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Q9BZA7

- PC11X_HUMAN

UniProt

Q9BZA7 - PC11X_HUMAN

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Protein

Protocadherin-11 X-linked

Gene
PCDH11X, KIAA1326, PCDH11, PCDHX
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Potential calcium-dependent cell-adhesion protein.

GO - Molecular functioni

  1. calcium ion binding Source: InterPro

GO - Biological processi

  1. homophilic cell adhesion Source: InterPro
  2. negative regulation of phosphatase activity Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Protocadherin-11 X-linked
Short name:
Protocadherin-11
Alternative name(s):
Protocadherin on the X chromosome
Short name:
PCDH-X
Protocadherin-S
Gene namesi
Name:PCDH11X
Synonyms:KIAA1326, PCDH11, PCDHX
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome X

Organism-specific databases

HGNCiHGNC:8656. PCDH11X.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini24 – 812789Extracellular Reviewed predictionAdd
BLAST
Transmembranei813 – 83321Helical; Reviewed predictionAdd
BLAST
Topological domaini834 – 1347514Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. extracellular vesicular exosome Source: UniProt
  2. integral component of plasma membrane Source: ProtInc
  3. plasma membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32996.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323 Reviewed predictionAdd
BLAST
Chaini24 – 13471324Protocadherin-11 X-linkedPRO_0000232758Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi27 – 271N-linked (GlcNAc...) Reviewed prediction
Glycosylationi48 – 481N-linked (GlcNAc...) Reviewed prediction
Glycosylationi54 – 541N-linked (GlcNAc...) Reviewed prediction
Glycosylationi344 – 3441N-linked (GlcNAc...) Reviewed prediction
Glycosylationi553 – 5531N-linked (GlcNAc...) Reviewed prediction
Glycosylationi773 – 7731N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9BZA7.
PRIDEiQ9BZA7.

PTM databases

PhosphoSiteiQ9BZA7.

Expressioni

Tissue specificityi

Expressed strongly in fetal brain and brain (cortex, amygdala, thalamus, substantia nigra, hippocampus, caudate nucleus and corpus callosum). Expressed at low level in testis.2 Publications

Gene expression databases

ArrayExpressiQ9BZA7.
BgeeiQ9BZA7.
GenevestigatoriQ9BZA7.

Organism-specific databases

HPAiHPA000432.

Interactioni

Protein-protein interaction databases

BioGridi118142. 1 interaction.
IntActiQ9BZA7. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ9BZA7.
SMRiQ9BZA7. Positions 35-774.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini26 – 139114Cadherin 1Add
BLAST
Domaini140 – 249110Cadherin 2Add
BLAST
Domaini250 – 355106Cadherin 3Add
BLAST
Domaini362 – 466105Cadherin 4Add
BLAST
Domaini467 – 570104Cadherin 5Add
BLAST
Domaini571 – 673103Cadherin 6Add
BLAST
Domaini677 – 795119Cadherin 7Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi868 – 8758Poly-Lys

Sequence similaritiesi

Contains 7 cadherin domains.

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG145470.
HOVERGENiHBG053523.
InParanoidiQ9BZA7.
KOiK16498.
OMAiSTREYAI.
OrthoDBiEOG7WMCHN.
PhylomeDBiQ9BZA7.
TreeFamiTF320624.

Family and domain databases

Gene3Di2.60.40.60. 6 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR013164. Cadherin_N.
IPR013585. Protocadherin.
[Graphical view]
PfamiPF00028. Cadherin. 6 hits.
PF08266. Cadherin_2. 1 hit.
PF08374. Protocadherin. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 6 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 6 hits.
PROSITEiPS00232. CADHERIN_1. 5 hits.
PS50268. CADHERIN_2. 7 hits.
[Graphical view]

Sequences (8)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 8 isoformsi produced by alternative splicing. Align

Note: Additional isoforms seem to exist.

