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Protein

Protocadherin-11 Y-linked

Gene

PCDH11Y

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Potential calcium-dependent cell-adhesion protein.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Protocadherin-11 Y-linked
Short name:
Protocadherin-11
Alternative name(s):
Protocadherin on the Y chromosome
Short name:
PCDH-Y
Protocadherin prostate cancer
Short name:
Protocadherin-PC
Protocadherin-22
Gene namesi
Name:PCDH11Y
Synonyms:PCDH11, PCDH22, PCDHY
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome Y

Organism-specific databases

HGNCiHGNC:15813. PCDH11Y.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini29 – 844816ExtracellularSequence analysisAdd
BLAST
Transmembranei845 – 86521HelicalSequence analysisAdd
BLAST
Topological domaini866 – 1340475CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Involvement in diseasei

A chromosomal aberration involving PCDH11Y is a cause of multiple congenital abnormalities, including severe bilateral vesicoureteral reflux (VUR) with ureterovesical junction defects. Translocation t(Y;3)(p11;p12) with ROBO2.

Organism-specific databases

PharmGKBiPA32997.

Polymorphism and mutation databases

BioMutaiPCDH11Y.
DMDMi74762719.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2828Sequence analysisAdd
BLAST
Chaini29 – 13401312Protocadherin-11 Y-linkedPRO_0000232764Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi59 – 591N-linked (GlcNAc...)Sequence analysis
Glycosylationi80 – 801N-linked (GlcNAc...)Sequence analysis
Glycosylationi86 – 861N-linked (GlcNAc...)Sequence analysis
Glycosylationi376 – 3761N-linked (GlcNAc...)Sequence analysis
Glycosylationi585 – 5851N-linked (GlcNAc...)Sequence analysis
Glycosylationi805 – 8051N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ9BZA8.
PaxDbiQ9BZA8.
PeptideAtlasiQ9BZA8.
PRIDEiQ9BZA8.

PTM databases

iPTMnetiQ9BZA8.
PhosphoSiteiQ9BZA8.

Expressioni

Tissue specificityi

Expressed strongly in fetal brain and brain (cortex, amygdala, thalamus, substantia nigra, hippocampus, caudate nucleus and corpus callosum). Expressed at low level in testis. Expressed in apoptosis-resistant cells.4 Publications

Gene expression databases

BgeeiQ9BZA8.
ExpressionAtlasiQ9BZA8. baseline and differential.
GenevisibleiQ9BZA8. HS.

Organism-specific databases

HPAiHPA000432.

Interactioni

Subunit structurei

Interacts with CTNNB1.1 Publication

Protein-protein interaction databases

STRINGi9606.ENSP00000362186.

Structurei

3D structure databases

ProteinModelPortaliQ9BZA8.
SMRiQ9BZA8. Positions 270-381.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini58 – 171114Cadherin 1PROSITE-ProRule annotationAdd
BLAST
Domaini172 – 281110Cadherin 2PROSITE-ProRule annotationAdd
BLAST
Domaini282 – 387106Cadherin 3PROSITE-ProRule annotationAdd
BLAST
Domaini394 – 498105Cadherin 4PROSITE-ProRule annotationAdd
BLAST
Domaini499 – 602104Cadherin 5PROSITE-ProRule annotationAdd
BLAST
Domaini603 – 705103Cadherin 6PROSITE-ProRule annotationAdd
BLAST
Domaini709 – 827119Cadherin 7PROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi900 – 9078Poly-Lys

Sequence similaritiesi

Contains 7 cadherin domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
GeneTreeiENSGT00840000129706.
HOVERGENiHBG053523.
InParanoidiQ9BZA8.
KOiK16498.
OMAiNIREDPM.
OrthoDBiEOG7WMCHN.
PhylomeDBiQ9BZA8.
TreeFamiTF320624.

Family and domain databases

Gene3Di2.60.40.60. 6 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR013164. Cadherin_N.
IPR013585. Protocadherin.
[Graphical view]
PfamiPF00028. Cadherin. 6 hits.
PF08266. Cadherin_2. 1 hit.
PF08374. Protocadherin. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 6 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 6 hits.
PROSITEiPS00232. CADHERIN_1. 5 hits.
PS50268. CADHERIN_2. 7 hits.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Additional isoforms seem to exist.

