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Protein

FERM domain-containing protein 8

Gene

FRMD8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
FERM domain-containing protein 8
Gene namesi
Name:FRMD8
ORF Names:FKSG44
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:25462. FRMD8.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162388963.

Polymorphism and mutation databases

BioMutaiFRMD8.
DMDMi74733481.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 464464FERM domain-containing protein 8PRO_0000295778Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineCombined sources
Modified residuei24 – 241PhosphoserineBy similarity
Modified residuei383 – 3831PhosphoserineCombined sources
Modified residuei387 – 3871PhosphoserineCombined sources
Modified residuei408 – 4081PhosphoserineCombined sources
Modified residuei419 – 4191PhosphothreonineBy similarity
Modified residuei439 – 4391PhosphoserineCombined sources
Modified residuei446 – 4461PhosphoserineCombined sources

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9BZ67.
MaxQBiQ9BZ67.
PaxDbiQ9BZ67.
PRIDEiQ9BZ67.

PTM databases

iPTMnetiQ9BZ67.
PhosphoSiteiQ9BZ67.

Expressioni

Gene expression databases

BgeeiQ9BZ67.
CleanExiHS_FRMD8.
ExpressionAtlasiQ9BZ67. baseline and differential.
GenevisibleiQ9BZ67. HS.

Organism-specific databases

HPAiHPA002861.
HPA005506.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
GRAMD3Q96HH93EBI-5773072,EBI-2832937
PLEKHF2Q9H8W43EBI-5773072,EBI-742388

Protein-protein interaction databases

BioGridi123761. 7 interactions.
IntActiQ9BZ67. 4 interactions.
STRINGi9606.ENSP00000319726.

Structurei

3D structure databases

ProteinModelPortaliQ9BZ67.
SMRiQ9BZ67. Positions 59-322.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini30 – 376347FERMPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 FERM domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG4335. Eukaryota.
ENOG410ZV6V. LUCA.
GeneTreeiENSGT00530000063721.
HOGENOMiHOG000285969.
HOVERGENiHBG104171.
InParanoidiQ9BZ67.
OMAiAFFHGEV.
OrthoDBiEOG79PJP6.
PhylomeDBiQ9BZ67.
TreeFamiTF317921.

Family and domain databases

Gene3Di1.20.80.10. 1 hit.
InterProiIPR019749. Band_41_domain.
IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
IPR019748. FERM_central.
IPR000299. FERM_domain.
[Graphical view]
PfamiPF00373. FERM_M. 1 hit.
[Graphical view]
SMARTiSM00295. B41. 1 hit.
[Graphical view]
SUPFAMiSSF47031. SSF47031. 1 hit.
PROSITEiPS50057. FERM_3. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9BZ67-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDGTEGSAGQ PGPAERSHRS SVSSVGARAA DVLVYLADDT VVPLAVENLP
60 70 80 90 100
SLSAHELHRA VREVLQLPDI ALDVFALWLV SPLLEVQLKP KHQPYKLGRQ
110 120 130 140 150
WPELLLRFTS APDDDVAMDE PFLQFRRNVF FPKRRELQIH DEEVLRLLYE
160 170 180 190 200
EAKGNVLAAR YPCDVEDCEA LGALVCRVQL GPYQPGRPAA CDLREKLDSF
210 220 230 240 250
LPAHLCKRGQ SLFAALRGRG ARAGPGEQGL LNAYRQVQEV SSDGGCEAAL
260 270 280 290 300
GTHYRAYLLK CHELPFYGCA FFHGEVDKPA QGFLHRGGRK PVSVAISLEG
310 320 330 340 350
VHVIDSREKH VLLGLRFQEL SWDHTSPEEE EPILWLEFDG DSEGTPVNKL
360 370 380 390 400
LKIYSKQAEL MSSLIEYCIE LSQAAEPAGP QDSATGSPSD PSSSLAPVQR
410 420 430 440 450
PKLRRQGSVV SSRIQHLSTI DYVEDGKGIR RVKPKRTTSF FSRQLSLGQG
460
SYTVVQPGDS LEQG
Length:464
Mass (Da):51,218
Last modified:June 1, 2001 - v1
Checksum:i1F880DFCA5C12D7A
GO
Isoform 2 (identifier: Q9BZ67-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     29-84: Missing.

Note: No experimental confirmation available.
Show »
Length:408
Mass (Da):45,134
Checksum:iB48B3053C3625769
GO
Isoform 3 (identifier: Q9BZ67-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     85-118: Missing.

