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Protein

Transmembrane gamma-carboxyglutamic acid protein 3

Gene

PRRG3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane gamma-carboxyglutamic acid protein 3
Alternative name(s):
Proline-rich gamma-carboxyglutamic acid protein 3
Short name:
Proline-rich Gla protein 3
Gene namesi
Name:PRRG3
Synonyms:PRGP3, TMG3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:30798. PRRG3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini20 – 78ExtracellularSequence analysisAdd BLAST59
Transmembranei79 – 101HelicalSequence analysisAdd BLAST23
Topological domaini102 – 231CytoplasmicSequence analysisAdd BLAST130

GO - Cellular componenti

  • extracellular region Source: InterPro
  • integral component of membrane Source: UniProtKB

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000130032.
PharmGKBiPA134963933.

Polymorphism and mutation databases

BioMutaiPRRG3.
DMDMi209572687.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PropeptideiPRO_00000225471 – 19Sequence analysisAdd BLAST19
ChainiPRO_000002254820 – 231Transmembrane gamma-carboxyglutamic acid protein 3Add BLAST212

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei224-carboxyglutamatePROSITE-ProRule annotation1
Modified residuei254-carboxyglutamatePROSITE-ProRule annotation1
Modified residuei264-carboxyglutamatePROSITE-ProRule annotation1
Modified residuei334-carboxyglutamatePROSITE-ProRule annotation1
Modified residuei354-carboxyglutamatePROSITE-ProRule annotation1
Disulfide bondi36 ↔ 41PROSITE-ProRule annotation
Modified residuei384-carboxyglutamatePROSITE-ProRule annotation1
Modified residuei394-carboxyglutamatePROSITE-ProRule annotation1
Modified residuei444-carboxyglutamatePROSITE-ProRule annotation1
Modified residuei454-carboxyglutamatePROSITE-ProRule annotation1
Modified residuei484-carboxyglutamatePROSITE-ProRule annotation1
Modified residuei514-carboxyglutamatePROSITE-ProRule annotation1
Modified residuei544-carboxyglutamatePROSITE-ProRule annotation1
Modified residuei584-carboxyglutamatePROSITE-ProRule annotation1

Post-translational modificationi

Gla residues are produced after subsequent post-translational modifications of glutamate by a vitamin K-dependent gamma-carboxylase.

Keywords - PTMi

Disulfide bond, Gamma-carboxyglutamic acid

Proteomic databases

EPDiQ9BZD7.
PaxDbiQ9BZD7.
PeptideAtlasiQ9BZD7.
PRIDEiQ9BZD7.

PTM databases

iPTMnetiQ9BZD7.
PhosphoSitePlusiQ9BZD7.

Expressioni

Tissue specificityi

Expressed in brain, lung, kidney and heart.1 Publication

Gene expression databases

BgeeiENSG00000130032.
CleanExiHS_PRRG3.
ExpressionAtlasiQ9BZD7. baseline and differential.
GenevisibleiQ9BZD7. HS.

Organism-specific databases

HPAiHPA060566.

Interactioni

Protein-protein interaction databases

BioGridi122515. 4 interactors.
STRINGi9606.ENSP00000359378.

Structurei

3D structure databases

ProteinModelPortaliQ9BZD7.
SMRiQ9BZD7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini20 – 65GlaPROSITE-ProRule annotationAdd BLAST46

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IK6Z. Eukaryota.
ENOG4111M35. LUCA.
GeneTreeiENSGT00530000063110.
HOGENOMiHOG000115997.
HOVERGENiHBG023183.
InParanoidiQ9BZD7.
OMAiEAKNAHS.
OrthoDBiEOG091G0JNL.
PhylomeDBiQ9BZD7.
TreeFamiTF332123.

