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Q9BZE1

- RM37_HUMAN

UniProt

Q9BZE1 - RM37_HUMAN

Protein

39S ribosomal protein L37, mitochondrial

Gene

MRPL37

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 93 (01 Oct 2014)
      Sequence version 2 (29 May 2007)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. poly(A) RNA binding Source: UniProtKB
    2. structural constituent of ribosome Source: UniProtKB

    GO - Biological processi

    1. translation Source: UniProtKB

    Keywords - Molecular functioni

    Ribonucleoprotein, Ribosomal protein

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    39S ribosomal protein L37, mitochondrial
    Short name:
    L37mt
    Short name:
    MRP-L37
    Alternative name(s):
    39S ribosomal protein L2, mitochondrial
    Short name:
    L2mt
    Short name:
    MRP-L2
    Gene namesi
    Name:MRPL37
    Synonyms:MRPL2, RPML2
    ORF Names:HSPC235
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:14034. MRPL37.

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrial ribosome Source: UniProtKB
    2. mitochondrion Source: HPA

    Keywords - Cellular componenti

    Mitochondrion

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA30968.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 2929MitochondrionBy similarityAdd
    BLAST
    Chaini30 – 42339439S ribosomal protein L37, mitochondrialPRO_0000045905Add
    BLAST

    Proteomic databases

    MaxQBiQ9BZE1.
    PaxDbiQ9BZE1.
    PRIDEiQ9BZE1.

    PTM databases

    PhosphoSiteiQ9BZE1.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9BZE1.
    BgeeiQ9BZE1.
    CleanExiHS_MRPL2.
    HS_MRPL37.
    GenevestigatoriQ9BZE1.

    Organism-specific databases

    HPAiHPA025767.
    HPA025826.
    HPA025951.

    Interactioni

    Protein-protein interaction databases

    BioGridi119410. 28 interactions.
    DIPiDIP-59718N.
    IntActiQ9BZE1. 4 interactions.
    MINTiMINT-8051999.
    STRINGi9606.ENSP00000354086.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9BZE1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ribosomal protein S30/L37 family.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiNOG68060.
    HOGENOMiHOG000253919.
    HOVERGENiHBG080542.
    InParanoidiQ9BZE1.
    KOiK17418.
    OrthoDBiEOG7B05D6.
    PhylomeDBiQ9BZE1.
    TreeFamiTF323297.

    Family and domain databases

    InterProiIPR010793. Ribosomal_L37/S30.
    [Graphical view]
    PfamiPF07147. PDCD9. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9BZE1-1 [UniParc]FASTAAdd to Basket

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    MALASGPARR ALAGSGQLGL GGFGAPRRGA YEWGVRSTRK SEPPPLDRVY    50
    EIPGLEPITF AGKMHFVPWL ARPIFPPWDR GYKDPRFYRS PPLHEHPLYK 100
    DQACYIFHHR CRLLEGVKQA LWLTKTKLIE GLPEKVLSLV DDPRNHIENQ 150
    DECVLNVISH ARLWQTTEEI PKRETYCPVI VDNLIQLCKS QILKHPSLAR 200
    RICVQNSTFS ATWNRESLLL QVRGSGGARL STKDPLPTIA SREEIEATKN 250
    HVLETFYPIS PIIDLHECNI YDVKNDTGFQ EGYPYPYPHT LYLLDKANLR 300
    PHRLQPDQLR AKMILFAFGS ALAQARLLYG NDAKVLEQPV VVQSVGTDGR 350
    VFHFLVFQLN TTDLDCNEGV KNLAWVDSDQ LLYQHFWCLP VIKKRVVVEP 400
    VGPVGFKPET FRKFLALYLH GAA 423
    Length:423
    Mass (Da):48,117
    Last modified:May 29, 2007 - v2
    Checksum:i9556DAF4349F6EEB
    GO

    Sequence cautioni

    The sequence AAF36155.1 differs from that shown. Reason: Frameshift at positions 9, 13, 25, 30 and 326.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti322 – 3221L → V.1 Publication
    Corresponds to variant rs2275408 [ dbSNP | Ensembl ].
    VAR_025269
    Natural varianti366 – 3661C → S.3 Publications
    Corresponds to variant rs13571 [ dbSNP | Ensembl ].
    VAR_025270

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF325707 mRNA. Translation: AAG52881.1.
    AF151069 mRNA. Translation: AAF36155.1. Frameshift.
    DQ205685 Genomic DNA. Translation: ABA27099.1.
    AL357673, AL161644 Genomic DNA. Translation: CAH73897.1.
    AL161644, AL357673 Genomic DNA. Translation: CAI23564.1.
    BC000041 mRNA. Translation: AAH00041.1.
    AB051344 Genomic DNA. Translation: BAB54934.1.
    CCDSiCCDS589.1.
    RefSeqiNP_057575.2. NM_016491.3.
    UniGeneiHs.584908.