Isoform 1 (identifier: Q9BZA7-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MDLLSGTYIF AVLLACVVFH SGAQEKNYTI REEMPENVLI GDLLKDLNLS     50
LIPNKSLTTA MQFKLVYKTG DVPLIRIEED TGEIFTTGAR IDREKLCAGI 100
PRDEHCFYEV EVAILPDEIF RLVKIRFLIE DINDNAPLFP ATVINISIPE 150
NSAINSKYTL PAAVDPDVGI NGVQNYELIK SQNIFGLDVI ETPEGDKMPQ 200
LIVQKELDRE EKDTYVMKVK VEDGGFPQRS STAILQVSVT DTNDNHPVFK 250
ETEIEVSIPE NAPVGTSVTQ LHATDADIGE NAKIHFSFSN LVSNIARRLF 300
HLNATTGLIT IKEPLDREET PNHKLLVLAS DGGLMPARAM VLVNVTDVND 350
NVPSIDIRYI VNPVNDTVVL SENIPLNTKI ALITVTDKDA DHNGRVTCFT 400
DHEIPFRLRP VFSNQFLLET AAYLDYESTK EYAIKLLAAD AGKPPLNQSA 450
MLFIKVKDEN DNAPVFTQSF VTVSIPENNS PGIQLTKVSA MDADSGPNAK 500
INYLLGPDAP PEFSLDCRTG MLTVVKKLDR EKEDKYLFTI LAKDNGVPPL 550
TSNVTVFVSI IDQNDNSPVF THNEYNFYVP ENLPRHGTVG LITVTDPDYG 600
DNSAVTLSIL DENDDFTIDS QTGVIRPNIS FDREKQESYT FYVKAEDGGR 650
VSRSSSAKVT INVVDVNDNK PVFIVPPSNC SYELVLPSTN PGTVVFQVIA 700
VDNDTGMNAE VRYSIVGGNT RDLFAIDQET GNITLMEKCD VTDLGLHRVL 750
VKANDLGQPD SLFSVVIVNL FVNESVTNAT LINELVRKST EAPVTPNTEI 800
ADVSSPTSDY VKILVAAVAG TITVVVVIFI TAVVRCRQAP HLKAAQKNKQ 850
NSEWATPNPE NRQMIMMKKK KKKKKHSPKN LLLNFVTIEE TKADDVDSDG 900
NRVTLDLPID LEEQTMGKYN WVTTPTTFKP DSPDLARHYK SASPQPAFQI 950
QPETPLNSKH HIIQELPLDN TFVACDSISK CSSSSSDPYS VSDCGYPVTT 1000
FEVPVSVHTR PPMKEVVRSC TPMKESTTME IWIHPQPQRK SEGKVAGKSQ 1050
RRVTFHLPEG SQESSSDGGL GDHDAGSLTS TSHGLPLGYP QEEYFDRATP 1100
SNRTEGDGNS DPESTFIPGL KKAAEITVQP TVEEASDNCT QECLIYGHSD 1150
ACWMPASLDH SSSSQAQASA LCHSPPLSQA STQHHSPRVT QTIALCHSPP 1200
VTQTIALCHS PPPIQVSALH HSPPLVQATA LHHSPPSAQA SALCYSPPLA 1250
QAAAISHSSP LPQVIALHRS QAQSSVSLQQ GWVQGADGLC SVDQGVQGSA 1300
TSQFYTMSER LHPSDDSIKV IPLTTFTPRQ QARPSRGDSP IMEEHPL 1347
Length:1,347
Mass (Da):147,558
Last modified:June 1, 2001 - v1
Checksum:i0227FA6C521FDA84
GO
Isoform 2 (identifier: Q9BZA7-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1012-1025: PMKEVVRSCTPMKE → TDSRTSTIEICSEI
     1026-1347: Missing.

Show »
Length:1,025
Mass (Da):113,215
Checksum:i51EE095ED7035A10
GO
Isoform 3 (identifier: Q9BZA7-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1039-1048: Missing.

Show »
Length:1,337
Mass (Da):146,517
Checksum:iA96D3B41173C8508
GO
Isoform 4 (identifier: Q9BZA7-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1039-1048: Missing.
     1116-1123: Missing.

