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Q9BZE1 (RM37_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
39S ribosomal protein L37, mitochondrial

Short name=L37mt
Short name=MRP-L37
Alternative name(s):
39S ribosomal protein L2, mitochondrial
Short name=L2mt
Short name=MRP-L2
Gene names
Name:MRPL37
Synonyms:MRPL2, RPML2
ORF Names:HSPC235
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length423 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Subcellular location

Mitochondrion.

Sequence similarities

Belongs to the ribosomal protein S30/L37 family.

Sequence caution

The sequence AAF36155.1 differs from that shown. Reason: Frameshift at positions 9, 13, 25, 30 and 326.

Ontologies

Keywords
   Cellular componentMitochondrion
   Coding sequence diversityPolymorphism
   DomainTransit peptide
   Molecular functionRibonucleoprotein
Ribosomal protein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processtranslation

Non-traceable author statement Ref.6. Source: UniProtKB

   Cellular_componentmitochondrial ribosome

Non-traceable author statement Ref.6. Source: UniProtKB

mitochondrion

Inferred from direct assay. Source: HPA

   Molecular_functionpoly(A) RNA binding

Inferred from direct assay PubMed 22658674. Source: UniProtKB

structural constituent of ribosome

Non-traceable author statement Ref.6. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 2929Mitochondrion By similarity
Chain30 – 42339439S ribosomal protein L37, mitochondrial
PRO_0000045905

Natural variations

Natural variant3221L → V. Ref.3
Corresponds to variant rs2275408 [ dbSNP | Ensembl ].
VAR_025269
Natural variant3661C → S. Ref.1 Ref.2 Ref.3
Corresponds to variant rs13571 [ dbSNP | Ensembl ].
VAR_025270

Sequences

Sequence LengthMass (Da)Tools
Q9BZE1 [UniParc].

Last modified May 29, 2007. Version 2.
Checksum: 9556DAF4349F6EEB

FASTA42348,117
        10         20         30         40         50         60 
MALASGPARR ALAGSGQLGL GGFGAPRRGA YEWGVRSTRK SEPPPLDRVY EIPGLEPITF 

        70         80         90        100        110        120 
AGKMHFVPWL ARPIFPPWDR GYKDPRFYRS PPLHEHPLYK DQACYIFHHR CRLLEGVKQA 

       130        140        150        160        170        180 
LWLTKTKLIE GLPEKVLSLV DDPRNHIENQ DECVLNVISH ARLWQTTEEI PKRETYCPVI 

       190        200        210        220        230        240 
VDNLIQLCKS QILKHPSLAR RICVQNSTFS ATWNRESLLL QVRGSGGARL STKDPLPTIA 

       250        260        270        280        290        300 
SREEIEATKN HVLETFYPIS PIIDLHECNI YDVKNDTGFQ EGYPYPYPHT LYLLDKANLR 

       310        320        330        340        350        360 
PHRLQPDQLR AKMILFAFGS ALAQARLLYG NDAKVLEQPV VVQSVGTDGR VFHFLVFQLN 

       370        380        390        400        410        420 
TTDLDCNEGV KNLAWVDSDQ LLYQHFWCLP VIKKRVVVEP VGPVGFKPET FRKFLALYLH 


GAA 

« Hide

References

« Hide 'large scale' references
[1]"Novel gene located on human chromosome 1."
Levshenkova E.V., Bashirova A.A., Markelov M.L., Frolova E.I.
Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT SER-366.
Tissue: Skeletal muscle.
[2]"Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells."
Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X. expand/collapse author list , Gu J., Chen S.-J., Chen Z.
Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT SER-366.
Tissue: Umbilical cord blood.
[3]NIEHS SNPs program
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS VAL-322 AND SER-366.
[4]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Placenta.
[6]"The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders."
Kenmochi N., Suzuki T., Uechi T., Magoori M., Kuniba M., Higa S., Watanabe K., Tanaka T.
Genomics 77:65-70(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 399-423.
[7]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Web resources

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF325707 mRNA. Translation: AAG52881.1.
AF151069 mRNA. Translation: AAF36155.1. Frameshift.
DQ205685 Genomic DNA. Translation: ABA27099.1.
AL357673, AL161644 Genomic DNA. Translation: CAH73897.1.
AL161644, AL357673 Genomic DNA. Translation: CAI23564.1.
BC000041 mRNA. Translation: AAH00041.1.
AB051344 Genomic DNA. Translation: BAB54934.1.
CCDSCCDS589.1.
RefSeqNP_057575.2. NM_016491.3.
UniGeneHs.584908.

3D structure databases

ProteinModelPortalQ9BZE1.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid119410. 27 interactions.
DIPDIP-59718N.
IntActQ9BZE1. 4 interactions.
MINTMINT-8051999.
STRING9606.ENSP00000354086.

PTM databases

PhosphoSiteQ9BZE1.

Polymorphism databases

DMDM152083350.

Proteomic databases

MaxQBQ9BZE1.
PaxDbQ9BZE1.
PRIDEQ9BZE1.

Protocols and materials databases

DNASU51253.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000360840; ENSP00000354086; ENSG00000116221.
GeneID51253.
KEGGhsa:51253.
UCSCuc001cxa.4. human.

Organism-specific databases

CTD51253.
GeneCardsGC01P054649.
HGNCHGNC:14034. MRPL37.
HPAHPA025767.
HPA025826.
HPA025951.
MIM611843. gene.
neXtProtNX_Q9BZE1.
PharmGKBPA30968.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG68060.
HOGENOMHOG000253919.
HOVERGENHBG080542.
InParanoidQ9BZE1.
KOK17418.
OrthoDBEOG7B05D6.
PhylomeDBQ9BZE1.
TreeFamTF323297.

Gene expression databases

ArrayExpressQ9BZE1.
BgeeQ9BZE1.
CleanExHS_MRPL2.
HS_MRPL37.
GenevestigatorQ9BZE1.

Family and domain databases

InterProIPR010793. Ribosomal_L37/S30.
[Graphical view]
PfamPF07147. PDCD9. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiMRPL37.
GenomeRNAi51253.
NextBio54402.
PROQ9BZE1.
SOURCESearch...

Entry information

Entry nameRM37_HUMAN
AccessionPrimary (citable) accession number: Q9BZE1
Secondary accession number(s): Q96Q67, Q9BWR1, Q9P0P3
Entry history
Integrated into UniProtKB/Swiss-Prot: February 7, 2006
Last sequence update: May 29, 2007
Last modified: July 9, 2014
This is version 91 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Ribosomal proteins

Ribosomal proteins families and list of entries

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM