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Q9BZ29

- DOCK9_HUMAN

UniProt

Q9BZ29 - DOCK9_HUMAN

Protein

Dedicator of cytokinesis protein 9

Gene

DOCK9

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 124 (01 Oct 2014)
      Sequence version 2 (19 Oct 2002)
      Previous versions | rss
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    Functioni

    Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP. Overexpression induces filopodia formation.2 Publications

    GO - Molecular functioni

    1. protein binding Source: IntAct
    2. Rho guanyl-nucleotide exchange factor activity Source: Ensembl

    GO - Biological processi

    1. blood coagulation Source: Reactome
    2. small GTPase mediated signal transduction Source: InterPro

    Keywords - Molecular functioni

    Guanine-nucleotide releasing factor

    Enzyme and pathway databases

    ReactomeiREACT_24970. Factors involved in megakaryocyte development and platelet production.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Dedicator of cytokinesis protein 9
    Alternative name(s):
    Cdc42 guanine nucleotide exchange factor zizimin-1
    Gene namesi
    Name:DOCK9
    Synonyms:KIAA1058
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 13

    Organism-specific databases

    HGNCiHGNC:14132. DOCK9.

    Subcellular locationi

    Endomembrane system Curated
    Note: Associated with membranes.Curated

    GO - Cellular componenti

    1. cytosol Source: Reactome
    2. endomembrane system Source: UniProtKB-SubCell
    3. membrane Source: UniProtKB

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134877754.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 20692069Dedicator of cytokinesis protein 9PRO_0000189999Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei21 – 211Phosphoserine1 Publication
    Modified residuei1235 – 12351Phosphoserine1 Publication
    Modified residuei1241 – 12411Phosphothreonine2 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ9BZ29.
    PaxDbiQ9BZ29.
    PRIDEiQ9BZ29.

    PTM databases

    PhosphoSiteiQ9BZ29.

    Expressioni

    Tissue specificityi

    Widely expressed, with highest expression in heart and placenta. Expressed at intermediate level in kidney, brain, lung and skeletal muscle.1 Publication

    Gene expression databases

    ArrayExpressiQ9BZ29.
    BgeeiQ9BZ29.
    GenevestigatoriQ9BZ29.

    Organism-specific databases

    HPAiCAB034061.

    Interactioni

    Subunit structurei

    Homodimer Probable. Interacts preferentially with nucleotide-depleted CDC42.2 PublicationsCurated

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    NEBP209292EBI-2695893,EBI-1049657
    SMAD2Q157963EBI-2695893,EBI-1040141
    SMAD3P840223EBI-2695893,EBI-347161

    Protein-protein interaction databases

    BioGridi116930. 7 interactions.
    IntActiQ9BZ29. 13 interactions.
    MINTiMINT-4657670.

    Structurei

    Secondary structure

    1
    2069
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi178 – 1836
    Helixi190 – 1945
    Beta strandi198 – 2069
    Beta strandi208 – 2103
    Beta strandi212 – 2209
    Beta strandi227 – 2304
    Turni232 – 2343
    Beta strandi248 – 2525
    Beta strandi254 – 2563
    Beta strandi258 – 2625
    Helixi266 – 29126
    Helixi1610 – 162819
    Helixi1631 – 165121
    Beta strandi1677 – 16793
    Helixi1682 – 16854
    Turni1686 – 16883
    Helixi1690 – 16956
    Beta strandi1708 – 17103
    Helixi1711 – 172717
    Helixi1731 – 17333
    Helixi1734 – 17385
    Turni1739 – 17413
    Helixi1742 – 17476
    Helixi1751 – 177424
    Beta strandi1781 – 17888
    Helixi1804 – 18074
    Helixi1808 – 18103
    Beta strandi1814 – 18207
    Helixi1825 – 184016
    Helixi1842 – 18443
    Beta strandi1845 – 18484
    Helixi1856 – 18583
    Beta strandi1863 – 187311
    Helixi1877 – 18826
    Helixi1887 – 18893
    Beta strandi1890 – 190213
    Beta strandi1904 – 19096
    Turni1912 – 19143
    Beta strandi1916 – 192914
    Beta strandi1931 – 194515
    Helixi1947 – 196721
    Helixi1973 – 198412
    Beta strandi1987 – 19893
    Helixi1993 – 19997
    Helixi2013 – 203725
    Turni2041 – 20433
    Helixi2044 – 206421

