ID   OSBL7_HUMAN             Reviewed;         842 AA.
AC   Q9BZF2; D3DTT6; Q6PIV6;
DT   11-FEB-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   27-MAR-2024, entry version 167.
DE   RecName: Full=Oxysterol-binding protein-related protein 7;
DE            Short=ORP-7;
DE            Short=OSBP-related protein 7;
GN   Name=OSBPL7; Synonyms=ORP7;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RX   PubMed=11483621;
RA   Lehto M., Laitinen S., Chinetti G., Johansson M., Ehnholm C., Staels B.,
RA   Ikonen E., Olkkonen V.M.;
RT   "The OSBP-related protein family in humans.";
RL   J. Lipid Res. 42:1203-1213(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   TISSUE=Cerebellum;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16625196; DOI=10.1038/nature04689;
RA   Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA   Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA   Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA   Chang J.L., Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA   DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S.,
RA   Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E.,
RA   Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K.,
RA   LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J.,
RA   Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A.,
RA   Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K.,
RA   Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA   Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA   Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT   "DNA sequence of human chromosome 17 and analysis of rearrangement in the
RT   human lineage.";
RL   Nature 440:1045-1049(2006).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC   TISSUE=Blood, and Pancreas;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [6]
RP   SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RX   PubMed=14593528; DOI=10.1007/s00441-003-0817-y;
RA   Lehto M., Tienari J., Lehtonen S., Lehtonen E., Olkkonen V.M.;
RT   "Subfamily III of mammalian oxysterol-binding protein (OSBP) homologues:
RT   the expression and intracellular localization of ORP3, ORP6, and ORP7.";
RL   Cell Tissue Res. 315:39-57(2004).
RN   [7]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-171; SER-217; SER-226;
RP   SER-256 AND SER-272, AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE
RP   ANALYSIS].
RC   TISSUE=Erythroleukemia;
RX   PubMed=23186163; DOI=10.1021/pr300630k;
RA   Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA   Mohammed S.;
RT   "Toward a comprehensive characterization of a human cancer cell
RT   phosphoproteome.";
RL   J. Proteome Res. 12:260-271(2013).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:14593528}.
CC       Endoplasmic reticulum membrane {ECO:0000269|PubMed:14593528}. Cell
CC       membrane {ECO:0000269|PubMed:14593528}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q9BZF2-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q9BZF2-2; Sequence=VSP_057227, VSP_057228;
CC   -!- TISSUE SPECIFICITY: Expressed in epithelium of small and large
CC       intestines (at protein level). Expressed in stomach, duodenum, jejunum,
CC       ascending colon, spleen, thymus, lymph node, trachea and leukocytes.
CC       {ECO:0000269|PubMed:14593528}.
CC   -!- DEVELOPMENTAL STAGE: Expressed in fetal lung and thymus.
CC       {ECO:0000269|PubMed:14593528}.
CC   -!- SIMILARITY: Belongs to the OSBP family. {ECO:0000305}.
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DR   EMBL; AF323729; AAG53410.1; -; mRNA.
DR   EMBL; AK289523; BAF82212.1; -; mRNA.
DR   EMBL; AC003665; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471109; EAW94800.1; -; Genomic_DNA.
DR   EMBL; CH471109; EAW94801.1; -; Genomic_DNA.
DR   EMBL; CH471109; EAW94802.1; -; Genomic_DNA.
DR   EMBL; CH471109; EAW94803.1; -; Genomic_DNA.
DR   EMBL; BC028010; AAH28010.1; -; mRNA.
DR   EMBL; BC065482; AAH65482.1; -; mRNA.
DR   CCDS; CCDS11515.1; -. [Q9BZF2-1]
DR   RefSeq; NP_665741.1; NM_145798.2. [Q9BZF2-1]
DR   AlphaFoldDB; Q9BZF2; -.
DR   SMR; Q9BZF2; -.
DR   BioGRID; 125382; 15.
DR   ELM; Q9BZF2; -.
DR   IntAct; Q9BZF2; 1.
DR   STRING; 9606.ENSP00000007414; -.
DR   GlyGen; Q9BZF2; 2 sites, 1 O-linked glycan (2 sites).
DR   iPTMnet; Q9BZF2; -.
DR   MetOSite; Q9BZF2; -.
DR   PhosphoSitePlus; Q9BZF2; -.
DR   BioMuta; OSBPL7; -.
