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Q9BZA7

- PC11X_HUMAN

UniProt

Q9BZA7 - PC11X_HUMAN

Protein

Protocadherin-11 X-linked

Gene

PCDH11X

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
    • BLAST
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    • History
      Entry version 110 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Potential calcium-dependent cell-adhesion protein.

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro

    GO - Biological processi

    1. homophilic cell adhesion Source: InterPro
    2. negative regulation of phosphatase activity Source: UniProtKB

    Keywords - Biological processi

    Cell adhesion

    Keywords - Ligandi

    Calcium

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protocadherin-11 X-linked
    Short name:
    Protocadherin-11
    Alternative name(s):
    Protocadherin on the X chromosome
    Short name:
    PCDH-X
    Protocadherin-S
    Gene namesi
    Name:PCDH11X
    Synonyms:KIAA1326, PCDH11, PCDHX
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome X

    Organism-specific databases

    HGNCiHGNC:8656. PCDH11X.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular vesicular exosome Source: UniProt
    2. integral component of plasma membrane Source: ProtInc
    3. plasma membrane Source: ProtInc

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA32996.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323Sequence AnalysisAdd
    BLAST
    Chaini24 – 13471324Protocadherin-11 X-linkedPRO_0000232758Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi27 – 271N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi48 – 481N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi54 – 541N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi344 – 3441N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi553 – 5531N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi773 – 7731N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ9BZA7.
    PRIDEiQ9BZA7.

    PTM databases

    PhosphoSiteiQ9BZA7.

    Expressioni

    Tissue specificityi

    Expressed strongly in fetal brain and brain (cortex, amygdala, thalamus, substantia nigra, hippocampus, caudate nucleus and corpus callosum). Expressed at low level in testis.2 Publications

    Gene expression databases

    ArrayExpressiQ9BZA7.
    BgeeiQ9BZA7.
    GenevestigatoriQ9BZA7.

    Organism-specific databases

    HPAiHPA000432.

    Interactioni

    Protein-protein interaction databases

    BioGridi118142. 1 interaction.
    IntActiQ9BZA7. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9BZA7.
    SMRiQ9BZA7. Positions 35-774.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini24 – 812789ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini834 – 1347514CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei813 – 83321HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini26 – 139114Cadherin 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini140 – 249110Cadherin 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini250 – 355106Cadherin 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini362 – 466105Cadherin 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini467 – 570104Cadherin 5PROSITE-ProRule annotationAdd
    BLAST
    Domaini571 – 673103Cadherin 6PROSITE-ProRule annotationAdd
    BLAST
    Domaini677 – 795119Cadherin 7PROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi868 – 8758Poly-Lys

    Sequence similaritiesi

    Contains 7 cadherin domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG145470.
    HOVERGENiHBG053523.
    InParanoidiQ9BZA7.
    KOiK16498.
    OMAiSTREYAI.
    OrthoDBiEOG7WMCHN.
    PhylomeDBiQ9BZA7.
    TreeFamiTF320624.

    Family and domain databases

    Gene3Di2.60.40.60. 6 hits.
    InterProiIPR002126. Cadherin.
    IPR015919. Cadherin-like.
    IPR020894. Cadherin_CS.
    IPR013164. Cadherin_N.
    IPR013585. Protocadherin.
    [Graphical view]
    PfamiPF00028. Cadherin. 6 hits.
    PF08266. Cadherin_2. 1 hit.
    PF08374. Protocadherin. 1 hit.
    [Graphical view]
    PRINTSiPR00205. CADHERIN.
    SMARTiSM00112. CA. 6 hits.
    [Graphical view]
    SUPFAMiSSF49313. SSF49313. 6 hits.
    PROSITEiPS00232. CADHERIN_1. 5 hits.
    PS50268. CADHERIN_2. 7 hits.
    [Graphical view]

    Sequences (8)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 8 isoformsi produced by alternative splicing. Align

    Note: Additional isoforms seem to exist.

    Isoform 1 (identifier: Q9BZA7-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MDLLSGTYIF AVLLACVVFH SGAQEKNYTI REEMPENVLI GDLLKDLNLS     50
    LIPNKSLTTA MQFKLVYKTG DVPLIRIEED TGEIFTTGAR IDREKLCAGI 100
    PRDEHCFYEV EVAILPDEIF RLVKIRFLIE DINDNAPLFP ATVINISIPE 150
    NSAINSKYTL PAAVDPDVGI NGVQNYELIK SQNIFGLDVI ETPEGDKMPQ 200
    LIVQKELDRE EKDTYVMKVK VEDGGFPQRS STAILQVSVT DTNDNHPVFK 250
    ETEIEVSIPE NAPVGTSVTQ LHATDADIGE NAKIHFSFSN LVSNIARRLF 300
    HLNATTGLIT IKEPLDREET PNHKLLVLAS DGGLMPARAM VLVNVTDVND 350
    NVPSIDIRYI VNPVNDTVVL SENIPLNTKI ALITVTDKDA DHNGRVTCFT 400
    DHEIPFRLRP VFSNQFLLET AAYLDYESTK EYAIKLLAAD AGKPPLNQSA 450
    MLFIKVKDEN DNAPVFTQSF VTVSIPENNS PGIQLTKVSA MDADSGPNAK 500
    INYLLGPDAP PEFSLDCRTG MLTVVKKLDR EKEDKYLFTI LAKDNGVPPL 550
    TSNVTVFVSI IDQNDNSPVF THNEYNFYVP ENLPRHGTVG LITVTDPDYG 600
    DNSAVTLSIL DENDDFTIDS QTGVIRPNIS FDREKQESYT FYVKAEDGGR 650
    VSRSSSAKVT INVVDVNDNK PVFIVPPSNC SYELVLPSTN PGTVVFQVIA 700
    VDNDTGMNAE VRYSIVGGNT RDLFAIDQET GNITLMEKCD VTDLGLHRVL 750
    VKANDLGQPD SLFSVVIVNL FVNESVTNAT LINELVRKST EAPVTPNTEI 800
    ADVSSPTSDY VKILVAAVAG TITVVVVIFI TAVVRCRQAP HLKAAQKNKQ 850
    NSEWATPNPE NRQMIMMKKK KKKKKHSPKN LLLNFVTIEE TKADDVDSDG 900
    NRVTLDLPID LEEQTMGKYN WVTTPTTFKP DSPDLARHYK SASPQPAFQI 950
    QPETPLNSKH HIIQELPLDN TFVACDSISK CSSSSSDPYS VSDCGYPVTT 1000
    FEVPVSVHTR PPMKEVVRSC TPMKESTTME IWIHPQPQRK SEGKVAGKSQ 1050
    RRVTFHLPEG SQESSSDGGL GDHDAGSLTS TSHGLPLGYP QEEYFDRATP 1100
    SNRTEGDGNS DPESTFIPGL KKAAEITVQP TVEEASDNCT QECLIYGHSD 1150
    ACWMPASLDH SSSSQAQASA LCHSPPLSQA STQHHSPRVT QTIALCHSPP 1200
    VTQTIALCHS PPPIQVSALH HSPPLVQATA LHHSPPSAQA SALCYSPPLA 1250
    QAAAISHSSP LPQVIALHRS QAQSSVSLQQ GWVQGADGLC SVDQGVQGSA 1300
    TSQFYTMSER LHPSDDSIKV IPLTTFTPRQ QARPSRGDSP IMEEHPL 1347
    Length:1,347
    Mass (Da):147,558
    Last modified:June 1, 2001 - v1
    Checksum:i0227FA6C521FDA84
    GO
    Isoform 2 (identifier: Q9BZA7-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1012-1025: PMKEVVRSCTPMKE → TDSRTSTIEICSEI
         1026-1347: Missing.

    Show »
    Length:1,025
    Mass (Da):113,215
    Checksum:i51EE095ED7035A10
    GO
    Isoform 3 (identifier: Q9BZA7-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1039-1048: Missing.

    Show »
    Length:1,337
    Mass (Da):146,517
    Checksum:iA96D3B41173C8508
    GO
    Isoform 4 (identifier: Q9BZA7-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1039-1048: Missing.
         1116-1123: Missing.

