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Q9BZE4

- NOG1_HUMAN

UniProt

Q9BZE4 - NOG1_HUMAN

Protein

Nucleolar GTP-binding protein 1

Gene

GTPBP4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 131 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Involved in the biogenesis of the 60S ribosomal subunit.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi175 – 1828GTPPROSITE-ProRule annotation
    Nucleotide bindingi221 – 2255GTPPROSITE-ProRule annotation
    Nucleotide bindingi289 – 2924GTPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. GTPase activity Source: HGNC
    2. GTP binding Source: HGNC
    3. poly(A) RNA binding Source: UniProtKB
    4. protein binding Source: IntAct

    GO - Biological processi

    1. GTP catabolic process Source: GOC
    2. negative regulation of cell-cell adhesion Source: HGNC
    3. negative regulation of cell migration Source: HGNC
    4. negative regulation of cell proliferation Source: HGNC
    5. negative regulation of collagen binding Source: HGNC
    6. negative regulation of DNA replication Source: HGNC
    7. negative regulation of protein ubiquitination Source: HGNC
    8. osteoblast differentiation Source: UniProt
    9. protein stabilization Source: HGNC
    10. regulation of cyclin-dependent protein serine/threonine kinase activity Source: HGNC
    11. ribosome biogenesis Source: UniProtKB-KW

    Keywords - Biological processi

    Ribosome biogenesis

    Keywords - Ligandi

    GTP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Nucleolar GTP-binding protein 1
    Alternative name(s):
    Chronic renal failure gene protein
    GTP-binding protein NGB
    Gene namesi
    Name:GTPBP4
    Synonyms:CRFG, NOG1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 10

    Organism-specific databases

    HGNCiHGNC:21535. GTPBP4.

    Subcellular locationi

    Nucleusnucleolus 3 Publications

    GO - Cellular componenti

    1. cytoplasm Source: HGNC
    2. Golgi apparatus Source: HPA
    3. membrane Source: UniProtKB
    4. nuclear membrane Source: HPA
    5. nucleolus Source: HPA
    6. nucleus Source: HGNC
    7. perinuclear region of cytoplasm Source: HGNC

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134922009.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 634633Nucleolar GTP-binding protein 1PRO_0000195023Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanine1 Publication
    Modified residuei103 – 1031N6-acetyllysine1 Publication
    Modified residuei468 – 4681Phosphoserine4 Publications
    Modified residuei470 – 4701Phosphoserine4 Publications
    Modified residuei472 – 4721Phosphoserine3 Publications
    Modified residuei522 – 5221N6-acetyllysine1 Publication
    Modified residuei558 – 5581Phosphoserine1 Publication

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ9BZE4.
    PaxDbiQ9BZE4.
    PRIDEiQ9BZE4.

    2D gel databases

    SWISS-2DPAGEQ9BZE4.

    PTM databases

    PhosphoSiteiQ9BZE4.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9BZE4.
    BgeeiQ9BZE4.
    CleanExiHS_GTPBP4.
    GenevestigatoriQ9BZE4.

    Organism-specific databases

    HPAiHPA039618.
    HPA056468.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    NF2P352409EBI-1056249,EBI-1014472

