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Protein

Oxysterol-binding protein-related protein 7

Gene

OSBPL7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • cholesterol binding Source: BHF-UCL

GO - Biological processi

  • cellular response to cholesterol Source: BHF-UCL
  • lipid transport Source: UniProtKB-KW
  • positive regulation of proteasomal protein catabolic process Source: BHF-UCL
Complete GO annotation...

Keywords - Biological processi

Lipid transport, Transport

Keywords - Ligandi

Lipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Oxysterol-binding protein-related protein 7
Short name:
ORP-7
Short name:
OSBP-related protein 7
Gene namesi
Name:OSBPL7
Synonyms:ORP7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:16387. OSBPL7.

Subcellular locationi

GO - Cellular componenti

  • autophagosome Source: BHF-UCL
  • cytosol Source: BHF-UCL
  • endoplasmic reticulum membrane Source: UniProtKB-SubCell
  • perinuclear endoplasmic reticulum Source: BHF-UCL
  • plasma membrane Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32831.

Polymorphism and mutation databases

BioMutaiOSBPL7.
DMDMi20139132.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 842842Oxysterol-binding protein-related protein 7PRO_0000100377Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei171 – 1711PhosphothreonineCombined sources
Modified residuei217 – 2171PhosphoserineCombined sources
Modified residuei226 – 2261PhosphoserineCombined sources
Modified residuei256 – 2561PhosphoserineCombined sources
Modified residuei272 – 2721PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9BZF2.
MaxQBiQ9BZF2.
PaxDbiQ9BZF2.
PeptideAtlasiQ9BZF2.
PRIDEiQ9BZF2.

PTM databases

iPTMnetiQ9BZF2.
PhosphoSiteiQ9BZF2.

Expressioni

Tissue specificityi

Expressed in epithelium of small and large intestines (at protein level). Expressed in stomach, duodenum, jejunum, ascending colon, spleen, thymus, lymph node, trachea and leukocytes.1 Publication

Developmental stagei

Expressed in fetal lung and thymus.1 Publication

Gene expression databases

BgeeiQ9BZF2.
CleanExiHS_OSBPL7.
ExpressionAtlasiQ9BZF2. baseline and differential.
GenevisibleiQ9BZF2. HS.

Organism-specific databases

HPAiHPA036076.
HPA053083.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000007414.

