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Protein

Histone-lysine N-methyltransferase NSD3

Gene

WHSC1L1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Histone methyltransferase. Preferentially methylates 'Lys-4' and 'Lys-27' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation, while 'Lys-27' is a mark for transcriptional repression.1 Publication

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri701 – 748PHD-type 1PROSITE-ProRule annotationAdd BLAST48
Zinc fingeri749 – 805PHD-type 2PROSITE-ProRule annotationAdd BLAST57
Zinc fingeri862 – 955PHD-type 3PROSITE-ProRule annotationAdd BLAST94
Zinc fingeri1321 – 1368PHD-type 4; atypicalPROSITE-ProRule annotationAdd BLAST48

GO - Molecular functioni

  • histone-lysine N-methyltransferase activity Source: UniProtKB
  • zinc ion binding Source: InterPro

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Methyltransferase, Transferase

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

Metal-binding, S-adenosyl-L-methionine, Zinc

Enzyme and pathway databases

BioCyciZFISH:HS07446-MONOMER.
ReactomeiR-HSA-3214841. PKMTs methylate histone lysines.

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferase NSD3 (EC:2.1.1.43)
Alternative name(s):
Nuclear SET domain-containing protein 3
Protein whistle
WHSC1-like 1 isoform 9 with methyltransferase activity to lysine
Wolf-Hirschhorn syndrome candidate 1-like protein 1
Short name:
WHSC1-like protein 1
Gene namesi
Name:WHSC1L1
Synonyms:NSD3
ORF Names:DC28
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:12767. WHSC1L1.

Subcellular locationi

GO - Cellular componenti

  • chromosome Source: UniProtKB-SubCell
  • nucleoplasm Source: Reactome
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleus

Pathology & Biotechi

Involvement in diseasei

Defects in WHSC1L1 may be involved in non small cell lung carcinomas (NSCLC). Amplified or overexpressed in NSCLC.

A chromosomal aberration involving WHSC1L1 is found in childhood acute myeloid leukemia. Translocation t(8;11)(p11.2;p15) with NUP98.

Keywords - Diseasei

Proto-oncogene

Organism-specific databases

DisGeNETi54904.
MalaCardsiWHSC1L1.
OpenTargetsiENSG00000147548.
PharmGKBiPA37370.

Chemistry databases

ChEMBLiCHEMBL3108646.

Polymorphism and mutation databases

BioMutaiWHSC1L1.
DMDMi74761342.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002595211 – 1437Histone-lysine N-methyltransferase NSD3Add BLAST1437

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei150PhosphoserineCombined sources1
Cross-linki218Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki245Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei457PhosphoserineCombined sources1
Cross-linki532Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei585PhosphoserineCombined sources1
Modified residuei587PhosphoserineCombined sources1
Modified residuei590PhosphoserineCombined sources1
Modified residuei655PhosphoserineCombined sources1
Modified residuei790N6-acetyllysineCombined sources1
Cross-linki1151Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9BZ95.
MaxQBiQ9BZ95.
PaxDbiQ9BZ95.
PeptideAtlasiQ9BZ95.
PRIDEiQ9BZ95.

PTM databases

iPTMnetiQ9BZ95.
PhosphoSitePlusiQ9BZ95.

Expressioni

Tissue specificityi

Highly expressed in brain, heart and skeletal muscle. Expressed at lower level in liver and lung.1 Publication

Gene expression databases

BgeeiENSG00000147548.
ExpressionAtlasiQ9BZ95. baseline and differential.
GenevisibleiQ9BZ95. HS.

Organism-specific databases

HPAiCAB013721.
HPA005659.
HPA018893.

Interactioni

Subunit structurei

Interacts with BRD4.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
ATMQ133153EBI-3390132,EBI-495465
DAXXQ9UER72EBI-3390132,EBI-77321
HEL25V9HWG03EBI-3390132,EBI-10183977
HOXC4P090172EBI-3390132,EBI-3923226
MLLT6Q6P2C63EBI-3390132,EBI-5773143
MNDAP412182EBI-3390132,EBI-2829677
RAD51Q066094EBI-3390132,EBI-297202
SLU7O953912EBI-3390132,EBI-750559

Protein-protein interaction databases

BioGridi120250. 53 interactors.
IntActiQ9BZ95. 36 interactors.
MINTiMINT-4830664.
STRINGi9606.ENSP00000313983.

