Q9BZE1 (RM37_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
39S ribosomal protein L37, mitochondrial
Short name=L37mt
Short name=MRP-L37

Alternative name(s):
39S ribosomal protein L2, mitochondrial
Short name=L2mt
Short name=MRP-L2

Gene names

Name:	MRPL37
Synonyms:	MRPL2, RPML2
ORF Names:	HSPC235

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	423 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Mitochondrion.
Sequence similarities	Belongs to the ribosomal protein S30/L37 family.
Sequence caution	The sequence AAF36155.1 differs from that shown. Reason: Frameshift at positions 9, 13, 25, 30 and 326.

Ontologies

Keywords
Cellular component	Mitochondrion
Coding sequence diversity	Polymorphism
Domain	Transit peptide
Molecular function	Ribonucleoprotein Ribosomal protein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	translation Non-traceable author statement Ref.6. Source: UniProtKB
Cellular_component	mitochondrial ribosome Non-traceable author statement Ref.6. Source: UniProtKB
Molecular_function	structural constituent of ribosome Non-traceable author statement Ref.6. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – 29	29	Mitochondrion By similarity
	Chain	30 – 423	394	39S ribosomal protein L37, mitochondrial		PRO_0000045905
Natural variations
	Natural variant	322	1	L → V. Ref.3 Corresponds to variant rs2275408 [ dbSNP | Ensembl ].		VAR_025269
	Natural variant	366	1	C → S. Ref.1 Ref.2 Ref.3 Corresponds to variant rs13571 [ dbSNP | Ensembl ].		VAR_025270

Sequences

	Sequence		Length	Mass (Da)
	Q9BZE1 [UniParc]. Last modified May 29, 2007. Version 2. Checksum: 9556DAF4349F6EEB	FASTA	423	48,117
	10 20 30 40 50 60 MALASGPARR ALAGSGQLGL GGFGAPRRGA YEWGVRSTRK SEPPPLDRVY EIPGLEPITF 70 80 90 100 110 120 AGKMHFVPWL ARPIFPPWDR GYKDPRFYRS PPLHEHPLYK DQACYIFHHR CRLLEGVKQA 130 140 150 160 170 180 LWLTKTKLIE GLPEKVLSLV DDPRNHIENQ DECVLNVISH ARLWQTTEEI PKRETYCPVI 190 200 210 220 230 240 VDNLIQLCKS QILKHPSLAR RICVQNSTFS ATWNRESLLL QVRGSGGARL STKDPLPTIA 250 260 270 280 290 300 SREEIEATKN HVLETFYPIS PIIDLHECNI YDVKNDTGFQ EGYPYPYPHT LYLLDKANLR 310 320 330 340 350 360 PHRLQPDQLR AKMILFAFGS ALAQARLLYG NDAKVLEQPV VVQSVGTDGR VFHFLVFQLN 370 380 390 400 410 420 TTDLDCNEGV KNLAWVDSDQ LLYQHFWCLP VIKKRVVVEP VGPVGFKPET FRKFLALYLH GAA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Novel gene located on human chromosome 1." Levshenkova E.V., Bashirova A.A., Markelov M.L., Frolova E.I. Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT SER-366. Tissue: Skeletal muscle.
[2]	"Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells." Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X. , Gu J., Chen S.-J., Chen Z. Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT SER-366. Tissue: Umbilical cord blood.
[3]	NIEHS SNPs program Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS VAL-322 AND SER-366.
[4]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Placenta.
[6]	"The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders." Kenmochi N., Suzuki T., Uechi T., Magoori M., Kuniba M., Higa S., Watanabe K., Tanaka T. Genomics 77:65-70(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 399-423.
[7]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Web resources

NIEHS-SNPs

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF325707 mRNA. Translation: AAG52881.1. AF151069 mRNA. Translation: AAF36155.1. Frameshift. DQ205685 Genomic DNA. Translation: ABA27099.1. AL357673, AL161644 Genomic DNA. Translation: CAH73897.1. AL161644, AL357673 Genomic DNA. Translation: CAI23564.1. BC000041 mRNA. Translation: AAH00041.1. AB051344 Genomic DNA. Translation: BAB54934.1.
IPI	IPI00162330.
RefSeq	NP_057575.2. NM_016491.3.
UniGene	Hs.584908.
3D structure databases
ProteinModelPortal	Q9BZE1.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-59718N.
IntAct	Q9BZE1. 1 interaction.
STRING	9606.ENSP00000354086.
PTM databases
PhosphoSite	Q9BZE1.
Polymorphism databases
DMDM	152083350.
Proteomic databases
PaxDb	Q9BZE1.
PRIDE	Q9BZE1.
Protocols and materials databases
DNASU	51253.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000360840; ENSP00000354086; ENSG00000116221.
GeneID	51253.
KEGG	hsa:51253.
UCSC	uc001cxa.4. human.
Organism-specific databases
CTD	51253.
GeneCards	GC01P054649.
HGNC	HGNC:14034. MRPL37.
HPA	HPA025767. HPA025826. HPA025951.
MIM	611843. gene.
neXtProt	NX_Q9BZE1.
PharmGKB	PA30968.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG68060.
HOGENOM	HOG000253919.
HOVERGEN	HBG080542.
InParanoid	Q9BZE1.
OMA	HARLWHS.
OrthoDB	EOG4CNQR3.
PhylomeDB	Q9BZE1.
Gene expression databases
ArrayExpress	Q9BZE1.
Bgee	Q9BZE1.
CleanEx	HS_MRPL2. HS_MRPL37.
Genevestigator	Q9BZE1.
GermOnline	ENSG00000116221. Homo sapiens.
Family and domain databases
InterPro	IPR010793. Ribosomal_L37/S30. [Graphical view]
Pfam	PF07147. PDCD9. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	51253.
NextBio	54402.
SOURCE	Search...

Entry information

Entry name

RM37_HUMAN

Accession

Primary (citable) accession number: Q9BZE1
Secondary accession number(s): Q96Q67, Q9BWR1, Q9P0P3

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 7, 2006
Last sequence update:	May 29, 2007
Last modified:	April 3, 2013
This is version 81 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.