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1WG7NMR-A165-301[»]
    2WM9X-ray2.20A1605-2067[»]
    2WMNX-ray2.39A1605-2067[»]
    2WMOX-ray2.20A1605-2067[»]
    ProteinModelPortaliQ9BZ29.
    SMRiQ9BZ29. Positions 171-307, 1609-2068.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9BZ29.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini174 – 281108PHPROSITE-ProRule annotationAdd
    BLAST
    Domaini640 – 818179DHR-1Add
    BLAST
    Domaini1605 – 2069465DHR-2Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni75 – 13561Interaction with activated CDC42By similarityAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili1948 – 198235Sequence AnalysisAdd
    BLAST
    Coiled coili2034 – 206734Sequence AnalysisAdd
    BLAST

    Domaini

    The DHR-2 domain is necessary and sufficient for the GEF activity.

    Sequence similaritiesi

    Belongs to the DOCK family.Curated
    Contains 1 DHR-1 domain.Curated
    Contains 1 DHR-2 domain.Curated
    Contains 1 PH domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil, Repeat

    Phylogenomic databases

    eggNOGiNOG242127.
    HOVERGENiHBG107819.
    InParanoidiQ9BZ29.
    OMAiHKDLFGA.
    PhylomeDBiQ9BZ29.
    TreeFamiTF313629.

    Family and domain databases

    Gene3Di2.30.29.30. 1 hit.
    InterProiIPR016024. ARM-type_fold.
    IPR027007. DHR-1_domain.
    IPR027357. DHR-2.
    IPR026791. DOCK.
    IPR010703. DOCK_C.
    IPR021816. DOCK_C/D_N.
    IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    [Graphical view]
    PANTHERiPTHR23317. PTHR23317. 1 hit.
    PfamiPF06920. Ded_cyto. 1 hit.
    PF14429. DOCK-C2. 1 hit.
    PF11878. DUF3398. 1 hit.
    PF00169. PH. 1 hit.
    [Graphical view]
    SMARTiSM00233. PH. 1 hit.
    [Graphical view]
    SUPFAMiSSF48371. SSF48371. 5 hits.
    PROSITEiPS51650. DHR_1. 1 hit.
    PS51651. DHR_2. 1 hit.
    PS50003. PH_DOMAIN. 1 hit.
    [Graphical view]

    Sequences (5)i

    Sequence statusi: Complete.