DR   DMDM; 20139132; -.
DR   EPD; Q9BZF2; -.
DR   jPOST; Q9BZF2; -.
DR   MassIVE; Q9BZF2; -.
DR   MaxQB; Q9BZF2; -.
DR   PaxDb; 9606-ENSP00000007414; -.
DR   PeptideAtlas; Q9BZF2; -.
DR   ProteomicsDB; 79830; -. [Q9BZF2-1]
DR   Pumba; Q9BZF2; -.
DR   Antibodypedia; 30177; 66 antibodies from 20 providers.
DR   DNASU; 114881; -.
DR   Ensembl; ENST00000007414.8; ENSP00000007414.3; ENSG00000006025.13. [Q9BZF2-1]
DR   Ensembl; ENST00000613735.4; ENSP00000479827.1; ENSG00000006025.13. [Q9BZF2-2]
DR   GeneID; 114881; -.
DR   KEGG; hsa:114881; -.
DR   MANE-Select; ENST00000007414.8; ENSP00000007414.3; NM_145798.3; NP_665741.1.
DR   UCSC; uc002ilx.2; human. [Q9BZF2-1]
DR   AGR; HGNC:16387; -.
DR   CTD; 114881; -.
DR   DisGeNET; 114881; -.
DR   GeneCards; OSBPL7; -.
DR   HGNC; HGNC:16387; OSBPL7.
DR   HPA; ENSG00000006025; Low tissue specificity.
DR   MIM; 606735; gene.
DR   neXtProt; NX_Q9BZF2; -.
DR   OpenTargets; ENSG00000006025; -.
DR   PharmGKB; PA32831; -.
DR   VEuPathDB; HostDB:ENSG00000006025; -.
DR   eggNOG; KOG1737; Eukaryota.
DR   GeneTree; ENSGT00940000157439; -.
DR   HOGENOM; CLU_007105_4_1_1; -.
DR   InParanoid; Q9BZF2; -.
DR   OMA; TTDPCER; -.
DR   OrthoDB; 960at2759; -.
DR   PhylomeDB; Q9BZF2; -.
DR   TreeFam; TF320922; -.
DR   PathwayCommons; Q9BZF2; -.
DR   Reactome; R-HSA-192105; Synthesis of bile acids and bile salts.
DR   SignaLink; Q9BZF2; -.
DR   BioGRID-ORCS; 114881; 18 hits in 1156 CRISPR screens.
DR   ChiTaRS; OSBPL7; human.
DR   GenomeRNAi; 114881; -.
DR   Pharos; Q9BZF2; Tbio.
DR   PRO; PR:Q9BZF2; -.
DR   Proteomes; UP000005640; Chromosome 17.
DR   RNAct; Q9BZF2; Protein.
DR   Bgee; ENSG00000006025; Expressed in mucosa of transverse colon and 135 other cell types or tissues.
DR   ExpressionAtlas; Q9BZF2; baseline and differential.
DR   GO; GO:0005776; C:autophagosome; IDA:BHF-UCL.
DR   GO; GO:0005829; C:cytosol; IDA:BHF-UCL.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR   GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR   GO; GO:0097038; C:perinuclear endoplasmic reticulum; IDA:BHF-UCL.
DR   GO; GO:0005886; C:plasma membrane; IDA:BHF-UCL.
DR   GO; GO:0015485; F:cholesterol binding; IDA:BHF-UCL.
DR   GO; GO:0015248; F:sterol transporter activity; IBA:GO_Central.
DR   GO; GO:0006699; P:bile acid biosynthetic process; TAS:Reactome.
DR   GO; GO:0071397; P:cellular response to cholesterol; IMP:BHF-UCL.
DR   GO; GO:1901800; P:positive regulation of proteasomal protein catabolic process; IMP:BHF-UCL.
DR   GO; GO:0010506; P:regulation of autophagy; NAS:ParkinsonsUK-UCL.
DR   CDD; cd13287; PH_ORP3_ORP6_ORP7; 1.
DR   Gene3D; 2.40.160.120; -; 1.
DR   Gene3D; 3.30.70.3490; -; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR037239; OSBP_sf.
DR   InterPro; IPR000648; Oxysterol-bd.
DR   InterPro; IPR018494; Oxysterol-bd_CS.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR041680; PH_8.
DR   InterPro; IPR001849; PH_domain.
