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Q9BZE1

- RM37_HUMAN

UniProt

Q9BZE1 - RM37_HUMAN

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Protein

39S ribosomal protein L37, mitochondrial

Gene
MRPL37, MRPL2, RPML2, HSPC235
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. poly(A) RNA binding Source: UniProtKB
  2. structural constituent of ribosome Source: UniProtKB

GO - Biological processi

  1. translation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Names & Taxonomyi

Protein namesi
Recommended name:
39S ribosomal protein L37, mitochondrial
Short name:
L37mt
Short name:
MRP-L37
Alternative name(s):
39S ribosomal protein L2, mitochondrial
Short name:
L2mt
Short name:
MRP-L2
Gene namesi
Name:MRPL37
Synonyms:MRPL2, RPML2
ORF Names:HSPC235
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:14034. MRPL37.

Subcellular locationi

GO - Cellular componenti

  1. mitochondrial ribosome Source: UniProtKB
  2. mitochondrion Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30968.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2929Mitochondrion By similarityAdd
BLAST
Chaini30 – 42339439S ribosomal protein L37, mitochondrialPRO_0000045905Add
BLAST

Proteomic databases

MaxQBiQ9BZE1.
PaxDbiQ9BZE1.
PRIDEiQ9BZE1.

PTM databases

PhosphoSiteiQ9BZE1.

Expressioni

Gene expression databases

ArrayExpressiQ9BZE1.
BgeeiQ9BZE1.
CleanExiHS_MRPL2.
HS_MRPL37.
GenevestigatoriQ9BZE1.

Organism-specific databases

HPAiHPA025767.
HPA025826.
HPA025951.

Interactioni

Protein-protein interaction databases

BioGridi119410. 28 interactions.
DIPiDIP-59718N.
IntActiQ9BZE1. 4 interactions.
MINTiMINT-8051999.
STRINGi9606.ENSP00000354086.

Structurei

3D structure databases

ProteinModelPortaliQ9BZE1.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiNOG68060.
HOGENOMiHOG000253919.
HOVERGENiHBG080542.
InParanoidiQ9BZE1.
KOiK17418.
OrthoDBiEOG7B05D6.
PhylomeDBiQ9BZE1.
TreeFamiTF323297.

Family and domain databases

InterProiIPR010793. Ribosomal_L37/S30.
[Graphical view]
PfamiPF07147. PDCD9. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9BZE1-1 [UniParc]FASTAAdd to Basket

« Hide

MALASGPARR ALAGSGQLGL GGFGAPRRGA YEWGVRSTRK SEPPPLDRVY    50
EIPGLEPITF AGKMHFVPWL ARPIFPPWDR GYKDPRFYRS PPLHEHPLYK 100
DQACYIFHHR CRLLEGVKQA LWLTKTKLIE GLPEKVLSLV DDPRNHIENQ 150
DECVLNVISH ARLWQTTEEI PKRETYCPVI VDNLIQLCKS QILKHPSLAR 200
RICVQNSTFS ATWNRESLLL QVRGSGGARL STKDPLPTIA SREEIEATKN 250
HVLETFYPIS PIIDLHECNI YDVKNDTGFQ EGYPYPYPHT LYLLDKANLR 300
PHRLQPDQLR AKMILFAFGS ALAQARLLYG NDAKVLEQPV VVQSVGTDGR 350
VFHFLVFQLN TTDLDCNEGV KNLAWVDSDQ LLYQHFWCLP VIKKRVVVEP 400
VGPVGFKPET FRKFLALYLH GAA 423
Length:423
Mass (Da):48,117
Last modified:May 29, 2007 - v2
Checksum:i9556DAF4349F6EEB
GO

Sequence cautioni

The sequence AAF36155.1 differs from that shown. Reason: Frameshift at positions 9, 13, 25, 30 and 326.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti322 – 3221L → V.1 Publication
Corresponds to variant rs2275408 [ dbSNP | Ensembl ].
VAR_025269
Natural varianti366 – 3661C → S.3 Publications
Corresponds to variant rs13571 [ dbSNP | Ensembl ].
VAR_025270

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF325707 mRNA. Translation: AAG52881.1.
AF151069 mRNA. Translation: AAF36155.1. Frameshift.
DQ205685 Genomic DNA. Translation: ABA27099.1.
AL357673, AL161644 Genomic DNA. Translation: CAH73897.1.
AL161644, AL357673 Genomic DNA. Translation: CAI23564.1.
BC000041 mRNA. Translation: AAH00041.1.
AB051344 Genomic DNA. Translation: BAB54934.1.
CCDSiCCDS589.1.
RefSeqiNP_057575.2. NM_016491.3.
UniGeneiHs.584908.

