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Protein

Protocadherin-11 Y-linked

Gene

PCDH11Y

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Potential calcium-dependent cell-adhesion protein.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Protocadherin-11 Y-linked
Short name:
Protocadherin-11
Alternative name(s):
Protocadherin on the Y chromosome
Short name:
PCDH-Y
Protocadherin prostate cancer
Short name:
Protocadherin-PC
Protocadherin-22
Gene namesi
Name:PCDH11Y
Synonyms:PCDH11, PCDH22, PCDHY
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome Y

Organism-specific databases

HGNCiHGNC:15813. PCDH11Y.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini29 – 844ExtracellularSequence analysisAdd BLAST816
Transmembranei845 – 865HelicalSequence analysisAdd BLAST21
Topological domaini866 – 1340CytoplasmicSequence analysisAdd BLAST475

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Involvement in diseasei

A chromosomal aberration involving PCDH11Y is a cause of multiple congenital abnormalities, including severe bilateral vesicoureteral reflux (VUR) with ureterovesical junction defects. Translocation t(Y;3)(p11;p12) with ROBO2.

Organism-specific databases

DisGeNETi83259.
OpenTargetsiENSG00000099715.
PharmGKBiPA32997.

Polymorphism and mutation databases

BioMutaiPCDH11Y.
DMDMi74762719.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Sequence analysisAdd BLAST28
ChainiPRO_000023276429 – 1340Protocadherin-11 Y-linkedAdd BLAST1312

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi59N-linked (GlcNAc...)Sequence analysis1
Glycosylationi80N-linked (GlcNAc...)Sequence analysis1
Glycosylationi86N-linked (GlcNAc...)Sequence analysis1
Glycosylationi376N-linked (GlcNAc...)Sequence analysis1
Glycosylationi585N-linked (GlcNAc...)Sequence analysis1
Glycosylationi805N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9BZA8.
PeptideAtlasiQ9BZA8.
PRIDEiQ9BZA8.

PTM databases

iPTMnetiQ9BZA8.
PhosphoSitePlusiQ9BZA8.

Expressioni

Tissue specificityi

Expressed strongly in fetal brain and brain (cortex, amygdala, thalamus, substantia nigra, hippocampus, caudate nucleus and corpus callosum). Expressed at low level in testis. Expressed in apoptosis-resistant cells.4 Publications

Gene expression databases

BgeeiENSG00000099715.
ExpressionAtlasiQ9BZA8. baseline and differential.
GenevisibleiQ9BZA8. HS.

Organism-specific databases

HPAiHPA000432.

Interactioni

Subunit structurei

Interacts with CTNNB1.1 Publication

Protein-protein interaction databases

STRINGi9606.ENSP00000362186.

Structurei

3D structure databases

ProteinModelPortaliQ9BZA8.
SMRiQ9BZA8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini58 – 171Cadherin 1PROSITE-ProRule annotationAdd BLAST114
Domaini172 – 281Cadherin 2PROSITE-ProRule annotationAdd BLAST110
Domaini282 – 387Cadherin 3PROSITE-ProRule annotationAdd BLAST106
Domaini394 – 498Cadherin 4PROSITE-ProRule annotationAdd BLAST105
Domaini499 – 602Cadherin 5PROSITE-ProRule annotationAdd BLAST104
Domaini603 – 705Cadherin 6PROSITE-ProRule annotationAdd BLAST103
Domaini709 – 827Cadherin 7PROSITE-ProRule annotationAdd BLAST119

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi900 – 907Poly-Lys8

Sequence similaritiesi

Contains 7 cadherin domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
GeneTreeiENSGT00850000132246.
HOVERGENiHBG053523.
InParanoidiQ9BZA8.
KOiK16498.
OMAiDSPIMET.
OrthoDBiEOG091G011P.
PhylomeDBiQ9BZA8.
TreeFamiTF320624.