DR   PANTHER; PTHR10972; OXYSTEROL-BINDING PROTEIN-RELATED; 1.
DR   PANTHER; PTHR10972:SF85; OXYSTEROL-BINDING PROTEIN-RELATED PROTEIN 7; 1.
DR   Pfam; PF01237; Oxysterol_BP; 1.
DR   Pfam; PF15409; PH_8; 1.
DR   SMART; SM00233; PH; 1.
DR   SUPFAM; SSF144000; Oxysterol-binding protein-like; 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   PROSITE; PS01013; OSBP; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
DR   Genevisible; Q9BZF2; HS.
PE   1: Evidence at protein level;
KW   Alternative splicing; Cell membrane; Cytoplasm; Endoplasmic reticulum;
KW   Lipid transport; Lipid-binding; Membrane; Phosphoprotein;
KW   Reference proteome; Transport.
FT   CHAIN           1..842
FT                   /note="Oxysterol-binding protein-related protein 7"
FT                   /id="PRO_0000100377"
FT   DOMAIN          47..142
FT                   /note="PH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00145"
FT   REGION          1..28
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          330..369
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        14..28
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        339..369
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         171
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0007744|PubMed:23186163"
FT   MOD_RES         217
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:23186163"
FT   MOD_RES         226
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:23186163"
FT   MOD_RES         256
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:23186163"
FT   MOD_RES         272
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:23186163"
FT   VAR_SEQ         343..357
FT                   /note="SEASTGQRRLHSLST -> RPGGQGDWCGERASS (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:14702039,
FT                   ECO:0000303|PubMed:15489334"
FT                   /id="VSP_057227"
FT   VAR_SEQ         358..842
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:14702039,
FT                   ECO:0000303|PubMed:15489334"
FT                   /id="VSP_057228"
FT   VARIANT         148
FT                   /note="M -> I (in dbSNP:rs8076196)"
FT                   /id="VAR_060080"
FT   VARIANT         156
FT                   /note="T -> I (in dbSNP:rs35437144)"
FT                   /id="VAR_053551"
FT   VARIANT         169
FT                   /note="A -> E (in dbSNP:rs8071195)"
FT                   /id="VAR_060081"
SQ   SEQUENCE   842 AA;  95432 MW;  6DE6ED596CEE6FE3 CRC64;
     MDFQERDPPF LPESAQSSKP SSAQQASELW EVVEEPRVRL GTEGVMPERQ EGHLLKKRKW
     PLKGWHKRYF VLEDGILHYA TTRQDITKGK LHGSIDVRLS VMSINKKAQR IDLDTEDNIY
     HLKIKSQDLF QSWVAQLRAH RLAHRLDMPR GSLPSTAHRK VPGAQLPTAA TASALPGLGP
     REKVSSWLRD SDGLDRCSHE LSECQGKLQE LHRLLQSLES LHRIPSAPVI PTHQASVTTE
     RPKKGKRTSR MWCTQSFAKD DTIGRVGRLH GSVPNLSRYL ESRDSSGTRG LPPTDYAHLQ
     RSFWALAQKV HSSLSSVLAA LTMERDQLRD MHQGSELSRM GVSEASTGQR RLHSLSTSSD
     TTADSFSSLN PEEQEALYMK GRELTPQLSQ TSILSLADSH TEFFDACEVL LSASSSENEG
     SEEEESCTSE ITTSLSEEML DLRGAERCQK GGCVPGRPMG PPRRRCLPAA SGPGADVSLW
     NILRNNIGKD LSKVSMPVQL NEPLNTLQRL CEELEYSSLL DQASRIADPC ERMVYIAAFA
     VSAYSSTYHR AGCKPFNPVL GETYECERPD RGFRFISEQV SHHPPISACH AESENFAFWQ
     DMKWKNKFWG KSLEIVPVGT VNVSLPRFGD HFEWNKVTSC IHNVLSGQRW IEHYGEVLIR
     NTQDSSCHCK ITFCKAKYWS SNVHEVQGAV LSRSGRVLHR LFGKWHEGLY RGPTPGGQCI
     WKPNSMPPDH ERNFGFTQFA LELNELTAEL KRSLPSTDTR LRPDQRYLEE GNIQAAEAQK
     RRIEQLQRDR RKVMEENNIV HQARFFRRQT DSSGKEWWVT NNTYWRLRAE PGYGNMDGAV
     LW
//