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Protein

UPF0193 protein EVG1

Gene

C22orf23

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
UPF0193 protein EVG1
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

HGNCiHGNC:18589. C22orf23.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38355.

Polymorphism and mutation databases

BioMutaiC22orf23.
DMDMi20177878.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 217217UPF0193 protein EVG1PRO_0000221089Add
BLAST

Proteomic databases

PaxDbiQ9BZE7.
PRIDEiQ9BZE7.

Expressioni

Gene expression databases

BgeeiQ9BZE7.
CleanExiHS_C22orf23.
ExpressionAtlasiQ9BZE7. baseline and differential.
GenevisibleiQ9BZE7. HS.

Organism-specific databases

HPAiHPA001149.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CCNDBP1O952733EBI-10303102,EBI-748961

Protein-protein interaction databases

BioGridi124168. 2 interactions.
IntActiQ9BZE7. 1 interaction.
STRINGi9606.ENSP00000249079.

Structurei

3D structure databases

ProteinModelPortaliQ9BZE7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UPF0193 (EVG1) family.Curated

Phylogenomic databases

eggNOGiENOG410IWMY. Eukaryota.
ENOG4111W8U. LUCA.
GeneTreeiENSGT00390000010231.
HOGENOMiHOG000007741.
HOVERGENiHBG023403.
InParanoidiQ9BZE7.
OMAiMDTMKRG.
OrthoDBiEOG7KH9KG.
PhylomeDBiQ9BZE7.
TreeFamiTF323579.

Family and domain databases

InterProiIPR007914. UPF0193.
[Graphical view]
PfamiPF05250. UPF0193. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9BZE7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASQKQMEVV TKGTGFRRRP KTITYTPGTC ELLRVMMKES KLTNIQQRHI
60 70 80 90 100
MDIMKRGDAL PLQCSPTSSQ RVLPSKQIAS PIYLPPILAA RPHLRPANMC
110 120 130 140 150
QANGAYSREQ FKPQATRDLE KEKQRLQNIF ATGKDMEERK RKAPPARQKA
160 170 180 190 200
PAPELDRFEE LVKEIQERKE FLADMEALGQ GKQYRGIILA EISQKLREME
210
DIDHRRSEEL RKGLATT
Length:217
Mass (Da):24,956
Last modified:June 1, 2001 - v1
Checksum:i884349333B6E60F0
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti33 – 331L → F in BAB71442 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti136 – 1361M → L.
Corresponds to variant rs35562630 [ dbSNP | Ensembl ].
VAR_057346

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF324466 mRNA. Translation: AAK07640.1.
AK057349 mRNA. Translation: BAB71442.1.
CR456440 mRNA. Translation: CAG30326.1.
AL031587 Genomic DNA. Translation: CAI18965.1.
CH471095 Genomic DNA. Translation: EAW60200.1.
BC031998 mRNA. Translation: AAH31998.1.
CCDSiCCDS13962.1.
RefSeqiNP_001193991.1. NM_001207062.1.
NP_115950.3. NM_032561.4.
UniGeneiHs.517612.

Genome annotation databases

EnsembliENST00000249079; ENSP00000249079; ENSG00000128346.
ENST00000403026; ENSP00000384618; ENSG00000128346.
ENST00000403305; ENSP00000384667; ENSG00000128346.
GeneIDi84645.
KEGGihsa:84645.
UCSCiuc003auj.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF324466 mRNA. Translation: AAK07640.1.
AK057349 mRNA. Translation: BAB71442.1.
CR456440 mRNA. Translation: CAG30326.1.
AL031587 Genomic DNA. Translation: CAI18965.1.
CH471095 Genomic DNA. Translation: EAW60200.1.
BC031998 mRNA. Translation: AAH31998.1.
CCDSiCCDS13962.1.
RefSeqiNP_001193991.1. NM_001207062.1.
NP_115950.3. NM_032561.4.
UniGeneiHs.517612.

3D structure databases

ProteinModelPortaliQ9BZE7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124168. 2 interactions.
IntActiQ9BZE7. 1 interaction.
STRINGi9606.ENSP00000249079.

Polymorphism and mutation databases

BioMutaiC22orf23.
DMDMi20177878.

Proteomic databases

PaxDbiQ9BZE7.
PRIDEiQ9BZE7.

Protocols and materials databases

DNASUi84645.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000249079; ENSP00000249079; ENSG00000128346.
ENST00000403026; ENSP00000384618; ENSG00000128346.
ENST00000403305; ENSP00000384667; ENSG00000128346.
GeneIDi84645.
KEGGihsa:84645.
UCSCiuc003auj.3. human.

Organism-specific databases

CTDi84645.
GeneCardsiC22orf23.
H-InvDBHIX0016458.
HIX0041276.
HGNCiHGNC:18589. C22orf23.
HPAiHPA001149.
neXtProtiNX_Q9BZE7.
PharmGKBiPA38355.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IWMY. Eukaryota.
ENOG4111W8U. LUCA.
GeneTreeiENSGT00390000010231.
HOGENOMiHOG000007741.
HOVERGENiHBG023403.
InParanoidiQ9BZE7.
OMAiMDTMKRG.
OrthoDBiEOG7KH9KG.
PhylomeDBiQ9BZE7.
TreeFamiTF323579.

Miscellaneous databases

ChiTaRSiC22orf23. human.
GenomeRNAii84645.
NextBioi74589.
PROiQ9BZE7.

Gene expression databases

BgeeiQ9BZE7.
CleanExiHS_C22orf23.
ExpressionAtlasiQ9BZE7. baseline and differential.
GenevisibleiQ9BZE7. HS.

Family and domain databases

InterProiIPR007914. UPF0193.
[Graphical view]
PfamiPF05250. UPF0193. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Testis.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "The DNA sequence of human chromosome 22."
    Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M.
    , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
    Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Skin.

Entry informationi

Entry nameiEVG1_HUMAN
AccessioniPrimary (citable) accession number: Q9BZE7
Secondary accession number(s): Q5JYU9, Q96M68
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: June 1, 2001
Last modified: March 16, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families
  5. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.