Show »
Length:1,329
Mass (Da):145,662
Checksum:iDA7DC585324AD261
GO
Isoform 5 (identifier: Q9BZA7-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1012-1048: Missing.

Show »
Length:1,310
Mass (Da):143,350
Checksum:i948FE29C9EA7D312
GO
Isoform 6 (identifier: Q9BZA7-6) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1049-1065: SQRRVTFHLPEGSQESS → TVLTSSSPSAMTLSYLD
     1066-1347: Missing.

Show »
Length:1,065
Mass (Da):117,642
Checksum:i71AB11952A3EEA81
GO
Isoform 7 (identifier: Q9BZA7-7) [UniParc]FASTAAdd to Basket

Also known as: Protocadherin-Xa

The sequence of this isoform differs from the canonical sequence as follows:
     1012-1021: PMKEVVRSCT → VGIQVSNTTF
     1022-1347: Missing.

Note: No experimental confirmation available.

Show »
Length:1,021
Mass (Da):112,726
Checksum:i9F4471F5C597F902
GO
Isoform 8 (identifier: Q9BZA7-8) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1116-1123: Missing.

Show »
Length:1,339
Mass (Da):146,703
Checksum:iCD1D563B7D8FE105
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti42 – 421D → G in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_036109
Natural varianti1018 – 10181R → Q.
Corresponds to variant rs4252205 [ dbSNP | Ensembl ].
VAR_048575

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1012 – 104837Missing in isoform 5. VSP_017979Add
BLAST
Alternative sequencei1012 – 102514PMKEV…TPMKE → TDSRTSTIEICSEI in isoform 2. VSP_017980Add
BLAST
Alternative sequencei1012 – 102110PMKEVVRSCT → VGIQVSNTTF in isoform 7. VSP_017981
Alternative sequencei1022 – 1347326Missing in isoform 7. VSP_017982Add
BLAST
Alternative sequencei1026 – 1347322Missing in isoform 2. VSP_017983Add
BLAST
Alternative sequencei1039 – 104810Missing in isoform 3 and isoform 4. VSP_017984
Alternative sequencei1049 – 106517SQRRV…SQESS → TVLTSSSPSAMTLSYLD in isoform 6. VSP_017985Add
BLAST
Alternative sequencei1066 – 1347282Missing in isoform 6. VSP_017986Add
BLAST
Alternative sequencei1116 – 11238Missing in isoform 8 and isoform 4. VSP_017987