Structurei

Secondary structure

11437
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi154 – 158Combined sources5
Beta strandi963 – 969Combined sources7
Beta strandi972 – 978Combined sources7
Turni981 – 983Combined sources3
Helixi986 – 989Combined sources4
Beta strandi997 – 1002Combined sources6
Turni1003 – 1006Combined sources4
Beta strandi1007 – 1012Combined sources6
Helixi1013 – 1015Combined sources3
Beta strandi1016 – 1018Combined sources3
Helixi1025 – 1062Combined sources38
Helixi1092 – 1094Combined sources3
Beta strandi1104 – 1106Combined sources3
Beta strandi1110 – 1112Combined sources3
Helixi1115 – 1118Combined sources4
Turni1125 – 1127Combined sources3
Helixi1131 – 1133Combined sources3
Helixi1138 – 1141Combined sources4
Beta strandi1147 – 1151Combined sources5
Beta strandi1153 – 1155Combined sources3
Beta strandi1157 – 1163Combined sources7
Beta strandi1170 – 1173Combined sources4
Beta strandi1177 – 1179Combined sources3
Helixi1181 – 1193Combined sources13
Beta strandi1201 – 1205Combined sources5
Beta strandi1208 – 1211Combined sources4
Beta strandi1213 – 1216Combined sources4
Helixi1218 – 1221Combined sources4
Beta strandi1229 – 1237Combined sources9
Beta strandi1240 – 1249Combined sources10
Turni1325 – 1327Combined sources3
Beta strandi1331 – 1335Combined sources5
Helixi1348 – 1350Combined sources3
Beta strandi1357 – 1359Combined sources3
Helixi1363 – 1365Combined sources3
Turni1368 – 1370Combined sources3
Beta strandi1375 – 1377Combined sources3
Beta strandi1379 – 1382Combined sources4
Turni1387 – 1389Combined sources3
Turni1391 – 1393Combined sources3
Turni1398 – 1401Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DAQNMR-A957-1053[»]
2NCZNMR-B152-163[»]
2ND1NMR-B593-605[»]
4GNDX-ray2.27A/C1310-1413[»]
4GNEX-ray1.47A1310-1413[»]
4GNFX-ray1.55A1310-1413[»]
4GNGX-ray1.73A/D1310-1413[»]
4RXJX-ray2.10A953-1064[»]
4YZ8X-ray1.80A1054-1285[»]
ProteinModelPortaliQ9BZ95.
SMRiQ9BZ95.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9BZ95.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini270 – 333PWWP 1PROSITE-ProRule annotationAdd BLAST64
Domaini960 – 1022PWWP 2PROSITE-ProRule annotationAdd BLAST63
Domaini1093 – 1143AWSPROSITE-ProRule annotationAdd BLAST51
Domaini1145 – 1262SETPROSITE-ProRule annotationAdd BLAST118
Domaini1269 – 1285Post-SETPROSITE-ProRule annotationAdd BLAST17

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili1033 – 1069Sequence analysisAdd BLAST37

Sequence similaritiesi

Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET2 subfamily.PROSITE-ProRule annotation
Contains 1 AWS domain.PROSITE-ProRule annotation
Contains 4 PHD-type zinc fingers.PROSITE-ProRule annotation
Contains 1 post-SET domain.PROSITE-ProRule annotation
Contains 2 PWWP domains.PROSITE-ProRule annotation
Contains 1 SET domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri701 – 748PHD-type 1PROSITE-ProRule annotationAdd BLAST48
Zinc fingeri749 – 805PHD-type 2PROSITE-ProRule annotationAdd BLAST57
Zinc fingeri862 – 955PHD-type 3PROSITE-ProRule annotationAdd BLAST94
Zinc fingeri1321 – 1368PHD-type 4; atypicalPROSITE-ProRule annotationAdd BLAST48

Keywords - Domaini

Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1081. Eukaryota.
COG2940. LUCA.
GeneTreeiENSGT00780000121845.
HOVERGENiHBG079979.
InParanoidiQ9BZ95.
KOiK11425.
OMAiMEKDIHK.
OrthoDBiEOG091G00XD.
PhylomeDBiQ9BZ95.
TreeFamiTF329088.

