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Q9BZF3 (OSBL6_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 107. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Oxysterol-binding protein-related protein 6

Short name=ORP-6
Short name=OSBP-related protein 6
Gene names
Name:OSBPL6
Synonyms:ORP6
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length934 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Tissue specificity

Widely expressed.

Sequence similarities

Belongs to the OSBP family.

Contains 1 PH domain.

Sequence caution

The sequence BAB55223.1 differs from that shown. Reason: Erroneous initiation.

The sequence BAD92135.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Binary interactions

With

Entry

#Exp.

IntAct

Notes

ORFQ9Q2G43EBI-2372709,EBI-6248094From a different organism.

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9BZF3-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9BZF3-2)

The sequence of this isoform differs from the canonical sequence as follows:
     431-466: Missing.
Isoform 3 (identifier: Q9BZF3-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-34: MSSDEKGISPAHKTSTPTHRSASSSTSSQRDSRQ → MHQLSLIRGNRGR
     329-329: Q → QEGPPAKGQFSTTRRRQRLAAAVATT
Isoform 4 (identifier: Q9BZF3-4)

The sequence of this isoform differs from the canonical sequence as follows:
     298-328: Missing.
Isoform 5 (identifier: Q9BZF3-5)

The sequence of this isoform differs from the canonical sequence as follows:
     329-329: Q → QEGPPAKGQFSTTRRRQRLAAAVATT

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.11
Chain2 – 934933Oxysterol-binding protein-related protein 6
PRO_0000100375

Regions

Domain86 – 18196PH

Amino acid modifications

Modified residue21N-acetylserine Ref.11

Natural variations

Alternative sequence1 – 3434MSSDE…RDSRQ → MHQLSLIRGNRGR in isoform 3.
VSP_036559
Alternative sequence298 – 32831Missing in isoform 4.
VSP_036560
Alternative sequence3291Q → QEGPPAKGQFSTTRRRQRLA AAVATT in isoform 3 and isoform 5.
VSP_036561
Alternative sequence431 – 46636Missing in isoform 2.
VSP_010013
Natural variant531R → Q.
Corresponds to variant rs35032920 [ dbSNP | Ensembl ].
VAR_057663
Natural variant581P → L.
Corresponds to variant rs34874235 [ dbSNP | Ensembl ].
VAR_053550

Experimental info

Sequence conflict3191S → G in BAB55223. Ref.4
Sequence conflict3501A → V in BAG62123. Ref.4
Sequence conflict4871S → P in BAC04248. Ref.4
Sequence conflict7141N → S in BAB55223. Ref.4

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: D20F90EA34C81497

FASTA934106,306
        10         20         30         40         50         60 
MSSDEKGISP AHKTSTPTHR SASSSTSSQR DSRQSIHILE RTASSSTEPS VSRQLLEPEP 

        70         80         90        100        110        120 
VPLSKEADSW EIIEGLKIGQ TNVQKPDKHE GFMLKKRKWP LKGWHKRFFV LDNGMLKYSK 

       130        140        150        160        170        180 
APLDIQKGKV HGSIDVGLSV MSIKKKARRI DLDTEEHIYH LKVKSQDWFD AWVSKLRHHR 

       190        200        210        220        230        240 
LYRQNEIVRS PRDASFHIFP STSTAESSPA ANVSVMDGKM QPNSFPWQSP LPCSNSLPAT 

       250        260        270        280        290        300 
CTTGQSKVAA WLQDSEEMDR CAEDLAHCQS NLVELSKLLQ NLEILQRTQS APNFTDMQAN 

       310        320        330        340        350        360 
CVDISKKDKR VTRRWRTKSV SKDTKIQLQV PFSATMSPVR LHSSNPNLCA DIEFQTPPSH 

       370        380        390        400        410        420 
LTDPLESSTD YTKLQEEFCL IAQKVHSLLK SAFNSIAIEK EKLKQMVSEQ DHSKGHSTQM 

       430        440        450        460        470        480 
ARLRQSLSQA LNQNAELRSR LNRIHSESII CDQVVSVNII PSPDEAGEQI HVSLPLSQQV 

       490        500        510        520        530        540 
ANESRLSMSE SVSEFFDAQE VLLSASSSEN EASDDESYIS DVSDNISEDN TSVADNISRQ 

       550        560        570        580        590        600 
ILNGELTGGA FRNGRRACLP APCPDTSNIN LWNILRNNIG KDLSKVSMPV ELNEPLNTLQ 

       610        620        630        640        650        660 
HLCEEMEYSE LLDKASETDD PYERMVLVAA FAVSGYCSTY FRAGSKPFNP VLGETYECIR 

       670        680        690        700        710        720 
EDKGFRFFSE QVSHHPPISA CHCESKNFVF WQDIRWKNKF WGKSMEILPV GTLNVMLPKY 

       730        740        750        760        770        780 
GDYYVWNKVT TCIHNILSGR RWIEHYGEVT IRNTKSSVCI CKLTFVKVNY WNSNMNEVQG 

       790        800        810        820        830        840 
VVIDQEGKAV YRLFGKWHEG LYCGVAPSAK CIWRPGSMPT NYELYYGFTR FAIELNELDP 

       850        860        870        880        890        900 
VLKDLLPPTD ARFRPDQRFL EEGNLEAAAS EKQRVEELQR SRRRYMEENN LEHIPKFFKK 

       910        920        930 
VIDANQREAW VSNDTYWELR KDPGFSKVDS PVLW 

« Hide

Isoform 2 [UniParc].