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti242 – 2443TND → PNA in AAK82655. 1 Publication
Sequence conflicti242 – 2443TND → PNA in AAK82656. 1 Publication
Sequence conflicti252 – 2521T → P in AAK82655. 1 Publication
Sequence conflicti252 – 2521T → P in AAK82656. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB026187 mRNA. Translation: BAA90765.1.
AJ276804 mRNA. Translation: CAC13123.1.
AF332218 mRNA. Translation: AAK13470.1.
AF332219 mRNA. Translation: AAK13471.1.
AF206516 mRNA. Translation: AAK82655.1.
AF217288 mRNA. Translation: AAK82656.1.
AY861432 mRNA. Translation: AAX56122.1.
AY861433 mRNA. Translation: AAX56123.1.
AY861434 mRNA. Translation: AAX56124.1.
AY861435 mRNA. Translation: AAX56125.1.
AL121869, AC004388, AL133274 Genomic DNA. Translation: CAI41412.1.
AL121869
, AC004388, AL133274, AL133321 Genomic DNA. Translation: CAI41413.1.
AL121869
, AC004388, AL133274, AL133321 Genomic DNA. Translation: CAI41414.1.
AL133321
, AC004388, AL121869, AL133274 Genomic DNA. Translation: CAI41435.1.
AL133321
, AC004388, AL121869, AL133274 Genomic DNA. Translation: CAI41436.1.
AL133274, AC004388, AL121869 Genomic DNA. Translation: CAI41629.1.
AL133274
, AC004388, AL121869, AL133321 Genomic DNA. Translation: CAI41630.1.
AL133274
, AC004388, AL121869, AL133321 Genomic DNA. Translation: CAI41631.1.
AJ564931 mRNA. Translation: CAD92410.1.
AJ564932 mRNA. Translation: CAD92411.1.
AJ564933 mRNA. Translation: CAD92412.1.
AJ564934 mRNA. Translation: CAD92413.1.
AJ564935 mRNA. Translation: CAD92414.1.
AJ564936 mRNA. Translation: CAD92415.1.
AJ564942 mRNA. Translation: CAD92421.1.
AJ564945 mRNA. Translation: CAD92424.1.
AJ564946 mRNA. Translation: CAD92425.1.
AJ564947 mRNA. Translation: CAD92426.1.
AB037747 mRNA. Translation: BAA92564.1.
CCDSiCCDS14461.1. [Q9BZA7-1]
CCDS14462.1. [Q9BZA7-3]
CCDS14463.1. [Q9BZA7-2]
CCDS14464.1. [Q9BZA7-7]
CCDS55458.1. [Q9BZA7-6]
CCDS55459.1. [Q9BZA7-8]
CCDS55460.1. [Q9BZA7-4]
CCDS55461.1. [Q9BZA7-5]
RefSeqiNP_001161832.1. NM_001168360.1. [Q9BZA7-8]
NP_001161833.1. NM_001168361.1. [Q9BZA7-6]
NP_001161834.1. NM_001168362.1. [Q9BZA7-5]
NP_001161835.1. NM_001168363.1. [Q9BZA7-4]
NP_116749.1. NM_032967.2. [Q9BZA7-2]
NP_116750.1. NM_032968.3. [Q9BZA7-1]
NP_116751.1. NM_032969.3. [Q9BZA7-3]
UniGeneiHs.655673.

Genome annotation databases

EnsembliENST00000361655; ENSP00000355105; ENSG00000102290. [Q9BZA7-4]
ENST00000361724; ENSP00000355040; ENSG00000102290. [Q9BZA7-7]
ENST00000373088; ENSP00000362180; ENSG00000102290. [Q9BZA7-5]
ENST00000373094; ENSP00000362186; ENSG00000102290. [Q9BZA7-1]
ENST00000373097; ENSP00000362189; ENSG00000102290. [Q9BZA7-3]
ENST00000395337; ENSP00000378746; ENSG00000102290. [Q9BZA7-2]
ENST00000406881; ENSP00000384758; ENSG00000102290. [Q9BZA7-8]
ENST00000504220; ENSP00000423762; ENSG00000102290. [Q9BZA7-6]
GeneIDi27328.
KEGGihsa:27328.
UCSCiuc004efh.2. human. [Q9BZA7-2]
uc004efj.1. human. [Q9BZA7-7]
uc004efk.2. human. [Q9BZA7-1]
uc004efl.2. human. [Q9BZA7-3]
uc004efm.2. human. [Q9BZA7-8]
uc004efn.2. human. [Q9BZA7-4]
uc004efo.2. human. [Q9BZA7-5]
uc010nmv.2. human. [Q9BZA7-6]

