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Protein

BarH-like 1 homeobox protein

Gene

BARHL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi178 – 237HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000125492-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
BarH-like 1 homeobox protein
Gene namesi
Name:BARHL1
ORF Names:FKSG31
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:953. BARHL1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi56751.
OpenTargetsiENSG00000125492.
PharmGKBiPA25257.

Polymorphism and mutation databases

BioMutaiBARHL1.
DMDMi29336920.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000488261 – 327BarH-like 1 homeobox proteinAdd BLAST327

Proteomic databases

PaxDbiQ9BZE3.
PRIDEiQ9BZE3.

PTM databases

iPTMnetiQ9BZE3.
PhosphoSitePlusiQ9BZE3.

Expressioni

Gene expression databases

BgeeiENSG00000125492.
CleanExiHS_BARHL1.
GenevisibleiQ9BZE3. HS.

Organism-specific databases

HPAiHPA004809.

Interactioni

Protein-protein interaction databases

BioGridi121195. 3 interactors.
STRINGi9606.ENSP00000263610.

Structurei

3D structure databases

ProteinModelPortaliQ9BZE3.
SMRiQ9BZE3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the BAR homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0488. Eukaryota.
ENOG411188D. LUCA.
GeneTreeiENSGT00860000133665.
HOGENOMiHOG000231533.
HOVERGENiHBG050663.
InParanoidiQ9BZE3.
KOiK09360.
OMAiSDSEYKG.
OrthoDBiEOG091G13SM.
PhylomeDBiQ9BZE3.
TreeFamiTF316128.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9BZE3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEGSNGFGID SILSHRAGSP ALPKGDPLLG DCRSPLELSP RSESSSDCSS
60 70 80 90 100
PASPGRDCLE TGTPRPGGAS GPGLDSHLQP GQLSAPAQSR TVTSSFLIRD
110 120 130 140 150
ILADCKPLAA CAPYSSSGQP AAPEPGGRLA AKAAEDFRDK LDKSGSNASS
160 170 180 190 200
DSEYKVKEEG DREISSSRDS PPVRLKKPRK ARTAFTDHQL AQLERSFERQ
210 220 230 240 250
KYLSVQDRME LAASLNLTDT QVKTWYQNRR TKWKRQTAVG LELLAEAGNY
260 270 280 290 300
SALQRMFPSP YFYPQSLVSN LDPGAALYLY RGPSAPPPAL QRPLVPRILI
310 320
HGLQGASEPP PPLPPLAGVL PRAAQPR
Length:327
Mass (Da):35,074
Last modified:June 1, 2001 - v1
Checksum:i5BFCE201BC6359D6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF325688 mRNA. Translation: AAG50279.1.
AF321618 mRNA. Translation: AAK52674.1.
AK054797 mRNA. Translation: BAB70807.1.
AL354735 Genomic DNA. Translation: CAI16566.1.
CH471090 Genomic DNA. Translation: EAW88005.1.
BC136956 mRNA. Translation: AAI36957.1.
BC136969 mRNA. Translation: AAI36970.1.
AJ237816 Genomic DNA. Translation: CAB92439.1.
CCDSiCCDS6950.1.
RefSeqiNP_064448.1. NM_020064.3.
UniGeneiHs.283809.

Genome annotation databases

EnsembliENST00000263610; ENSP00000263610; ENSG00000125492.
ENST00000542090; ENSP00000444704; ENSG00000125492.
GeneIDi56751.
KEGGihsa:56751.
UCSCiuc004cbp.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF325688 mRNA. Translation: AAG50279.1.
AF321618 mRNA. Translation: AAK52674.1.
AK054797 mRNA. Translation: BAB70807.1.
AL354735 Genomic DNA. Translation: CAI16566.1.
CH471090 Genomic DNA. Translation: EAW88005.1.
BC136956 mRNA. Translation: AAI36957.1.
BC136969 mRNA. Translation: AAI36970.1.
AJ237816 Genomic DNA. Translation: CAB92439.1.
CCDSiCCDS6950.1.
RefSeqiNP_064448.1. NM_020064.3.
UniGeneiHs.283809.

3D structure databases

ProteinModelPortaliQ9BZE3.
SMRiQ9BZE3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121195. 3 interactors.
STRINGi9606.ENSP00000263610.

PTM databases

iPTMnetiQ9BZE3.
PhosphoSitePlusiQ9BZE3.

Polymorphism and mutation databases

BioMutaiBARHL1.
DMDMi29336920.

Proteomic databases

PaxDbiQ9BZE3.
PRIDEiQ9BZE3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000263610; ENSP00000263610; ENSG00000125492.
ENST00000542090; ENSP00000444704; ENSG00000125492.
GeneIDi56751.
KEGGihsa:56751.
UCSCiuc004cbp.2. human.

Organism-specific databases

CTDi56751.
DisGeNETi56751.
GeneCardsiBARHL1.
HGNCiHGNC:953. BARHL1.
HPAiHPA004809.
MIMi605211. gene.
neXtProtiNX_Q9BZE3.
OpenTargetsiENSG00000125492.
PharmGKBiPA25257.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0488. Eukaryota.
ENOG411188D. LUCA.
GeneTreeiENSGT00860000133665.
HOGENOMiHOG000231533.
HOVERGENiHBG050663.
InParanoidiQ9BZE3.
KOiK09360.
OMAiSDSEYKG.
OrthoDBiEOG091G13SM.
PhylomeDBiQ9BZE3.
TreeFamiTF316128.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000125492-MONOMER.

Miscellaneous databases

GenomeRNAii56751.
PROiQ9BZE3.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000125492.
CleanExiHS_BARHL1.
GenevisibleiQ9BZE3. HS.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBARH1_HUMAN
AccessioniPrimary (citable) accession number: Q9BZE3
Secondary accession number(s): Q5T6V2, Q9NY88
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 25, 2003
Last sequence update: June 1, 2001
Last modified: November 30, 2016
This is version 136 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.