    Protein-protein interaction databases

    BioGridi117104. 33 interactions.
    IntActiQ9BZE4. 11 interactions.
    MINTiMINT-4728537.
    STRINGi9606.ENSP00000354040.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9BZE4.
    SMRiQ9BZE4. Positions 6-346.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini169 – 340172OBG-type GPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily.PROSITE-ProRule annotation
    Contains 1 OBG-type G (guanine nucleotide-binding) domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG1084.
    HOGENOMiHOG000164071.
    HOVERGENiHBG052642.
    KOiK06943.
    OMAiRAKSIAD.
    OrthoDBiEOG72G175.
    PhylomeDBiQ9BZE4.
    TreeFamiTF300430.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR006073. GTP_binding_domain.
    IPR024926. NOG1.
    IPR010674. NOG1_Rossman_fold_dom.
    IPR012973. NOG_C.
    IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    [Graphical view]
    PfamiPF06858. NOG1. 1 hit.
    PF08155. NOGCT. 1 hit.
    [Graphical view]
    PIRSFiPIRSF038919. NOG1. 1 hit.
    PRINTSiPR00326. GTP1OBG.
    SUPFAMiSSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00231. small_GTP. 1 hit.
    PROSITEiPS51710. G_OBG. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9BZE4-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAHYNFKKIT VVPSAKDFID LTLSKTQRKT PTVIHKHYQI HRIRHFYMRK    50
    VKFTQQNYHD RLSQILTDFP KLDDIHPFYA DLMNILYDKD HYKLALGQIN 100
    IAKNLVDNVA KDYVRLMKYG DSLYRCKQLK RAALGRMCTV IKRQKQSLEY 150
    LEQVRQHLSR LPTIDPNTRT LLLCGYPNVG KSSFINKVTR ADVDVQPYAF 200
    TTKSLFVGHM DYKYLRWQVV DTPGILDHPL EDRNTIEMQA ITALAHLRAA 250
    VLYVMDLSEQ CGHGLREQLE LFQNIRPLFI NKPLIVVANK CDVKRIAELS 300
    EDDQKIFTDL QSEGFPVIET STLTEEGVIK VKTEACDRLL AHRVETKMKG 350
    NKVNEVLNRL HLAIPTRRDD KERPPFIPEG VVARRKRMET EESRKKRERD 400
    LELEMGDDYI LDLQKYWDLM NLSEKHDKIP EIWEGHNIAD YIDPAIMKKL 450
    EELEKEEELR TAAGEYDSVS ESEDEEMLEI RQLAKQIREK KKLKILESKE 500
    KNTQGPRMPR TAKKVQRTVL EKEMRSLGVD MDDKDDAHYA VQARRSRSIT 550
    RKRKREDSAP PSSVARSGSC SRTPRDVSGL RDVKMVKKAK TMMKNAQKKM 600
    NRLGKKGEAD RHVFDMKPKH LLSGKRKAGK KDRR 634
    Length:634
    Mass (Da):73,964
    Last modified:January 23, 2007 - v3
    Checksum:i0A05E65E65D6DB62
    GO
    Isoform 2 (identifier: Q9BZE4-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-47: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:587
    Mass (Da):68,273
    Checksum:i185E3546E24D4BE8
    GO
    Isoform 3 (identifier: Q9BZE4-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-116: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:518
    Mass (Da):60,051
    Checksum:i7F5B0AADB755446E
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti593 – 5931Missing in AAD09830. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti525 – 5251R → H.1 Publication
    Corresponds to variant rs3207775 [ dbSNP | Ensembl ].
    VAR_068801

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 116116Missing in isoform 3. CuratedVSP_056146Add
    BLAST
    Alternative sequencei1 – 4747Missing in isoform 2. 1 PublicationVSP_056147Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF120334 mRNA. Translation: AAD09830.1.
    AF325353 mRNA. Translation: AAK13444.1.
    AK001548 mRNA. Translation: BAG50937.1.
    AK001552 mRNA. Translation: BAA91752.1.
    AK301721 mRNA. Translation: BAH13539.1.
    AK302219 mRNA. Translation: BAG63575.1.
    AL359878, AC022536 Genomic DNA. Translation: CAI13664.1.
    CH471072 Genomic DNA. Translation: EAW86526.1.
    BC038975 mRNA. Translation: AAH38975.1.
    CCDSiCCDS31132.1.
    RefSeqiNP_036473.2. NM_012341.2.
    UniGeneiHs.215766.

    Genome annotation databases

    EnsembliENST00000360803; ENSP00000354040; ENSG00000107937.
    ENST00000538293; ENSP00000444277; ENSG00000107937.
    ENST00000545048; ENSP00000445473; ENSG00000107937.
    GeneIDi23560.
    KEGGihsa:23560.
    UCSCiuc001ift.3. human.

    Polymorphism databases

    DMDMi17368711.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF120334 mRNA. Translation: AAD09830.1 .
    AF325353 mRNA. Translation: AAK13444.1 .
    AK001548 mRNA. Translation: BAG50937.1 .
    AK001552 mRNA. Translation: BAA91752.1 .
    AK301721 mRNA. Translation: BAH13539.1 .
    AK302219 mRNA. Translation: BAG63575.1 .
    AL359878 , AC022536 Genomic DNA. Translation: CAI13664.1 .
    CH471072 Genomic DNA. Translation: EAW86526.1 .
    BC038975 mRNA. Translation: AAH38975.1 .
    CCDSi CCDS31132.1.
    RefSeqi NP_036473.2. NM_012341.2.
    UniGenei Hs.215766.