Isoform 1 (identifier: Q9BZA8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFRVGFLIIS SSSSLSPLLL VSVVRVNTTN CHKCLLSGTY IFAVLLVCVV
60 70 80 90 100
FHSGAQEKNY TIREEIPENV LIGNLLKDLN LSLIPNKSLT TTMQFKLVYK
110 120 130 140 150
TGDVPLIRIE EDTGEIFTTG ARIDREKLCA GIPRDEHCFY EVEVAILPDE
160 170 180 190 200
IFRLVKIRFL IEDINDNAPL FPATVINISI PENSAINSKY TLPAAVDPDV
210 220 230 240 250
GINGVQNYEL IKSQNIFGLD VIETPEGDKM PQLIVQKELD REEKDTYVMK
260 270 280 290 300
VKVEDGGFPQ RSSTAILQVS VTDTNDNHPV FKETEIEVSI PENAPVGTSV
310 320 330 340 350
TQLHATDADI GENAKIHFSF SNLVSNIARR LFHLNATTGL ITIKEPLDRE
360 370 380 390 400
ETPNHKLLVL ASDGGLMPAR AMVLVNVTDV NDNVPSIDIR YIVNPVNDTV
410 420 430 440 450
VLSENIPLNT KIALITVTDK DADHNGRVTC FTDHEIPFRL RPVFSNQFLL
460 470 480 490 500
ENAAYLDYES TKEYAIKLLA ADAGKPPLNQ SAMLFIKVKD ENDNAPVFTQ
510 520 530 540 550
SFVTVSIPEN NSPGIQLMKV SATDADSGPN AEINYLLGPD APPEFSLDRR
560 570 580 590 600
TGMLTVVKKL DREKEDKYLF TILAKDNGVP PLTSNVTVFV SIIDQNDNSP
610 620 630 640 650
VFTHNEYKFY VPENLPRHGT VGLITVTDPD YGDNSAVTLS ILDENDDFTI
660 670 680 690 700
DSQTGVIRPN ISFDREKQES YTFYVKAEDG GRVSRSSSAK VTINVVDVND
710 720 730 740 750
NKPVFIVPPY NYSYELVLPS TNPGTVVFQV IAVDNDTGMN AEVRYSIVGG
760 770 780 790 800
NTRDLFAIDQ ETGNITLMEK CDVTDLGLHR VLVKANDLGQ PDSLFSVVIV
810 820 830 840 850
NLFVNESVTN ATLINELVRK SIEAPVTPNT EIADVSSPTS DYVKILVAAV
860 870 880 890 900
AGTITVVVVI FITAVVRCRQ APHLKAAQKN MQNSEWATPN PENRQMIMMK
910 920 930 940 950
KKKKKKKHSP KNLLLNVVTI EETKADDVDS DGNRVTLDLP IDLEEQTMGK
960 970 980 990 1000
YNWVTTPTTF KPDSPDLARH YKSASPQPAF QIQPETPLNL KHHIIQELPL
1010 1020 1030 1040 1050
DNTFVACDSI SNCSSSSSDP YSVSDCGYPV TTFEVPVSVH TRPSQRRVTF
1060 1070 1080 1090 1100
HLPEGSQESS SDGGLGDHDA GSLTSTSHGL PLGYPQEEYF DRATPSNRTE
1110 1120 1130 1140 1150
GDGNSDPEST FIPGLKKEIT VQPTVEEASD NCTQECLIYG HSDACWMPAS
1160 1170 1180 1190 1200
LDHSSSSQAQ ASALCHSPPL SQASTQHHSP PVTQTIVLCH SPPVTQTIAL
1210 1220 1230 1240 1250
CHSPPPIQVS ALHHSPPLVQ GTALHHSPPS AQASALCYSP PLAQAAAISH
1260 1270 1280 1290 1300
SSSLPQVIAL HRSQAQSSVS LQQGWVQGAN GLCSVDQGVQ GSATSQFYTM
1310 1320 1330 1340
SERLHPSDDS IKVIPLTTFA PRQQARPSRG DSPIMETHPL
Length:1,340
Mass (Da):146,775
Last modified:June 1, 2001 - v1
Checksum:i10C1A56510FF4014
GO
Isoform 2 (identifier: Q9BZA8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1044-1048: SQRRV → TDSRT
     1049-1340: Missing.

Show »
Length:1,048
Mass (Da):115,920
Checksum:iAC0796ACEBD304E9
GO
Isoform 3 (identifier: Q9BZA8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-21: MFRVGFLIISSSSSLSPLLLV → MTVGFNSDIS
     1044-1048: SQRRV → TDSRT
     1049-1340: Missing.

Show »
Length:1,037
Mass (Da):114,723
Checksum:i72CB8AB1EBA9ACCC
GO
Isoform 4 (identifier: Q9BZA8-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1044-1053: SQRRVTFHLP → VGIQVSNTTF
     1054-1340: Missing.