    Show »
    Length:1,329
    Mass (Da):145,662
    Checksum:iDA7DC585324AD261
    GO
    Isoform 5 (identifier: Q9BZA7-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1012-1048: Missing.

    Show »
    Length:1,310
    Mass (Da):143,350
    Checksum:i948FE29C9EA7D312
    GO
    Isoform 6 (identifier: Q9BZA7-6) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1049-1065: SQRRVTFHLPEGSQESS → TVLTSSSPSAMTLSYLD
         1066-1347: Missing.

    Show »
    Length:1,065
    Mass (Da):117,642
    Checksum:i71AB11952A3EEA81
    GO
    Isoform 7 (identifier: Q9BZA7-7) [UniParc]FASTAAdd to Basket

    Also known as: Protocadherin-Xa

    The sequence of this isoform differs from the canonical sequence as follows:
         1012-1021: PMKEVVRSCT → VGIQVSNTTF
         1022-1347: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:1,021
    Mass (Da):112,726
    Checksum:i9F4471F5C597F902
    GO
    Isoform 8 (identifier: Q9BZA7-8) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1116-1123: Missing.

    Show »
    Length:1,339
    Mass (Da):146,703
    Checksum:iCD1D563B7D8FE105
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti242 – 2443TND → PNA in AAK82655. 1 PublicationCurated
    Sequence conflicti242 – 2443TND → PNA in AAK82656. 1 PublicationCurated
    Sequence conflicti252 – 2521T → P in AAK82655. 1 PublicationCurated
    Sequence conflicti252 – 2521T → P in AAK82656. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti42 – 421D → G in a colorectal cancer sample; somatic mutation. 1 Publication
    VAR_036109
    Natural varianti1018 – 10181R → Q.
    Corresponds to variant rs4252205 [ dbSNP | Ensembl ].
    VAR_048575

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1012 – 104837Missing in isoform 5. 2 PublicationsVSP_017979Add
    BLAST
    Alternative sequencei1012 – 102514PMKEV…TPMKE → TDSRTSTIEICSEI in isoform 2. 1 PublicationVSP_017980Add
    BLAST
    Alternative sequencei1012 – 102110PMKEVVRSCT → VGIQVSNTTF in isoform 7. 2 PublicationsVSP_017981
    Alternative sequencei1022 – 1347326Missing in isoform 7. 2 PublicationsVSP_017982Add
    BLAST
    Alternative sequencei1026 – 1347322Missing in isoform 2. 1 PublicationVSP_017983Add
    BLAST
    Alternative sequencei1039 – 104810Missing in isoform 3 and isoform 4. 2 PublicationsVSP_017984
    Alternative sequencei1049 – 106517SQRRV…SQESS → TVLTSSSPSAMTLSYLD in isoform 6. 1 PublicationVSP_017985Add
    BLAST
    Alternative sequencei1066 – 1347282Missing in isoform 6. 1 PublicationVSP_017986Add
    BLAST
    Alternative sequencei1116 – 11238Missing in isoform 8 and isoform 4. 1 PublicationVSP_017987