    This entry describes 5 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9BZ29-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSQPPLLPAS AETRKFTRAL SKPGTAAELR QSVSEVVRGS VLLAKPKLIE     50
    PLDYENVIVQ KKTQILNDCL REMLLFPYDD FQTAILRRQG RYICSTVPAK 100
    AEEEAQSLFV TECIKTYNSD WHLVNYKYED YSGEFRQLPN KVVKLDKLPV 150
    HVYEVDEEVD KDEDAASLGS QKGGITKHGW LYKGNMNSAI SVTMRSFKRR 200
    FFHLIQLGDG SYNLNFYKDE KISKEPKGSI FLDSCMGVVQ NNKVRRFAFE 250
    LKMQDKSSYL LAADSEVEME EWITILNKIL QLNFEAAMQE KRNGDSHEDD 300
    EQSKLEGSGS GLDSYLPELA KSAREAEIKL KSESRVKLFY LDPDAQKLDF 350
    SSAEPEVKSF EEKFGKRILV KCNDLSFNLQ CCVAENEEGP TTNVEPFFVT 400
    LSLFDIKYNR KISADFHVDL NHFSVRQMLA TTSPALMNGS GQSPSVLKGI 450
    LHEAAMQYPK QGIFSVTCPH PDIFLVARIE KVLQGSITHC AEPYMKSSDS 500
    SKVAQKVLKN AKQACQRLGQ YRMPFAWAAR TLFKDASGNL DKNARFSAIY 550
    RQDSNKLSND DMLKLLADFR KPEKMAKLPV ILGNLDITID NVSSDFPNYV 600
    NSSYIPTKQF ETCSKTPITF EVEEFVPCIP KHTQPYTIYT NHLYVYPKYL 650
    KYDSQKSFAK ARNIAICIEF KDSDEEDSQP LKCIYGRPGG PVFTRSAFAA 700
    VLHHHQNPEF YDEIKIELPT QLHEKHHLLL TFFHVSCDNS SKGSTKKRDV 750
    VETQVGYSWL PLLKDGRVVT SEQHIPVSAN LPSGYLGYQE LGMGRHYGPE 800
    IKWVDGGKPL LKISTHLVST VYTQDQHLHN FFQYCQKTES GAQALGNELV 850
    KYLKSLHAME GHVMIAFLPT ILNQLFRVLT RATQEEVAVN VTRVIIHVVA 900
    QCHEEGLESH LRSYVKYAYK AEPYVASEYK TVHEELTKSM TTILKPSADF 950
    LTSNKLLKYS WFFFDVLIKS MAQHLIENSK VKLLRNQRFP ASYHHAVETV 1000
    VNMLMPHITQ KFRDNPEASK NANHSLAVFI KRCFTFMDRG FVFKQINNYI 1050
    SCFAPGDPKT LFEYKFEFLR VVCNHEHYIP LNLPMPFGKG RIQRYQDLQL 1100
    DYSLTDEFCR NHFLVGLLLR EVGTALQEFR EVRLIAISVL KNLLIKHSFD 1150
    DRYASRSHQA RIATLYLPLF GLLIENVQRI NVRDVSPFPV NAGMTVKDES 1200
    LALPAVNPLV TPQKGSTLDN SLHKDLLGAI SGIASPYTTS TPNINSVRNA 1250
    DSRGSLISTD SGNSLPERNS EKSNSLDKHQ QSSTLGNSVV RCDKLDQSEI 1300
    KSLLMCFLYI LKSMSDDALF TYWNKASTSE LMDFFTISEV CLHQFQYMGK 1350
    RYIARTGMMH ARLQQLGSLD NSLTFNHSYG HSDADVLHQS LLEANIATEV 1400
    CLTALDTLSL FTLAFKNQLL ADHGHNPLMK KVFDVYLCFL QKHQSETALK 1450
    NVFTALRSLI YKFPSTFYEG RADMCAALCY EILKCCNSKL SSIRTEASQL 1500
    LYFLMRNNFD YTGKKSFVRT HLQVIISVSQ LIADVVGIGG TRFQQSLSII 1550
    NNCANSDRLI KHTSFSSDVK DLTKRIRTVL MATAQMKEHE NDPEMLVDLQ 1600
    YSLAKSYAST PELRKTWLDS MARIHVKNGD LSEAAMCYVH VTALVAEYLT 1650
    RKEAVQWEPP LLPHSHSACL RRSRGGVFRQ GCTAFRVITP NIDEEASMME 1700
    DVGMQDVHFN EDVLMELLEQ CADGLWKAER YELIADIYKL IIPIYEKRRD 1750
    FERLAHLYDT LHRAYSKVTE VMHSGRRLLG TYFRVAFFGQ AAQYQFTDSE 1800
    TDVEGFFEDE DGKEYIYKEP KLTPLSEISQ RLLKLYSDKF GSENVKMIQD 1850
    SGKVNPKDLD SKYAYIQVTH VIPFFDEKEL QERKTEFERS HNIRRFMFEM 1900
    PFTQTGKRQG GVEEQCKRRT ILTAIHCFPY VKKRIPVMYQ HHTDLNPIEV 1950
    AIDEMSKKVA ELRQLCSSAE VDMIKLQLKL QGSVSVQVNA GPLAYARAFL 2000
    DDTNTKRYPD NKVKLLKEVF RQFVEACGQA LAVNERLIKE DQLEYQEEMK 2050
    ANYREMAKEL SEIMHEQLG 2069
    Length:2,069
    Mass (Da):236,446
    Last modified:October 19, 2002 - v2
    Checksum:i95073CD751745AAE
    GO
    Isoform 2 (identifier: Q9BZ29-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-43: MSQPPLLPAS...SEVVRGSVLL → MQADKCRTSS...VEAESPGPVP