Structurei

3D structure databases

ProteinModelPortaliQ9BZF2.
SMRiQ9BZF2. Positions 45-144, 463-842.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini47 – 14296PHPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the OSBP family.Curated
Contains 1 PH domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1737. Eukaryota.
ENOG410XP9E. LUCA.
GeneTreeiENSGT00760000119155.
HOGENOMiHOG000231072.
HOVERGENiHBG058934.
InParanoidiQ9BZF2.
OMAiNNIVHQA.
OrthoDBiEOG780RKR.
PhylomeDBiQ9BZF2.
TreeFamiTF320922.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR000648. Oxysterol-bd.
IPR018494. Oxysterol-bd_CS.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
[Graphical view]
PANTHERiPTHR10972. PTHR10972. 3 hits.
PfamiPF01237. Oxysterol_BP. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
PROSITEiPS01013. OSBP. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9BZF2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDFQERDPPF LPESAQSSKP SSAQQASELW EVVEEPRVRL GTEGVMPERQ
60 70 80 90 100
EGHLLKKRKW PLKGWHKRYF VLEDGILHYA TTRQDITKGK LHGSIDVRLS
110 120 130 140 150
VMSINKKAQR IDLDTEDNIY HLKIKSQDLF QSWVAQLRAH RLAHRLDMPR
160 170 180 190 200
GSLPSTAHRK VPGAQLPTAA TASALPGLGP REKVSSWLRD SDGLDRCSHE
210 220 230 240 250
LSECQGKLQE LHRLLQSLES LHRIPSAPVI PTHQASVTTE RPKKGKRTSR
260 270 280 290 300
MWCTQSFAKD DTIGRVGRLH GSVPNLSRYL ESRDSSGTRG LPPTDYAHLQ
310 320 330 340 350
RSFWALAQKV HSSLSSVLAA LTMERDQLRD MHQGSELSRM GVSEASTGQR
360 370 380 390 400
RLHSLSTSSD TTADSFSSLN PEEQEALYMK GRELTPQLSQ TSILSLADSH
410 420 430 440 450
TEFFDACEVL LSASSSENEG SEEEESCTSE ITTSLSEEML DLRGAERCQK
460 470 480 490 500
GGCVPGRPMG PPRRRCLPAA SGPGADVSLW NILRNNIGKD LSKVSMPVQL
510 520 530 540 550
NEPLNTLQRL CEELEYSSLL DQASRIADPC ERMVYIAAFA VSAYSSTYHR
560 570 580 590 600
AGCKPFNPVL GETYECERPD RGFRFISEQV SHHPPISACH AESENFAFWQ
610 620 630 640 650
DMKWKNKFWG KSLEIVPVGT VNVSLPRFGD HFEWNKVTSC IHNVLSGQRW
660 670 680 690 700
IEHYGEVLIR NTQDSSCHCK ITFCKAKYWS SNVHEVQGAV LSRSGRVLHR
710 720 730 740 750
LFGKWHEGLY RGPTPGGQCI WKPNSMPPDH ERNFGFTQFA LELNELTAEL
760 770 780 790 800
KRSLPSTDTR LRPDQRYLEE GNIQAAEAQK RRIEQLQRDR RKVMEENNIV
810 820 830 840
HQARFFRRQT DSSGKEWWVT NNTYWRLRAE PGYGNMDGAV LW
Length:842
Mass (Da):95,432
Last modified:June 1, 2001 - v1
Checksum:i6DE6ED596CEE6FE3
GO
Isoform 2 (identifier: Q9BZF2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     343-357: SEASTGQRRLHSLST → RPGGQGDWCGERASS
     358-842: Missing.

Show »
Length:357
Mass (Da):40,186
Checksum:iE14AB73FCCB16D1C
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti148 – 1481M → I.
Corresponds to variant rs8076196 [ dbSNP | Ensembl ].
VAR_060080
Natural varianti156 – 1561T → I.
Corresponds to variant rs35437144 [ dbSNP | Ensembl ].
VAR_053551
Natural varianti169 – 1691A → E.
Corresponds to variant rs8071195 [ dbSNP | Ensembl ].
VAR_060081

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei343 – 35715SEAST…HSLST → RPGGQGDWCGERASS in isoform 2. 2 PublicationsVSP_057227Add
BLAST
Alternative sequencei358 – 842485Missing in isoform 2. 2 PublicationsVSP_057228Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF323729 mRNA. Translation: AAG53410.1.
AK289523 mRNA. Translation: BAF82212.1.
AC003665 Genomic DNA. No translation available.
CH471109 Genomic DNA. Translation: EAW94800.1.
CH471109 Genomic DNA. Translation: EAW94801.1.
CH471109 Genomic DNA. Translation: EAW94802.1.
CH471109 Genomic DNA. Translation: EAW94803.1.
BC028010 mRNA. Translation: AAH28010.1.
BC065482 mRNA. Translation: AAH65482.1.
CCDSiCCDS11515.1. [Q9BZF2-1]
RefSeqiNP_665741.1. NM_145798.2. [Q9BZF2-1]
XP_011522576.1. XM_011524274.1. [Q9BZF2-1]
UniGeneiHs.463320.