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB026187 mRNA. Translation: BAA90765.1.
    AJ276804 mRNA. Translation: CAC13123.1.
    AF332218 mRNA. Translation: AAK13470.1.
    AF332219 mRNA. Translation: AAK13471.1.
    AF206516 mRNA. Translation: AAK82655.1.
    AF217288 mRNA. Translation: AAK82656.1.
    AY861432 mRNA. Translation: AAX56122.1.
    AY861433 mRNA. Translation: AAX56123.1.
    AY861434 mRNA. Translation: AAX56124.1.
    AY861435 mRNA. Translation: AAX56125.1.
    AL121869, AC004388, AL133274 Genomic DNA. Translation: CAI41412.1.
    AL121869
    , AC004388, AL133274, AL133321 Genomic DNA. Translation: CAI41413.1.
    AL121869
    , AC004388, AL133274, AL133321 Genomic DNA. Translation: CAI41414.1.
    AL133321
    , AC004388, AL121869, AL133274 Genomic DNA. Translation: CAI41435.1.
    AL133321
    , AC004388, AL121869, AL133274 Genomic DNA. Translation: CAI41436.1.
    AL133274, AC004388, AL121869 Genomic DNA. Translation: CAI41629.1.
    AL133274
    , AC004388, AL121869, AL133321 Genomic DNA. Translation: CAI41630.1.
    AL133274
    , AC004388, AL121869, AL133321 Genomic DNA. Translation: CAI41631.1.
    AJ564931 mRNA. Translation: CAD92410.1.
    AJ564932 mRNA. Translation: CAD92411.1.
    AJ564933 mRNA. Translation: CAD92412.1.
    AJ564934 mRNA. Translation: CAD92413.1.
    AJ564935 mRNA. Translation: CAD92414.1.
    AJ564936 mRNA. Translation: CAD92415.1.
    AJ564942 mRNA. Translation: CAD92421.1.
    AJ564945 mRNA. Translation: CAD92424.1.
    AJ564946 mRNA. Translation: CAD92425.1.
    AJ564947 mRNA. Translation: CAD92426.1.
    AB037747 mRNA. Translation: BAA92564.1.
    CCDSiCCDS14461.1. [Q9BZA7-1]
    CCDS14462.1. [Q9BZA7-3]
    CCDS55458.1. [Q9BZA7-6]
    CCDS55459.1. [Q9BZA7-8]
    CCDS55460.1. [Q9BZA7-4]
    CCDS55461.1. [Q9BZA7-5]
    RefSeqiNP_001161832.1. NM_001168360.1. [Q9BZA7-8]
    NP_001161833.1. NM_001168361.1. [Q9BZA7-6]
    NP_001161834.1. NM_001168362.1. [Q9BZA7-5]
    NP_001161835.1. NM_001168363.1. [Q9BZA7-4]
    NP_116749.1. NM_032967.2. [Q9BZA7-2]
    NP_116750.1. NM_032968.3. [Q9BZA7-1]
    NP_116751.1. NM_032969.3. [Q9BZA7-3]
    UniGeneiHs.655673.

    Genome annotation databases

    EnsembliENST00000361655; ENSP00000355105; ENSG00000102290. [Q9BZA7-4]
    ENST00000361724; ENSP00000355040; ENSG00000102290. [Q9BZA7-7]
    ENST00000373088; ENSP00000362180; ENSG00000102290. [Q9BZA7-5]
    ENST00000373094; ENSP00000362186; ENSG00000102290. [Q9BZA7-1]
    ENST00000373097; ENSP00000362189; ENSG00000102290. [Q9BZA7-3]
    ENST00000395337; ENSP00000378746; ENSG00000102290. [Q9BZA7-2]
    ENST00000406881; ENSP00000384758; ENSG00000102290. [Q9BZA7-8]
    ENST00000504220; ENSP00000423762; ENSG00000102290. [Q9BZA7-6]
    GeneIDi27328.
    KEGGihsa:27328.
    UCSCiuc004efh.2. human. [Q9BZA7-2]
    uc004efj.1. human. [Q9BZA7-7]
    uc004efk.2. human. [Q9BZA7-1]
    uc004efl.2. human. [Q9BZA7-3]
    uc004efm.2. human. [Q9BZA7-8]
    uc004efn.2. human. [Q9BZA7-4]
    uc004efo.2. human. [Q9BZA7-5]
    uc010nmv.2. human. [Q9BZA7-6]

