 580 590 600 ISRQILNGEL TGGAFRNGRR ACLPAPCPDT SNINLWNILR NNIGKDLSKV SMPVELNEPL 610 620 630 640 650 660 NTLQHLCEEM EYSELLDKAS ETDDPYERMV LVAAFAVSGY CSTYFRAGSK PFNPVLGETY 670 680 690 700 710 720 ECIREDKGFR FFSEQVSHHP PISACHCESK NFVFWQDIRW KNKFWGKSME ILPVGTLNVM 730 740 750 760 770 780 LPKYGDYYVW NKVTTCIHNI LSGRRWIEHY GEVTIRNTKS SVCICKLTFV KVNYWNSNMN 790 800 810 820 830 840 EVQGVVIDQE GKAVYRLFGK WHEGLYCGVA PSAKCIWRPG SMPTNYELYY GFTRFAIELN 850 860 870 880 890 900 ELDPVLKDLL PPTDARFRPD QRFLEEGNLE AAASEKQRVE ELQRSRRRYM EENNLEHIPK 910 920 930 FFKKVIDANQ REAWVSNDTY WELRKDPGFS KVDSPVLW
	Isoform 4 [UniParc]. Checksum: 612100E10BD6C501	FASTA	903	102,635
	10 20 30 40 50 60 MSSDEKGISP AHKTSTPTHR SASSSTSSQR DSRQSIHILE RTASSSTEPS VSRQLLEPEP 70 80 90 100 110 120 VPLSKEADSW EIIEGLKIGQ TNVQKPDKHE GFMLKKRKWP LKGWHKRFFV LDNGMLKYSK 130 140 150 160 170 180 APLDIQKGKV HGSIDVGLSV MSIKKKARRI DLDTEEHIYH LKVKSQDWFD AWVSKLRHHR 190 200 210 220 230 240 LYRQNEIVRS PRDASFHIFP STSTAESSPA ANVSVMDGKM QPNSFPWQSP LPCSNSLPAT 250 260 270 280 290 300 CTTGQSKVAA WLQDSEEMDR CAEDLAHCQS NLVELSKLLQ NLEILQRTQS APNFTDMQVP 310 320 330 340 350 360 FSATMSPVRL HSSNPNLCAD IEFQTPPSHL TDPLESSTDY TKLQEEFCLI AQKVHSLLKS 370 380 390 400 410 420 AFNSIAIEKE KLKQMVSEQD HSKGHSTQMA RLRQSLSQAL NQNAELRSRL NRIHSESIIC 430 440 450 460 470 480 DQVVSVNIIP SPDEAGEQIH VSLPLSQQVA NESRLSMSES VSEFFDAQEV LLSASSSENE 490 500 510 520 530 540 ASDDESYISD VSDNISEDNT SVADNISRQI LNGELTGGAF RNGRRACLPA PCPDTSNINL 550 560 570 580 590 600 WNILRNNIGK DLSKVSMPVE LNEPLNTLQH LCEEMEYSEL LDKASETDDP YERMVLVAAF 610 620 630 640 650 660 AVSGYCSTYF RAGSKPFNPV LGETYECIRE DKGFRFFSEQ VSHHPPISAC HCESKNFVFW 670 680 690 700 710 720 QDIRWKNKFW GKSMEILPVG TLNVMLPKYG DYYVWNKVTT CIHNILSGRR WIEHYGEVTI 730 740 750 760 770 780 RNTKSSVCIC KLTFVKVNYW NSNMNEVQGV VIDQEGKAVY RLFGKWHEGL YCGVAPSAKC 790 800 810 820 830 840 IWRPGSMPTN YELYYGFTRF AIELNELDPV LKDLLPPTDA RFRPDQRFLE EGNLEAAASE 850 860 870 880 890 900 KQRVEELQRS RRRYMEENNL EHIPKFFKKV IDANQREAWV SNDTYWELRK DPGFSKVDSP VLW
