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Q9BZ29

- DOCK9_HUMAN

UniProt

Q9BZ29 - DOCK9_HUMAN

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Protein
Dedicator of cytokinesis protein 9
Gene
DOCK9, KIAA1058
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP. Overexpression induces filopodia formation.2 Publications

GO - Molecular functioni

  1. Rho guanyl-nucleotide exchange factor activity Source: Ensembl
  2. protein binding Source: IntAct
Complete GO annotation...

GO - Biological processi

  1. blood coagulation Source: Reactome
  2. small GTPase mediated signal transduction Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Guanine-nucleotide releasing factor

Enzyme and pathway databases

ReactomeiREACT_24970. Factors involved in megakaryocyte development and platelet production.

Names & Taxonomyi

Protein namesi
Recommended name:
Dedicator of cytokinesis protein 9
Alternative name(s):
Cdc42 guanine nucleotide exchange factor zizimin-1
Gene namesi
Name:DOCK9
Synonyms:KIAA1058
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 13

Organism-specific databases

HGNCiHGNC:14132. DOCK9.

Subcellular locationi

Endomembrane system Inferred
Note: Associated with membranes Inferred.

GO - Cellular componenti

  1. cytosol Source: Reactome
  2. endomembrane system Source: UniProtKB-SubCell
  3. membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134877754.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 20692069Dedicator of cytokinesis protein 9
PRO_0000189999Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei21 – 211Phosphoserine1 Publication
Modified residuei1235 – 12351Phosphoserine1 Publication
Modified residuei1241 – 12411Phosphothreonine2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9BZ29.
PaxDbiQ9BZ29.
PRIDEiQ9BZ29.

PTM databases

PhosphoSiteiQ9BZ29.

Expressioni

Tissue specificityi

Widely expressed, with highest expression in heart and placenta. Expressed at intermediate level in kidney, brain, lung and skeletal muscle.1 Publication

Gene expression databases

ArrayExpressiQ9BZ29.
BgeeiQ9BZ29.
GenevestigatoriQ9BZ29.

Organism-specific databases

HPAiCAB034061.

Interactioni

Subunit structurei

Homodimer Inferred. Interacts preferentially with nucleotide-depleted CDC42.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
NEBP209292EBI-2695893,EBI-1049657
SMAD2Q157963EBI-2695893,EBI-1040141
SMAD3P840223EBI-2695893,EBI-347161

Protein-protein interaction databases

BioGridi116930. 7 interactions.
IntActiQ9BZ29. 13 interactions.
MINTiMINT-4657670.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi178 – 1836
Helixi190 – 1945
Beta strandi198 – 2069
Beta strandi208 – 2103
Beta strandi212 – 2209
Beta strandi227 – 2304
Turni232 – 2343
Beta strandi248 – 2525
Beta strandi254 – 2563
Beta strandi258 – 2625
Helixi266 – 29126
Helixi1610 – 162819
Helixi1631 – 165121
Beta strandi1677 – 16793
Helixi1682 – 16854
Turni1686 – 16883
Helixi1690 – 16956
Beta strandi1708 – 17103
Helixi1711 – 172717
Helixi1731 – 17333
Helixi1734 – 17385
Turni1739 – 17413
Helixi1742 – 17476
Helixi1751 – 177424
Beta strandi1781 – 17888
Helixi1804 – 18074
Helixi1808 – 18103
Beta strandi1814 – 18207
Helixi1825 – 184016
Helixi1842 – 18443
Beta strandi1845 – 18484
Helixi1856 – 18583
Beta strandi1863 – 187311
Helixi1877 – 18826
Helixi1887 – 18893
Beta strandi1890 – 190213
Beta strandi1904 – 19096
Turni1912 – 19143
Beta strandi1916 – 192914
Beta strandi1931 – 194515
Helixi1947 – 196721
Helixi1973 – 198412
Beta strandi1987 – 19893
Helixi1993 – 19997
Helixi2013 – 203725
Turni2041 – 20433
Helixi2044 – 206421

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1WG7NMR-A165-301[»]
2WM9X-ray2.20A1605-2067[»]
2WMNX-ray2.39A1605-2067[»]
2WMOX-ray2.20A1605-2067[»]
ProteinModelPortaliQ9BZ29.
SMRiQ9BZ29. Positions 171-307, 1609-2068.