Show »
Length:1,053
Mass (Da):116,406
Checksum:i0DD1C6721B4F6553
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti917 – 9171V → F.2 Publications
Corresponds to variant rs2524543 [ dbSNP | Ensembl ].
VAR_026020
Natural varianti1012 – 10121N → K.2 Publications
Corresponds to variant rs2563389 [ dbSNP | Ensembl ].
VAR_026021
Natural varianti1320 – 13201A → T.
Corresponds to variant rs2556900 [ dbSNP | Ensembl ].
VAR_048576

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 2121MFRVG…PLLLV → MTVGFNSDIS in isoform 3. 2 PublicationsVSP_017996Add
BLAST
Alternative sequencei1044 – 105310SQRRVTFHLP → VGIQVSNTTF in isoform 4. 1 PublicationVSP_017997
Alternative sequencei1044 – 10485SQRRV → TDSRT in isoform 2 and isoform 3. 3 PublicationsVSP_017998
Alternative sequencei1049 – 1340292Missing in isoform 2 and isoform 3. 3 PublicationsVSP_017999Add
BLAST
Alternative sequencei1054 – 1340287Missing in isoform 4. 1 PublicationVSP_018000Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ276803 mRNA. Translation: CAC13122.1.
AF277053 mRNA. Translation: AAL55729.1.
AF332216 mRNA. Translation: AAK13468.1.
AF332217 mRNA. Translation: AAK13469.1.
AJ564958 mRNA. Translation: CAD92429.1.
AJ564959 mRNA. Translation: CAD92430.1.
AJ564960 mRNA. Translation: CAD92431.1.
AJ564961 mRNA. Translation: CAD92432.1.
AJ564962 mRNA. Translation: CAD92433.1.
AJ564963 mRNA. Translation: CAD92434.1.
AJ564966 mRNA. Translation: CAD92437.1.
AJ564969 mRNA. Translation: CAD92440.1.
CCDSiCCDS14776.1. [Q9BZA8-3]
CCDS14777.1. [Q9BZA8-2]
CCDS76066.1. [Q9BZA8-1]
RefSeqiNP_001265548.1. NM_001278619.1. [Q9BZA8-3]
NP_116753.1. NM_032971.2. [Q9BZA8-3]
NP_116754.1. NM_032972.2. [Q9BZA8-2]
NP_116755.1. NM_032973.2. [Q9BZA8-1]
UniGeneiHs.655673.
Hs.661308.
Hs.689829.
Hs.689830.
Hs.689831.

Genome annotation databases

EnsembliENST00000215473; ENSP00000215473; ENSG00000099715. [Q9BZA8-4]
ENST00000333703; ENSP00000330552; ENSG00000099715. [Q9BZA8-3]
ENST00000362095; ENSP00000355419; ENSG00000099715. [Q9BZA8-2]
ENST00000400457; ENSP00000383306; ENSG00000099715. [Q9BZA8-1]
ENST00000622698; ENSP00000482115; ENSG00000099715. [Q9BZA8-3]
GeneIDi83259.
KEGGihsa:83259.
UCSCiuc004fql.3. human. [Q9BZA8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ276803 mRNA. Translation: CAC13122.1.
AF277053 mRNA. Translation: AAL55729.1.
AF332216 mRNA. Translation: AAK13468.1.
AF332217 mRNA. Translation: AAK13469.1.
AJ564958 mRNA. Translation: CAD92429.1.
AJ564959 mRNA. Translation: CAD92430.1.
AJ564960 mRNA. Translation: CAD92431.1.
AJ564961 mRNA. Translation: CAD92432.1.
AJ564962 mRNA. Translation: CAD92433.1.
AJ564963 mRNA. Translation: CAD92434.1.
AJ564966 mRNA. Translation: CAD92437.1.
AJ564969 mRNA. Translation: CAD92440.1.
CCDSiCCDS14776.1. [Q9BZA8-3]
CCDS14777.1. [Q9BZA8-2]
CCDS76066.1. [Q9BZA8-1]
RefSeqiNP_001265548.1. NM_001278619.1. [Q9BZA8-3]
NP_116753.1. NM_032971.2. [Q9BZA8-3]
NP_116754.1. NM_032972.2. [Q9BZA8-2]
NP_116755.1. NM_032973.2. [Q9BZA8-1]
UniGeneiHs.655673.
Hs.661308.
Hs.689829.
Hs.689830.
Hs.689831.

3D structure databases

ProteinModelPortaliQ9BZA8.
SMRiQ9BZA8. Positions 270-381.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000362186.

PTM databases

iPTMnetiQ9BZA8.
PhosphoSiteiQ9BZA8.

Polymorphism and mutation databases

BioMutaiPCDH11Y.
DMDMi74762719.

