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Q9BZD3 (GCOM2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified January 22, 2014. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Putative GRINL1B complex locus protein 2
Alternative name(s):
Glutamate receptor-like protein 1B
Gene names
Name:GCOM2
Synonyms:GRINL1B
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length368 AA.
Sequence statusComplete.
Protein existenceUncertain

General annotation (Comments)

Sequence similarities

Belongs to the GRINL1 family.

Caution

Could be the product of a pseudogene.

Ontologies

Keywords
   Coding sequence diversityPolymorphism
   DomainCoiled coil
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentDNA-directed RNA polymerase II, holoenzyme

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 368368Putative GRINL1B complex locus protein 2
PRO_0000326229

Regions

Coiled coil15 – 3925 Potential
Coiled coil301 – 33535 Potential
Compositional bias277 – 2804Poly-Arg

Natural variations

Natural variant1761R → H in an acute myeloid leukemia sample; somatic mutation. Ref.3
VAR_054145

Sequences

Sequence LengthMass (Da)Tools
Q9BZD3 [UniParc].

Last modified March 18, 2008. Version 2.
Checksum: A642B1D9A908BCB6

FASTA36841,713
        10         20         30         40         50         60 
MCLLPRGFEP QAPEDLAQRS LVELREMLKL QERLLRNEKF ICKLPDKGKK IFDSFAKLKA 

        70         80         90        100        110        120 
AIAECEEVRR KNELFHPVSL DCKLRQKAIA EVDVGTDKAR NSDPILDTSS LVPGCSSVDN 

       130        140        150        160        170        180 
IKSSQTSQNQ GLGRPTLEGD EETSEVEYTV NKGPASSNRD RVPPSSEASE HHPQHRVSSQ 

       190        200        210        220        230        240 
AEDTSSSFDN LFIDRLQRIT IADQGEQQSE ENASTKNLTG LSSGTQKKPH YMEVLEMRAK 

       250        260        270        280        290        300 
NPGPQLRKFK TNVLPFRQND SSSHCQKSGS PISSKERRRR DKQHLDDITA ARLLPLHHMP 

       310        320        330        340        350        360 
TQLLSIEESL ALQKQQKQNY EEMQAKLAAQ KLAERPNIKM RSYNPEGESS GRYREVRDED 


DDWSSDEF 

« Hide

References

« Hide 'large scale' references
[1]"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. expand/collapse author list , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"Assignment of GRINL1B, a glutamate receptor-like processed gene, to human chromosome 4q12 by in situ hybridization."
Mohan Raj B.K., Roginski R.S., Finkernagel S.W., Sciorra L.J.
Cytogenet. Cell Genet. 95:238-239(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 4-112, IDENTIFICATION.
[3]"DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome."
Ley T.J., Mardis E.R., Ding L., Fulton B., McLellan M.D., Chen K., Dooling D., Dunford-Shore B.H., McGrath S., Hickenbotham M., Cook L., Abbott R., Larson D.E., Koboldt D.C., Pohl C., Smith S., Hawkins A., Abbott S. expand/collapse author list , Locke D., Hillier L.W., Miner T., Fulton L., Magrini V., Wylie T., Glasscock J., Conyers J., Sander N., Shi X., Osborne J.R., Minx P., Gordon D., Chinwalla A., Zhao Y., Ries R.E., Payton J.E., Westervelt P., Tomasson M.H., Watson M., Baty J., Ivanovich J., Heath S., Shannon W.D., Nagarajan R., Walter M.J., Link D.C., Graubert T.A., DiPersio J.F., Wilson R.K.
Nature 456:66-72(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT [LARGE SCALE ANALYSIS] HIS-176.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC096727 Genomic DNA. No translation available.
AF326970 Genomic DNA. Translation: AAG50023.1.

3D structure databases

ProteinModelPortalQ9BZD3.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ9BZD3.

Polymorphism databases

DMDM172046229.

Proteomic databases

PRIDEQ9BZD3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

GeneCardsGC04P068905.
HGNCHGNC:15712. GCOM2.
MIM608311. gene.
neXtProtNX_Q9BZD3.
GenAtlasSearch...

Phylogenomic databases

HOVERGENHBG098324.

Gene expression databases

GenevestigatorQ9BZD3.

Family and domain databases

InterProIPR026213. GRINL1.
[Graphical view]
PRINTSPR02085. POLR2GRINL1.
ProtoNetSearch...

Other

PROQ9BZD3.
SOURCESearch...

Entry information

Entry nameGCOM2_HUMAN
AccessionPrimary (citable) accession number: Q9BZD3
Entry history
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: March 18, 2008
Last modified: January 22, 2014
This is version 59 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 4

Human chromosome 4: entries, gene names and cross-references to MIM