Genome annotation databases

EnsembliENST00000007414; ENSP00000007414; ENSG00000006025. [Q9BZF2-1]
ENST00000392507; ENSP00000376295; ENSG00000006025. [Q9BZF2-1]
ENST00000613735; ENSP00000479827; ENSG00000006025. [Q9BZF2-2]
GeneIDi114881.
KEGGihsa:114881.
UCSCiuc002ilx.2. human. [Q9BZF2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF323729 mRNA. Translation: AAG53410.1.
AK289523 mRNA. Translation: BAF82212.1.
AC003665 Genomic DNA. No translation available.
CH471109 Genomic DNA. Translation: EAW94800.1.
CH471109 Genomic DNA. Translation: EAW94801.1.
CH471109 Genomic DNA. Translation: EAW94802.1.
CH471109 Genomic DNA. Translation: EAW94803.1.
BC028010 mRNA. Translation: AAH28010.1.
BC065482 mRNA. Translation: AAH65482.1.
CCDSiCCDS11515.1. [Q9BZF2-1]
RefSeqiNP_665741.1. NM_145798.2. [Q9BZF2-1]
XP_011522576.1. XM_011524274.1. [Q9BZF2-1]
UniGeneiHs.463320.

3D structure databases

ProteinModelPortaliQ9BZF2.
SMRiQ9BZF2. Positions 45-144, 463-842.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000007414.

PTM databases

iPTMnetiQ9BZF2.
PhosphoSiteiQ9BZF2.

Polymorphism and mutation databases

BioMutaiOSBPL7.
DMDMi20139132.

Proteomic databases

EPDiQ9BZF2.
MaxQBiQ9BZF2.
PaxDbiQ9BZF2.
PeptideAtlasiQ9BZF2.
PRIDEiQ9BZF2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000007414; ENSP00000007414; ENSG00000006025. [Q9BZF2-1]
ENST00000392507; ENSP00000376295; ENSG00000006025. [Q9BZF2-1]
ENST00000613735; ENSP00000479827; ENSG00000006025. [Q9BZF2-2]
GeneIDi114881.
KEGGihsa:114881.
UCSCiuc002ilx.2. human. [Q9BZF2-1]

Organism-specific databases

CTDi114881.
GeneCardsiOSBPL7.
HGNCiHGNC:16387. OSBPL7.
HPAiHPA036076.
HPA053083.
MIMi606735. gene.
neXtProtiNX_Q9BZF2.
PharmGKBiPA32831.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1737. Eukaryota.
ENOG410XP9E. LUCA.
GeneTreeiENSGT00760000119155.
HOGENOMiHOG000231072.
HOVERGENiHBG058934.
InParanoidiQ9BZF2.
OMAiNNIVHQA.
OrthoDBiEOG780RKR.
PhylomeDBiQ9BZF2.
TreeFamiTF320922.

Miscellaneous databases

ChiTaRSiOSBPL7. human.
GenomeRNAii114881.
PROiQ9BZF2.
SOURCEiSearch...

Gene expression databases

BgeeiQ9BZF2.
CleanExiHS_OSBPL7.
ExpressionAtlasiQ9BZF2. baseline and differential.
GenevisibleiQ9BZF2. HS.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR000648. Oxysterol-bd.
IPR018494. Oxysterol-bd_CS.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
[Graphical view]
PANTHERiPTHR10972. PTHR10972. 3 hits.
PfamiPF01237. Oxysterol_BP. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
PROSITEiPS01013. OSBP. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The OSBP-related protein family in humans."
    Lehto M., Laitinen S., Chinetti G., Johansson M., Ehnholm C., Staels B., Ikonen E., Olkkonen V.M.
    J. Lipid Res. 42:1203-1213(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Cerebellum.
  3. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Blood and Pancreas.
  6. "Subfamily III of mammalian oxysterol-binding protein (OSBP) homologues: the expression and intracellular localization of ORP3, ORP6, and ORP7."
    Lehto M., Tienari J., Lehtonen S., Lehtonen E., Olkkonen V.M.
    Cell Tissue Res. 315:39-57(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
  7. "Toward a comprehensive characterization of a human cancer cell phosphoproteome."
    Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J., Mohammed S.
    J. Proteome Res. 12:260-271(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-171; SER-217; SER-226; SER-256 AND SER-272, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Erythroleukemia.

Entry informationi

Entry nameiOSBL7_HUMAN
AccessioniPrimary (citable) accession number: Q9BZF2
Secondary accession number(s): D3DTT6, Q6PIV6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 11, 2002
Last sequence update: June 1, 2001
Last modified: July 6, 2016
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.