Family and domain databases

Gene3Di3.30.40.10. 3 hits.
InterProiIPR006560. AWS_dom.
IPR003616. Post-SET_dom.
IPR000313. PWWP_dom.
IPR001214. SET_dom.
IPR019786. Zinc_finger_PHD-type_CS.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF00855. PWWP. 2 hits.
PF00856. SET. 1 hit.
[Graphical view]
SMARTiSM00570. AWS. 1 hit.
SM00249. PHD. 5 hits.
SM00508. PostSET. 1 hit.
SM00293. PWWP. 2 hits.
SM00317. SET. 1 hit.
[Graphical view]
SUPFAMiSSF57903. SSF57903. 3 hits.
PROSITEiPS51215. AWS. 1 hit.
PS50868. POST_SET. 1 hit.
PS50812. PWWP. 2 hits.
PS50280. SET. 1 hit.
PS01359. ZF_PHD_1. 1 hit.
PS50016. ZF_PHD_2. 2 hits.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9BZ95-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDFSFSFMQG IMGNTIQQPP QLIDSANIRQ EDAFDNNSDI AEDGGQTPYE
60 70 80 90 100
ATLQQGFQYP ATTEDLPPLT NGYPSSISVY ETQTKYQSYN QYPNGSANGF
110 120 130 140 150
GAVRNFSPTD YYHSEIPNTR PHEILEKPSP PQPPPPPSVP QTVIPKKTGS
160 170 180 190 200
PEIKLKITKT IQNGRELFES SLCGDLLNEV QASEHTKSKH ESRKEKRKKS
210 220 230 240 250
NKHDSSRSEE RKSHKIPKLE PEEQNRPNER VDTVSEKPRE EPVLKEEAPV
260 270 280 290 300
QPILSSVPTT EVSTGVKFQV GDLVWSKVGT YPWWPCMVSS DPQLEVHTKI
310 320 330 340 350
NTRGAREYHV QFFSNQPERA WVHEKRVREY KGHKQYEELL AEATKQASNH
360 370 380 390 400
SEKQKIRKPR PQRERAQWDI GIAHAEKALK MTREERIEQY TFIYIDKQPE
410 420 430 440 450
EALSQAKKSV ASKTEVKKTR RPRSVLNTQP EQTNAGEVAS SLSSTEIRRH
460 470 480 490 500
SQRRHTSAEE EEPPPVKIAW KTAAARKSLP ASITMHKGSL DLQKCNMSPV
510 520 530 540 550
VKIEQVFALQ NATGDGKFID QFVYSTKGIG NKTEISVRGQ DRLIISTPNQ
560 570 580 590 600
RNEKPTQSVS SPEATSGSTG SVEKKQQRRS IRTRSESEKS TEVVPKKKIK
610 620 630 640 650
KEQVETVPQA TVKTGLQKGA SEISDSCKPL KKRSRASTDV EMTSSAYRDT
660 670 680 690 700
SDSDSRGLSD LQVGFGKQVD SPSATADADV SDVQSMDSSL SRRGTGMSKK
710 720 730 740 750
DTVCQICESS GDSLIPCEGE CCKHFHLECL GLASLPDSKF ICMECKTGQH
760 770 780 790 800
PCFSCKVSGK DVKRCSVGAC GKFYHEACVR KFPTAIFESK GFRCPQHCCS
810 820 830 840 850
ACSMEKDIHK ASKGRMMRCL RCPVAYHSGD ACIAAGSMLV SSYILICSNH
860 870 880 890 900
SKRSSNSSAV NVGFCFVCAR GLIVQDHSDP MFSSYAYKSH YLLNESNRAE
910 920 930 940 950
LMKLPMIPSS SASKKKCEKG GRLLCCESCP ASFHPECLSI EMPEGCWNCN
960 970 980 990 1000
DCKAGKKLHY KQIVWVKLGN YRWWPAEICN PRSVPLNIQG LKHDLGDFPV
1010 1020 1030 1040 1050
FFFGSHDYYW VHQGRVFPYV EGDKSFAEGQ TSINKTFKKA LEEAAKRFQE
1060 1070 1080 1090 1100
LKAQRESKEA LEIEKNSRKP PPYKHIKANK VIGKVQIQVA DLSEIPRCNC
1110 1120 1130 1140 1150
KPADENPCGL ESECLNRMLQ YECHPQVCPA GDRCQNQCFT KRLYPDAEII
1160 1170 1180 1190 1200
KTERRGWGLR TKRSIKKGEF VNEYVGELID EEECRLRIKR AHENSVTNFY
1210 1220 1230 1240 1250
MLTVTKDRII DAGPKGNYSR FMNHSCNPNC ETQKWTVNGD VRVGLFALCD
1260 1270 1280 1290 1300
IPAGMELTFN YNLDCLGNGR TECHCGADNC SGFLGVRPKS ACASTNEEKA
1310 1320 1330 1340 1350
KNAKLKQKRR KIKTEPKQMH EDYCFQCGDG GELVMCDKKD CPKAYHLLCL
1360 1370 1380 1390 1400
NLTQPPYGKW ECPWHQCDEC SSAAVSFCEF CPHSFCKDHE KGALVPSALE
1410 1420 1430
GRLCCSEHDP MAPVSPEYWS KIKCKWESQD HGEEVKE
Length:1,437
Mass (Da):161,613
Last modified:June 1, 2001 - v1
Checksum:i87E54997A996F7CC
GO
Isoform 2 (identifier: Q9BZ95-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     871-919: Missing.

