Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Contactin-associated protein-like 3

Gene

CNTNAP3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Biological processi

  • cell adhesion Source: UniProtKB-KW
  • cell recognition Source: UniProtKB

Keywordsi

Biological processCell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Contactin-associated protein-like 3
Alternative name(s):
Cell recognition molecule Caspr3
Gene namesi
Name:CNTNAP3
Synonyms:CASPR3, KIAA1714
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000106714.17
HGNCiHGNC:13834 CNTNAP3
MIMi610517 gene
neXtProtiNX_Q9BZ76

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini26 – 1245ExtracellularSequence analysisAdd BLAST1220
Transmembranei1246 – 1266HelicalSequence analysisAdd BLAST21
Topological domaini1267 – 1288CytoplasmicSequence analysisAdd BLAST22

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000106714
PharmGKBiPA134963289

Polymorphism and mutation databases

BioMutaiCNTNAP3
DMDMi209572752

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000001950926 – 1288Contactin-associated protein-like 3Add BLAST1263

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi31 ↔ 177By similarity
Glycosylationi285N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi332 ↔ 364By similarity
Glycosylationi359N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi441N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi497N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi513 ↔ 545By similarity
Disulfide bondi551 ↔ 562By similarity
Disulfide bondi556 ↔ 571By similarity
Disulfide bondi573 ↔ 583By similarity
Glycosylationi623N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi706N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi931 ↔ 958By similarity
Disulfide bondi962 ↔ 975By similarity
Disulfide bondi969 ↔ 984By similarity
Disulfide bondi986 ↔ 996By similarity
Glycosylationi1023N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1073N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1120N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1167 ↔ 1203By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ9BZ76
PaxDbiQ9BZ76
PeptideAtlasiQ9BZ76
PRIDEiQ9BZ76

PTM databases

iPTMnetiQ9BZ76
PhosphoSitePlusiQ9BZ76

Expressioni

Gene expression databases

BgeeiENSG00000106714
CleanExiHS_CNTNAP3
ExpressionAtlasiQ9BZ76 baseline and differential
GenevisibleiQ9BZ76 HS

Organism-specific databases

HPAiHPA015604
HPA047731

Interactioni

Protein-protein interaction databases

BioGridi123011, 54 interactors
STRINGi9606.ENSP00000297668

Structurei

3D structure databases

ProteinModelPortaliQ9BZ76
SMRiQ9BZ76
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 177F5/8 type CPROSITE-ProRule annotationAdd BLAST147
Domaini183 – 364Laminin G-like 1PROSITE-ProRule annotationAdd BLAST182
Domaini370 – 545Laminin G-like 2PROSITE-ProRule annotationAdd BLAST176
Domaini551 – 583EGF-like 1PROSITE-ProRule annotationAdd BLAST33
Domaini584 – 792Fibrinogen C-terminalPROSITE-ProRule annotationAdd BLAST209
Domaini793 – 958Laminin G-like 3PROSITE-ProRule annotationAdd BLAST166
Domaini962 – 996EGF-like 2PROSITE-ProRule annotationAdd BLAST35
Domaini1015 – 1203Laminin G-like 4PROSITE-ProRule annotationAdd BLAST189

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi42 – 48Poly-Ser7

Sequence similaritiesi

Belongs to the neurexin family.Curated

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3516 Eukaryota
ENOG410XPHG LUCA
GeneTreeiENSGT00760000118991
HOGENOMiHOG000230964
HOVERGENiHBG057718
InParanoidiQ9BZ76
OMAiDHCQQEL
OrthoDBiEOG091G00LF
PhylomeDBiQ9BZ76
TreeFamiTF321823

Family and domain databases

Gene3Di2.60.120.260, 1 hit
InterProiView protein in InterPro
IPR028873 CASPR3
IPR013320 ConA-like_dom_sf
IPR000742 EGF-like_dom
IPR000421 FA58C
IPR036056 Fibrinogen-like_C
IPR002181 Fibrinogen_a/b/g_C_dom
IPR008979 Galactose-bd-like_sf
IPR001791 Laminin_G
PANTHERiPTHR43925:SF6 PTHR43925:SF6, 1 hit
PfamiView protein in Pfam
PF00754 F5_F8_type_C, 1 hit
PF02210 Laminin_G_2, 4 hits
SMARTiView protein in SMART
SM00181 EGF, 2 hits
SM00231 FA58C, 1 hit
SM00282 LamG, 4 hits
SUPFAMiSSF49785 SSF49785, 1 hit
SSF49899 SSF49899, 4 hits
SSF56496 SSF56496, 1 hit
PROSITEiView protein in PROSITE
PS50026 EGF_3, 2 hits
PS01285 FA58C_1, 1 hit
PS01286 FA58C_2, 1 hit
PS50022 FA58C_3, 1 hit
PS51406 FIBRINOGEN_C_2, 1 hit
PS50025 LAM_G_DOMAIN, 4 hits