Family and domain databases

Gene3Di2.60.40.60. 6 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR013164. Cadherin_N.
IPR013585. Protocadherin.
[Graphical view]
PfamiPF00028. Cadherin. 6 hits.
PF08266. Cadherin_2. 1 hit.
PF08374. Protocadherin. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 6 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 6 hits.
PROSITEiPS00232. CADHERIN_1. 5 hits.
PS50268. CADHERIN_2. 7 hits.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Additional isoforms seem to exist.
Isoform 1 (identifier: Q9BZA8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFRVGFLIIS SSSSLSPLLL VSVVRVNTTN CHKCLLSGTY IFAVLLVCVV
60 70 80 90 100
FHSGAQEKNY TIREEIPENV LIGNLLKDLN LSLIPNKSLT TTMQFKLVYK
110 120 130 140 150
TGDVPLIRIE EDTGEIFTTG ARIDREKLCA GIPRDEHCFY EVEVAILPDE
160 170 180 190 200
IFRLVKIRFL IEDINDNAPL FPATVINISI PENSAINSKY TLPAAVDPDV
210 220 230 240 250
GINGVQNYEL IKSQNIFGLD VIETPEGDKM PQLIVQKELD REEKDTYVMK
260 270 280 290 300
VKVEDGGFPQ RSSTAILQVS VTDTNDNHPV FKETEIEVSI PENAPVGTSV
310 320 330 340 350
TQLHATDADI GENAKIHFSF SNLVSNIARR LFHLNATTGL ITIKEPLDRE
360 370 380 390 400
ETPNHKLLVL ASDGGLMPAR AMVLVNVTDV NDNVPSIDIR YIVNPVNDTV
410 420 430 440 450
VLSENIPLNT KIALITVTDK DADHNGRVTC FTDHEIPFRL RPVFSNQFLL
460 470 480 490 500
ENAAYLDYES TKEYAIKLLA ADAGKPPLNQ SAMLFIKVKD ENDNAPVFTQ
510 520 530 540 550
SFVTVSIPEN NSPGIQLMKV SATDADSGPN AEINYLLGPD APPEFSLDRR
560 570 580 590 600
TGMLTVVKKL DREKEDKYLF TILAKDNGVP PLTSNVTVFV SIIDQNDNSP
610 620 630 640 650
VFTHNEYKFY VPENLPRHGT VGLITVTDPD YGDNSAVTLS ILDENDDFTI
660 670 680 690 700
DSQTGVIRPN ISFDREKQES YTFYVKAEDG GRVSRSSSAK VTINVVDVND
710 720 730 740 750
NKPVFIVPPY NYSYELVLPS TNPGTVVFQV IAVDNDTGMN AEVRYSIVGG
760 770 780 790 800
NTRDLFAIDQ ETGNITLMEK CDVTDLGLHR VLVKANDLGQ PDSLFSVVIV
810 820 830 840 850
NLFVNESVTN ATLINELVRK SIEAPVTPNT EIADVSSPTS DYVKILVAAV
860 870 880 890 900
AGTITVVVVI FITAVVRCRQ APHLKAAQKN MQNSEWATPN PENRQMIMMK
910 920 930 940 950
KKKKKKKHSP KNLLLNVVTI EETKADDVDS DGNRVTLDLP IDLEEQTMGK
960 970 980 990 1000
YNWVTTPTTF KPDSPDLARH YKSASPQPAF QIQPETPLNL KHHIIQELPL
1010 1020 1030 1040 1050
DNTFVACDSI SNCSSSSSDP YSVSDCGYPV TTFEVPVSVH TRPSQRRVTF
1060 1070 1080 1090 1100
HLPEGSQESS SDGGLGDHDA GSLTSTSHGL PLGYPQEEYF DRATPSNRTE
1110 1120 1130 1140 1150
GDGNSDPEST FIPGLKKEIT VQPTVEEASD NCTQECLIYG HSDACWMPAS
1160 1170 1180 1190 1200
LDHSSSSQAQ ASALCHSPPL SQASTQHHSP PVTQTIVLCH SPPVTQTIAL
1210 1220 1230 1240 1250
CHSPPPIQVS ALHHSPPLVQ GTALHHSPPS AQASALCYSP PLAQAAAISH
1260 1270 1280 1290 1300
SSSLPQVIAL HRSQAQSSVS LQQGWVQGAN GLCSVDQGVQ GSATSQFYTM
1310 1320 1330 1340
SERLHPSDDS IKVIPLTTFA PRQQARPSRG DSPIMETHPL
Length:1,340
Mass (Da):146,775
Last modified:June 1, 2001 - v1
Checksum:i10C1A56510FF4014
GO
Isoform 2 (identifier: Q9BZA8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1044-1048: SQRRV → TDSRT
     1049-1340: Missing.

