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Protein

Transmembrane gamma-carboxyglutamic acid protein 3

Gene

PRRG3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane gamma-carboxyglutamic acid protein 3
Alternative name(s):
Proline-rich gamma-carboxyglutamic acid protein 3
Short name:
Proline-rich Gla protein 3
Gene namesi
Name:PRRG3
Synonyms:PRGP3, TMG3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:30798. PRRG3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini20 – 7859ExtracellularSequence analysisAdd
BLAST
Transmembranei79 – 10123HelicalSequence analysisAdd
BLAST
Topological domaini102 – 231130CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • extracellular region Source: InterPro
  • integral component of membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134963933.

Polymorphism and mutation databases

BioMutaiPRRG3.
DMDMi209572687.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Propeptidei1 – 1919Sequence analysisPRO_0000022547Add
BLAST
Chaini20 – 231212Transmembrane gamma-carboxyglutamic acid protein 3PRO_0000022548Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei22 – 2214-carboxyglutamatePROSITE-ProRule annotation
Modified residuei25 – 2514-carboxyglutamatePROSITE-ProRule annotation
Modified residuei26 – 2614-carboxyglutamatePROSITE-ProRule annotation
Modified residuei33 – 3314-carboxyglutamatePROSITE-ProRule annotation
Modified residuei35 – 3514-carboxyglutamatePROSITE-ProRule annotation
Disulfide bondi36 ↔ 41PROSITE-ProRule annotation
Modified residuei38 – 3814-carboxyglutamatePROSITE-ProRule annotation
Modified residuei39 – 3914-carboxyglutamatePROSITE-ProRule annotation
Modified residuei44 – 4414-carboxyglutamatePROSITE-ProRule annotation
Modified residuei45 – 4514-carboxyglutamatePROSITE-ProRule annotation
Modified residuei48 – 4814-carboxyglutamatePROSITE-ProRule annotation
Modified residuei51 – 5114-carboxyglutamatePROSITE-ProRule annotation
Modified residuei54 – 5414-carboxyglutamatePROSITE-ProRule annotation
Modified residuei58 – 5814-carboxyglutamatePROSITE-ProRule annotation

Post-translational modificationi

Gla residues are produced after subsequent post-translational modifications of glutamate by a vitamin K-dependent gamma-carboxylase.

Keywords - PTMi

Disulfide bond, Gamma-carboxyglutamic acid

Proteomic databases

EPDiQ9BZD7.
PaxDbiQ9BZD7.
PRIDEiQ9BZD7.

PTM databases

iPTMnetiQ9BZD7.
PhosphoSiteiQ9BZD7.

Expressioni

Tissue specificityi

Expressed in brain, lung, kidney and heart.1 Publication

Gene expression databases

BgeeiQ9BZD7.
CleanExiHS_PRRG3.
ExpressionAtlasiQ9BZD7. baseline and differential.
GenevisibleiQ9BZD7. HS.

Organism-specific databases

HPAiHPA060566.

Interactioni

Protein-protein interaction databases

BioGridi122515. 4 interactions.
STRINGi9606.ENSP00000359378.

Structurei

3D structure databases

ProteinModelPortaliQ9BZD7.
SMRiQ9BZD7. Positions 24-63.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini20 – 6546GlaPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 Gla (gamma-carboxy-glutamate) domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IK6Z. Eukaryota.
ENOG4111M35. LUCA.
GeneTreeiENSGT00530000063110.
HOGENOMiHOG000115997.
HOVERGENiHBG023183.
InParanoidiQ9BZD7.
OMAiEAKNAHS.
PhylomeDBiQ9BZD7.
TreeFamiTF332123.

Family and domain databases

Gene3Di4.10.740.10. 1 hit.
InterProiIPR017857. Coagulation_fac_subgr_Gla_dom.
IPR000294. GLA_domain.
[Graphical view]
PfamiPF00594. Gla. 1 hit.
[Graphical view]
PRINTSiPR00001. GLABLOOD.
SMARTiSM00069. GLA. 1 hit.
[Graphical view]
SUPFAMiSSF57630. SSF57630. 1 hit.
PROSITEiPS00011. GLA_1. 1 hit.
PS50998. GLA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9BZD7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVFLEAKDA HSVLKRFPRA NEFLEELRQG TIERECMEEI CSYEEVKEVF
60 70 80 90 100
ENKEKTMEFW KGYPNAVYSV RDPSQSSDAM YVVVPLLGVA LLIVIALFII
110 120 130 140 150
WRCQLQKATR HHPSYAQNRY LASRAGHTLP RVMVYRGTVH SQGEPSGHRE
160 170 180 190 200
AANSPQVVLG PSRGGRTTVR LESTLYLPEL SLSRLSSTTP PPSYEEVTAP
210 220 230
QESSSEEASV SYSDPPPKYE EIVAANPGAD K
Length:231
Mass (Da):25,875
Last modified:October 14, 2008 - v2
Checksum:iB012F1A2784917B2
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti189 – 1891T → P in BAC11069 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti153 – 1531N → S.4 Publications
Corresponds to variant rs4323608 [ dbSNP | Ensembl ].
VAR_046712