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9BZ76-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASVAWAVLK VLLLLPTQTW SPVGAGNPPD CDAPLASALP RSSFSSSSEL
60 70 80 90 100
SSSHGPGFSR LNRRDGAGGW TPLVSNKYQW LQIDLGERME VTAVATQGGY
110 120 130 140 150
GSSDWVTSYL LMFSDGGRNW KQYRREESIW GFPGNTNADS VVHYRLQPPF
160 170 180 190 200
EARFLRFLPL AWNPRGRIGM RIEVYGCAYK SEVVYFDGQS ALLYRLDKKP
210 220 230 240 250
LKPIRDVISL KFKAMQSNGI LLHREGQHGN HITLELIKGK LVFFLNSGNA
260 270 280 290 300
KLPSTIAPVT LTLGSLLDDQ HWHSVLIELL DTQVNFTVDK HTHHFQAKGD
310 320 330 340 350
SSYLDLNFEI SFGGIPTPGR SRAFRRKSFH GCLENLYYNG VDVTELAKKH
360 370 380 390 400
KPQILMMGNV SFSCPQPQTV PVTFLSSRSY LALPGNSGED KVSVTFQFRT
410 420 430 440 450
WNRAGHLLFG ELRRGSGSFV LFLKDGKLKL SLFQPGQSPR NVTAGAGLND
460 470 480 490 500
GQWHSVSFSA KWSHMNVVVD DDTAVQPLVA VLIDSGDTYY FGGCLDNSSG
510 520 530 540 550
SGCKSPLGGF QGCLRLITIG DKAVDPILVQ QGALGSFRDL QIDSCGITDR
560 570 580 590 600
CLPSYCEHGG ECSQSWDTFS CDCLGTGYTG ETCHSSLYEQ SCEAHKHRGN
610 620 630 640 650
PSGLYYIDAD GSGPLGPFLV YCNMTADAAW TVVQHGGPDA VTLRGAPSGH
660 670 680 690 700
PRSAVSFAYA AGAGQLRSAV NLAERCEQRL ALRCGTARRP DSRDGTPLSW
710 720 730 740 750
WVGRTNETHT SWGGSLPDAQ KCTCGLEGNC IDSQYYCNCD AGRNEWTSDT
760 770 780 790 800
IVLSQKEHLP VTQIVMTDAG RPHSEAAYTL GPLLCRGDQS FWNSASFNTE
810 820 830 840 850
TSYLHFPAFH GELTADVCFF FKTTVSSGVF MENLGITDFI RIELRAPTEV
860 870 880 890 900
TFSFDVGNGP CEVTVQSPTP FNDNQWHHVR AERNVKGASL QVDQLPQKMQ
910 920 930 940 950
PAPADGHVRL QLNSQLFIGG TATRQRGFLG CIRSLQLNGV ALDLEERATV
960 970 980 990 1000
TPGVEPGCAG HCSTYGHLCR NGGRCREKRR GVTCDCAFSA YDGPFCSNEI
1010 1020 1030 1040 1050
SAYFATGSSM TYHFQEHYTL SENSSSLVSS LHRDVTLTRE MITLSFRTTR
1060 1070 1080 1090 1100
TPSLLLYVSS FYEEYLSVIL ANNGSLQIRY KLDRHQNPDA FTFDFKNMAD
1110 1120 1130 1140 1150
GQLHQVKINR EEAVVMVEVN QSTKKQVILS SGTEFNAVKS LILGKVLEAA
1160 1170 1180 1190 1200
GADPDTRRAA TSGFTGCLSA VRFGRAAPLK AALRPSGPSR VTVRGHVAPM
1210 1220 1230 1240 1250
ARCAAGAASG SPARELAPRL AGGAGRSGPA DEGEPLVNAD RRDSAVIGGV
1260 1270 1280
IAVVIFILLC ITAIAIRIYQ QRKLRKENES KVSKKEEC
Length:1,288
Mass (Da):140,690
Last modified:October 14, 2008 - v3
Checksum:iF41F1CE8A83D417E
GO
Isoform 2 (identifier: Q9BZ76-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1120-1127: NQSTKKQV → IPQMQKSN
     1128-1288: Missing.

Note: No experimental confirmation available.
Show »
Length:1,127
Mass (Da):124,116
Checksum:iCB24B889FE46BEB1
GO

Sequence cautioni

The sequence BAB21805 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti21S → R in AAG52889 (PubMed:12093160).Curated1
Sequence conflicti33A → S in AAG52889 (PubMed:12093160).Curated1
Sequence conflicti89M → I in AAG52889 (PubMed:12093160).Curated1
Sequence conflicti711S → Y in AAG52889 (PubMed:12093160).Curated1
Sequence conflicti711S → Y in BAB21805 (PubMed:11214970).Curated1
Sequence conflicti714G → V in BAB21805 (PubMed:11214970).Curated1
Sequence conflicti769 – 771AGR → TGQ in AAG52889 (PubMed:12093160).Curated3
Sequence conflicti777A → D in AAG52889 (PubMed:12093160).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_046710628A → S. Corresponds to variant dbSNP:rs1758272Ensembl.1
Natural variantiVAR_046711845R → H1 PublicationCorresponds to variant dbSNP:rs7852039Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0035351120 – 1127NQSTKKQV → IPQMQKSN in isoform 2. 1 Publication8
Alternative sequenceiVSP_0035361128 – 1288Missing in isoform 2. 1 PublicationAdd BLAST161

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF333769 mRNA Translation: AAG52889.2
AB051501 mRNA Translation: BAB21805.2 Different initiation.
AL162501 Genomic DNA No translation available.
AL353729 Genomic DNA No translation available.
CCDSiCCDS6616.1 [Q9BZ76-1]
RefSeqiNP_387504.2, NM_033655.3 [Q9BZ76-1]
UniGeneiHs.128474
Hs.521495
Hs.604441

Genome annotation databases

EnsembliENST00000297668; ENSP00000297668; ENSG00000106714 [Q9BZ76-1]
GeneIDi79937
KEGGihsa:79937
UCSCiuc004abi.4 human [Q9BZ76-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCNTP3_HUMAN
AccessioniPrimary (citable) accession number: Q9BZ76
Secondary accession number(s): B1AMA0, Q9C0E9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 5, 2001
Last sequence update: October 14, 2008
Last modified: May 23, 2018
This is version 161 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health