Miscellaneous databases

EvolutionaryTraceiQ9BZ29.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini174 – 281108PH
Add
BLAST
Domaini640 – 818179DHR-1
Add
BLAST
Domaini1605 – 2069465DHR-2
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni75 – 13561Interaction with activated CDC42 By similarity
Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili1948 – 198235 Reviewed prediction
Add
BLAST
Coiled coili2034 – 206734 Reviewed prediction
Add
BLAST

Domaini

The DHR-2 domain is necessary and sufficient for the GEF activity.

Sequence similaritiesi

Belongs to the DOCK family.
Contains 1 DHR-1 domain.
Contains 1 DHR-2 domain.
Contains 1 PH domain.

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiNOG242127.
HOVERGENiHBG107819.
InParanoidiQ9BZ29.
OMAiHKDLFGA.
PhylomeDBiQ9BZ29.
TreeFamiTF313629.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR016024. ARM-type_fold.
IPR027007. DHR-1_domain.
IPR027357. DHR-2.
IPR026791. DOCK.
IPR010703. DOCK_C.
IPR021816. DOCK_C/D_N.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
[Graphical view]
PANTHERiPTHR23317. PTHR23317. 1 hit.
PfamiPF06920. Ded_cyto. 1 hit.
PF14429. DOCK-C2. 1 hit.
PF11878. DUF3398. 1 hit.
PF00169. PH. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 5 hits.
PROSITEiPS51650. DHR_1. 1 hit.
PS51651. DHR_2. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9BZ29-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MSQPPLLPAS AETRKFTRAL SKPGTAAELR QSVSEVVRGS VLLAKPKLIE     50
PLDYENVIVQ KKTQILNDCL REMLLFPYDD FQTAILRRQG RYICSTVPAK 100
AEEEAQSLFV TECIKTYNSD WHLVNYKYED YSGEFRQLPN KVVKLDKLPV 150
HVYEVDEEVD KDEDAASLGS QKGGITKHGW LYKGNMNSAI SVTMRSFKRR 200
FFHLIQLGDG SYNLNFYKDE KISKEPKGSI FLDSCMGVVQ NNKVRRFAFE 250
LKMQDKSSYL LAADSEVEME EWITILNKIL QLNFEAAMQE KRNGDSHEDD 300
EQSKLEGSGS GLDSYLPELA KSAREAEIKL KSESRVKLFY LDPDAQKLDF 350
SSAEPEVKSF EEKFGKRILV KCNDLSFNLQ CCVAENEEGP TTNVEPFFVT 400
LSLFDIKYNR KISADFHVDL NHFSVRQMLA TTSPALMNGS GQSPSVLKGI 450
LHEAAMQYPK QGIFSVTCPH PDIFLVARIE KVLQGSITHC AEPYMKSSDS 500
SKVAQKVLKN AKQACQRLGQ YRMPFAWAAR TLFKDASGNL DKNARFSAIY 550
RQDSNKLSND DMLKLLADFR KPEKMAKLPV ILGNLDITID NVSSDFPNYV 600
NSSYIPTKQF ETCSKTPITF EVEEFVPCIP KHTQPYTIYT NHLYVYPKYL 650
KYDSQKSFAK ARNIAICIEF KDSDEEDSQP LKCIYGRPGG PVFTRSAFAA 700
VLHHHQNPEF YDEIKIELPT QLHEKHHLLL TFFHVSCDNS SKGSTKKRDV 750
VETQVGYSWL PLLKDGRVVT SEQHIPVSAN LPSGYLGYQE LGMGRHYGPE 800
IKWVDGGKPL LKISTHLVST VYTQDQHLHN FFQYCQKTES GAQALGNELV 850
KYLKSLHAME GHVMIAFLPT ILNQLFRVLT RATQEEVAVN VTRVIIHVVA 900
QCHEEGLESH LRSYVKYAYK AEPYVASEYK TVHEELTKSM TTILKPSADF 950
LTSNKLLKYS WFFFDVLIKS MAQHLIENSK VKLLRNQRFP ASYHHAVETV 1000
VNMLMPHITQ KFRDNPEASK NANHSLAVFI KRCFTFMDRG FVFKQINNYI 1050
SCFAPGDPKT LFEYKFEFLR VVCNHEHYIP LNLPMPFGKG RIQRYQDLQL 1100
DYSLTDEFCR NHFLVGLLLR EVGTALQEFR EVRLIAISVL KNLLIKHSFD 1150
DRYASRSHQA RIATLYLPLF GLLIENVQRI NVRDVSPFPV NAGMTVKDES 1200
LALPAVNPLV TPQKGSTLDN SLHKDLLGAI SGIASPYTTS TPNINSVRNA 1250
DSRGSLISTD SGNSLPERNS EKSNSLDKHQ QSSTLGNSVV RCDKLDQSEI 1300
KSLLMCFLYI LKSMSDDALF TYWNKASTSE LMDFFTISEV CLHQFQYMGK 1350
RYIARTGMMH ARLQQLGSLD NSLTFNHSYG HSDADVLHQS LLEANIATEV 1400
CLTALDTLSL FTLAFKNQLL ADHGHNPLMK KVFDVYLCFL QKHQSETALK 1450
NVFTALRSLI YKFPSTFYEG RADMCAALCY EILKCCNSKL SSIRTEASQL 1500
LYFLMRNNFD YTGKKSFVRT HLQVIISVSQ LIADVVGIGG TRFQQSLSII 1550
NNCANSDRLI KHTSFSSDVK DLTKRIRTVL MATAQMKEHE NDPEMLVDLQ 1600
YSLAKSYAST PELRKTWLDS MARIHVKNGD LSEAAMCYVH VTALVAEYLT 1650
RKEAVQWEPP LLPHSHSACL RRSRGGVFRQ GCTAFRVITP NIDEEASMME 1700
DVGMQDVHFN EDVLMELLEQ CADGLWKAER YELIADIYKL IIPIYEKRRD 1750
FERLAHLYDT LHRAYSKVTE VMHSGRRLLG TYFRVAFFGQ AAQYQFTDSE 1800
TDVEGFFEDE DGKEYIYKEP KLTPLSEISQ RLLKLYSDKF GSENVKMIQD 1850
SGKVNPKDLD SKYAYIQVTH VIPFFDEKEL QERKTEFERS HNIRRFMFEM 1900
PFTQTGKRQG GVEEQCKRRT ILTAIHCFPY VKKRIPVMYQ HHTDLNPIEV 1950
AIDEMSKKVA ELRQLCSSAE VDMIKLQLKL QGSVSVQVNA GPLAYARAFL 2000
DDTNTKRYPD NKVKLLKEVF RQFVEACGQA LAVNERLIKE DQLEYQEEMK 2050
ANYREMAKEL SEIMHEQLG 2069
Length:2,069
Mass (Da):236,446
Last modified:October 19, 2002 - v2
Checksum:i95073CD751745AAE
GO
Isoform 2 (identifier: Q9BZ29-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-43: MSQPPLLPAS...SEVVRGSVLL → MQADKCRTSS...VEAESPGPVP