    Polymorphism databases

    DMDMi74761344.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB026187 mRNA. Translation: BAA90765.1 .
    AJ276804 mRNA. Translation: CAC13123.1 .
    AF332218 mRNA. Translation: AAK13470.1 .
    AF332219 mRNA. Translation: AAK13471.1 .
    AF206516 mRNA. Translation: AAK82655.1 .
    AF217288 mRNA. Translation: AAK82656.1 .
    AY861432 mRNA. Translation: AAX56122.1 .
    AY861433 mRNA. Translation: AAX56123.1 .
    AY861434 mRNA. Translation: AAX56124.1 .
    AY861435 mRNA. Translation: AAX56125.1 .
    AL121869 , AC004388 , AL133274 Genomic DNA. Translation: CAI41412.1 .
    AL121869
    , AC004388 , AL133274 , AL133321 Genomic DNA. Translation: CAI41413.1 .
    AL121869
    , AC004388 , AL133274 , AL133321 Genomic DNA. Translation: CAI41414.1 .
    AL133321
    , AC004388 , AL121869 , AL133274 Genomic DNA. Translation: CAI41435.1 .
    AL133321
    , AC004388 , AL121869 , AL133274 Genomic DNA. Translation: CAI41436.1 .
    AL133274 , AC004388 , AL121869 Genomic DNA. Translation: CAI41629.1 .
    AL133274
    , AC004388 , AL121869 , AL133321 Genomic DNA. Translation: CAI41630.1 .
    AL133274
    , AC004388 , AL121869 , AL133321 Genomic DNA. Translation: CAI41631.1 .
    AJ564931 mRNA. Translation: CAD92410.1 .
    AJ564932 mRNA. Translation: CAD92411.1 .
    AJ564933 mRNA. Translation: CAD92412.1 .
    AJ564934 mRNA. Translation: CAD92413.1 .
    AJ564935 mRNA. Translation: CAD92414.1 .
    AJ564936 mRNA. Translation: CAD92415.1 .
    AJ564942 mRNA. Translation: CAD92421.1 .
    AJ564945 mRNA. Translation: CAD92424.1 .
    AJ564946 mRNA. Translation: CAD92425.1 .
    AJ564947 mRNA. Translation: CAD92426.1 .
    AB037747 mRNA. Translation: BAA92564.1 .
    CCDSi CCDS14461.1. [Q9BZA7-1 ]
    CCDS14462.1. [Q9BZA7-3 ]
    CCDS55458.1. [Q9BZA7-6 ]
    CCDS55459.1. [Q9BZA7-8 ]
    CCDS55460.1. [Q9BZA7-4 ]
    CCDS55461.1. [Q9BZA7-5 ]
    RefSeqi NP_001161832.1. NM_001168360.1. [Q9BZA7-8 ]
    NP_001161833.1. NM_001168361.1. [Q9BZA7-6 ]
    NP_001161834.1. NM_001168362.1. [Q9BZA7-5 ]
    NP_001161835.1. NM_001168363.1. [Q9BZA7-4 ]
    NP_116749.1. NM_032967.2. [Q9BZA7-2 ]
    NP_116750.1. NM_032968.3. [Q9BZA7-1 ]
    NP_116751.1. NM_032969.3. [Q9BZA7-3 ]
    UniGenei Hs.655673.

    3D structure databases

    ProteinModelPortali Q9BZA7.
    SMRi Q9BZA7. Positions 35-774.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 118142. 1 interaction.
    IntActi Q9BZA7. 1 interaction.

    PTM databases

    PhosphoSitei Q9BZA7.

    Polymorphism databases

    DMDMi 74761344.

    Proteomic databases

    PaxDbi Q9BZA7.
    PRIDEi Q9BZA7.

    Protocols and materials databases

    DNASUi 27328.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000361655 ; ENSP00000355105 ; ENSG00000102290 . [Q9BZA7-4 ]
    ENST00000361724 ; ENSP00000355040 ; ENSG00000102290 . [Q9BZA7-7 ]
    ENST00000373088 ; ENSP00000362180 ; ENSG00000102290 . [Q9BZA7-5 ]
    ENST00000373094 ; ENSP00000362186 ; ENSG00000102290 . [Q9BZA7-1 ]
    ENST00000373097 ; ENSP00000362189 ; ENSG00000102290 . [Q9BZA7-3 ]
    ENST00000395337 ; ENSP00000378746 ; ENSG00000102290 . [Q9BZA7-2 ]
    ENST00000406881 ; ENSP00000384758 ; ENSG00000102290 . [Q9BZA7-8 ]
    ENST00000504220 ; ENSP00000423762 ; ENSG00000102290 . [Q9BZA7-6 ]
    GeneIDi 27328.
    KEGGi hsa:27328.
    UCSCi uc004efh.2. human. [Q9BZA7-2 ]
    uc004efj.1. human. [Q9BZA7-7 ]
    uc004efk.2. human. [Q9BZA7-1 ]
    uc004efl.2. human. [Q9BZA7-3 ]
    uc004efm.2. human. [Q9BZA7-8 ]
    uc004efn.2. human. [Q9BZA7-4 ]
    uc004efo.2. human. [Q9BZA7-5 ]
    uc010nmv.2. human. [Q9BZA7-6 ]