    3D structure databases

    ProteinModelPortali Q9BZE4.
    SMRi Q9BZE4. Positions 6-346.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 117104. 33 interactions.
    IntActi Q9BZE4. 11 interactions.
    MINTi MINT-4728537.
    STRINGi 9606.ENSP00000354040.

    PTM databases

    PhosphoSitei Q9BZE4.

    Polymorphism databases

    DMDMi 17368711.

    2D gel databases

    SWISS-2DPAGE Q9BZE4.

    Proteomic databases

    MaxQBi Q9BZE4.
    PaxDbi Q9BZE4.
    PRIDEi Q9BZE4.

    Protocols and materials databases

    DNASUi 23560.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000360803 ; ENSP00000354040 ; ENSG00000107937 .
    ENST00000538293 ; ENSP00000444277 ; ENSG00000107937 .
    ENST00000545048 ; ENSP00000445473 ; ENSG00000107937 .
    GeneIDi 23560.
    KEGGi hsa:23560.
    UCSCi uc001ift.3. human.

    Organism-specific databases

    CTDi 23560.
    GeneCardsi GC10P001034.
    HGNCi HGNC:21535. GTPBP4.
    HPAi HPA039618.
    HPA056468.
    neXtProti NX_Q9BZE4.
    PharmGKBi PA134922009.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG1084.
    HOGENOMi HOG000164071.
    HOVERGENi HBG052642.
    KOi K06943.
    OMAi RAKSIAD.
    OrthoDBi EOG72G175.
    PhylomeDBi Q9BZE4.
    TreeFami TF300430.

    Miscellaneous databases

    ChiTaRSi GTPBP4. human.
    GeneWikii GTPBP4.
    GenomeRNAii 23560.
    NextBioi 35468847.
    PROi Q9BZE4.

    Gene expression databases

    ArrayExpressi Q9BZE4.
    Bgeei Q9BZE4.
    CleanExi HS_GTPBP4.
    Genevestigatori Q9BZE4.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR006073. GTP_binding_domain.
    IPR024926. NOG1.
    IPR010674. NOG1_Rossman_fold_dom.
    IPR012973. NOG_C.
    IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    [Graphical view ]
    Pfami PF06858. NOG1. 1 hit.
    PF08155. NOGCT. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF038919. NOG1. 1 hit.
    PRINTSi PR00326. GTP1OBG.
    SUPFAMi SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00231. small_GTP. 1 hit.
    PROSITEi PS51710. G_OBG. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of a novel GTP-binding protein, NGB."
      Cheng J.Q., Cao C.H., Testa J.R., Golemis E.A., Jiang C., Yuan W., Nicosia S.V.
      Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "Identification of a novel nuclear guanosine triphosphate-binding protein differentially expressed in renal disease."
      Laping N.J., Olson B.A., Zhu Y.
      J. Am. Soc. Nephrol. 12:883-890(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION.
      Tissue: Kidney.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT HIS-525.
      Tissue: Testis.
    4. "The DNA sequence and comparative analysis of human chromosome 10."
      Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
      , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
      Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Uterus.
    7. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    8. Bienvenut W.V.
      Submitted (OCT-2004) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 2-7; 9-25; 37-42; 53-71; 94-111; 119-125; 146-155; 161-169; 191-213; 217-248; 267-276; 296-330; 353-359; 372-384; 398-425; 429-448; 450-460 AND 526-544, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT ALA-2, SUBCELLULAR LOCATION, IDENTIFICATION BY MASS SPECTROMETRY.
      Tissue: Cervix carcinoma.
    9. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
      Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    10. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
      Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    11. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-468; SER-470; SER-472 AND SER-558, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    12. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-468; SER-470 AND SER-472, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    13. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
      Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-103 AND LYS-522, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    14. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-468; SER-470 AND SER-472, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    15. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    16. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-468 AND SER-470, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiNOG1_HUMAN
    AccessioniPrimary (citable) accession number: Q9BZE4
    Secondary accession number(s): B3KMC5
    , B4DY13, B7Z7A3, O95446, Q5T3R8, Q9NVJ8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 24, 2001
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 131 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 10
      Human chromosome 10: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3