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Protein

Kinetochore protein Nuf2

Gene

NUF2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity (PubMed:12438418, PubMed:14654001, PubMed:15062103, PubMed:15235793, PubMed:15239953, PubMed:15548592, PubMed:17535814). Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore (PubMed:15548592). The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules (PubMed:23085020).8 Publications

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Enzyme and pathway databases

ReactomeiR-HSA-2467813. Separation of Sister Chromatids.
R-HSA-2500257. Resolution of Sister Chromatid Cohesion.
R-HSA-5663220. RHO GTPases Activate Formins.
R-HSA-68877. Mitotic Prometaphase.

Names & Taxonomyi

Protein namesi
Recommended name:
Kinetochore protein Nuf2
Short name:
hNuf2
Short name:
hNuf2R
Short name:
hsNuf2
Alternative name(s):
Cell division cycle-associated protein 1
Gene namesi
Name:NUF2
Synonyms:CDCA1, NUF2R
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:14621. NUF2.

Subcellular locationi

  • Nucleus
  • Chromosomecentromerekinetochore

  • Note: Localizes to kinetochores from late prophase to anaphase. Localizes specifically to the outer plate of the kinetochore. NDC80 is required for efficient kinetochore localization.

GO - Cellular componenti

  • chromosome, centromeric region Source: UniProtKB
  • condensed chromosome kinetochore Source: UniProtKB-SubCell
  • cytosol Source: Reactome
  • membrane Source: UniProtKB
  • Ndc80 complex Source: UniProtKB
  • nucleus Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Centromere, Chromosome, Kinetochore, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162398215.

Polymorphism and mutation databases

BioMutaiNUF2.
DMDMi115311829.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 464464Kinetochore protein Nuf2PRO_0000249813Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineCombined sources
Modified residuei247 – 2471PhosphoserineBy similarity

Post-translational modificationi

Can be phosphorylated by AURKA and AURKB.1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9BZD4.
MaxQBiQ9BZD4.
PaxDbiQ9BZD4.
PeptideAtlasiQ9BZD4.
PRIDEiQ9BZD4.

PTM databases

iPTMnetiQ9BZD4.
PhosphoSiteiQ9BZD4.

Expressioni

Gene expression databases

BgeeiQ9BZD4.
CleanExiHS_NUF2.
ExpressionAtlasiQ9BZD4. baseline and differential.
GenevisibleiQ9BZD4. HS.

Interactioni

Subunit structurei

Component of the NDC80 complex, which consists of NDC80/HEC1, CDCA1, SPBC24 and SPBC25. The NDC80 complex is formed by two subcomplexes composed of NDC80/HEC1-CDCA1 and SPBC24-SPBC25. Each subcomplex is formed by parallel interactions through the coiled-coil domains of individual subunits. Formation of a tetrameric complex is mediated by interactions between the C-terminal regions of both subunits of the NDC80/HEC1-CDCA1 subcomplex and the N-terminal regions of both subunits of the SPBC24-SPBC25 complex. The tetrameric NDC80 complex has an elongated rod-like structure with globular domains at either end. May interact with AURKB/Aurora-B. Directly interacts with CENPE; this interaction determines CENPE kinetochore localization.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
CENPEQ022249EBI-724102,EBI-1375040
NDC80O1477713EBI-724102,EBI-715849

Protein-protein interaction databases

BioGridi123673. 46 interactions.
DIPiDIP-36119N.
IntActiQ9BZD4. 41 interactions.
MINTiMINT-1390492.
STRINGi9606.ENSP00000271452.

Structurei

Secondary structure

1
464
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi11 – 2111Combined sources
Helixi25 – 295Combined sources
Helixi33 – 353Combined sources
Beta strandi37 – 393Combined sources
Helixi42 – 5716Combined sources
Helixi62 – 643Combined sources
Helixi76 – 794Combined sources
Turni80 – 823Combined sources
Helixi83 – 9816Combined sources
Helixi106 – 1105Combined sources
Helixi114 – 14431Combined sources
Helixi147 – 16418Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2VE7X-ray2.88C/D1-169[»]
3IZ0electron microscopy-D/F1-169[»]
ProteinModelPortaliQ9BZD4.
SMRiQ9BZD4. Positions 4-156.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9BZD4.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 385385Interaction with the N-terminus of NDC80Add
BLAST
Regioni386 – 46479Interaction with the C-terminus of NDC80 and the SPBC24-SPBC25 subcomplexAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili147 – 345199Sequence analysisAdd
BLAST
Coiled coili389 – 45971Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the NUF2 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG4438. Eukaryota.
ENOG410ZI4C. LUCA.
GeneTreeiENSGT00390000004199.
HOGENOMiHOG000290701.
HOVERGENiHBG082069.
InParanoidiQ9BZD4.
KOiK11548.
OMAiDCYAKID.
PhylomeDBiQ9BZD4.
TreeFamiTF101067.