Show »
Length:2,068
Mass (Da):236,425
Checksum:iC2654DB8162F26F1
GO
Isoform 3 (identifier: Q9BZ29-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1355-1378: RTGMMHARLQQLGSLDNSLTFNHS → SVRKISSVLGISVDNG

Note: No experimental confirmation available.

Show »
Length:2,061
Mass (Da):235,361
Checksum:iDEB17F98C3573D68
GO
Isoform 4 (identifier: Q9BZ29-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1791-1804: Missing.
     2068-2069: LG → ICPLEEKTSVLPNSLHIFNAISGTPTSTMVHGMTSSSSVV

Note: Produced by exon skipping that results in a frameshift. No experimental confirmation available.

Show »
Length:2,093
Mass (Da):238,846
Checksum:iA540EC1EDDCFFDB5
GO
Isoform 5 (identifier: Q9BZ29-6) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-43: MSQPPLLPAS...SEVVRGSVLL → MQADKCRTSS...VEAESPGPVP
     1234-1254: ASPYTTSTPNINSVRNADSRG → GNAPCSCGLLSTITLKVSWSQ
     1255-2069: Missing.

Note: No experimental confirmation available.

Show »
Length:1,253
Mass (Da):142,650
Checksum:i7BA871F8ACA17693
GO

Sequence cautioni

The sequence BAA83010.2 differs from that shown. Reason: Erroneous initiation.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti455 – 4551A → T.
Corresponds to variant rs56010605 [ dbSNP | Ensembl ].
VAR_062000
Natural varianti1416 – 14161K → E.
Corresponds to variant rs16955934 [ dbSNP | Ensembl ].
VAR_053067

