Reviewed, UniProtKB/Swiss-Prot Q9BZ81 (MAGB5_HUMAN)

Names and origin

Protein names

Recommended name:
    Melanoma-associated antigen B5
Alternative name(s):
    MAGE-B5 antigen
    Cancer/testis antigen 3.3
      Short name=CT3.3

Gene names

Name:

MAGEB5

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	275 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Tissue specificity	Expressed in testis. Not expressed in other normal tissues, but is expressed in tumors of different histological origins.
Sequence similarities	Contains 1 MAGE domain.

Ontologies

Keywords
Molecular function	Tumor antigen
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 275	275	Melanoma-associated antigen B5		PRO_0000156716
Regions
	Domain	40 – 239	200	MAGE

Sequences

	Sequence		Length	Mass (Da)
	Q9BZ81-1 [UniParc]. Last modified September 11, 2007. Version 2. Checksum: 57EDE75D76D07004	FASTA	275	31,906
	10 20 30 40 50 60 MTSAGVFNAG SDERANSRDE EYPCSSEVSP STESSCSNFI NIKVGLLEQF LLYKFKMKQR 70 80 90 100 110 120 ILKEDMLKIV NPRYQNQFAE IHRRASEHIE VVFAVDLKEV NPTCHLYDLV SKLKLPNNGR 130 140 150 160 170 180 IHVGKVLPKT GLLMTFLVVI FLKGNCANKE DTWKFLDMMQ IYDGKKYYIY GEPRKLITQD 190 200 210 220 230 240 FVRLTYLEYH QVPCSYPAHY QFLWGPRAYT ETSKMKVLEY LAKVNDIAPG AFSSQYEEAL 250 260 270 QDEEESPSQR CSRNWHYCSG QDCLRAKFSS FSQPY

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The DNA sequence of the human X chromosome." Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C. , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R. Nature 434:325-337(2005) [PubMed: 15772651] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"MAGE-B5, MAGE-B6, MAGE-C2, and MAGE-C3: four new members of the MAGE family with tumor-specific expression." Lucas S., De Plaen E., Boon T. Int. J. Cancer 87:55-60(2000) [PubMed: 10861452] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 125-235. Tissue: Blood.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF333705 Genomic DNA. Translation: AAK00357.1.
IPI	IPI00233074.
UniGene	Hs.224079
3D structure databases
ModBase	Search...
Genome annotation databases
Ensembl	ENSG00000188408. Homo sapiens. [Contig view]
Organism-specific databases
GeneCards	GC0XP026144.
H-InvDB	HIX0056572. HIX0056590.
HGNC	HGNC:23795. MAGEB5.
MIM	300466. gene.
PharmGKB	PA134913823.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	Q9BZ81.
HOVERGEN	Q9BZ81.
OMA	Q9BZ81. DERANSR.
Gene expression databases
ArrayExpress	Q9BZ81.
CleanEx	HS_MAGEB5.
Family and domain databases
InterPro	IPR002190. MAGE. [Graphical view]
PANTHER	PTHR11736. MAGE. 1 hit.
Pfam	PF01454. MAGE. 1 hit. [Graphical view]
PROSITE	PS50838. MAGE. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
SOURCE	Search...

Entry information

Entry name

MAGB5_HUMAN

Accession

Primary (citable) accession number: Q9BZ81

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 16, 2004
Last sequence update:	September 11, 2007
Last modified:	June 16, 2009
This is version 43 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)