Show »
Length:1,048
Mass (Da):115,920
Checksum:iAC0796ACEBD304E9
GO
Isoform 3 (identifier: Q9BZA8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-21: MFRVGFLIISSSSSLSPLLLV → MTVGFNSDIS
     1044-1048: SQRRV → TDSRT
     1049-1340: Missing.

Show »
Length:1,037
Mass (Da):114,723
Checksum:i72CB8AB1EBA9ACCC
GO
Isoform 4 (identifier: Q9BZA8-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1044-1053: SQRRVTFHLP → VGIQVSNTTF
     1054-1340: Missing.

Show »
Length:1,053
Mass (Da):116,406
Checksum:i0DD1C6721B4F6553
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_026020917V → F.2 PublicationsCorresponds to variant rs2524543dbSNPEnsembl.1
Natural variantiVAR_0260211012N → K.2 PublicationsCorresponds to variant rs2563389dbSNPEnsembl.1
Natural variantiVAR_0485761320A → T.Corresponds to variant rs2556900dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0179961 – 21MFRVG…PLLLV → MTVGFNSDIS in isoform 3. 2 PublicationsAdd BLAST21
Alternative sequenceiVSP_0179971044 – 1053SQRRVTFHLP → VGIQVSNTTF in isoform 4. 1 Publication10
Alternative sequenceiVSP_0179981044 – 1048SQRRV → TDSRT in isoform 2 and isoform 3. 3 Publications5
Alternative sequenceiVSP_0179991049 – 1340Missing in isoform 2 and isoform 3. 3 PublicationsAdd BLAST292
Alternative sequenceiVSP_0180001054 – 1340Missing in isoform 4. 1 PublicationAdd BLAST287

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ276803 mRNA. Translation: CAC13122.1.
AF277053 mRNA. Translation: AAL55729.1.
AF332216 mRNA. Translation: AAK13468.1.
AF332217 mRNA. Translation: AAK13469.1.
AJ564958 mRNA. Translation: CAD92429.1.
AJ564959 mRNA. Translation: CAD92430.1.
AJ564960 mRNA. Translation: CAD92431.1.
AJ564961 mRNA. Translation: CAD92432.1.
AJ564962 mRNA. Translation: CAD92433.1.
AJ564963 mRNA. Translation: CAD92434.1.
AJ564966 mRNA. Translation: CAD92437.1.
AJ564969 mRNA. Translation: CAD92440.1.
CCDSiCCDS14776.1. [Q9BZA8-3]
CCDS14777.1. [Q9BZA8-2]
CCDS76066.1. [Q9BZA8-1]
RefSeqiNP_001265548.1. NM_001278619.1. [Q9BZA8-3]
NP_116753.1. NM_032971.2. [Q9BZA8-3]
NP_116754.1. NM_032972.2. [Q9BZA8-2]
NP_116755.1. NM_032973.2. [Q9BZA8-1]
XP_016885571.1. XM_017030082.1. [Q9BZA8-3]
UniGeneiHs.655673.
Hs.661308.
Hs.689829.
Hs.689830.
Hs.689831.