Polymorphism databases

DMDMi74761344.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB026187 mRNA. Translation: BAA90765.1 .
AJ276804 mRNA. Translation: CAC13123.1 .
AF332218 mRNA. Translation: AAK13470.1 .
AF332219 mRNA. Translation: AAK13471.1 .
AF206516 mRNA. Translation: AAK82655.1 .
AF217288 mRNA. Translation: AAK82656.1 .
AY861432 mRNA. Translation: AAX56122.1 .
AY861433 mRNA. Translation: AAX56123.1 .
AY861434 mRNA. Translation: AAX56124.1 .
AY861435 mRNA. Translation: AAX56125.1 .
AL121869 , AC004388 , AL133274 Genomic DNA. Translation: CAI41412.1 .
AL121869
, AC004388 , AL133274 , AL133321 Genomic DNA. Translation: CAI41413.1 .
AL121869
, AC004388 , AL133274 , AL133321 Genomic DNA. Translation: CAI41414.1 .
AL133321
, AC004388 , AL121869 , AL133274 Genomic DNA. Translation: CAI41435.1 .
AL133321
, AC004388 , AL121869 , AL133274 Genomic DNA. Translation: CAI41436.1 .
AL133274 , AC004388 , AL121869 Genomic DNA. Translation: CAI41629.1 .
AL133274
, AC004388 , AL121869 , AL133321 Genomic DNA. Translation: CAI41630.1 .
AL133274
, AC004388 , AL121869 , AL133321 Genomic DNA. Translation: CAI41631.1 .
AJ564931 mRNA. Translation: CAD92410.1 .
AJ564932 mRNA. Translation: CAD92411.1 .
AJ564933 mRNA. Translation: CAD92412.1 .
AJ564934 mRNA. Translation: CAD92413.1 .
AJ564935 mRNA. Translation: CAD92414.1 .
AJ564936 mRNA. Translation: CAD92415.1 .
AJ564942 mRNA. Translation: CAD92421.1 .
AJ564945 mRNA. Translation: CAD92424.1 .
AJ564946 mRNA. Translation: CAD92425.1 .
AJ564947 mRNA. Translation: CAD92426.1 .
AB037747 mRNA. Translation: BAA92564.1 .
CCDSi CCDS14461.1. [Q9BZA7-1 ]
CCDS14462.1. [Q9BZA7-3 ]
CCDS14463.1. [Q9BZA7-2 ]
CCDS14464.1. [Q9BZA7-7 ]
CCDS55458.1. [Q9BZA7-6 ]
CCDS55459.1. [Q9BZA7-8 ]
CCDS55460.1. [Q9BZA7-4 ]
CCDS55461.1. [Q9BZA7-5 ]
RefSeqi NP_001161832.1. NM_001168360.1. [Q9BZA7-8 ]
NP_001161833.1. NM_001168361.1. [Q9BZA7-6 ]
NP_001161834.1. NM_001168362.1. [Q9BZA7-5 ]
NP_001161835.1. NM_001168363.1. [Q9BZA7-4 ]
NP_116749.1. NM_032967.2. [Q9BZA7-2 ]
NP_116750.1. NM_032968.3. [Q9BZA7-1 ]
NP_116751.1. NM_032969.3. [Q9BZA7-3 ]
UniGenei Hs.655673.

3D structure databases

ProteinModelPortali Q9BZA7.
SMRi Q9BZA7. Positions 35-774.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 118142. 1 interaction.
IntActi Q9BZA7. 1 interaction.

PTM databases

PhosphoSitei Q9BZA7.

Polymorphism databases

DMDMi 74761344.

Proteomic databases

PaxDbi Q9BZA7.
PRIDEi Q9BZA7.

Protocols and materials databases

DNASUi 27328.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000361655 ; ENSP00000355105 ; ENSG00000102290 . [Q9BZA7-4 ]
ENST00000361724 ; ENSP00000355040 ; ENSG00000102290 . [Q9BZA7-7 ]
ENST00000373088 ; ENSP00000362180 ; ENSG00000102290 . [Q9BZA7-5 ]
ENST00000373094 ; ENSP00000362186 ; ENSG00000102290 . [Q9BZA7-1 ]
ENST00000373097 ; ENSP00000362189 ; ENSG00000102290 . [Q9BZA7-3 ]
ENST00000395337 ; ENSP00000378746 ; ENSG00000102290 . [Q9BZA7-2 ]
ENST00000406881 ; ENSP00000384758 ; ENSG00000102290 . [Q9BZA7-8 ]
ENST00000504220 ; ENSP00000423762 ; ENSG00000102290 . [Q9BZA7-6 ]
GeneIDi 27328.
KEGGi hsa:27328.
UCSCi uc004efh.2. human. [Q9BZA7-2 ]
uc004efj.1. human. [Q9BZA7-7 ]
uc004efk.2. human. [Q9BZA7-1 ]
uc004efl.2. human. [Q9BZA7-3 ]
uc004efm.2. human. [Q9BZA7-8 ]
uc004efn.2. human. [Q9BZA7-4 ]
uc004efo.2. human. [Q9BZA7-5 ]
uc010nmv.2. human. [Q9BZA7-6 ]

