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Protein

Melanoma-associated antigen B5

Gene

MAGEB5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Keywordsi

Molecular functionTumor antigen

Names & Taxonomyi

Protein namesi
Recommended name:
Melanoma-associated antigen B5
Alternative name(s):
Cancer/testis antigen 3.3
Short name:
CT3.3
MAGE-B5 antigen
Gene namesi
Name:MAGEB5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:23795. MAGEB5.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000188408.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001567161 – 275Melanoma-associated antigen B5Add BLAST275

Proteomic databases

PaxDbiQ9BZ81.
PeptideAtlasiQ9BZ81.
PRIDEiQ9BZ81.

PTM databases

iPTMnetiQ9BZ81.
PhosphoSitePlusiQ9BZ81.

Expressioni

Tissue specificityi

Expressed in testis. Not expressed in other normal tissues, but is expressed in tumors of different histological origins.

Gene expression databases

CleanExiHS_MAGEB5.

Organism-specific databases

HPAiHPA052627.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000368315.

Structurei

3D structure databases

ProteinModelPortaliQ9BZ81.
SMRiQ9BZ81.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini40 – 239MAGEPROSITE-ProRule annotationAdd BLAST200

Phylogenomic databases

eggNOGiKOG4562. Eukaryota.
ENOG4111S70. LUCA.
GeneTreeiENSGT00760000118824.
HOGENOMiHOG000231161.
HOVERGENiHBG006315.
InParanoidiQ9BZ81.
OMAiNCANKED.
OrthoDBiEOG091G0TJ0.
PhylomeDBiQ9BZ81.
TreeFamiTF328505.

Family and domain databases

InterProiView protein in InterPro
IPR030085. MAGEB5.
IPR002190. MHD_dom.
PANTHERiPTHR11736:SF103. PTHR11736:SF103. 1 hit.
PfamiView protein in Pfam
PF01454. MAGE. 1 hit.
SMARTiView protein in SMART
SM01373. MAGE. 1 hit.
PROSITEiView protein in PROSITE
PS50838. MAGE. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9BZ81-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSAGVFNAG SDERANSRDE EYPCSSEVSP STESSCSNFI NIKVGLLEQF
60 70 80 90 100
LLYKFKMKQR ILKEDMLKIV NPRYQNQFAE IHRRASEHIE VVFAVDLKEV
110 120 130 140 150
NPTCHLYDLV SKLKLPNNGR IHVGKVLPKT GLLMTFLVVI FLKGNCANKE
160 170 180 190 200
DTWKFLDMMQ IYDGKKYYIY GEPRKLITQD FVRLTYLEYH QVPCSYPAHY
210 220 230 240 250
QFLWGPRAYT ETSKMKVLEY LAKVNDIAPG AFSSQYEEAL QDEEESPSQR
260 270
CSRNWHYCSG QDCLRAKFSS FSQPY
Length:275
Mass (Da):31,906
Last modified:September 11, 2007 - v2
Checksum:i57EDE75D76D07004
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF333705 Genomic DNA. Translation: AAK00357.1.
CCDSiCCDS65233.1.
RefSeqiNP_001258681.1. NM_001271752.1.
UniGeneiHs.224079.

Genome annotation databases

EnsembliENST00000602297; ENSP00000473493; ENSG00000188408.
GeneIDi347541.
KEGGihsa:347541.
UCSCiuc031thc.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF333705 Genomic DNA. Translation: AAK00357.1.
CCDSiCCDS65233.1.
RefSeqiNP_001258681.1. NM_001271752.1.
UniGeneiHs.224079.

3D structure databases

ProteinModelPortaliQ9BZ81.
SMRiQ9BZ81.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000368315.

PTM databases

iPTMnetiQ9BZ81.
PhosphoSitePlusiQ9BZ81.

Proteomic databases

PaxDbiQ9BZ81.
PeptideAtlasiQ9BZ81.
PRIDEiQ9BZ81.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000602297; ENSP00000473493; ENSG00000188408.
GeneIDi347541.
KEGGihsa:347541.
UCSCiuc031thc.1. human.

Organism-specific databases

CTDi347541.
GeneCardsiMAGEB5.
HGNCiHGNC:23795. MAGEB5.
HPAiHPA052627.
MIMi300466. gene.
neXtProtiNX_Q9BZ81.
OpenTargetsiENSG00000188408.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4562. Eukaryota.
ENOG4111S70. LUCA.
GeneTreeiENSGT00760000118824.
HOGENOMiHOG000231161.
HOVERGENiHBG006315.
InParanoidiQ9BZ81.
OMAiNCANKED.
OrthoDBiEOG091G0TJ0.
PhylomeDBiQ9BZ81.
TreeFamiTF328505.

Miscellaneous databases

GenomeRNAii347541.
PROiPR:Q9BZ81.
SOURCEiSearch...

Gene expression databases

CleanExiHS_MAGEB5.

Family and domain databases

InterProiView protein in InterPro
IPR030085. MAGEB5.
IPR002190. MHD_dom.
PANTHERiPTHR11736:SF103. PTHR11736:SF103. 1 hit.
PfamiView protein in Pfam
PF01454. MAGE. 1 hit.
SMARTiView protein in SMART
SM01373. MAGE. 1 hit.
PROSITEiView protein in PROSITE
PS50838. MAGE. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMAGB5_HUMAN
AccessioniPrimary (citable) accession number: Q9BZ81
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: September 11, 2007
Last modified: March 15, 2017
This is version 104 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.