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Protein

39S ribosomal protein L37, mitochondrial

Gene

MRPL37

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. poly(A) RNA binding Source: UniProtKB
  2. structural constituent of ribosome Source: UniProtKB

GO - Biological processi

  1. translation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiREACT_267602. Mitochondrial translation termination.
REACT_267677. Mitochondrial translation elongation.
REACT_267680. Mitochondrial translation initiation.

Names & Taxonomyi

Protein namesi
Recommended name:
39S ribosomal protein L37, mitochondrial
Short name:
L37mt
Short name:
MRP-L37
Alternative name(s):
39S ribosomal protein L2, mitochondrial
Short name:
L2mt
Short name:
MRP-L2
Gene namesi
Name:MRPL37
Synonyms:MRPL2, RPML2
ORF Names:HSPC235
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:14034. MRPL37.

Subcellular locationi

GO - Cellular componenti

  1. mitochondrial ribosome Source: UniProtKB
  2. mitochondrion Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30968.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2929MitochondrionBy similarityAdd
BLAST
Chaini30 – 42339439S ribosomal protein L37, mitochondrialPRO_0000045905Add
BLAST

Proteomic databases

MaxQBiQ9BZE1.
PaxDbiQ9BZE1.
PRIDEiQ9BZE1.

PTM databases

PhosphoSiteiQ9BZE1.

Expressioni

Gene expression databases

BgeeiQ9BZE1.
CleanExiHS_MRPL2.
HS_MRPL37.
ExpressionAtlasiQ9BZE1. baseline and differential.
GenevestigatoriQ9BZE1.

Organism-specific databases

HPAiHPA025767.
HPA025826.
HPA025951.

Interactioni

Protein-protein interaction databases

BioGridi119410. 51 interactions.
DIPiDIP-59718N.
IntActiQ9BZE1. 4 interactions.
MINTiMINT-8051999.
STRINGi9606.ENSP00000354086.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3J7Yelectron microscopy3.4051-423[»]
ProteinModelPortaliQ9BZE1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein S30/L37 family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiNOG68060.
GeneTreeiENSGT00390000000867.
HOGENOMiHOG000253919.
HOVERGENiHBG080542.
InParanoidiQ9BZE1.
KOiK17418.
OrthoDBiEOG7B05D6.
PhylomeDBiQ9BZE1.
TreeFamiTF323297.

Family and domain databases

InterProiIPR010793. Ribosomal_L37/S30.
[Graphical view]
PfamiPF07147. PDCD9. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9BZE1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MALASGPARR ALAGSGQLGL GGFGAPRRGA YEWGVRSTRK SEPPPLDRVY
60 70 80 90 100
EIPGLEPITF AGKMHFVPWL ARPIFPPWDR GYKDPRFYRS PPLHEHPLYK
110 120 130 140 150
DQACYIFHHR CRLLEGVKQA LWLTKTKLIE GLPEKVLSLV DDPRNHIENQ
160 170 180 190 200
DECVLNVISH ARLWQTTEEI PKRETYCPVI VDNLIQLCKS QILKHPSLAR
210 220 230 240 250
RICVQNSTFS ATWNRESLLL QVRGSGGARL STKDPLPTIA SREEIEATKN
260 270 280 290 300
HVLETFYPIS PIIDLHECNI YDVKNDTGFQ EGYPYPYPHT LYLLDKANLR
310 320 330 340 350
PHRLQPDQLR AKMILFAFGS ALAQARLLYG NDAKVLEQPV VVQSVGTDGR
360 370 380 390 400
VFHFLVFQLN TTDLDCNEGV KNLAWVDSDQ LLYQHFWCLP VIKKRVVVEP
410 420
VGPVGFKPET FRKFLALYLH GAA
Length:423
Mass (Da):48,117
Last modified:May 29, 2007 - v2
Checksum:i9556DAF4349F6EEB
GO

Sequence cautioni

The sequence AAF36155.1 differs from that shown. Reason: Frameshift at positions 9, 13, 25, 30 and 326. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti322 – 3221L → V.1 Publication
Corresponds to variant rs2275408 [ dbSNP | Ensembl ].
VAR_025269
Natural varianti366 – 3661C → S.3 Publications
Corresponds to variant rs13571 [ dbSNP | Ensembl ].
VAR_025270

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF325707 mRNA. Translation: AAG52881.1.
AF151069 mRNA. Translation: AAF36155.1. Frameshift.
DQ205685 Genomic DNA. Translation: ABA27099.1.
AL357673, AL161644 Genomic DNA. Translation: CAH73897.1.
AL161644, AL357673 Genomic DNA. Translation: CAI23564.1.
BC000041 mRNA. Translation: AAH00041.1.
AB051344 Genomic DNA. Translation: BAB54934.1.
CCDSiCCDS589.1.
RefSeqiNP_057575.2. NM_016491.3.
UniGeneiHs.584908.

Genome annotation databases

EnsembliENST00000360840; ENSP00000354086; ENSG00000116221.
GeneIDi51253.
KEGGihsa:51253.
UCSCiuc001cxa.4. human.

Polymorphism databases

DMDMi152083350.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF325707 mRNA. Translation: AAG52881.1.
AF151069 mRNA. Translation: AAF36155.1. Frameshift.
DQ205685 Genomic DNA. Translation: ABA27099.1.
AL357673, AL161644 Genomic DNA. Translation: CAH73897.1.
AL161644, AL357673 Genomic DNA. Translation: CAI23564.1.
BC000041 mRNA. Translation: AAH00041.1.
AB051344 Genomic DNA. Translation: BAB54934.1.
CCDSiCCDS589.1.
RefSeqiNP_057575.2. NM_016491.3.
UniGeneiHs.584908.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3J7Yelectron microscopy3.4051-423[»]
ProteinModelPortaliQ9BZE1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119410. 51 interactions.
DIPiDIP-59718N.
IntActiQ9BZE1. 4 interactions.
MINTiMINT-8051999.
STRINGi9606.ENSP00000354086.

PTM databases

PhosphoSiteiQ9BZE1.

Polymorphism databases

DMDMi152083350.

Proteomic databases

MaxQBiQ9BZE1.
PaxDbiQ9BZE1.
PRIDEiQ9BZE1.

Protocols and materials databases

DNASUi51253.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000360840; ENSP00000354086; ENSG00000116221.
GeneIDi51253.
KEGGihsa:51253.
UCSCiuc001cxa.4. human.

Organism-specific databases

CTDi51253.
GeneCardsiGC01P054649.
HGNCiHGNC:14034. MRPL37.
HPAiHPA025767.
HPA025826.
HPA025951.
MIMi611843. gene.
neXtProtiNX_Q9BZE1.
PharmGKBiPA30968.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG68060.
GeneTreeiENSGT00390000000867.
HOGENOMiHOG000253919.
HOVERGENiHBG080542.
InParanoidiQ9BZE1.
KOiK17418.
OrthoDBiEOG7B05D6.
PhylomeDBiQ9BZE1.
TreeFamiTF323297.

Enzyme and pathway databases

ReactomeiREACT_267602. Mitochondrial translation termination.
REACT_267677. Mitochondrial translation elongation.
REACT_267680. Mitochondrial translation initiation.

Miscellaneous databases

GeneWikiiMRPL37.
GenomeRNAii51253.
NextBioi54402.
PROiQ9BZE1.
SOURCEiSearch...

Gene expression databases

BgeeiQ9BZE1.
CleanExiHS_MRPL2.
HS_MRPL37.
ExpressionAtlasiQ9BZE1. baseline and differential.
GenevestigatoriQ9BZE1.

Family and domain databases

InterProiIPR010793. Ribosomal_L37/S30.
[Graphical view]
PfamiPF07147. PDCD9. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Novel gene located on human chromosome 1."
    Levshenkova E.V., Bashirova A.A., Markelov M.L., Frolova E.I.
    Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT SER-366.
    Tissue: Skeletal muscle.
  2. "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells."
    Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X.
    , Gu J., Chen S.-J., Chen Z.
    Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT SER-366.
    Tissue: Umbilical cord blood.
  3. NIEHS SNPs program
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS VAL-322 AND SER-366.
  4. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.
  6. "The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders."
    Kenmochi N., Suzuki T., Uechi T., Magoori M., Kuniba M., Higa S., Watanabe K., Tanaka T.
    Genomics 77:65-70(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 399-423.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiRM37_HUMAN
AccessioniPrimary (citable) accession number: Q9BZE1
Secondary accession number(s): Q96Q67, Q9BWR1, Q9P0P3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 7, 2006
Last sequence update: May 29, 2007
Last modified: January 7, 2015
This is version 96 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Ribosomal proteins
    Ribosomal proteins families and list of entries
  7. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.