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Q9BZD3

- GCOM2_HUMAN

UniProt

Q9BZD3 - GCOM2_HUMAN

Protein

Putative GRINL1B complex locus protein 2

Gene

GCOM2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Protein uncertaini
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    • History
      Entry version 61 (01 Oct 2014)
      Sequence version 2 (18 Mar 2008)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative GRINL1B complex locus protein 2
    Alternative name(s):
    Glutamate receptor-like protein 1B
    Gene namesi
    Name:GCOM2
    Synonyms:GRINL1B
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Unplaced

    Organism-specific databases

    HGNCiHGNC:15712. GCOM2.

    Subcellular locationi

    GO - Cellular componenti

    1. DNA-directed RNA polymerase II, holoenzyme Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 368368Putative GRINL1B complex locus protein 2PRO_0000326229Add
    BLAST

    Proteomic databases

    MaxQBiQ9BZD3.
    PRIDEiQ9BZD3.

    PTM databases

    PhosphoSiteiQ9BZD3.

    Expressioni

    Gene expression databases

    GenevestigatoriQ9BZD3.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9BZD3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili15 – 3925Sequence AnalysisAdd
    BLAST
    Coiled coili301 – 33535Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi277 – 2804Poly-Arg

    Sequence similaritiesi

    Belongs to the GRINL1 family.Curated

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    HOVERGENiHBG098324.

    Family and domain databases

    InterProiIPR026213. GRINL1.
    [Graphical view]
    PRINTSiPR02085. POLR2GRINL1.

    Sequencei

    Sequence statusi: Complete.

    Q9BZD3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MCLLPRGFEP QAPEDLAQRS LVELREMLKL QERLLRNEKF ICKLPDKGKK    50
    IFDSFAKLKA AIAECEEVRR KNELFHPVSL DCKLRQKAIA EVDVGTDKAR 100
    NSDPILDTSS LVPGCSSVDN IKSSQTSQNQ GLGRPTLEGD EETSEVEYTV 150
    NKGPASSNRD RVPPSSEASE HHPQHRVSSQ AEDTSSSFDN LFIDRLQRIT 200
    IADQGEQQSE ENASTKNLTG LSSGTQKKPH YMEVLEMRAK NPGPQLRKFK 250
    TNVLPFRQND SSSHCQKSGS PISSKERRRR DKQHLDDITA ARLLPLHHMP 300
    TQLLSIEESL ALQKQQKQNY EEMQAKLAAQ KLAERPNIKM RSYNPEGESS 350
    GRYREVRDED DDWSSDEF 368
    Length:368
    Mass (Da):41,713
    Last modified:March 18, 2008 - v2
    Checksum:iA642B1D9A908BCB6
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti176 – 1761R → H in an acute myeloid leukemia sample; somatic mutation. 1 Publication
    VAR_054145

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC096727 Genomic DNA. No translation available.
    AF326970 Genomic DNA. Translation: AAG50023.1.

    Polymorphism databases

    DMDMi172046229.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC096727 Genomic DNA. No translation available.
    AF326970 Genomic DNA. Translation: AAG50023.1 .

    3D structure databases

    ProteinModelPortali Q9BZD3.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q9BZD3.

    Polymorphism databases

    DMDMi 172046229.

    Proteomic databases

    MaxQBi Q9BZD3.
    PRIDEi Q9BZD3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    GeneCardsi GC04P068905.
    HGNCi HGNC:15712. GCOM2.
    MIMi 608311. gene.
    neXtProti NX_Q9BZD3.
    GenAtlasi Search...

    Phylogenomic databases

    HOVERGENi HBG098324.

    Miscellaneous databases

    PROi Q9BZD3.
    SOURCEi Search...

    Gene expression databases

    Genevestigatori Q9BZD3.

    Family and domain databases

    InterProi IPR026213. GRINL1.
    [Graphical view ]
    PRINTSi PR02085. POLR2GRINL1.
    ProtoNeti Search...

    Publicationsi

    1. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "Assignment of GRINL1B, a glutamate receptor-like processed gene, to human chromosome 4q12 by in situ hybridization."
      Mohan Raj B.K., Roginski R.S., Finkernagel S.W., Sciorra L.J.
      Cytogenet. Cell Genet. 95:238-239(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 4-112, IDENTIFICATION.
    3. Cited for: VARIANT [LARGE SCALE ANALYSIS] HIS-176.

    Entry informationi

    Entry nameiGCOM2_HUMAN
    AccessioniPrimary (citable) accession number: Q9BZD3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 18, 2008
    Last sequence update: March 18, 2008
    Last modified: October 1, 2014
    This is version 61 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    Could be the product of a pseudogene.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 4
      Human chromosome 4: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3