Organism-specific databases

CTDi 27328.
GeneCardsi GC0XP091034.
H-InvDB HIX0176577.
HGNCi HGNC:8656. PCDH11X.
HPAi HPA000432.
MIMi 300246. gene.
neXtProti NX_Q9BZA7.
PharmGKBi PA32996.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG145470.
HOVERGENi HBG053523.
InParanoidi Q9BZA7.
KOi K16498.
OMAi STREYAI.
OrthoDBi EOG7WMCHN.
PhylomeDBi Q9BZA7.
TreeFami TF320624.

Miscellaneous databases

GeneWikii PCDH11X.
GenomeRNAii 27328.
NextBioi 50358.
PROi Q9BZA7.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9BZA7.
Bgeei Q9BZA7.
Genevestigatori Q9BZA7.

Family and domain databases

Gene3Di 2.60.40.60. 6 hits.
InterProi IPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR013164. Cadherin_N.
IPR013585. Protocadherin.
[Graphical view ]
Pfami PF00028. Cadherin. 6 hits.
PF08266. Cadherin_2. 1 hit.
PF08374. Protocadherin. 1 hit.
[Graphical view ]
PRINTSi PR00205. CADHERIN.
SMARTi SM00112. CA. 6 hits.
[Graphical view ]
SUPFAMi SSF49313. SSF49313. 6 hits.
PROSITEi PS00232. CADHERIN_1. 5 hits.
PS50268. CADHERIN_2. 7 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of a novel protocadherin gene (PCDH11) on the human XY homology region in Xq21.3."
    Yoshida K., Sugano S.
    Genomics 62:540-543(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 7), TISSUE SPECIFICITY.
    Tissue: Brain.
  2. "Conservation of PCDHX in mammals; expression of human X/Y genes predominantly in brain."
    Blanco P., Sargent C.A., Boucher C., Mitchell M., Affara N.
    Mamm. Genome 11:906-914(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY.
    Tissue: Brain.
  3. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 3).
    Tissue: Brain.
  4. "Identification and cloning of a human chromosome X-linked protocadherin gene with seven extracellular domains and an unusual large cytoplasmic domain."
    Kools P.F.J., van Roy F.
    Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 5).
  5. "Delta-protocadherins: a subfamily of protocadherins expressed differentially in the mouse nervous system."
    Vanhalst K., Kools P., Staes K., van Roy F., Redies C.
    Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 4; 5; 6 AND 8).
    Tissue: Fetal brain.
  6. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "Protocadherin X (PCDHX) and Y (PCDHY) genes; multiple mRNA isoforms encoding variant signal peptides and cytoplasmic domains."
    Blanco-Arias P., Sargent C.A., Affara N.A.
    Mamm. Genome 15:41-52(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-1011; 1049-1114 AND 1124-1347, NUCLEOTIDE SEQUENCE [MRNA] OF 181-1347 (ISOFORM 7), ALTERNATIVE SPLICING.
  8. "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.
    DNA Res. 7:65-73(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 924-1347.
    Tissue: Brain.
  9. Cited for: VARIANT [LARGE SCALE ANALYSIS] GLY-42.

Entry informationi

Entry nameiPC11X_HUMAN
AccessioniPrimary (citable) accession number: Q9BZA7
Secondary accession number(s): A6NIQ4
, Q2TJH0, Q2TJH1, Q2TJH3, Q5JVZ0, Q70LR8, Q70LS7, Q70LS8, Q70LS9, Q70LT7, Q70LT8, Q70LT9, Q70LU0, Q70LU1, Q96RV4, Q96RW0, Q9BZA6, Q9H4E0, Q9P2M0, Q9P2X5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: June 1, 2001
Last modified: September 3, 2014
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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