Proteomic databases

EPDiQ9BZA8.
PaxDbiQ9BZA8.
PeptideAtlasiQ9BZA8.
PRIDEiQ9BZA8.

Protocols and materials databases

DNASUi83259.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000215473; ENSP00000215473; ENSG00000099715. [Q9BZA8-4]
ENST00000333703; ENSP00000330552; ENSG00000099715. [Q9BZA8-3]
ENST00000362095; ENSP00000355419; ENSG00000099715. [Q9BZA8-2]
ENST00000400457; ENSP00000383306; ENSG00000099715. [Q9BZA8-1]
ENST00000622698; ENSP00000482115; ENSG00000099715. [Q9BZA8-3]
GeneIDi83259.
KEGGihsa:83259.
UCSCiuc004fql.3. human. [Q9BZA8-1]

Organism-specific databases

CTDi83259.
GeneCardsiPCDH11Y.
H-InvDBHIX0177655.
HGNCiHGNC:15813. PCDH11Y.
HPAiHPA000432.
MIMi400022. gene.
neXtProtiNX_Q9BZA8.
PharmGKBiPA32997.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
GeneTreeiENSGT00840000129706.
HOVERGENiHBG053523.
InParanoidiQ9BZA8.
KOiK16498.
OMAiNIREDPM.
OrthoDBiEOG7WMCHN.
PhylomeDBiQ9BZA8.
TreeFamiTF320624.

Miscellaneous databases

ChiTaRSiPCDH11Y. human.
GenomeRNAii83259.
PROiQ9BZA8.
SOURCEiSearch...

Gene expression databases

BgeeiQ9BZA8.
ExpressionAtlasiQ9BZA8. baseline and differential.
GenevisibleiQ9BZA8. HS.

Family and domain databases

Gene3Di2.60.40.60. 6 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR013164. Cadherin_N.
IPR013585. Protocadherin.
[Graphical view]
PfamiPF00028. Cadherin. 6 hits.
PF08266. Cadherin_2. 1 hit.
PF08374. Protocadherin. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 6 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 6 hits.
PROSITEiPS00232. CADHERIN_1. 5 hits.
PS50268. CADHERIN_2. 7 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Conservation of PCDHX in mammals; expression of human X/Y genes predominantly in brain."
    Blanco P., Sargent C.A., Boucher C., Mitchell M., Affara N.
    Mamm. Genome 11:906-914(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), TISSUE SPECIFICITY.
    Tissue: Brain.
  2. "The emergence of protocadherin-PC expression during the acquisition of apoptosis-resistance by prostate cancer cells."
    Chen M.-W., Vacherot F., De La Taille A., Gil-Diez-De-Medina S., Shen R., Friedman R.A., Burchardt M., Chopin D.K., Buttyan R.
    Oncogene 21:7861-7871(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), INTERACTION WITH CTNNB1, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Tissue: Prostatic carcinoma.
  3. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), VARIANTS PHE-917 AND LYS-1012.
    Tissue: Brain.
  4. "Protocadherin X (PCDHX) and Y (PCDHY) genes; multiple mRNA isoforms encoding variant signal peptides and cytoplasmic domains."
    Blanco-Arias P., Sargent C.A., Affara N.A.
    Mamm. Genome 15:41-52(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-1109 AND 1119-1340, NUCLEOTIDE SEQUENCE [MRNA] OF 213-1340 (ISOFORM 4), TISSUE SPECIFICITY, ALTERNATIVE SPLICING.
  5. Cited for: CHROMOSOMAL TRANSLOCATION WITH ROBO2.
  6. "Expression and genetic variability of PCDH11Y, a gene specific to Homo sapiens and candidate for susceptibility to psychiatric disorders."
    Durand C.M., Kappeler C., Betancur C., Delorme R., Quach H., Goubran-Botros H., Melke J., Nygren G., Chabane N., Bellivier F., Szoke A., Schurhoff F., Rastam M., Anckarsaeter H., Gillberg C., Leboyer M., Bourgeron T.
    Am. J. Med. Genet. B Neuropsychiatr. Genet. 141:67-70(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS PHE-917 AND LYS-1012, TISSUE SPECIFICITY.

Entry informationi

Entry nameiPC11Y_HUMAN
AccessioniPrimary (citable) accession number: Q9BZA8
Secondary accession number(s): Q70LR6
, Q70LR8, Q70LS0, Q70LS1, Q70LS2, Q70LS3, Q70LS4, Q70LS5, Q8WY34, Q9BZA9, Q9H4E1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: June 1, 2001
Last modified: July 6, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome Y
    Human chromosome Y: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.