	Isoform 5 [UniParc]. Checksum: D0D688B86FECA73D	FASTA	959	108,959
	10 20 30 40 50 60 MSSDEKGISP AHKTSTPTHR SASSSTSSQR DSRQSIHILE RTASSSTEPS VSRQLLEPEP 70 80 90 100 110 120 VPLSKEADSW EIIEGLKIGQ TNVQKPDKHE GFMLKKRKWP LKGWHKRFFV LDNGMLKYSK 130 140 150 160 170 180 APLDIQKGKV HGSIDVGLSV MSIKKKARRI DLDTEEHIYH LKVKSQDWFD AWVSKLRHHR 190 200 210 220 230 240 LYRQNEIVRS PRDASFHIFP STSTAESSPA ANVSVMDGKM QPNSFPWQSP LPCSNSLPAT 250 260 270 280 290 300 CTTGQSKVAA WLQDSEEMDR CAEDLAHCQS NLVELSKLLQ NLEILQRTQS APNFTDMQAN 310 320 330 340 350 360 CVDISKKDKR VTRRWRTKSV SKDTKIQLQE GPPAKGQFST TRRRQRLAAA VATTVPFSAT 370 380 390 400 410 420 MSPVRLHSSN PNLCADIEFQ TPPSHLTDPL ESSTDYTKLQ EEFCLIAQKV HSLLKSAFNS 430 440 450 460 470 480 IAIEKEKLKQ MVSEQDHSKG HSTQMARLRQ SLSQALNQNA ELRSRLNRIH SESIICDQVV 490 500 510 520 530 540 SVNIIPSPDE AGEQIHVSLP LSQQVANESR LSMSESVSEF FDAQEVLLSA SSSENEASDD 550 560 570 580 590 600 ESYISDVSDN ISEDNTSVAD NISRQILNGE LTGGAFRNGR RACLPAPCPD TSNINLWNIL 610 620 630 640 650 660 RNNIGKDLSK VSMPVELNEP LNTLQHLCEE MEYSELLDKA SETDDPYERM VLVAAFAVSG 670 680 690 700 710 720 YCSTYFRAGS KPFNPVLGET YECIREDKGF RFFSEQVSHH PPISACHCES KNFVFWQDIR 730 740 750 760 770 780 WKNKFWGKSM EILPVGTLNV MLPKYGDYYV WNKVTTCIHN ILSGRRWIEH YGEVTIRNTK 790 800 810 820 830 840 SSVCICKLTF VKVNYWNSNM NEVQGVVIDQ EGKAVYRLFG KWHEGLYCGV APSAKCIWRP 850 860 870 880 890 900 GSMPTNYELY YGFTRFAIEL NELDPVLKDL LPPTDARFRP DQRFLEEGNL EAAASEKQRV 910 920 930 940 950 EELQRSRRRY MEENNLEHIP KFFKKVIDAN QREAWVSNDT YWELRKDPGF SKVDSPVLW