Family and domain databases

InterProiIPR005549. Kinetochore_Nuf2.
[Graphical view]
PfamiPF03800. Nuf2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9BZD4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METLSFPRYN VAEIVIHIRN KILTGADGKN LTKNDLYPNP KPEVLHMIYM
60 70 80 90 100
RALQIVYGIR LEHFYMMPVN SEVMYPHLME GFLPFSNLVT HLDSFLPICR
110 120 130 140 150
VNDFETADIL CPKAKRTSRF LSGIINFIHF REACRETYME FLWQYKSSAD
160 170 180 190 200
KMQQLNAAHQ EALMKLERLD SVPVEEQEEF KQLSDGIQEL QQSLNQDFHQ
210 220 230 240 250
KTIVLQEGNS QKKSNISEKT KRLNELKLSV VSLKEIQESL KTKIVDSPEK
260 270 280 290 300
LKNYKEKMKD TVQKLKNARQ EVVEKYEIYG DSVDCLPSCQ LEVQLYQKKI
310 320 330 340 350
QDLSDNREKL ASILKESLNL EDQIESDESE LKKLKTEENS FKRLMIVKKE
360 370 380 390 400
KLATAQFKIN KKHEDVKQYK RTVIEDCNKV QEKRGAVYER VTTINQEIQK
410 420 430 440 450
IKLGIQQLKD AAEREKLKSQ EIFLNLKTAL EKYHDGIEKA AEDSYAKIDE
460
KTAELKRKMF KMST
Length:464
Mass (Da):54,304
Last modified:September 19, 2006 - v2
Checksum:i250BFED5AD87153B
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti229 – 2291S → L.2 Publications
Corresponds to variant rs11802875 [ dbSNP | Ensembl ].
VAR_027490
Natural varianti239 – 2391S → R.
Corresponds to variant rs16852767 [ dbSNP | Ensembl ].
VAR_027491

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB050577 mRNA. Translation: BAB59141.1.
AB050578 mRNA. Translation: BAB59142.1.
AF326731 mRNA. Translation: AAK01426.1.
AK093348 mRNA. Translation: BAC04140.1.
AL592435 Genomic DNA. Translation: CAI16706.1.
BC008489 mRNA. Translation: AAH08489.1.
BC021171 mRNA. Translation: AAH21171.2.
CCDSiCCDS1245.1.
RefSeqiNP_113611.2. NM_031423.3.
NP_663735.2. NM_145697.2.
UniGeneiHs.651950.

Genome annotation databases

EnsembliENST00000271452; ENSP00000271452; ENSG00000143228.
ENST00000367900; ENSP00000356875; ENSG00000143228.
GeneIDi83540.
KEGGihsa:83540.
UCSCiuc001gcq.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB050577 mRNA. Translation: BAB59141.1.
AB050578 mRNA. Translation: BAB59142.1.
AF326731 mRNA. Translation: AAK01426.1.
AK093348 mRNA. Translation: BAC04140.1.
AL592435 Genomic DNA. Translation: CAI16706.1.
BC008489 mRNA. Translation: AAH08489.1.
BC021171 mRNA. Translation: AAH21171.2.
CCDSiCCDS1245.1.
RefSeqiNP_113611.2. NM_031423.3.
NP_663735.2. NM_145697.2.
UniGeneiHs.651950.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2VE7X-ray2.88C/D1-169[»]
3IZ0electron microscopy-D/F1-169[»]
ProteinModelPortaliQ9BZD4.
SMRiQ9BZD4. Positions 4-156.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123673. 46 interactions.
DIPiDIP-36119N.
IntActiQ9BZD4. 41 interactions.
MINTiMINT-1390492.
STRINGi9606.ENSP00000271452.

PTM databases

iPTMnetiQ9BZD4.
PhosphoSiteiQ9BZD4.

Polymorphism and mutation databases

BioMutaiNUF2.
DMDMi115311829.

Proteomic databases

EPDiQ9BZD4.
MaxQBiQ9BZD4.
PaxDbiQ9BZD4.
PeptideAtlasiQ9BZD4.
PRIDEiQ9BZD4.

Protocols and materials databases

DNASUi83540.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000271452; ENSP00000271452; ENSG00000143228.
ENST00000367900; ENSP00000356875; ENSG00000143228.
GeneIDi83540.
KEGGihsa:83540.
UCSCiuc001gcq.2. human.

Organism-specific databases

CTDi83540.
GeneCardsiNUF2.
HGNCiHGNC:14621. NUF2.
MIMi611772. gene.
neXtProtiNX_Q9BZD4.
PharmGKBiPA162398215.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4438. Eukaryota.
ENOG410ZI4C. LUCA.
GeneTreeiENSGT00390000004199.
HOGENOMiHOG000290701.
HOVERGENiHBG082069.
InParanoidiQ9BZD4.
KOiK11548.
OMAiDCYAKID.
PhylomeDBiQ9BZD4.
TreeFamiTF101067.

Enzyme and pathway databases

ReactomeiR-HSA-2467813. Separation of Sister Chromatids.
R-HSA-2500257. Resolution of Sister Chromatid Cohesion.
R-HSA-5663220. RHO GTPases Activate Formins.
R-HSA-68877. Mitotic Prometaphase.