Show »
Length:1,388
Mass (Da):156,070
Checksum:i0832BD51DAB0DCFF
GO
Isoform 3 (identifier: Q9BZ95-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     620-645: ASEISDSCKPLKKRSRASTDVEMTSS → SADRGVQGSVRFSDSSVSAAIEETVD
     646-1437: Missing.

Show »
Length:645
Mass (Da):72,621
Checksum:iDE98E24AB088AC91
GO
Isoform 4 (identifier: Q9BZ95-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     67-129: Missing.

Note: No experimental confirmation available.
Show »
Length:1,374
Mass (Da):154,519
Checksum:i3013E618C16E19E0
GO
Isoform 5 (identifier: Q9BZ95-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1196-1206: Missing.

Note: No experimental confirmation available.
Show »
Length:1,426
Mass (Da):160,314
Checksum:i9CB22AD6F0A765A7
GO

Sequence cautioni

The sequence AAG44637 differs from that shown. Reason: Frameshift at several positions.Curated
The sequence AAI07735 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence BAA91110 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti436G → R in AAI15007 (PubMed:15489334).Curated1
Sequence conflicti578R → G in AAI15007 (PubMed:15489334).Curated1
Sequence conflicti829G → E in CAC28350 (PubMed:11374904).Curated1
Sequence conflicti829G → E in CAC28351 (PubMed:11374904).Curated1
Sequence conflicti926C → R in AAI15007 (PubMed:15489334).Curated1
Sequence conflicti1308K → R in AAI15007 (PubMed:15489334).Curated1
Sequence conflicti1430D → G in AAI15007 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_061215186T → M.Corresponds to variant rs13034dbSNPEnsembl.1
Natural variantiVAR_028950383R → P.Corresponds to variant rs2234552dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_02142767 – 129Missing in isoform 4. 1 PublicationAdd BLAST63
Alternative sequenceiVSP_021428620 – 645ASEIS…EMTSS → SADRGVQGSVRFSDSSVSAA IEETVD in isoform 3. 5 PublicationsAdd BLAST26
Alternative sequenceiVSP_021429646 – 1437Missing in isoform 3. 5 PublicationsAdd BLAST792
Alternative sequenceiVSP_021430871 – 919Missing in isoform 2. 1 PublicationAdd BLAST49
Alternative sequenceiVSP_0544891196 – 1206Missing in isoform 5. 1 PublicationAdd BLAST11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF332468 mRNA. Translation: AAK00354.1.
AF332469 mRNA. Translation: AAK00355.1.
AJ295990 mRNA. Translation: CAC28350.1.
AJ295991 mRNA. Translation: CAC28351.1.
AJ295992 mRNA. Translation: CAC28352.1.
AF255649 mRNA. Translation: AAG44637.1. Frameshift.
AK000360 mRNA. Translation: BAA91110.1. Different initiation.
AK022560 mRNA. Translation: BAB14099.1.
AK127594 mRNA. No translation available.
CH471080 Genomic DNA. Translation: EAW63320.1.