    Genome annotation databases

    EnsembliENST00000360840; ENSP00000354086; ENSG00000116221.
    GeneIDi51253.
    KEGGihsa:51253.
    UCSCiuc001cxa.4. human.

    Polymorphism databases

    DMDMi152083350.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    NIEHS-SNPs

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF325707 mRNA. Translation: AAG52881.1 .
    AF151069 mRNA. Translation: AAF36155.1 . Frameshift.
    DQ205685 Genomic DNA. Translation: ABA27099.1 .
    AL357673 , AL161644 Genomic DNA. Translation: CAH73897.1 .
    AL161644 , AL357673 Genomic DNA. Translation: CAI23564.1 .
    BC000041 mRNA. Translation: AAH00041.1 .
    AB051344 Genomic DNA. Translation: BAB54934.1 .
    CCDSi CCDS589.1.
    RefSeqi NP_057575.2. NM_016491.3.
    UniGenei Hs.584908.

    3D structure databases

    ProteinModelPortali Q9BZE1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 119410. 28 interactions.
    DIPi DIP-59718N.
    IntActi Q9BZE1. 4 interactions.
    MINTi MINT-8051999.
    STRINGi 9606.ENSP00000354086.

    PTM databases

    PhosphoSitei Q9BZE1.

    Polymorphism databases

    DMDMi 152083350.

    Proteomic databases

    MaxQBi Q9BZE1.
    PaxDbi Q9BZE1.
    PRIDEi Q9BZE1.

    Protocols and materials databases

    DNASUi 51253.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000360840 ; ENSP00000354086 ; ENSG00000116221 .
    GeneIDi 51253.
    KEGGi hsa:51253.
    UCSCi uc001cxa.4. human.

    Organism-specific databases

    CTDi 51253.
    GeneCardsi GC01P054649.
    HGNCi HGNC:14034. MRPL37.
    HPAi HPA025767.
    HPA025826.
    HPA025951.
    MIMi 611843. gene.
    neXtProti NX_Q9BZE1.
    PharmGKBi PA30968.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG68060.
    HOGENOMi HOG000253919.
    HOVERGENi HBG080542.
    InParanoidi Q9BZE1.
    KOi K17418.
    OrthoDBi EOG7B05D6.
    PhylomeDBi Q9BZE1.
    TreeFami TF323297.

    Miscellaneous databases

    GeneWikii MRPL37.
    GenomeRNAii 51253.
    NextBioi 54402.
    PROi Q9BZE1.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9BZE1.
    Bgeei Q9BZE1.
    CleanExi HS_MRPL2.
    HS_MRPL37.
    Genevestigatori Q9BZE1.

    Family and domain databases

    InterProi IPR010793. Ribosomal_L37/S30.
    [Graphical view ]
    Pfami PF07147. PDCD9. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Novel gene located on human chromosome 1."
      Levshenkova E.V., Bashirova A.A., Markelov M.L., Frolova E.I.
      Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT SER-366.
      Tissue: Skeletal muscle.
    2. "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells."
      Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X.
      , Gu J., Chen S.-J., Chen Z.
      Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT SER-366.
      Tissue: Umbilical cord blood.
    3. NIEHS SNPs program
      Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS VAL-322 AND SER-366.
    4. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Placenta.
    6. "The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders."
      Kenmochi N., Suzuki T., Uechi T., Magoori M., Kuniba M., Higa S., Watanabe K., Tanaka T.
      Genomics 77:65-70(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 399-423.
    7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiRM37_HUMAN
    AccessioniPrimary (citable) accession number: Q9BZE1
    Secondary accession number(s): Q96Q67, Q9BWR1, Q9P0P3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 7, 2006
    Last sequence update: May 29, 2007
    Last modified: October 1, 2014
    This is version 93 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. Ribosomal proteins
      Ribosomal proteins families and list of entries
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3