Miscellaneous databases

EvolutionaryTraceiQ9BZD4.
GeneWikiiNUF2.
GenomeRNAii83540.
NextBioi72453.
PROiQ9BZD4.
SOURCEiSearch...

Gene expression databases

BgeeiQ9BZD4.
CleanExiHS_NUF2.
ExpressionAtlasiQ9BZD4. baseline and differential.
GenevisibleiQ9BZD4. HS.

Family and domain databases

InterProiIPR005549. Kinetochore_Nuf2.
[Graphical view]
PfamiPF03800. Nuf2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A conserved protein, Nuf2, is implicated in connecting the centromere to the spindle during chromosome segregation: a link between the kinetochore function and the spindle checkpoint."
    Nabetani A., Koujin T., Tsutsumi C., Haraguchi T., Hiraoka Y.
    Chromosoma 110:322-334(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT LEU-229.
  2. "The Ndc80p complex from Saccharomyces cerevisiae contains conserved centromere components and has a function in chromosome segregation."
    Wigge P.A., Kilmartin J.V.
    J. Cell Biol. 152:349-360(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT LEU-229.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  4. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Chronic myeloid leukemia cell and Lung.
  6. "hNuf2 inhibition blocks stable kinetochore-microtubule attachment and induces mitotic cell death in HeLa cells."
    DeLuca J.G., Moree B., Hickey J.M., Kilmartin J.V., Salmon E.D.
    J. Cell Biol. 159:549-555(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  7. "Nuf2 and Hec1 are required for retention of the checkpoint proteins Mad1 and Mad2 to kinetochores."
    DeLuca J.G., Howell B.J., Canman J.C., Hickey J.M., Fang G., Salmon E.D.
    Curr. Biol. 13:2103-2109(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.
  8. "Kinetochore localization and microtubule interaction of the human spindle checkpoint kinase Mps1."
    Stucke V.M., Baumann C., Nigg E.A.
    Chromosoma 113:1-15(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.
  9. "The RanGAP1-RanBP2 complex is essential for microtubule-kinetochore interactions in vivo."
    Joseph J., Liu S.-T., Jablonski S.A., Yen T.J., Dasso M.
    Curr. Biol. 14:611-617(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  10. "Timing and checkpoints in the regulation of mitotic progression."
    Meraldi P., Draviam V.M., Sorger P.K.
    Dev. Cell 7:45-60(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.
  11. "Identification of two novel components of the human NDC80 kinetochore complex."
    Bharadwaj R., Qi W., Yu H.
    J. Biol. Chem. 279:13076-13085(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY, IDENTIFICATION IN THE NDC80 COMPLEX.
  12. "Identification of the substrates and interaction proteins of aurora kinases from a protein-protein interaction model."
    Tien A.-C., Lin M.-H., Su L.-J., Hong Y.-R., Cheng T.-S., Lee Y.-C.G., Lin W.-J., Still I.H., Huang C.-Y.F.
    Mol. Cell. Proteomics 3:93-104(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH AURKB AND NDC80, PHOSPHORYLATION BY AURKA AND AURKB.
  13. "Architecture of the human Ndc80-Hec1 complex, a critical constituent of the outer kinetochore."
    Ciferri C., De Luca J., Monzani S., Ferrari K.J., Ristic D., Wyman C., Stark H., Kilmartin J., Salmon E.D., Musacchio A.
    J. Biol. Chem. 280:29088-29095(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION OF THE NDC80 COMPLEX, SUBCELLULAR LOCATION.
  14. "Hec1 and Nuf2 are core components of the kinetochore outer plate essential for organizing microtubule attachment sites."
    DeLuca J.G., Dong Y., Hergert P., Strauss J., Hickey J.M., Salmon E.D., McEwen B.F.
    Mol. Biol. Cell 16:519-531(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  15. "Human NUF2 interacts with centromere-associated protein E and is essential for a stable spindle microtubule-kinetochore attachment."
    Liu D., Ding X., Du J., Cai X., Huang Y., Ward T., Shaw A., Yang Y., Hu R., Jin C., Yao X.
    J. Biol. Chem. 282:21415-21424(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH CENPE, SUBCELLULAR LOCATION.
  16. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  17. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  18. "The kinetochore-bound Ska1 complex tracks depolymerizing microtubules and binds to curved protofilaments."
    Schmidt J.C., Arthanari H., Boeszoermenyi A., Dashkevich N.M., Wilson-Kubalek E.M., Monnier N., Markus M., Oberer M., Milligan R.A., Bathe M., Wagner G., Grishchuk E.L., Cheeseman I.M.
    Dev. Cell 23:968-980(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  19. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiNUF2_HUMAN
AccessioniPrimary (citable) accession number: Q9BZD4
Secondary accession number(s): Q8WU69, Q96HJ4, Q96Q78
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: September 19, 2006
Last modified: May 11, 2016
This is version 123 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.