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Protein

39S ribosomal protein L37, mitochondrial

Gene

MRPL37

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • RNA binding Source: UniProtKB
  • structural constituent of ribosome Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-5368286. Mitochondrial translation initiation.
R-HSA-5389840. Mitochondrial translation elongation.
R-HSA-5419276. Mitochondrial translation termination.

Names & Taxonomyi

Protein namesi
Recommended name:
39S ribosomal protein L37, mitochondrial
Short name:
L37mt
Short name:
MRP-L37
Alternative name(s):
39S ribosomal protein L2, mitochondrial
Short name:
L2mt
Short name:
MRP-L2
Mitochondrial large ribosomal subunit protein mL371 Publication
Gene namesi
Name:MRPL37
Synonyms:MRPL2, RPML2
ORF Names:HSPC235
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:14034. MRPL37.

Subcellular locationi

GO - Cellular componenti

  • mitochondrial inner membrane Source: Reactome
  • mitochondrial large ribosomal subunit Source: UniProtKB
  • mitochondrial ribosome Source: UniProtKB
  • mitochondrion Source: HPA

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

DisGeNETi51253.
OpenTargetsiENSG00000116221.
PharmGKBiPA30968.

Polymorphism and mutation databases

BioMutaiMRPL37.
DMDMi152083350.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 29MitochondrionBy similarityAdd BLAST29
ChainiPRO_000004590530 – 42339S ribosomal protein L37, mitochondrialAdd BLAST394

Proteomic databases

EPDiQ9BZE1.
MaxQBiQ9BZE1.
PaxDbiQ9BZE1.
PeptideAtlasiQ9BZE1.
PRIDEiQ9BZE1.

PTM databases

iPTMnetiQ9BZE1.
PhosphoSitePlusiQ9BZE1.
SwissPalmiQ9BZE1.

Expressioni

Gene expression databases

BgeeiENSG00000116221.
CleanExiHS_MRPL2.
HS_MRPL37.
ExpressionAtlasiQ9BZE1. baseline and differential.
GenevisibleiQ9BZE1. HS.

Organism-specific databases

HPAiHPA025767.
HPA025826.
HPA025951.

Interactioni

Subunit structurei

Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins. mL37 forms a heterodimer with mL65.2 Publications

Protein-protein interaction databases

BioGridi119410. 72 interactors.
DIPiDIP-59718N.
IntActiQ9BZE1. 17 interactors.
MINTiMINT-8051999.
STRINGi9606.ENSP00000354086.

Structurei

Secondary structure

1423
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni36 – 38Combined sources3
Helixi48 – 51Combined sources4
Beta strandi62 – 65Combined sources4
Beta strandi68 – 71Combined sources4
Helixi85 – 87Combined sources3
Beta strandi93 – 95Combined sources3
Beta strandi104 – 107Combined sources4
Helixi117 – 124Combined sources8
Beta strandi126 – 131Combined sources6
Helixi134 – 138Combined sources5
Helixi151 – 162Combined sources12
Beta strandi165 – 170Combined sources6
Helixi173 – 189Combined sources17
Helixi190 – 192Combined sources3
Helixi196 – 199Combined sources4
Beta strandi200 – 205Combined sources6
Beta strandi210 – 213Combined sources4
Beta strandi215 – 217Combined sources3
Beta strandi220 – 222Combined sources3
Beta strandi226 – 234Combined sources9
Helixi242 – 248Combined sources7
Beta strandi257 – 259Combined sources3
Beta strandi265 – 270Combined sources6
Beta strandi287 – 292Combined sources6
Turni300 – 302Combined sources3
Helixi306 – 328Combined sources23
Beta strandi342 – 345Combined sources4
Beta strandi348 – 350Combined sources3
Beta strandi354 – 357Combined sources4
Beta strandi372 – 377Combined sources6
Helixi408 – 419Combined sources12

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J7Yelectron microscopy3.4051-423[»]
3J9Melectron microscopy3.5051-423[»]
ProteinModelPortaliQ9BZE1.
SMRiQ9BZE1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiENOG410IKEJ. Eukaryota.
ENOG410ZT8U. LUCA.
GeneTreeiENSGT00390000000867.
HOGENOMiHOG000253919.
HOVERGENiHBG080542.
InParanoidiQ9BZE1.
KOiK17418.
PhylomeDBiQ9BZE1.
TreeFamiTF323297.

Family and domain databases

InterProiView protein in InterPro
IPR010793. Ribosomal_L37/S30.
PfamiView protein in Pfam
PF07147. PDCD9. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9BZE1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALASGPARR ALAGSGQLGL GGFGAPRRGA YEWGVRSTRK SEPPPLDRVY
60 70 80 90 100
EIPGLEPITF AGKMHFVPWL ARPIFPPWDR GYKDPRFYRS PPLHEHPLYK
110 120 130 140 150
DQACYIFHHR CRLLEGVKQA LWLTKTKLIE GLPEKVLSLV DDPRNHIENQ
160 170 180 190 200
DECVLNVISH ARLWQTTEEI PKRETYCPVI VDNLIQLCKS QILKHPSLAR
210 220 230 240 250
RICVQNSTFS ATWNRESLLL QVRGSGGARL STKDPLPTIA SREEIEATKN
260 270 280 290 300
HVLETFYPIS PIIDLHECNI YDVKNDTGFQ EGYPYPYPHT LYLLDKANLR
310 320 330 340 350
PHRLQPDQLR AKMILFAFGS ALAQARLLYG NDAKVLEQPV VVQSVGTDGR
360 370 380 390 400
VFHFLVFQLN TTDLDCNEGV KNLAWVDSDQ LLYQHFWCLP VIKKRVVVEP
410 420
VGPVGFKPET FRKFLALYLH GAA
Length:423
Mass (Da):48,117
Last modified:May 29, 2007 - v2
Checksum:i9556DAF4349F6EEB
GO

Sequence cautioni

The sequence AAF36155 differs from that shown. Reason: Frameshift at positions 9, 13, 25, 30 and 326.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_025269322L → V1 PublicationCorresponds to variant dbSNP:rs2275408Ensembl.1
Natural variantiVAR_025270366C → S3 PublicationsCorresponds to variant dbSNP:rs13571Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF325707 mRNA. Translation: AAG52881.1.
AF151069 mRNA. Translation: AAF36155.1. Frameshift.
DQ205685 Genomic DNA. Translation: ABA27099.1.
AL357673, AL161644 Genomic DNA. Translation: CAH73897.1.
AL161644, AL357673 Genomic DNA. Translation: CAI23564.1.
BC000041 mRNA. Translation: AAH00041.1.
AB051344 Genomic DNA. Translation: BAB54934.1.
CCDSiCCDS589.1.
RefSeqiNP_057575.2. NM_016491.3.
UniGeneiHs.584908.

Genome annotation databases

EnsembliENST00000360840; ENSP00000354086; ENSG00000116221.
GeneIDi51253.
KEGGihsa:51253.
UCSCiuc001cxa.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiRM37_HUMAN
AccessioniPrimary (citable) accession number: Q9BZE1
Secondary accession number(s): Q96Q67, Q9BWR1, Q9P0P3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 7, 2006
Last sequence update: May 29, 2007
Last modified: July 5, 2017
This is version 120 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Ribosomal proteins
    Ribosomal proteins families and list of entries
  7. SIMILARITY comments
    Index of protein domains and families