Genome annotation databases

EnsembliENST00000360840; ENSP00000354086; ENSG00000116221.
GeneIDi51253.
KEGGihsa:51253.
UCSCiuc001cxa.4. human.

Polymorphism databases

DMDMi152083350.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF325707 mRNA. Translation: AAG52881.1 .
AF151069 mRNA. Translation: AAF36155.1 . Frameshift.
DQ205685 Genomic DNA. Translation: ABA27099.1 .
AL357673 , AL161644 Genomic DNA. Translation: CAH73897.1 .
AL161644 , AL357673 Genomic DNA. Translation: CAI23564.1 .
BC000041 mRNA. Translation: AAH00041.1 .
AB051344 Genomic DNA. Translation: BAB54934.1 .
CCDSi CCDS589.1.
RefSeqi NP_057575.2. NM_016491.3.
UniGenei Hs.584908.

3D structure databases

ProteinModelPortali Q9BZE1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 119410. 28 interactions.
DIPi DIP-59718N.
IntActi Q9BZE1. 4 interactions.
MINTi MINT-8051999.
STRINGi 9606.ENSP00000354086.

PTM databases

PhosphoSitei Q9BZE1.

Polymorphism databases

DMDMi 152083350.

Proteomic databases

MaxQBi Q9BZE1.
PaxDbi Q9BZE1.
PRIDEi Q9BZE1.

Protocols and materials databases

DNASUi 51253.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000360840 ; ENSP00000354086 ; ENSG00000116221 .
GeneIDi 51253.
KEGGi hsa:51253.
UCSCi uc001cxa.4. human.

Organism-specific databases

CTDi 51253.
GeneCardsi GC01P054649.
HGNCi HGNC:14034. MRPL37.
HPAi HPA025767.
HPA025826.
HPA025951.
MIMi 611843. gene.
neXtProti NX_Q9BZE1.
PharmGKBi PA30968.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG68060.
HOGENOMi HOG000253919.
HOVERGENi HBG080542.
InParanoidi Q9BZE1.
KOi K17418.
OrthoDBi EOG7B05D6.
PhylomeDBi Q9BZE1.
TreeFami TF323297.

Miscellaneous databases

GeneWikii MRPL37.
GenomeRNAii 51253.
NextBioi 54402.
PROi Q9BZE1.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9BZE1.
Bgeei Q9BZE1.
CleanExi HS_MRPL2.
HS_MRPL37.
Genevestigatori Q9BZE1.

Family and domain databases

InterProi IPR010793. Ribosomal_L37/S30.
[Graphical view ]
Pfami PF07147. PDCD9. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Novel gene located on human chromosome 1."
    Levshenkova E.V., Bashirova A.A., Markelov M.L., Frolova E.I.
    Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT SER-366.
    Tissue: Skeletal muscle.
  2. "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells."
    Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X.
    , Gu J., Chen S.-J., Chen Z.
    Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT SER-366.
    Tissue: Umbilical cord blood.
  3. NIEHS SNPs program
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS VAL-322 AND SER-366.
  4. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.
  6. "The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders."
    Kenmochi N., Suzuki T., Uechi T., Magoori M., Kuniba M., Higa S., Watanabe K., Tanaka T.
    Genomics 77:65-70(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 399-423.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiRM37_HUMAN
AccessioniPrimary (citable) accession number: Q9BZE1
Secondary accession number(s): Q96Q67, Q9BWR1, Q9P0P3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 7, 2006
Last sequence update: May 29, 2007
Last modified: September 3, 2014
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Ribosomal proteins
    Ribosomal proteins families and list of entries
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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