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF326350 mRNA. Translation: AAK00955.1.
AK074574 mRNA. Translation: BAC11069.1.
CH471169 Genomic DNA. Translation: EAW99407.1.
BC128256 mRNA. Translation: AAI28257.1.
BC128409 mRNA. Translation: AAI28410.1.
CCDSiCCDS14699.1.
RefSeqiNP_076987.3. NM_024082.3.
XP_005274804.1. XM_005274747.2.
XP_011529499.1. XM_011531197.1.
UniGeneiHs.209253.
Hs.592236.

Genome annotation databases

EnsembliENST00000370353; ENSP00000359378; ENSG00000130032.
ENST00000538575; ENSP00000440217; ENSG00000130032.
GeneIDi79057.
KEGGihsa:79057.
UCSCiuc004few.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF326350 mRNA. Translation: AAK00955.1.
AK074574 mRNA. Translation: BAC11069.1.
CH471169 Genomic DNA. Translation: EAW99407.1.
BC128256 mRNA. Translation: AAI28257.1.
BC128409 mRNA. Translation: AAI28410.1.
CCDSiCCDS14699.1.
RefSeqiNP_076987.3. NM_024082.3.
XP_005274804.1. XM_005274747.2.
XP_011529499.1. XM_011531197.1.
UniGeneiHs.209253.
Hs.592236.

3D structure databases

ProteinModelPortaliQ9BZD7.
SMRiQ9BZD7. Positions 24-63.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122515. 4 interactions.
STRINGi9606.ENSP00000359378.

PTM databases

iPTMnetiQ9BZD7.
PhosphoSiteiQ9BZD7.

Polymorphism and mutation databases

BioMutaiPRRG3.
DMDMi209572687.

Proteomic databases

EPDiQ9BZD7.
PaxDbiQ9BZD7.
PRIDEiQ9BZD7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000370353; ENSP00000359378; ENSG00000130032.
ENST00000538575; ENSP00000440217; ENSG00000130032.
GeneIDi79057.
KEGGihsa:79057.
UCSCiuc004few.3. human.

Organism-specific databases

CTDi79057.
GeneCardsiPRRG3.
H-InvDBHIX0056169.
HGNCiHGNC:30798. PRRG3.
HPAiHPA060566.
MIMi300685. gene.
neXtProtiNX_Q9BZD7.
PharmGKBiPA134963933.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IK6Z. Eukaryota.
ENOG4111M35. LUCA.
GeneTreeiENSGT00530000063110.
HOGENOMiHOG000115997.
HOVERGENiHBG023183.
InParanoidiQ9BZD7.
OMAiEAKNAHS.
PhylomeDBiQ9BZD7.
TreeFamiTF332123.

Miscellaneous databases

GenomeRNAii79057.
PROiQ9BZD7.
SOURCEiSearch...

Gene expression databases

BgeeiQ9BZD7.
CleanExiHS_PRRG3.
ExpressionAtlasiQ9BZD7. baseline and differential.
GenevisibleiQ9BZD7. HS.

Family and domain databases

Gene3Di4.10.740.10. 1 hit.
InterProiIPR017857. Coagulation_fac_subgr_Gla_dom.
IPR000294. GLA_domain.
[Graphical view]
PfamiPF00594. Gla. 1 hit.
[Graphical view]
PRINTSiPR00001. GLABLOOD.
SMARTiSM00069. GLA. 1 hit.
[Graphical view]
SUPFAMiSSF57630. SSF57630. 1 hit.
PROSITEiPS00011. GLA_1. 1 hit.
PS50998. GLA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of two novel transmembrane gamma-carboxyglutamic acid proteins expressed broadly in fetal and adult tissues."
    Kulman J.D., Harris J.E., Xie L., Davie E.W.
    Proc. Natl. Acad. Sci. U.S.A. 98:1370-1375(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT SER-153, TISSUE SPECIFICITY.
    Tissue: Spinal cord.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT SER-153.
    Tissue: Embryo.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT SER-153.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT SER-153.

Entry informationi

Entry nameiTMG3_HUMAN
AccessioniPrimary (citable) accession number: Q9BZD7
Secondary accession number(s): A1A523, A1A575, Q8N2N6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: October 14, 2008
Last modified: July 6, 2016
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.