CH471080 Genomic DNA. Translation: EAW63321.1.
BC012059 mRNA. Translation: AAH12059.1.
BC062631 mRNA. Translation: AAH62631.1.
BC101717 mRNA. Translation: AAI01718.1.
BC107734 mRNA. Translation: AAI07735.1. Sequence problems.
BC113469 mRNA. Translation: AAI13470.1.
BC115006 mRNA. Translation: AAI15007.1.
BC143510 mRNA. Translation: AAI43511.1.
AC087362 Genomic DNA. No translation available.
AC087623 Genomic DNA. No translation available.
CCDSiCCDS43729.1. [Q9BZ95-1]
CCDS6105.1. [Q9BZ95-3]
RefSeqiNP_060248.2. NM_017778.2. [Q9BZ95-3]
NP_075447.1. NM_023034.1. [Q9BZ95-1]
UniGeneiHs.434966.
Hs.608111.
Hs.655314.

Genome annotation databases

EnsembliENST00000316985; ENSP00000313410; ENSG00000147548. [Q9BZ95-3]
ENST00000317025; ENSP00000313983; ENSG00000147548. [Q9BZ95-1]
ENST00000433384; ENSP00000393284; ENSG00000147548. [Q9BZ95-2]
ENST00000527502; ENSP00000434730; ENSG00000147548. [Q9BZ95-5]
GeneIDi54904.
KEGGihsa:54904.
UCSCiuc003xli.4. human. [Q9BZ95-1]

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement, Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF332468 mRNA. Translation: AAK00354.1.
AF332469 mRNA. Translation: AAK00355.1.
AJ295990 mRNA. Translation: CAC28350.1.
AJ295991 mRNA. Translation: CAC28351.1.
AJ295992 mRNA. Translation: CAC28352.1.
AF255649 mRNA. Translation: AAG44637.1. Frameshift.
AK000360 mRNA. Translation: BAA91110.1. Different initiation.
AK022560 mRNA. Translation: BAB14099.1.
AK127594 mRNA. No translation available.
CH471080 Genomic DNA. Translation: EAW63320.1.
CH471080 Genomic DNA. Translation: EAW63321.1.
BC012059 mRNA. Translation: AAH12059.1.
BC062631 mRNA. Translation: AAH62631.1.
BC101717 mRNA. Translation: AAI01718.1.
BC107734 mRNA. Translation: AAI07735.1. Sequence problems.
BC113469 mRNA. Translation: AAI13470.1.
BC115006 mRNA. Translation: AAI15007.1.
BC143510 mRNA. Translation: AAI43511.1.
AC087362 Genomic DNA. No translation available.
AC087623 Genomic DNA. No translation available.
CCDSiCCDS43729.1. [Q9BZ95-1]
CCDS6105.1. [Q9BZ95-3]
RefSeqiNP_060248.2. NM_017778.2. [Q9BZ95-3]
NP_075447.1. NM_023034.1. [Q9BZ95-1]
UniGeneiHs.434966.
Hs.608111.
Hs.655314.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DAQNMR-A957-1053[»]
2NCZNMR-B152-163[»]
2ND1NMR-B593-605[»]
4GNDX-ray2.27A/C1310-1413[»]
4GNEX-ray1.47A1310-1413[»]
4GNFX-ray1.55A1310-1413[»]
4GNGX-ray1.73A/D1310-1413[»]
4RXJX-ray2.10A953-1064[»]
4YZ8X-ray1.80A1054-1285[»]
ProteinModelPortaliQ9BZ95.
SMRiQ9BZ95.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120250. 53 interactors.
IntActiQ9BZ95. 36 interactors.
MINTiMINT-4830664.
STRINGi9606.ENSP00000313983.