Family and domain databases

Gene3Di4.10.740.10. 1 hit.
InterProiView protein in InterPro
IPR017857. Coagulation_fac_subgr_Gla_dom.
IPR000294. GLA_domain.
PfamiView protein in Pfam
PF00594. Gla. 1 hit.
PRINTSiPR00001. GLABLOOD.
SMARTiView protein in SMART
SM00069. GLA. 1 hit.
SUPFAMiSSF57630. SSF57630. 1 hit.
PROSITEiView protein in PROSITE
PS00011. GLA_1. 1 hit.
PS50998. GLA_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9BZD7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVFLEAKDA HSVLKRFPRA NEFLEELRQG TIERECMEEI CSYEEVKEVF
60 70 80 90 100
ENKEKTMEFW KGYPNAVYSV RDPSQSSDAM YVVVPLLGVA LLIVIALFII
110 120 130 140 150
WRCQLQKATR HHPSYAQNRY LASRAGHTLP RVMVYRGTVH SQGEPSGHRE
160 170 180 190 200
AANSPQVVLG PSRGGRTTVR LESTLYLPEL SLSRLSSTTP PPSYEEVTAP
210 220 230
QESSSEEASV SYSDPPPKYE EIVAANPGAD K
Length:231
Mass (Da):25,875
Last modified:October 14, 2008 - v2
Checksum:iB012F1A2784917B2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti189T → P in BAC11069 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_046712153N → S4 PublicationsCorresponds to variant dbSNP:rs4323608Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF326350 mRNA. Translation: AAK00955.1.
AK074574 mRNA. Translation: BAC11069.1.
CH471169 Genomic DNA. Translation: EAW99407.1.
BC128256 mRNA. Translation: AAI28257.1.
BC128409 mRNA. Translation: AAI28410.1.
CCDSiCCDS14699.1.
RefSeqiNP_076987.3. NM_024082.3.
XP_005274804.1. XM_005274747.3.
XP_011529499.1. XM_011531197.2.
UniGeneiHs.209253.
Hs.592236.

Genome annotation databases

EnsembliENST00000370353; ENSP00000359378; ENSG00000130032.
ENST00000538575; ENSP00000440217; ENSG00000130032.
GeneIDi79057.
KEGGihsa:79057.
UCSCiuc004few.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF326350 mRNA. Translation: AAK00955.1.
AK074574 mRNA. Translation: BAC11069.1.
CH471169 Genomic DNA. Translation: EAW99407.1.
BC128256 mRNA. Translation: AAI28257.1.
BC128409 mRNA. Translation: AAI28410.1.
CCDSiCCDS14699.1.
RefSeqiNP_076987.3. NM_024082.3.
XP_005274804.1. XM_005274747.3.
XP_011529499.1. XM_011531197.2.
UniGeneiHs.209253.
Hs.592236.

3D structure databases

ProteinModelPortaliQ9BZD7.
SMRiQ9BZD7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122515. 4 interactors.
STRINGi9606.ENSP00000359378.

PTM databases

iPTMnetiQ9BZD7.
PhosphoSitePlusiQ9BZD7.

Polymorphism and mutation databases

BioMutaiPRRG3.
DMDMi209572687.

Proteomic databases

EPDiQ9BZD7.
PaxDbiQ9BZD7.
PeptideAtlasiQ9BZD7.
PRIDEiQ9BZD7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000370353; ENSP00000359378; ENSG00000130032.
ENST00000538575; ENSP00000440217; ENSG00000130032.
GeneIDi79057.
KEGGihsa:79057.
UCSCiuc004few.3. human.

Organism-specific databases

CTDi79057.
GeneCardsiPRRG3.
H-InvDBiHIX0056169.
HGNCiHGNC:30798. PRRG3.
HPAiHPA060566.
MIMi300685. gene.
neXtProtiNX_Q9BZD7.
OpenTargetsiENSG00000130032.
PharmGKBiPA134963933.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IK6Z. Eukaryota.
ENOG4111M35. LUCA.
GeneTreeiENSGT00530000063110.
HOGENOMiHOG000115997.
HOVERGENiHBG023183.
InParanoidiQ9BZD7.
OMAiEAKNAHS.
OrthoDBiEOG091G0JNL.
PhylomeDBiQ9BZD7.
TreeFamiTF332123.

Miscellaneous databases

GenomeRNAii79057.
PROiPR:Q9BZD7.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000130032.
CleanExiHS_PRRG3.
ExpressionAtlasiQ9BZD7. baseline and differential.
GenevisibleiQ9BZD7. HS.

Family and domain databases

Gene3Di4.10.740.10. 1 hit.
InterProiView protein in InterPro
IPR017857. Coagulation_fac_subgr_Gla_dom.
IPR000294. GLA_domain.
PfamiView protein in Pfam
PF00594. Gla. 1 hit.
PRINTSiPR00001. GLABLOOD.
SMARTiView protein in SMART
SM00069. GLA. 1 hit.
SUPFAMiSSF57630. SSF57630. 1 hit.
PROSITEiView protein in PROSITE
PS00011. GLA_1. 1 hit.
PS50998. GLA_2. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiTMG3_HUMAN
AccessioniPrimary (citable) accession number: Q9BZD7
Secondary accession number(s): A1A523, A1A575, Q8N2N6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: October 14, 2008
Last modified: March 15, 2017
This is version 125 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.