Genome annotation databases

EnsembliENST00000215473; ENSP00000215473; ENSG00000099715. [Q9BZA8-4]
ENST00000333703; ENSP00000330552; ENSG00000099715. [Q9BZA8-3]
ENST00000362095; ENSP00000355419; ENSG00000099715. [Q9BZA8-2]
ENST00000400457; ENSP00000383306; ENSG00000099715. [Q9BZA8-1]
ENST00000622698; ENSP00000482115; ENSG00000099715. [Q9BZA8-3]
GeneIDi83259.
KEGGihsa:83259.
UCSCiuc004fql.3. human. [Q9BZA8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ276803 mRNA. Translation: CAC13122.1.
AF277053 mRNA. Translation: AAL55729.1.
AF332216 mRNA. Translation: AAK13468.1.
AF332217 mRNA. Translation: AAK13469.1.
AJ564958 mRNA. Translation: CAD92429.1.
AJ564959 mRNA. Translation: CAD92430.1.
AJ564960 mRNA. Translation: CAD92431.1.
AJ564961 mRNA. Translation: CAD92432.1.
AJ564962 mRNA. Translation: CAD92433.1.
AJ564963 mRNA. Translation: CAD92434.1.
AJ564966 mRNA. Translation: CAD92437.1.
AJ564969 mRNA. Translation: CAD92440.1.
CCDSiCCDS14776.1. [Q9BZA8-3]
CCDS14777.1. [Q9BZA8-2]
CCDS76066.1. [Q9BZA8-1]
RefSeqiNP_001265548.1. NM_001278619.1. [Q9BZA8-3]
NP_116753.1. NM_032971.2. [Q9BZA8-3]
NP_116754.1. NM_032972.2. [Q9BZA8-2]
NP_116755.1. NM_032973.2. [Q9BZA8-1]
XP_016885571.1. XM_017030082.1. [Q9BZA8-3]
UniGeneiHs.655673.
Hs.661308.
Hs.689829.
Hs.689830.
Hs.689831.

3D structure databases

ProteinModelPortaliQ9BZA8.
SMRiQ9BZA8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000362186.

PTM databases

iPTMnetiQ9BZA8.
PhosphoSitePlusiQ9BZA8.

Polymorphism and mutation databases

BioMutaiPCDH11Y.
DMDMi74762719.

Proteomic databases

PaxDbiQ9BZA8.
PeptideAtlasiQ9BZA8.
PRIDEiQ9BZA8.

Protocols and materials databases

DNASUi83259.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000215473; ENSP00000215473; ENSG00000099715. [Q9BZA8-4]
ENST00000333703; ENSP00000330552; ENSG00000099715. [Q9BZA8-3]
ENST00000362095; ENSP00000355419; ENSG00000099715. [Q9BZA8-2]
ENST00000400457; ENSP00000383306; ENSG00000099715. [Q9BZA8-1]
ENST00000622698; ENSP00000482115; ENSG00000099715. [Q9BZA8-3]
GeneIDi83259.
KEGGihsa:83259.
UCSCiuc004fql.3. human. [Q9BZA8-1]

Organism-specific databases

CTDi83259.
DisGeNETi83259.
GeneCardsiPCDH11Y.
H-InvDBHIX0177655.
HGNCiHGNC:15813. PCDH11Y.
HPAiHPA000432.
MIMi400022. gene.
neXtProtiNX_Q9BZA8.
OpenTargetsiENSG00000099715.
PharmGKBiPA32997.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
GeneTreeiENSGT00850000132246.
HOVERGENiHBG053523.
InParanoidiQ9BZA8.
KOiK16498.
OMAiDSPIMET.
OrthoDBiEOG091G011P.
PhylomeDBiQ9BZA8.
TreeFamiTF320624.

Miscellaneous databases

ChiTaRSiPCDH11Y. human.
GenomeRNAii83259.
PROiQ9BZA8.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000099715.
ExpressionAtlasiQ9BZA8. baseline and differential.
GenevisibleiQ9BZA8. HS.

Family and domain databases

Gene3Di2.60.40.60. 6 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR013164. Cadherin_N.
IPR013585. Protocadherin.
[Graphical view]
PfamiPF00028. Cadherin. 6 hits.
PF08266. Cadherin_2. 1 hit.
PF08374. Protocadherin. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 6 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 6 hits.
PROSITEiPS00232. CADHERIN_1. 5 hits.
PS50268. CADHERIN_2. 7 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPC11Y_HUMAN
AccessioniPrimary (citable) accession number: Q9BZA8
Secondary accession number(s): Q70LR6
, Q70LR8, Q70LS0, Q70LS1, Q70LS2, Q70LS3, Q70LS4, Q70LS5, Q8WY34, Q9BZA9, Q9H4E1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: June 1, 2001
Last modified: November 2, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome Y
    Human chromosome Y: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.