Chemistry databases

ChEMBLiCHEMBL3108646.

PTM databases

iPTMnetiQ9BZ95.
PhosphoSitePlusiQ9BZ95.

Polymorphism and mutation databases

BioMutaiWHSC1L1.
DMDMi74761342.

Proteomic databases

EPDiQ9BZ95.
MaxQBiQ9BZ95.
PaxDbiQ9BZ95.
PeptideAtlasiQ9BZ95.
PRIDEiQ9BZ95.

Protocols and materials databases

DNASUi54904.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000316985; ENSP00000313410; ENSG00000147548. [Q9BZ95-3]
ENST00000317025; ENSP00000313983; ENSG00000147548. [Q9BZ95-1]
ENST00000433384; ENSP00000393284; ENSG00000147548. [Q9BZ95-2]
ENST00000527502; ENSP00000434730; ENSG00000147548. [Q9BZ95-5]
GeneIDi54904.
KEGGihsa:54904.
UCSCiuc003xli.4. human. [Q9BZ95-1]

Organism-specific databases

CTDi54904.
DisGeNETi54904.
GeneCardsiWHSC1L1.
HGNCiHGNC:12767. WHSC1L1.
HPAiCAB013721.
HPA005659.
HPA018893.
MalaCardsiWHSC1L1.
MIMi607083. gene.
neXtProtiNX_Q9BZ95.
OpenTargetsiENSG00000147548.
PharmGKBiPA37370.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1081. Eukaryota.
COG2940. LUCA.
GeneTreeiENSGT00780000121845.
HOVERGENiHBG079979.
InParanoidiQ9BZ95.
KOiK11425.
OMAiMEKDIHK.
OrthoDBiEOG091G00XD.
PhylomeDBiQ9BZ95.
TreeFamiTF329088.

Enzyme and pathway databases

BioCyciZFISH:HS07446-MONOMER.
ReactomeiR-HSA-3214841. PKMTs methylate histone lysines.

Miscellaneous databases

ChiTaRSiWHSC1L1. human.
EvolutionaryTraceiQ9BZ95.
GeneWikiiWHSC1L1.
GenomeRNAii54904.
PROiQ9BZ95.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000147548.
ExpressionAtlasiQ9BZ95. baseline and differential.
GenevisibleiQ9BZ95. HS.

Family and domain databases

Gene3Di3.30.40.10. 3 hits.
InterProiIPR006560. AWS_dom.
IPR003616. Post-SET_dom.
IPR000313. PWWP_dom.
IPR001214. SET_dom.
IPR019786. Zinc_finger_PHD-type_CS.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF00855. PWWP. 2 hits.
PF00856. SET. 1 hit.
[Graphical view]
SMARTiSM00570. AWS. 1 hit.
SM00249. PHD. 5 hits.
SM00508. PostSET. 1 hit.
SM00293. PWWP. 2 hits.
SM00317. SET. 1 hit.
[Graphical view]
SUPFAMiSSF57903. SSF57903. 3 hits.
PROSITEiPS51215. AWS. 1 hit.
PS50868. POST_SET. 1 hit.
PS50812. PWWP. 2 hits.
PS50280. SET. 1 hit.
PS01359. ZF_PHD_1. 1 hit.
PS50016. ZF_PHD_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNSD3_HUMAN
AccessioniPrimary (citable) accession number: Q9BZ95
Secondary accession number(s): B7ZL11
, D3DSX1, Q1RMD3, Q3B796, Q6ZSA5, Q9BYU8, Q9BYU9, Q9H2M8, Q9H9W9, Q9NXA6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: June 1, 2001
Last modified: November 2, 2016
This is version 151 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.