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The OSBP-related protein family in humans." Lehto M., Laitinen S., Chinetti G., Johansson M., Ehnholm C., Staels B., Ikonen E., Olkkonen V.M. J. Lipid Res. 42:1203-1213(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]	"A family of 12 human genes containing oxysterol-binding domains." Jaworski C.J., Moreira E., Li A., Lee R., Rodriguez I.R. Genomics 78:185-196(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[3]	Guo J.H., Zan Q., Yu L. Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 4), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 195-934 (ISOFORM 1). Tissue: Placenta, Teratocarcinoma and Trachea.
[5]	Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F. Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5). Tissue: Brain.
[6]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]	"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage." Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III, Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N., Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J. Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Embryonic kidney.
[9]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[10]	"Large-scale proteomics analysis of the human kinome." Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G., Mann M., Daub H. Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, MASS SPECTROMETRY, CLEAVAGE OF INITIATOR METHIONINE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF323728 mRNA. Translation: AAG53409.1. AF392448 mRNA. Translation: AAL40661.1. AF462443 mRNA. Translation: AAP97711.1. AK027600 mRNA. Translation: BAB55223.1. Different initiation. AK093902 mRNA. Translation: BAC04248.1. AK300389 mRNA. Translation: BAG62123.1. AB208898 mRNA. Translation: BAD92135.1. Different initiation. AC009948 Genomic DNA. Translation: AAX88881.1. AC011743 Genomic DNA. Translation: AAY15090.1. AC011238 Genomic DNA. No translation available. CH471058 Genomic DNA. Translation: EAX11040.1. CH471058 Genomic DNA. Translation: EAX11041.1. CH471058 Genomic DNA. Translation: EAX11042.1. CH471058 Genomic DNA. Translation: EAX11043.1.
IPI	IPI00167804. IPI00220568. IPI00385134. IPI00789184. IPI00908339.
RefSeq	NP_001188409.1. NM_001201480.1. NP_001188410.1. NM_001201481.1. NP_001188411.1. NM_001201482.1. NP_115912.1. NM_032523.3. NP_665682.1. NM_145739.2.
UniGene	Hs.318775.
3D structure databases
ProteinModelPortal	Q9BZF3.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9BZF3. 2 interactions.
PTM databases
PhosphoSite	Q9BZF3.
Polymorphism databases
DMDM	20139133.
Proteomic databases
PaxDb	Q9BZF3.
PRIDE	Q9BZF3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000190611; ENSP00000190611; ENSG00000079156. ENST00000315022; ENSP00000318723; ENSG00000079156. ENST00000359685; ENSP00000352713; ENSG00000079156. ENST00000392505; ENSP00000376293; ENSG00000079156. ENST00000409045; ENSP00000387248; ENSG00000079156. ENST00000409631; ENSP00000386885; ENSG00000079156.
GeneID	114880.
KEGG	hsa:114880.
UCSC	uc002ulx.3. human. uc002uly.3. human. uc002ulz.3. human. uc002uma.3. human. uc010zfe.2. human.
Organism-specific databases
CTD	114880.
GeneCards	GC02P179023.
HGNC	HGNC:16388. OSBPL6.
HPA	HPA032131.
MIM	606734. gene.
neXtProt	NX_Q9BZF3.
PharmGKB	PA32830.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG281324.
HOVERGEN	HBG058934.
OMA	VTIRNTK.
OrthoDB	EOG49S65P.
Gene expression databases
ArrayExpress	Q9BZF3.
Bgee	Q9BZF3.
CleanEx	HS_OSBPL6.
Genevestigator	Q9BZF3.
GermOnline	ENSG00000079156. Homo sapiens.
Family and domain databases
Gene3D	2.30.29.30. 1 hit.
InterPro	IPR000648. Oxysterol-bd. IPR018494. Oxysterol-bd_CS. IPR011993. PH_like_dom. IPR001849. Pleckstrin_homology. [Graphical view]
PANTHER	PTHR10972. PTHR10972. 1 hit.
Pfam	PF01237. Oxysterol_BP. 1 hit. [Graphical view]
SMART	SM00233. PH. 1 hit. [Graphical view]
PROSITE	PS01013. OSBP. 1 hit. PS50003. PH_DOMAIN. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	OSBPL6. human.
GenomeRNAi	114880.
NextBio	79353.
SOURCE	Search...

Entry information

Entry name

OSBL6_HUMAN

Accession

Primary (citable) accession number: Q9BZF3
Secondary accession number(s): B4DTW1 , C4AMC0, C4AME4, D3DPF6, D3DPF7, Q4ZG68, Q53T68, Q59H61, Q7Z4Q1, Q8N9T0, Q96SR1

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 11, 2002
Last sequence update:	June 1, 2001
Last modified:	May 1, 2013
This is version 99 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.