Note: No experimental confirmation available.
Show »
Length:430
Mass (Da):47,228
Checksum:i076AD7F0718DC1BC
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti198 – 1981D → N in AAH51695 (PubMed:15489334).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei29 – 8456Missing in isoform 2. 1 PublicationVSP_027085Add
BLAST
Alternative sequencei85 – 11834Missing in isoform 3. 1 PublicationVSP_056059Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF334946 mRNA. Translation: AAG50295.1.
AK074850 mRNA. Translation: BAC11244.1.
AK304363 mRNA. Translation: BAG65203.1.
AP000944 Genomic DNA. No translation available.
BC044658 mRNA. Translation: AAH44658.1.
BC051695 mRNA. Translation: AAH51695.1.
CCDSiCCDS73320.1. [Q9BZ67-3]
CCDS76432.1. [Q9BZ67-2]
CCDS8102.1. [Q9BZ67-1]
RefSeqiNP_001287761.1. NM_001300832.1. [Q9BZ67-2]
NP_001287762.1. NM_001300833.1. [Q9BZ67-3]
NP_114110.1. NM_031904.3. [Q9BZ67-1]
UniGeneiHs.578433.

Genome annotation databases

EnsembliENST00000317568; ENSP00000319726; ENSG00000126391. [Q9BZ67-1]
ENST00000355991; ENSP00000348270; ENSG00000126391. [Q9BZ67-2]
ENST00000416776; ENSP00000392111; ENSG00000126391. [Q9BZ67-3]
GeneIDi83786.
KEGGihsa:83786.
UCSCiuc001odu.5. human. [Q9BZ67-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF334946 mRNA. Translation: AAG50295.1.
AK074850 mRNA. Translation: BAC11244.1.
AK304363 mRNA. Translation: BAG65203.1.
AP000944 Genomic DNA. No translation available.
BC044658 mRNA. Translation: AAH44658.1.
BC051695 mRNA. Translation: AAH51695.1.
CCDSiCCDS73320.1. [Q9BZ67-3]
CCDS76432.1. [Q9BZ67-2]
CCDS8102.1. [Q9BZ67-1]
RefSeqiNP_001287761.1. NM_001300832.1. [Q9BZ67-2]
NP_001287762.1. NM_001300833.1. [Q9BZ67-3]
NP_114110.1. NM_031904.3. [Q9BZ67-1]
UniGeneiHs.578433.

3D structure databases

ProteinModelPortaliQ9BZ67.
SMRiQ9BZ67. Positions 59-322.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123761. 7 interactions.
IntActiQ9BZ67. 4 interactions.
STRINGi9606.ENSP00000319726.

PTM databases

iPTMnetiQ9BZ67.
PhosphoSiteiQ9BZ67.

Polymorphism and mutation databases

BioMutaiFRMD8.
DMDMi74733481.

Proteomic databases

EPDiQ9BZ67.
MaxQBiQ9BZ67.
PaxDbiQ9BZ67.
PRIDEiQ9BZ67.

Protocols and materials databases

DNASUi83786.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000317568; ENSP00000319726; ENSG00000126391. [Q9BZ67-1]
ENST00000355991; ENSP00000348270; ENSG00000126391. [Q9BZ67-2]
ENST00000416776; ENSP00000392111; ENSG00000126391. [Q9BZ67-3]
GeneIDi83786.
KEGGihsa:83786.
UCSCiuc001odu.5. human. [Q9BZ67-1]

Organism-specific databases

CTDi83786.
GeneCardsiFRMD8.
H-InvDBHIX0056170.
HGNCiHGNC:25462. FRMD8.
HPAiHPA002861.
HPA005506.
neXtProtiNX_Q9BZ67.
PharmGKBiPA162388963.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4335. Eukaryota.
ENOG410ZV6V. LUCA.
GeneTreeiENSGT00530000063721.
HOGENOMiHOG000285969.
HOVERGENiHBG104171.
InParanoidiQ9BZ67.
OMAiAFFHGEV.
OrthoDBiEOG79PJP6.
PhylomeDBiQ9BZ67.
TreeFamiTF317921.

Miscellaneous databases

ChiTaRSiFRMD8. human.
GenomeRNAii83786.
NextBioi35477330.
PROiQ9BZ67.

Gene expression databases

BgeeiQ9BZ67.
CleanExiHS_FRMD8.
ExpressionAtlasiQ9BZ67. baseline and differential.
GenevisibleiQ9BZ67. HS.

Family and domain databases

Gene3Di1.20.80.10. 1 hit.
InterProiIPR019749. Band_41_domain.
IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
IPR019748. FERM_central.
IPR000299. FERM_domain.
[Graphical view]
PfamiPF00373. FERM_M. 1 hit.
[Graphical view]
SMARTiSM00295. B41. 1 hit.
[Graphical view]
SUPFAMiSSF47031. SSF47031. 1 hit.
PROSITEiPS50057. FERM_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of FKSG44, a novel gene located on human chromosome 11q13."
    Wang Y.-G., Gong L.
    Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
    Tissue: Trachea.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Colon and Testis.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-439, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  6. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-446, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-383; SER-387 AND SER-408, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiFRMD8_HUMAN
AccessioniPrimary (citable) accession number: Q9BZ67
Secondary accession number(s): B4E2P1, Q86V56, Q8NCB5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: June 1, 2001
Last modified: March 16, 2016
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.