    Organism-specific databases

    CTDi 27328.
    GeneCardsi GC0XP091034.
    H-InvDB HIX0176577.
    HGNCi HGNC:8656. PCDH11X.
    HPAi HPA000432.
    MIMi 300246. gene.
    neXtProti NX_Q9BZA7.
    PharmGKBi PA32996.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG145470.
    HOVERGENi HBG053523.
    InParanoidi Q9BZA7.
    KOi K16498.
    OMAi STREYAI.
    OrthoDBi EOG7WMCHN.
    PhylomeDBi Q9BZA7.
    TreeFami TF320624.

    Miscellaneous databases

    GeneWikii PCDH11X.
    GenomeRNAii 27328.
    NextBioi 50358.
    PROi Q9BZA7.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9BZA7.
    Bgeei Q9BZA7.
    Genevestigatori Q9BZA7.

    Family and domain databases

    Gene3Di 2.60.40.60. 6 hits.
    InterProi IPR002126. Cadherin.
    IPR015919. Cadherin-like.
    IPR020894. Cadherin_CS.
    IPR013164. Cadherin_N.
    IPR013585. Protocadherin.
    [Graphical view ]
    Pfami PF00028. Cadherin. 6 hits.
    PF08266. Cadherin_2. 1 hit.
    PF08374. Protocadherin. 1 hit.
    [Graphical view ]
    PRINTSi PR00205. CADHERIN.
    SMARTi SM00112. CA. 6 hits.
    [Graphical view ]
    SUPFAMi SSF49313. SSF49313. 6 hits.
    PROSITEi PS00232. CADHERIN_1. 5 hits.
    PS50268. CADHERIN_2. 7 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of a novel protocadherin gene (PCDH11) on the human XY homology region in Xq21.3."
      Yoshida K., Sugano S.
      Genomics 62:540-543(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 7), TISSUE SPECIFICITY.
      Tissue: Brain.
    2. "Conservation of PCDHX in mammals; expression of human X/Y genes predominantly in brain."
      Blanco P., Sargent C.A., Boucher C., Mitchell M., Affara N.
      Mamm. Genome 11:906-914(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY.
      Tissue: Brain.
    3. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 3).
      Tissue: Brain.
    4. "Identification and cloning of a human chromosome X-linked protocadherin gene with seven extracellular domains and an unusual large cytoplasmic domain."
      Kools P.F.J., van Roy F.
      Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 5).
    5. "Delta-protocadherins: a subfamily of protocadherins expressed differentially in the mouse nervous system."
      Vanhalst K., Kools P., Staes K., van Roy F., Redies C.
      Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 4; 5; 6 AND 8).
      Tissue: Fetal brain.
    6. "The DNA sequence of the human X chromosome."
      Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
      , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
      Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "Protocadherin X (PCDHX) and Y (PCDHY) genes; multiple mRNA isoforms encoding variant signal peptides and cytoplasmic domains."
      Blanco-Arias P., Sargent C.A., Affara N.A.
      Mamm. Genome 15:41-52(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-1011; 1049-1114 AND 1124-1347, NUCLEOTIDE SEQUENCE [MRNA] OF 181-1347 (ISOFORM 7), ALTERNATIVE SPLICING.
    8. "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.
      DNA Res. 7:65-73(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 924-1347.
      Tissue: Brain.
    9. Cited for: VARIANT [LARGE SCALE ANALYSIS] GLY-42.

    Entry informationi

    Entry nameiPC11X_HUMAN
    AccessioniPrimary (citable) accession number: Q9BZA7
    Secondary accession number(s): A6NIQ4
    , Q2TJH0, Q2TJH1, Q2TJH3, Q5JVZ0, Q70LR8, Q70LS7, Q70LS8, Q70LS9, Q70LT7, Q70LT8, Q70LT9, Q70LU0, Q70LU1, Q96RV4, Q96RW0, Q9BZA6, Q9H4E0, Q9P2M0, Q9P2X5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 18, 2006
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 110 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome X
      Human chromosome X: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3