    Show »
    Length:2,068
    Mass (Da):236,425
    Checksum:iC2654DB8162F26F1
    GO
    Isoform 3 (identifier: Q9BZ29-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1355-1378: RTGMMHARLQQLGSLDNSLTFNHS → SVRKISSVLGISVDNG

    Note: No experimental confirmation available.

    Show »
    Length:2,061
    Mass (Da):235,361
    Checksum:iDEB17F98C3573D68
    GO
    Isoform 4 (identifier: Q9BZ29-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1791-1804: Missing.
         2068-2069: LG → ICPLEEKTSVLPNSLHIFNAISGTPTSTMVHGMTSSSSVV

    Note: Produced by exon skipping that results in a frameshift. No experimental confirmation available.

    Show »
    Length:2,093
    Mass (Da):238,846
    Checksum:iA540EC1EDDCFFDB5
    GO
    Isoform 5 (identifier: Q9BZ29-6) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-43: MSQPPLLPAS...SEVVRGSVLL → MQADKCRTSS...VEAESPGPVP
         1234-1254: ASPYTTSTPNINSVRNADSRG → GNAPCSCGLLSTITLKVSWSQ
         1255-2069: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:1,253
    Mass (Da):142,650
    Checksum:i7BA871F8ACA17693
    GO

    Sequence cautioni

    The sequence BAA83010.2 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti170 – 1701S → P in BAG54337. (PubMed:14702039)Curated
    Sequence conflicti296 – 2961S → P in BAG54337. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti455 – 4551A → T.
    Corresponds to variant rs56010605 [ dbSNP | Ensembl ].
    VAR_062000
    Natural varianti1416 – 14161K → E.
    Corresponds to variant rs16955934 [ dbSNP | Ensembl ].
    VAR_053067

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 4343MSQPP…GSVLL → MQADKCRTSSRSVKKELVIE SPLQYKDAAQGEVEAESPGP VP in isoform 2 and isoform 5. 2 PublicationsVSP_017128Add
    BLAST
    Alternative sequencei1234 – 125421ASPYT…ADSRG → GNAPCSCGLLSTITLKVSWS Q in isoform 5. 1 PublicationVSP_045683Add
    BLAST
    Alternative sequencei1255 – 2069815Missing in isoform 5. 1 PublicationVSP_045684Add
    BLAST
    Alternative sequencei1355 – 137824RTGMM…TFNHS → SVRKISSVLGISVDNG in isoform 3. CuratedVSP_004024Add
    BLAST
    Alternative sequencei1791 – 180414Missing in isoform 4. 1 PublicationVSP_007709Add
    BLAST
    Alternative sequencei2068 – 20692LG → ICPLEEKTSVLPNSLHIFNA ISGTPTSTMVHGMTSSSSVV in isoform 4. 1 PublicationVSP_007710

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF527605 mRNA. Translation: AAM90306.1.
    AB028981 mRNA. Translation: BAA83010.2. Different initiation.
    AK126492 mRNA. Translation: BAG54337.1.
    AL139084, AL161420 Genomic DNA. Translation: CAI13370.1.
    AL139084, AL161420, AL391122 Genomic DNA. Translation: CAI13372.1.
    AL161420, AL139084 Genomic DNA. Translation: CAI39569.1.
    AL161420 Genomic DNA. Translation: CAI39570.1.
    AL161420, AL139084, AL391122 Genomic DNA. Translation: CAI39574.1.
    AL161420 Genomic DNA. Translation: CAI39577.1.
    AL391122, AL139084, AL161420 Genomic DNA. Translation: CAI11061.1.
    BC043506 mRNA. Translation: AAH43506.1.
    CCDSiCCDS45062.1. [Q9BZ29-5]
    CCDS45063.1. [Q9BZ29-6]
    RefSeqiNP_001123520.1. NM_001130048.1. [Q9BZ29-5]
    NP_001123521.1. NM_001130049.1.
    NP_001123522.1. NM_001130050.1. [Q9BZ29-6]
    NP_056111.1. NM_015296.2. [Q9BZ29-1]
    UniGeneiHs.596105.

