Q9BZD3 (GCOM2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative GRINL1B complex locus protein 2

Alternative name(s):
Glutamate receptor-like protein 1B

Gene names

Name:	GCOM2
Synonyms:	GRINL1B

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	368 AA.
Sequence status	Complete.
Protein existence	Uncertain

General annotation (Comments)

Sequence similarities	Belongs to the GRINL1 family.
Caution	Could be the product of a pseudogene.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Domain	Coiled coil
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	DNA-directed RNA polymerase II, holoenzyme Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 368	368	Putative GRINL1B complex locus protein 2		PRO_0000326229
Regions
	Coiled coil	15 – 39	25	Potential
	Coiled coil	301 – 335	35	Potential
	Compositional bias	277 – 280	4	Poly-Arg
Natural variations
	Natural variant	176	1	R → H in an acute myeloid leukemia sample; somatic mutation. Ref.3		VAR_054145

Sequences

	Sequence		Length	Mass (Da)
	Q9BZD3 [UniParc]. Last modified March 18, 2008. Version 2. Checksum: A642B1D9A908BCB6	FASTA	368	41,713
	10 20 30 40 50 60 MCLLPRGFEP QAPEDLAQRS LVELREMLKL QERLLRNEKF ICKLPDKGKK IFDSFAKLKA 70 80 90 100 110 120 AIAECEEVRR KNELFHPVSL DCKLRQKAIA EVDVGTDKAR NSDPILDTSS LVPGCSSVDN 130 140 150 160 170 180 IKSSQTSQNQ GLGRPTLEGD EETSEVEYTV NKGPASSNRD RVPPSSEASE HHPQHRVSSQ 190 200 210 220 230 240 AEDTSSSFDN LFIDRLQRIT IADQGEQQSE ENASTKNLTG LSSGTQKKPH YMEVLEMRAK 250 260 270 280 290 300 NPGPQLRKFK TNVLPFRQND SSSHCQKSGS PISSKERRRR DKQHLDDITA ARLLPLHHMP 310 320 330 340 350 360 TQLLSIEESL ALQKQQKQNY EEMQAKLAAQ KLAERPNIKM RSYNPEGESS GRYREVRDED DDWSSDEF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"Assignment of GRINL1B, a glutamate receptor-like processed gene, to human chromosome 4q12 by in situ hybridization." Mohan Raj B.K., Roginski R.S., Finkernagel S.W., Sciorra L.J. Cytogenet. Cell Genet. 95:238-239(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 4-112, IDENTIFICATION.
[3]	"DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome." Ley T.J., Mardis E.R., Ding L., Fulton B., McLellan M.D., Chen K., Dooling D., Dunford-Shore B.H., McGrath S., Hickenbotham M., Cook L., Abbott R., Larson D.E., Koboldt D.C., Pohl C., Smith S., Hawkins A., Abbott S. , Locke D., Hillier L.W., Miner T., Fulton L., Magrini V., Wylie T., Glasscock J., Conyers J., Sander N., Shi X., Osborne J.R., Minx P., Gordon D., Chinwalla A., Zhao Y., Ries R.E., Payton J.E., Westervelt P., Tomasson M.H., Watson M., Baty J., Ivanovich J., Heath S., Shannon W.D., Nagarajan R., Walter M.J., Link D.C., Graubert T.A., DiPersio J.F., Wilson R.K. Nature 456:66-72(2008) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT [LARGE SCALE ANALYSIS] HIS-176.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC096727 Genomic DNA. No translation available. AF326970 Genomic DNA. Translation: AAG50023.1.
IPI	IPI00879306.
3D structure databases
ModBase	Search...
PTM databases
PhosphoSite	Q9BZD3.
Polymorphism databases
DMDM	172046229.
Proteomic databases
PRIDE	Q9BZD3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
GeneCards	GC04P068905.
HGNC	HGNC:15712. GCOM2.
MIM	608311. gene.
neXtProt	NX_Q9BZD3.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	HBG098324.
Gene expression databases
Genevestigator	Q9BZD3.
Family and domain databases
InterPro	IPR026213. GRINL1. [Graphical view]
PRINTS	PR02085. POLR2GRINL1.
ProtoNet	Search...
Other
SOURCE	Search...

Entry information

Entry name

GCOM2_HUMAN

Accession

Primary (citable) accession number: Q9BZD3

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 18, 2008
Last sequence update:	March 18, 2008
Last modified:	April 3, 2013
This is version 56 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.