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 4343MSQPP…GSVLL → MQADKCRTSSRSVKKELVIE SPLQYKDAAQGEVEAESPGP VP in isoform 2 and isoform 5.
VSP_017128Add
BLAST
Alternative sequencei1234 – 125421ASPYT…ADSRG → GNAPCSCGLLSTITLKVSWS Q in isoform 5.
VSP_045683Add
BLAST
Alternative sequencei1255 – 2069815Missing in isoform 5.
VSP_045684Add
BLAST
Alternative sequencei1355 – 137824RTGMM…TFNHS → SVRKISSVLGISVDNG in isoform 3.
VSP_004024Add
BLAST
Alternative sequencei1791 – 180414Missing in isoform 4.
VSP_007709Add
BLAST
Alternative sequencei2068 – 20692LG → ICPLEEKTSVLPNSLHIFNA ISGTPTSTMVHGMTSSSSVV in isoform 4.
VSP_007710

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti170 – 1701S → P in BAG54337. 1 Publication
Sequence conflicti296 – 2961S → P in BAG54337. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF527605 mRNA. Translation: AAM90306.1.
AB028981 mRNA. Translation: BAA83010.2. Different initiation.
AK126492 mRNA. Translation: BAG54337.1.
AL139084, AL161420 Genomic DNA. Translation: CAI13370.1.
AL139084, AL161420, AL391122 Genomic DNA. Translation: CAI13372.1.
AL161420, AL139084 Genomic DNA. Translation: CAI39569.1.
AL161420 Genomic DNA. Translation: CAI39570.1.
AL161420, AL139084, AL391122 Genomic DNA. Translation: CAI39574.1.
AL161420 Genomic DNA. Translation: CAI39577.1.
AL391122, AL139084, AL161420 Genomic DNA. Translation: CAI11061.1.
BC043506 mRNA. Translation: AAH43506.1.
CCDSiCCDS45062.1. [Q9BZ29-5]
CCDS45063.1. [Q9BZ29-6]
RefSeqiNP_001123520.1. NM_001130048.1. [Q9BZ29-5]
NP_001123521.1. NM_001130049.1.
NP_001123522.1. NM_001130050.1. [Q9BZ29-6]
NP_056111.1. NM_015296.2. [Q9BZ29-1]
UniGeneiHs.596105.

Genome annotation databases

EnsembliENST00000339416; ENSP00000341086; ENSG00000088387. [Q9BZ29-4]
ENST00000376460; ENSP00000365643; ENSG00000088387. [Q9BZ29-5]
ENST00000442173; ENSP00000406883; ENSG00000088387. [Q9BZ29-6]
GeneIDi23348.
KEGGihsa:23348.
UCSCiuc001vnt.2. human. [Q9BZ29-1]
uc001vnw.2. human. [Q9BZ29-5]

Polymorphism databases

DMDMi24212635.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF527605 mRNA. Translation: AAM90306.1 .
AB028981 mRNA. Translation: BAA83010.2 . Different initiation.
AK126492 mRNA. Translation: BAG54337.1 .
AL139084 , AL161420 Genomic DNA. Translation: CAI13370.1 .
AL139084 , AL161420 , AL391122 Genomic DNA. Translation: CAI13372.1 .
AL161420 , AL139084 Genomic DNA. Translation: CAI39569.1 .
AL161420 Genomic DNA. Translation: CAI39570.1 .
AL161420 , AL139084 , AL391122 Genomic DNA. Translation: CAI39574.1 .
AL161420 Genomic DNA. Translation: CAI39577.1 .
AL391122 , AL139084 , AL161420 Genomic DNA. Translation: CAI11061.1 .
BC043506 mRNA. Translation: AAH43506.1 .
CCDSi CCDS45062.1. [Q9BZ29-5 ]
CCDS45063.1. [Q9BZ29-6 ]
RefSeqi NP_001123520.1. NM_001130048.1. [Q9BZ29-5 ]
NP_001123521.1. NM_001130049.1.
NP_001123522.1. NM_001130050.1. [Q9BZ29-6 ]
NP_056111.1. NM_015296.2. [Q9BZ29-1 ]
UniGenei Hs.596105.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1WG7 NMR - A 165-301 [» ]
2WM9 X-ray 2.20 A 1605-2067 [» ]
2WMN X-ray 2.39 A 1605-2067 [» ]
2WMO X-ray 2.20 A 1605-2067 [» ]
ProteinModelPortali Q9BZ29.
SMRi Q9BZ29. Positions 171-307, 1609-2068.
ModBasei Search...

Protein-protein interaction databases

BioGridi 116930. 7 interactions.
IntActi Q9BZ29. 13 interactions.
MINTi MINT-4657670.

PTM databases

PhosphoSitei Q9BZ29.

Polymorphism databases

DMDMi 24212635.

Proteomic databases

MaxQBi Q9BZ29.
PaxDbi Q9BZ29.
PRIDEi Q9BZ29.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000339416 ; ENSP00000341086 ; ENSG00000088387 . [Q9BZ29-4 ]
ENST00000376460 ; ENSP00000365643 ; ENSG00000088387 . [Q9BZ29-5 ]
ENST00000442173 ; ENSP00000406883 ; ENSG00000088387 . [Q9BZ29-6 ]
GeneIDi 23348.
KEGGi hsa:23348.
UCSCi uc001vnt.2. human. [Q9BZ29-1 ]
uc001vnw.2. human. [Q9BZ29-5 ]

Organism-specific databases

CTDi 23348.
GeneCardsi GC13M099445.
HGNCi HGNC:14132. DOCK9.
HPAi CAB034061.
MIMi 607325. gene.
neXtProti NX_Q9BZ29.
PharmGKBi PA134877754.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG242127.
HOVERGENi HBG107819.
InParanoidi Q9BZ29.
OMAi HKDLFGA.
PhylomeDBi Q9BZ29.
TreeFami TF313629.

Enzyme and pathway databases

Reactomei REACT_24970. Factors involved in megakaryocyte development and platelet production.

Miscellaneous databases

ChiTaRSi DOCK9. human.
EvolutionaryTracei Q9BZ29.
GeneWikii Dock9.
GenomeRNAii 23348.
NextBioi 45323.
PROi Q9BZ29.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9BZ29.
Bgeei Q9BZ29.
Genevestigatori Q9BZ29.

Family and domain databases

Gene3Di 2.30.29.30. 1 hit.
InterProi IPR016024. ARM-type_fold.
IPR027007. DHR-1_domain.
IPR027357. DHR-2.
IPR026791. DOCK.
IPR010703. DOCK_C.
IPR021816. DOCK_C/D_N.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
[Graphical view ]
PANTHERi PTHR23317. PTHR23317. 1 hit.
Pfami PF06920. Ded_cyto. 1 hit.
PF14429. DOCK-C2. 1 hit.
PF11878. DUF3398. 1 hit.
PF00169. PH. 1 hit.
[Graphical view ]
SMARTi SM00233. PH. 1 hit.
[Graphical view ]
SUPFAMi SSF48371. SSF48371. 5 hits.
PROSITEi PS51650. DHR_1. 1 hit.
PS51651. DHR_2. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Zizimin1, a novel Cdc42 activator, reveals a new GEF domain for Rho proteins."
    Meller N., Irani-Tehrani M., Kiosses W.B., Del Pozo M.A., Schwartz M.A.
    Nat. Cell Biol. 4:639-647(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE (ISOFORM 1), FUNCTION, INTERACTION WITH CDC42, GEF ACTIVITY, TISSUE SPECIFICITY.
  2. "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Kikuno R., Nagase T., Ishikawa K., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 6:197-205(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Brain.
  3. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
    Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
    DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: SEQUENCE REVISION.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5).
    Tissue: Uterus.
  5. "The DNA sequence and analysis of human chromosome 13."
    Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
    Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ISOFORMS 1; 2; 3 AND 4).
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1551-2069 (ISOFORM 4).
    Tissue: Eye.
  7. "Identification of an evolutionarily conserved superfamily of DOCK180-related proteins with guanine nucleotide exchange activity."
    Cote J.-F., Vuori K.
    J. Cell Sci. 115:4901-4913(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NOMENCLATURE, GEF ACTIVITY.
  8. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
    Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.
    Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1241, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-21, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1235 AND THR-1241, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  11. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  12. "Solution structure of pleckstrin homology domain from human KIAA1058 protein."
    RIKEN structural genomics initiative (RSGI)
    Submitted (NOV-2004) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 165-301.
  13. "Activation of Rho GTPases by DOCK exchange factors is mediated by a nucleotide sensor."
    Yang J., Zhang Z., Roe S.M., Marshall C.J., Barford D.
    Science 325:1398-1402(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 1605-2069 IN COMPLEX WITH CDC42, FUNCTION, SUBUNIT.

Entry informationi

Entry nameiDOCK9_HUMAN
AccessioniPrimary (citable) accession number: Q9BZ29
Secondary accession number(s): B3KX25
, E9PFM9, Q5JUD4, Q5JUD6, Q5T2Q1, Q5TAN8, Q9BZ25, Q9BZ26, Q9BZ27, Q9BZ28, Q9UPU4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: October 19, 2002
Last modified: September 3, 2014
This is version 123 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

'Zizim' means 'spike' in Hebrew.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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