    Genome annotation databases

    EnsembliENST00000339416; ENSP00000341086; ENSG00000088387. [Q9BZ29-4]
    ENST00000376460; ENSP00000365643; ENSG00000088387. [Q9BZ29-5]
    ENST00000442173; ENSP00000406883; ENSG00000088387. [Q9BZ29-6]
    GeneIDi23348.
    KEGGihsa:23348.
    UCSCiuc001vnt.2. human. [Q9BZ29-1]
    uc001vnw.2. human. [Q9BZ29-5]

    Polymorphism databases

    DMDMi24212635.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF527605 mRNA. Translation: AAM90306.1 .
    AB028981 mRNA. Translation: BAA83010.2 . Different initiation.
    AK126492 mRNA. Translation: BAG54337.1 .
    AL139084 , AL161420 Genomic DNA. Translation: CAI13370.1 .
    AL139084 , AL161420 , AL391122 Genomic DNA. Translation: CAI13372.1 .
    AL161420 , AL139084 Genomic DNA. Translation: CAI39569.1 .
    AL161420 Genomic DNA. Translation: CAI39570.1 .
    AL161420 , AL139084 , AL391122 Genomic DNA. Translation: CAI39574.1 .
    AL161420 Genomic DNA. Translation: CAI39577.1 .
    AL391122 , AL139084 , AL161420 Genomic DNA. Translation: CAI11061.1 .
    BC043506 mRNA. Translation: AAH43506.1 .
    CCDSi CCDS45062.1. [Q9BZ29-5 ]
    CCDS45063.1. [Q9BZ29-6 ]
    RefSeqi NP_001123520.1. NM_001130048.1. [Q9BZ29-5 ]
    NP_001123521.1. NM_001130049.1.
    NP_001123522.1. NM_001130050.1. [Q9BZ29-6 ]
    NP_056111.1. NM_015296.2. [Q9BZ29-1 ]
    UniGenei Hs.596105.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1WG7 NMR - A 165-301 [» ]
    2WM9 X-ray 2.20 A 1605-2067 [» ]
    2WMN X-ray 2.39 A 1605-2067 [» ]
    2WMO X-ray 2.20 A 1605-2067 [» ]
    ProteinModelPortali Q9BZ29.
    SMRi Q9BZ29. Positions 171-307, 1609-2068.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 116930. 7 interactions.
    IntActi Q9BZ29. 13 interactions.
    MINTi MINT-4657670.

    PTM databases

    PhosphoSitei Q9BZ29.

    Polymorphism databases

    DMDMi 24212635.

    Proteomic databases

    MaxQBi Q9BZ29.
    PaxDbi Q9BZ29.
    PRIDEi Q9BZ29.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000339416 ; ENSP00000341086 ; ENSG00000088387 . [Q9BZ29-4 ]
    ENST00000376460 ; ENSP00000365643 ; ENSG00000088387 . [Q9BZ29-5 ]
    ENST00000442173 ; ENSP00000406883 ; ENSG00000088387 . [Q9BZ29-6 ]
    GeneIDi 23348.
    KEGGi hsa:23348.
    UCSCi uc001vnt.2. human. [Q9BZ29-1 ]
    uc001vnw.2. human. [Q9BZ29-5 ]

    Organism-specific databases

    CTDi 23348.
    GeneCardsi GC13M099445.
    HGNCi HGNC:14132. DOCK9.
    HPAi CAB034061.
    MIMi 607325. gene.
    neXtProti NX_Q9BZ29.
    PharmGKBi PA134877754.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG242127.
    HOVERGENi HBG107819.
    InParanoidi Q9BZ29.
    OMAi HKDLFGA.
    PhylomeDBi Q9BZ29.
    TreeFami TF313629.

    Enzyme and pathway databases

    Reactomei REACT_24970. Factors involved in megakaryocyte development and platelet production.

    Miscellaneous databases

    ChiTaRSi DOCK9. human.
    EvolutionaryTracei Q9BZ29.
    GeneWikii Dock9.
    GenomeRNAii 23348.
    NextBioi 45323.
    PROi Q9BZ29.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9BZ29.
    Bgeei Q9BZ29.
    Genevestigatori Q9BZ29.

    Family and domain databases

    Gene3Di 2.30.29.30. 1 hit.
    InterProi IPR016024. ARM-type_fold.
    IPR027007. DHR-1_domain.
    IPR027357. DHR-2.
    IPR026791. DOCK.
    IPR010703. DOCK_C.
    IPR021816. DOCK_C/D_N.
    IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    [Graphical view ]
    PANTHERi PTHR23317. PTHR23317. 1 hit.
    Pfami PF06920. Ded_cyto. 1 hit.
    PF14429. DOCK-C2. 1 hit.
    PF11878. DUF3398. 1 hit.
    PF00169. PH. 1 hit.
    [Graphical view ]
    SMARTi SM00233. PH. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48371. SSF48371. 5 hits.
    PROSITEi PS51650. DHR_1. 1 hit.
    PS51651. DHR_2. 1 hit.
    PS50003. PH_DOMAIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Zizimin1, a novel Cdc42 activator, reveals a new GEF domain for Rho proteins."
      Meller N., Irani-Tehrani M., Kiosses W.B., Del Pozo M.A., Schwartz M.A.
      Nat. Cell Biol. 4:639-647(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE (ISOFORM 1), FUNCTION, INTERACTION WITH CDC42, GEF ACTIVITY, TISSUE SPECIFICITY.
    2. "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Kikuno R., Nagase T., Ishikawa K., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
      DNA Res. 6:197-205(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Brain.
    3. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
      Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
      DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: SEQUENCE REVISION.
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5).
      Tissue: Uterus.
    5. "The DNA sequence and analysis of human chromosome 13."
      Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
      Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ISOFORMS 1; 2; 3 AND 4).
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1551-2069 (ISOFORM 4).
      Tissue: Eye.
    7. "Identification of an evolutionarily conserved superfamily of DOCK180-related proteins with guanine nucleotide exchange activity."
      Cote J.-F., Vuori K.
      J. Cell Sci. 115:4901-4913(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NOMENCLATURE, GEF ACTIVITY.
    8. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
      Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.
      Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1241, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    9. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-21, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    10. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1235 AND THR-1241, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    11. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    12. "Solution structure of pleckstrin homology domain from human KIAA1058 protein."
      RIKEN structural genomics initiative (RSGI)
      Submitted (NOV-2004) to the PDB data bank
      Cited for: STRUCTURE BY NMR OF 165-301.
    13. "Activation of Rho GTPases by DOCK exchange factors is mediated by a nucleotide sensor."
      Yang J., Zhang Z., Roe S.M., Marshall C.J., Barford D.
      Science 325:1398-1402(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 1605-2069 IN COMPLEX WITH CDC42, FUNCTION, SUBUNIT.

    Entry informationi

    Entry nameiDOCK9_HUMAN
    AccessioniPrimary (citable) accession number: Q9BZ29
    Secondary accession number(s): B3KX25
    , E9PFM9, Q5JUD4, Q5JUD6, Q5T2Q1, Q5TAN8, Q9BZ25, Q9BZ26, Q9BZ27, Q9BZ28, Q9UPU4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 19, 2002
    Last sequence update: October 19, 2002
    Last modified: October 1, 2014
    This is version 124 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    'Zizim' means 'spike' in Hebrew.

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 13
      Human chromosome 13: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3