Checksum: FDCF238AFD0D0B79
Show »

FASTA898102,293
Isoform 3 [UniParc].

Checksum: 275936D5B48740FF
Show »

FASTA938106,864
Isoform 4 [UniParc].

Checksum: 612100E10BD6C501
Show »

FASTA903102,635
Isoform 5 [UniParc].

Checksum: D0D688B86FECA73D
Show »

FASTA959108,959

References

« Hide 'large scale' references
[1]"The OSBP-related protein family in humans."
Lehto M., Laitinen S., Chinetti G., Johansson M., Ehnholm C., Staels B., Ikonen E., Olkkonen V.M.
J. Lipid Res. 42:1203-1213(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]"A family of 12 human genes containing oxysterol-binding domains."
Jaworski C.J., Moreira E., Li A., Lee R., Rodriguez I.R.
Genomics 78:185-196(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[3]Guo J.H., Zan Q., Yu L.
Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
[4]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 4), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 195-934 (ISOFORM 1).
Tissue: Placenta, Teratocarcinoma and Trachea.
[5]Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F.
Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5).
Tissue: Brain.
[6]"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. expand/collapse author list , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."
Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III, Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N., Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.
Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Embryonic kidney.
[9]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[10]"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[11]"Large-scale proteomics analysis of the human kinome."
Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G., Mann M., Daub H.
Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF323728 mRNA. Translation: AAG53409.1.
AF392448 mRNA. Translation: AAL40661.1.
AF462443 mRNA. Translation: AAP97711.1.
AK027600 mRNA. Translation: BAB55223.1. Different initiation.
AK093902 mRNA. Translation: BAC04248.1.
AK300389 mRNA. Translation: BAG62123.1.
AB208898 mRNA. Translation: BAD92135.1. Different initiation.
AC009948 Genomic DNA. Translation: AAX88881.1.
AC011743 Genomic DNA. Translation: AAY15090.1.
AC011238 Genomic DNA. No translation available.
CH471058 Genomic DNA. Translation: EAX11040.1.
CH471058 Genomic DNA. Translation: EAX11041.1.
CH471058 Genomic DNA. Translation: EAX11042.1.
CH471058 Genomic DNA. Translation: EAX11043.1.
RefSeqNP_001188409.1. NM_001201480.1.
NP_001188410.1. NM_001201481.1.
NP_001188411.1. NM_001201482.1.
NP_115912.1. NM_032523.3.
NP_665682.1. NM_145739.2.
UniGeneHs.318775.

3D structure databases

ProteinModelPortalQ9BZF3.
SMRQ9BZF3. Positions 94-180, 562-934.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid125381. 3 interactions.
IntActQ9BZF3. 3 interactions.

PTM databases

PhosphoSiteQ9BZF3.

Polymorphism databases

DMDM20139133.

Proteomic databases

PaxDbQ9BZF3.
PRIDEQ9BZF3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000190611; ENSP00000190611; ENSG00000079156. [Q9BZF3-1]
ENST00000315022; ENSP00000318723; ENSG00000079156. [Q9BZF3-3]
ENST00000359685; ENSP00000352713; ENSG00000079156. [Q9BZF3-2]
ENST00000392505; ENSP00000376293; ENSG00000079156. [Q9BZF3-5]
ENST00000409045; ENSP00000387248; ENSG00000079156. [Q9BZF3-4]
ENST00000409631; ENSP00000386885; ENSG00000079156. [Q9BZF3-2]
GeneID114880.
KEGGhsa:114880.
UCSCuc002ulx.3. human. [Q9BZF3-1]
uc002uly.3. human. [Q9BZF3-5]
uc002ulz.3. human. [Q9BZF3-2]
uc002uma.3. human. [Q9BZF3-3]
uc010zfe.2. human. [Q9BZF3-4]

Organism-specific databases

CTD114880.
GeneCardsGC02P179023.
HGNCHGNC:16388. OSBPL6.
HPAHPA032131.
MIM606734. gene.
neXtProtNX_Q9BZF3.
PharmGKBPA32830.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG281324.
HOVERGENHBG058934.
OMAVTIRNTK.
OrthoDBEOG780RKR.
PhylomeDBQ9BZF3.
TreeFamTF320922.

Gene expression databases

ArrayExpressQ9BZF3.
BgeeQ9BZF3.
CleanExHS_OSBPL6.
GenevestigatorQ9BZF3.

Family and domain databases

Gene3D2.30.29.30. 1 hit.
InterProIPR000648. Oxysterol-bd.
IPR018494. Oxysterol-bd_CS.
IPR011993. PH_like_dom.
IPR001849. Pleckstrin_homology.
[Graphical view]
PANTHERPTHR10972. PTHR10972. 1 hit.
PfamPF01237. Oxysterol_BP. 1 hit.
[Graphical view]
SMARTSM00233. PH. 1 hit.
[Graphical view]
PROSITEPS01013. OSBP. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSOSBPL6. human.
GenomeRNAi114880.
NextBio79353.
PROQ9BZF3.
SOURCESearch...

Entry information

Entry nameOSBL6_HUMAN
AccessionPrimary (citable) accession number: Q9BZF3
Secondary accession number(s): B4DTW1 expand/collapse secondary AC list , C4AMC0, C4AME4, D3DPF6, D3DPF7, Q4ZG68, Q53T68, Q59H61, Q7Z4Q1, Q8N9T0, Q96SR1
Entry history
Integrated into UniProtKB/Swiss-Prot: February 11, 2002
Last sequence update: June 1, 2001
Last modified: April 16, 2014
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 2

Human chromosome 2: entries, gene names and cross-references to MIM