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Q9BZF2 (OSBL7_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 97. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Oxysterol-binding protein-related protein 7

Short name=ORP-7
Short name=OSBP-related protein 7
Gene names
Name:OSBPL7
Synonyms:ORP7
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length842 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the OSBP family.

Contains 1 PH domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 842842Oxysterol-binding protein-related protein 7
PRO_0000100377

Regions

Domain47 – 14296PH

Natural variations

Natural variant1481M → I.
Corresponds to variant rs8076196 [ dbSNP | Ensembl ].
VAR_060080
Natural variant1561T → I.
Corresponds to variant rs35437144 [ dbSNP | Ensembl ].
VAR_053551
Natural variant1691A → E.
Corresponds to variant rs8071195 [ dbSNP | Ensembl ].
VAR_060081

Sequences

Sequence LengthMass (Da)Tools
Q9BZF2 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: 6DE6ED596CEE6FE3

FASTA84295,432
        10         20         30         40         50         60 
MDFQERDPPF LPESAQSSKP SSAQQASELW EVVEEPRVRL GTEGVMPERQ EGHLLKKRKW 

        70         80         90        100        110        120 
PLKGWHKRYF VLEDGILHYA TTRQDITKGK LHGSIDVRLS VMSINKKAQR IDLDTEDNIY 

       130        140        150        160        170        180 
HLKIKSQDLF QSWVAQLRAH RLAHRLDMPR GSLPSTAHRK VPGAQLPTAA TASALPGLGP 

       190        200        210        220        230        240 
REKVSSWLRD SDGLDRCSHE LSECQGKLQE LHRLLQSLES LHRIPSAPVI PTHQASVTTE 

       250        260        270        280        290        300 
RPKKGKRTSR MWCTQSFAKD DTIGRVGRLH GSVPNLSRYL ESRDSSGTRG LPPTDYAHLQ 

       310        320        330        340        350        360 
RSFWALAQKV HSSLSSVLAA LTMERDQLRD MHQGSELSRM GVSEASTGQR RLHSLSTSSD 

       370        380        390        400        410        420 
TTADSFSSLN PEEQEALYMK GRELTPQLSQ TSILSLADSH TEFFDACEVL LSASSSENEG 

       430        440        450        460        470        480 
SEEEESCTSE ITTSLSEEML DLRGAERCQK GGCVPGRPMG PPRRRCLPAA SGPGADVSLW 

       490        500        510        520        530        540 
NILRNNIGKD LSKVSMPVQL NEPLNTLQRL CEELEYSSLL DQASRIADPC ERMVYIAAFA 

       550        560        570        580        590        600 
VSAYSSTYHR AGCKPFNPVL GETYECERPD RGFRFISEQV SHHPPISACH AESENFAFWQ 

       610        620        630        640        650        660 
DMKWKNKFWG KSLEIVPVGT VNVSLPRFGD HFEWNKVTSC IHNVLSGQRW IEHYGEVLIR 

       670        680        690        700        710        720 
NTQDSSCHCK ITFCKAKYWS SNVHEVQGAV LSRSGRVLHR LFGKWHEGLY RGPTPGGQCI 

       730        740        750        760        770        780 
WKPNSMPPDH ERNFGFTQFA LELNELTAEL KRSLPSTDTR LRPDQRYLEE GNIQAAEAQK 

       790        800        810        820        830        840 
RRIEQLQRDR RKVMEENNIV HQARFFRRQT DSSGKEWWVT NNTYWRLRAE PGYGNMDGAV 


LW 

« Hide

References

« Hide 'large scale' references
[1]"The OSBP-related protein family in humans."
Lehto M., Laitinen S., Chinetti G., Johansson M., Ehnholm C., Staels B., Ikonen E., Olkkonen V.M.
J. Lipid Res. 42:1203-1213(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Pancreas.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF323729 mRNA. Translation: AAG53410.1.
CH471109 Genomic DNA. Translation: EAW94801.1.
CH471109 Genomic DNA. Translation: EAW94802.1.
CH471109 Genomic DNA. Translation: EAW94803.1.
BC065482 mRNA. Translation: AAH65482.1.
RefSeqNP_665741.1. NM_145798.2.
UniGeneHs.463320.

3D structure databases

ProteinModelPortalQ9BZF2.
SMRQ9BZF2. Positions 57-141, 463-842.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000007414.

PTM databases

PhosphoSiteQ9BZF2.

Polymorphism databases

DMDM20139132.

Proteomic databases

PaxDbQ9BZF2.
PRIDEQ9BZF2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000007414; ENSP00000007414; ENSG00000006025.
ENST00000392507; ENSP00000376295; ENSG00000006025.
GeneID114881.
KEGGhsa:114881.
UCSCuc002ilx.1. human.

Organism-specific databases

CTD114881.
GeneCardsGC17M045884.
HGNCHGNC:16387. OSBPL7.
HPAHPA036076.
HPA053083.
MIM606735. gene.
neXtProtNX_Q9BZF2.
PharmGKBPA32831.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG281324.
HOGENOMHOG000231072.
HOVERGENHBG058934.
InParanoidQ9BZF2.
OMAITKGKLH.
OrthoDBEOG780RKR.
PhylomeDBQ9BZF2.
TreeFamTF320922.

Gene expression databases

ArrayExpressQ9BZF2.
BgeeQ9BZF2.
CleanExHS_OSBPL7.
GenevestigatorQ9BZF2.

Family and domain databases

Gene3D2.30.29.30. 1 hit.
InterProIPR000648. Oxysterol-bd.
IPR018494. Oxysterol-bd_CS.
IPR011993. PH_like_dom.
IPR001849. Pleckstrin_homology.
[Graphical view]
PANTHERPTHR10972. PTHR10972. 1 hit.
PfamPF01237. Oxysterol_BP. 1 hit.
[Graphical view]
SMARTSM00233. PH. 1 hit.
[Graphical view]
PROSITEPS01013. OSBP. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi114881.
NextBio79359.
PROQ9BZF2.
SOURCESearch...

Entry information

Entry nameOSBL7_HUMAN
AccessionPrimary (citable) accession number: Q9BZF2
Secondary accession number(s): D3DTT6
Entry history
Integrated into UniProtKB/Swiss-Prot: February 11, 2002
Last sequence update: June 1, 2001
Last modified: March 19, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM