Q9BZ29 (DOCK9_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Dedicator of cytokinesis protein 9

Alternative name(s):
Cdc42 guanine nucleotide exchange factor zizimin-1

Gene names

Name:	DOCK9
Synonyms:	KIAA1058

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	2069 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP. Overexpression induces filopodia formation. Ref.1 Ref.13
Subunit structure	Homodimer Probable. Interacts preferentially with nucleotide-depleted CDC42. Ref.1 Ref.13
Subcellular location	Endomembrane system Probable. Note: Associated with membranes Probable.
Tissue specificity	Widely expressed, with highest expression in heart and placenta. Expressed at intermediate level in kidney, brain, lung and skeletal muscle. Ref.1
Domain	The DHR-2 domain is necessary and sufficient for the GEF activity.
Miscellaneous	'Zizim' means 'spike' in Hebrew.
Sequence similarities	Belongs to the DOCK family. Contains 1 DHR-1 domain. Contains 1 DHR-2 domain. Contains 1 PH domain.
Sequence caution	The sequence BAA83010.2 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Coiled coil Repeat
Molecular function	Guanine-nucleotide releasing factor
PTM	Phosphoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	blood coagulation Traceable author statement. Source: Reactome small GTPase mediated signal transduction Inferred from electronic annotation. Source: InterPro
Cellular_component	cytosol Traceable author statement. Source: Reactome endomembrane system Inferred from electronic annotation. Source: UniProtKB-SubCell membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	Rho guanyl-nucleotide exchange factor activity Inferred from electronic annotation. Source: Compara phospholipid binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
NEB	P20929	2	EBI-2695893,EBI-1049657
SMAD2	Q15796	3	EBI-2695893,EBI-1040141
SMAD3	P84022	3	EBI-2695893,EBI-347161

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9BZ29-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9BZ29-5)

The sequence of this isoform differs from the canonical sequence as follows:
     1-43: MSQPPLLPAS...SEVVRGSVLL → MQADKCRTSS...VEAESPGPVP

Isoform 3 (identifier: Q9BZ29-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1355-1378: RTGMMHARLQQLGSLDNSLTFNHS → SVRKISSVLGISVDNG

Note: No experimental confirmation available.

Isoform 4 (identifier: Q9BZ29-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1791-1804: Missing.
     2068-2069: LG → ICPLEEKTSVLPNSLHIFNAISGTPTSTMVHGMTSSSSVV

Note: Produced by exon skipping that results in a frameshift. No experimental confirmation available.

Isoform 5 (identifier: Q9BZ29-6)

The sequence of this isoform differs from the canonical sequence as follows:
     1-43: MSQPPLLPAS...SEVVRGSVLL → MQADKCRTSS...VEAESPGPVP
     1234-1254: ASPYTTSTPNINSVRNADSRG → GNAPCSCGLLSTITLKVSWSQ
     1255-2069: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 2069

2069

Dedicator of cytokinesis protein 9

PRO_0000189999

Regions

Domain

174 – 281

108

PH

Domain

640 – 818

179

DHR-1

Domain

1605 – 2069

465

DHR-2

Region

75 – 135

61

Interaction with activated CDC42 By similarity

Coiled coil

1948 – 1982

35

Potential

Coiled coil

2034 – 2067

34

Potential

Amino acid modifications

Modified residue

21

1

Phosphoserine Ref.9

Modified residue

927

1

Phosphoserine By similarity

Modified residue

1235

1

Phosphoserine Ref.10

Modified residue

1241

1

Phosphothreonine Ref.8 Ref.10

Natural variations

Alternative sequence

1 – 43

43

MSQPP…GSVLL → MQADKCRTSSRSVKKELVIE SPLQYKDAAQGEVEAESPGP VP in isoform 2 and isoform 5.

VSP_017128

Alternative sequence

1234 – 1254

21

ASPYT…ADSRG → GNAPCSCGLLSTITLKVSWS Q in isoform 5.

VSP_045683

Alternative sequence

1255 – 2069

815

Missing in isoform 5.

VSP_045684

Alternative sequence

1355 – 1378

24

RTGMM…TFNHS → SVRKISSVLGISVDNG in isoform 3.

VSP_004024

Alternative sequence

1791 – 1804

14

Missing in isoform 4.

VSP_007709

Alternative sequence

2068 – 2069

2

LG → ICPLEEKTSVLPNSLHIFNA ISGTPTSTMVHGMTSSSSVV in isoform 4.

VSP_007710

Natural variant

455

1

A → T.
Corresponds to variant rs56010605 [ dbSNP | Ensembl ].

VAR_062000

Natural variant

1416

1

K → E.
Corresponds to variant rs16955934 [ dbSNP | Ensembl ].

VAR_053067

Experimental info

Sequence conflict

170

1

S → P in BAG54337. Ref.4

Sequence conflict

296

1

S → P in BAG54337. Ref.4

Secondary structure

1

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2069

Helix Strand Turn

Details...

Beta strand

178 – 183

6

Helix

190 – 194

5

Beta strand

198 – 206

9

Beta strand

208 – 210

3

Beta strand

212 – 220

9

Beta strand

227 – 230

4

Turn

232 – 234

3

Beta strand

248 – 252

5

Beta strand

254 – 256

3

Beta strand

258 – 262

5

Helix

266 – 291

26

Helix

1610 – 1628

19

Helix

1631 – 1651

21

Beta strand

1677 – 1679

3

Helix

1682 – 1685

4

Turn

1686 – 1688

3

Helix

1690 – 1695

6

Beta strand

1708 – 1710

3

Helix

1711 – 1727

17

Helix

1731 – 1733

3

Helix

1734 – 1738

5

Turn

1739 – 1741

3

Helix

1742 – 1747

6

Helix

1751 – 1774

24

Beta strand

1781 – 1788

8

Helix

1808 – 1810

3

Beta strand

1814 – 1820

7

Helix

1825 – 1840

16

Helix

1842 – 1844

3

Beta strand

1845 – 1848

4

Helix

1856 – 1858

3

Beta strand

1863 – 1873

11

Helix

1877 – 1882

6

Helix

1887 – 1889

3

Beta strand

1890 – 1902

13

Beta strand

1904 – 1909

6

Turn

1912 – 1914

3

Beta strand

1916 – 1929

14

Beta strand

1931 – 1945

15

Helix

1947 – 1967

21

Helix

1973 – 1984

12

Beta strand

1987 – 1989

3

Helix

1993 – 1999

7

Helix

2013 – 2037

25

Turn

2041 – 2043

3

Helix

2044 – 2064

21

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 19, 2002. Version 2. Checksum: 95073CD751745AAE	FASTA	2,069	236,446
	10 20 30 40 50 60 MSQPPLLPAS AETRKFTRAL SKPGTAAELR QSVSEVVRGS VLLAKPKLIE PLDYENVIVQ 70 80 90 100 110 120 KKTQILNDCL REMLLFPYDD FQTAILRRQG RYICSTVPAK AEEEAQSLFV TECIKTYNSD 130 140 150 160 170 180 WHLVNYKYED YSGEFRQLPN KVVKLDKLPV HVYEVDEEVD KDEDAASLGS QKGGITKHGW 190 200 210 220 230 240 LYKGNMNSAI SVTMRSFKRR FFHLIQLGDG SYNLNFYKDE KISKEPKGSI FLDSCMGVVQ 250 260 270 280 290 300 NNKVRRFAFE LKMQDKSSYL LAADSEVEME EWITILNKIL QLNFEAAMQE KRNGDSHEDD 310 320 330 340 350 360 EQSKLEGSGS GLDSYLPELA KSAREAEIKL KSESRVKLFY LDPDAQKLDF SSAEPEVKSF 370 380 390 400 410 420 EEKFGKRILV KCNDLSFNLQ CCVAENEEGP TTNVEPFFVT LSLFDIKYNR KISADFHVDL 430 440 450 460 470 480 NHFSVRQMLA TTSPALMNGS GQSPSVLKGI LHEAAMQYPK QGIFSVTCPH PDIFLVARIE 490 500 510 520 530 540 KVLQGSITHC AEPYMKSSDS SKVAQKVLKN AKQACQRLGQ YRMPFAWAAR TLFKDASGNL 550 560 570 580 590 600 DKNARFSAIY RQDSNKLSND DMLKLLADFR KPEKMAKLPV ILGNLDITID NVSSDFPNYV 610 620 630 640 650 660 NSSYIPTKQF ETCSKTPITF EVEEFVPCIP KHTQPYTIYT NHLYVYPKYL KYDSQKSFAK 670 680 690 700 710 720 ARNIAICIEF KDSDEEDSQP LKCIYGRPGG PVFTRSAFAA VLHHHQNPEF YDEIKIELPT 730 740 750 760 770 780 QLHEKHHLLL TFFHVSCDNS SKGSTKKRDV VETQVGYSWL PLLKDGRVVT SEQHIPVSAN 790 800 810 820 830 840 LPSGYLGYQE LGMGRHYGPE IKWVDGGKPL LKISTHLVST VYTQDQHLHN FFQYCQKTES 850 860 870 880 890 900 GAQALGNELV KYLKSLHAME GHVMIAFLPT ILNQLFRVLT RATQEEVAVN VTRVIIHVVA 910 920 930 940 950 960 QCHEEGLESH LRSYVKYAYK AEPYVASEYK TVHEELTKSM TTILKPSADF LTSNKLLKYS 970 980 990 1000 1010 1020 WFFFDVLIKS MAQHLIENSK VKLLRNQRFP ASYHHAVETV VNMLMPHITQ KFRDNPEASK 1030 1040 1050 1060 1070 1080 NANHSLAVFI KRCFTFMDRG FVFKQINNYI SCFAPGDPKT LFEYKFEFLR VVCNHEHYIP 1090 1100 1110 1120 1130 1140 LNLPMPFGKG RIQRYQDLQL DYSLTDEFCR NHFLVGLLLR EVGTALQEFR EVRLIAISVL 1150 1160 1170 1180 1190 1200 KNLLIKHSFD DRYASRSHQA RIATLYLPLF GLLIENVQRI NVRDVSPFPV NAGMTVKDES 1210 1220 1230 1240 1250 1260 LALPAVNPLV TPQKGSTLDN SLHKDLLGAI SGIASPYTTS TPNINSVRNA DSRGSLISTD 1270 1280 1290 1300 1310 1320 SGNSLPERNS EKSNSLDKHQ QSSTLGNSVV RCDKLDQSEI KSLLMCFLYI LKSMSDDALF 1330 1340 1350 1360 1370 1380 TYWNKASTSE LMDFFTISEV CLHQFQYMGK RYIARTGMMH ARLQQLGSLD NSLTFNHSYG 1390 1400 1410 1420 1430 1440 HSDADVLHQS LLEANIATEV CLTALDTLSL FTLAFKNQLL ADHGHNPLMK KVFDVYLCFL 1450 1460 1470 1480 1490 1500 QKHQSETALK NVFTALRSLI YKFPSTFYEG RADMCAALCY EILKCCNSKL SSIRTEASQL 1510 1520 1530 1540 1550 1560 LYFLMRNNFD YTGKKSFVRT HLQVIISVSQ LIADVVGIGG TRFQQSLSII NNCANSDRLI 1570 1580 1590 1600 1610 1620 KHTSFSSDVK DLTKRIRTVL MATAQMKEHE NDPEMLVDLQ YSLAKSYAST PELRKTWLDS 1630 1640 1650 1660 1670 1680 MARIHVKNGD LSEAAMCYVH VTALVAEYLT RKEAVQWEPP LLPHSHSACL RRSRGGVFRQ 1690 1700 1710 1720 1730 1740 GCTAFRVITP NIDEEASMME DVGMQDVHFN EDVLMELLEQ CADGLWKAER YELIADIYKL 1750 1760 1770 1780 1790 1800 IIPIYEKRRD FERLAHLYDT LHRAYSKVTE VMHSGRRLLG TYFRVAFFGQ AAQYQFTDSE 1810 1820 1830 1840 1850 1860 TDVEGFFEDE DGKEYIYKEP KLTPLSEISQ RLLKLYSDKF GSENVKMIQD SGKVNPKDLD 1870 1880 1890 1900 1910 1920 SKYAYIQVTH VIPFFDEKEL QERKTEFERS HNIRRFMFEM PFTQTGKRQG GVEEQCKRRT 1930 1940 1950 1960 1970 1980 ILTAIHCFPY VKKRIPVMYQ HHTDLNPIEV AIDEMSKKVA ELRQLCSSAE VDMIKLQLKL 1990 2000 2010 2020 2030 2040 QGSVSVQVNA GPLAYARAFL DDTNTKRYPD NKVKLLKEVF RQFVEACGQA LAVNERLIKE 2050 2060 DQLEYQEEMK ANYREMAKEL SEIMHEQLG
	Isoform 2 [UniParc]. Checksum: C2654DB8162F26F1	FASTA	2,068	236,425
	10 20 30 40 50 60 MQADKCRTSS RSVKKELVIE SPLQYKDAAQ GEVEAESPGP VPAKPKLIEP LDYENVIVQK 70 80 90 100 110 120 KTQILNDCLR EMLLFPYDDF QTAILRRQGR YICSTVPAKA EEEAQSLFVT ECIKTYNSDW 130 140 150 160 170 180 HLVNYKYEDY SGEFRQLPNK VVKLDKLPVH VYEVDEEVDK DEDAASLGSQ KGGITKHGWL 190 200 210 220 230 240 YKGNMNSAIS VTMRSFKRRF FHLIQLGDGS YNLNFYKDEK ISKEPKGSIF LDSCMGVVQN 250 260 270 280 290 300 NKVRRFAFEL KMQDKSSYLL AADSEVEMEE WITILNKILQ LNFEAAMQEK RNGDSHEDDE 310 320 330 340 350 360 QSKLEGSGSG LDSYLPELAK SAREAEIKLK SESRVKLFYL DPDAQKLDFS SAEPEVKSFE 370 380 390 400 410 420 EKFGKRILVK CNDLSFNLQC CVAENEEGPT TNVEPFFVTL SLFDIKYNRK ISADFHVDLN 430 440 450 460 470 480 HFSVRQMLAT TSPALMNGSG QSPSVLKGIL HEAAMQYPKQ GIFSVTCPHP DIFLVARIEK 490 500 510 520 530 540 VLQGSITHCA EPYMKSSDSS KVAQKVLKNA KQACQRLGQY RMPFAWAART LFKDASGNLD 550 560 570 580 590 600 KNARFSAIYR QDSNKLSNDD MLKLLADFRK PEKMAKLPVI LGNLDITIDN VSSDFPNYVN 610 620 630 640 650 660 SSYIPTKQFE TCSKTPITFE VEEFVPCIPK HTQPYTIYTN HLYVYPKYLK YDSQKSFAKA 670 680 690 700 710 720 RNIAICIEFK DSDEEDSQPL KCIYGRPGGP VFTRSAFAAV LHHHQNPEFY DEIKIELPTQ 730 740 750 760 770 780 LHEKHHLLLT FFHVSCDNSS KGSTKKRDVV ETQVGYSWLP LLKDGRVVTS EQHIPVSANL 790 800 810 820 830 840 PSGYLGYQEL GMGRHYGPEI KWVDGGKPLL KISTHLVSTV YTQDQHLHNF FQYCQKTESG 850 860 870 880 890 900 AQALGNELVK YLKSLHAMEG HVMIAFLPTI LNQLFRVLTR ATQEEVAVNV TRVIIHVVAQ 910 920 930 940 950 960 CHEEGLESHL RSYVKYAYKA EPYVASEYKT VHEELTKSMT TILKPSADFL TSNKLLKYSW 970 980 990 1000 1010 1020 FFFDVLIKSM AQHLIENSKV KLLRNQRFPA SYHHAVETVV NMLMPHITQK FRDNPEASKN 1030 1040 1050 1060 1070 1080 ANHSLAVFIK RCFTFMDRGF VFKQINNYIS CFAPGDPKTL FEYKFEFLRV VCNHEHYIPL 1090 1100 1110 1120 1130 1140 NLPMPFGKGR IQRYQDLQLD YSLTDEFCRN HFLVGLLLRE VGTALQEFRE VRLIAISVLK 1150 1160 1170 1180 1190 1200 NLLIKHSFDD RYASRSHQAR IATLYLPLFG LLIENVQRIN VRDVSPFPVN AGMTVKDESL 1210 1220 1230 1240 1250 1260 ALPAVNPLVT PQKGSTLDNS LHKDLLGAIS GIASPYTTST PNINSVRNAD SRGSLISTDS 1270 1280 1290 1300 1310 1320 GNSLPERNSE KSNSLDKHQQ SSTLGNSVVR CDKLDQSEIK SLLMCFLYIL KSMSDDALFT 1330 1340 1350 1360 1370 1380 YWNKASTSEL MDFFTISEVC LHQFQYMGKR YIARTGMMHA RLQQLGSLDN SLTFNHSYGH 1390 1400 1410 1420 1430 1440 SDADVLHQSL LEANIATEVC LTALDTLSLF TLAFKNQLLA DHGHNPLMKK VFDVYLCFLQ 1450 1460 1470 1480 1490 1500 KHQSETALKN VFTALRSLIY KFPSTFYEGR ADMCAALCYE ILKCCNSKLS SIRTEASQLL 1510 1520 1530 1540 1550 1560 YFLMRNNFDY TGKKSFVRTH LQVIISVSQL IADVVGIGGT RFQQSLSIIN NCANSDRLIK 1570 1580 1590 1600 1610 1620 HTSFSSDVKD LTKRIRTVLM ATAQMKEHEN DPEMLVDLQY SLAKSYASTP ELRKTWLDSM 1630 1640 1650 1660 1670 1680 ARIHVKNGDL SEAAMCYVHV TALVAEYLTR KEAVQWEPPL LPHSHSACLR RSRGGVFRQG 1690 1700 1710 1720 1730 1740 CTAFRVITPN IDEEASMMED VGMQDVHFNE DVLMELLEQC ADGLWKAERY ELIADIYKLI 1750 1760 1770 1780 1790 1800 IPIYEKRRDF ERLAHLYDTL HRAYSKVTEV MHSGRRLLGT YFRVAFFGQA AQYQFTDSET 1810 1820 1830 1840 1850 1860 DVEGFFEDED GKEYIYKEPK LTPLSEISQR LLKLYSDKFG SENVKMIQDS GKVNPKDLDS 1870 1880 1890 1900 1910 1920 KYAYIQVTHV IPFFDEKELQ ERKTEFERSH NIRRFMFEMP FTQTGKRQGG VEEQCKRRTI 1930 1940 1950 1960 1970 1980 LTAIHCFPYV KKRIPVMYQH HTDLNPIEVA IDEMSKKVAE LRQLCSSAEV DMIKLQLKLQ 1990 2000 2010 2020 2030 2040 GSVSVQVNAG PLAYARAFLD DTNTKRYPDN KVKLLKEVFR QFVEACGQAL AVNERLIKED 2050 2060 QLEYQEEMKA NYREMAKELS EIMHEQLG
	Isoform 3 [UniParc]. Checksum: DEB17F98C3573D68	FASTA	2,061	235,361
	10 20 30 40 50 60 MSQPPLLPAS AETRKFTRAL SKPGTAAELR QSVSEVVRGS VLLAKPKLIE PLDYENVIVQ 70 80 90 100 110 120 KKTQILNDCL REMLLFPYDD FQTAILRRQG RYICSTVPAK AEEEAQSLFV TECIKTYNSD 130 140 150 160 170 180 WHLVNYKYED YSGEFRQLPN KVVKLDKLPV HVYEVDEEVD KDEDAASLGS QKGGITKHGW 190 200 210 220 230 240 LYKGNMNSAI SVTMRSFKRR FFHLIQLGDG SYNLNFYKDE KISKEPKGSI FLDSCMGVVQ 250 260 270 280 290 300 NNKVRRFAFE LKMQDKSSYL LAADSEVEME EWITILNKIL QLNFEAAMQE KRNGDSHEDD 310 320 330 340 350 360 EQSKLEGSGS GLDSYLPELA KSAREAEIKL KSESRVKLFY LDPDAQKLDF SSAEPEVKSF 370 380 390 400 410 420 EEKFGKRILV KCNDLSFNLQ CCVAENEEGP TTNVEPFFVT LSLFDIKYNR KISADFHVDL 430 440 450 460 470 480 NHFSVRQMLA TTSPALMNGS GQSPSVLKGI LHEAAMQYPK QGIFSVTCPH PDIFLVARIE 490 500 510 520 530 540 KVLQGSITHC AEPYMKSSDS SKVAQKVLKN AKQACQRLGQ YRMPFAWAAR TLFKDASGNL 550 560 570 580 590 600 DKNARFSAIY RQDSNKLSND DMLKLLADFR KPEKMAKLPV ILGNLDITID NVSSDFPNYV 610 620 630 640 650 660 NSSYIPTKQF ETCSKTPITF EVEEFVPCIP KHTQPYTIYT NHLYVYPKYL KYDSQKSFAK 670 680 690 700 710 720 ARNIAICIEF KDSDEEDSQP LKCIYGRPGG PVFTRSAFAA VLHHHQNPEF YDEIKIELPT 730 740 750 760 770 780 QLHEKHHLLL TFFHVSCDNS SKGSTKKRDV VETQVGYSWL PLLKDGRVVT SEQHIPVSAN 790 800 810 820 830 840 LPSGYLGYQE LGMGRHYGPE IKWVDGGKPL LKISTHLVST VYTQDQHLHN FFQYCQKTES 850 860 870 880 890 900 GAQALGNELV KYLKSLHAME GHVMIAFLPT ILNQLFRVLT RATQEEVAVN VTRVIIHVVA 910 920 930 940 950 960 QCHEEGLESH LRSYVKYAYK AEPYVASEYK TVHEELTKSM TTILKPSADF LTSNKLLKYS 970 980 990 1000 1010 1020 WFFFDVLIKS MAQHLIENSK VKLLRNQRFP ASYHHAVETV VNMLMPHITQ KFRDNPEASK 1030 1040 1050 1060 1070 1080 NANHSLAVFI KRCFTFMDRG FVFKQINNYI SCFAPGDPKT LFEYKFEFLR VVCNHEHYIP 1090 1100 1110 1120 1130 1140 LNLPMPFGKG RIQRYQDLQL DYSLTDEFCR NHFLVGLLLR EVGTALQEFR EVRLIAISVL 1150 1160 1170 1180 1190 1200 KNLLIKHSFD DRYASRSHQA RIATLYLPLF GLLIENVQRI NVRDVSPFPV NAGMTVKDES 1210 1220 1230 1240 1250 1260 LALPAVNPLV TPQKGSTLDN SLHKDLLGAI SGIASPYTTS TPNINSVRNA DSRGSLISTD 1270 1280 1290 1300 1310 1320 SGNSLPERNS EKSNSLDKHQ QSSTLGNSVV RCDKLDQSEI KSLLMCFLYI LKSMSDDALF 1330 1340 1350 1360 1370 1380 TYWNKASTSE LMDFFTISEV CLHQFQYMGK RYIASVRKIS SVLGISVDNG YGHSDADVLH 1390 1400 1410 1420 1430 1440 QSLLEANIAT EVCLTALDTL SLFTLAFKNQ LLADHGHNPL MKKVFDVYLC FLQKHQSETA 1450 1460 1470 1480 1490 1500 LKNVFTALRS LIYKFPSTFY EGRADMCAAL CYEILKCCNS KLSSIRTEAS QLLYFLMRNN 1510 1520 1530 1540 1550 1560 FDYTGKKSFV RTHLQVIISV SQLIADVVGI GGTRFQQSLS IINNCANSDR LIKHTSFSSD 1570 1580 1590 1600 1610 1620 VKDLTKRIRT VLMATAQMKE HENDPEMLVD LQYSLAKSYA STPELRKTWL DSMARIHVKN 1630 1640 1650 1660 1670 1680 GDLSEAAMCY VHVTALVAEY LTRKEAVQWE PPLLPHSHSA CLRRSRGGVF RQGCTAFRVI 1690 1700 1710 1720 1730 1740 TPNIDEEASM MEDVGMQDVH FNEDVLMELL EQCADGLWKA ERYELIADIY KLIIPIYEKR 1750 1760 1770 1780 1790 1800 RDFERLAHLY DTLHRAYSKV TEVMHSGRRL LGTYFRVAFF GQAAQYQFTD SETDVEGFFE 1810 1820 1830 1840 1850 1860 DEDGKEYIYK EPKLTPLSEI SQRLLKLYSD KFGSENVKMI QDSGKVNPKD LDSKYAYIQV 1870 1880 1890 1900 1910 1920 THVIPFFDEK ELQERKTEFE RSHNIRRFMF EMPFTQTGKR QGGVEEQCKR RTILTAIHCF 1930 1940 1950 1960 1970 1980 PYVKKRIPVM YQHHTDLNPI EVAIDEMSKK VAELRQLCSS AEVDMIKLQL KLQGSVSVQV 1990 2000 2010 2020 2030 2040 NAGPLAYARA FLDDTNTKRY PDNKVKLLKE VFRQFVEACG QALAVNERLI KEDQLEYQEE 2050 2060 MKANYREMAK ELSEIMHEQL G
	Isoform 4 [UniParc]. Checksum: A540EC1EDDCFFDB5	FASTA	2,093	238,846
	10 20 30 40 50 60 MSQPPLLPAS AETRKFTRAL SKPGTAAELR QSVSEVVRGS VLLAKPKLIE PLDYENVIVQ 70 80 90 100 110 120 KKTQILNDCL REMLLFPYDD FQTAILRRQG RYICSTVPAK AEEEAQSLFV TECIKTYNSD 130 140 150 160 170 180 WHLVNYKYED YSGEFRQLPN KVVKLDKLPV HVYEVDEEVD KDEDAASLGS QKGGITKHGW 190 200 210 220 230 240 LYKGNMNSAI SVTMRSFKRR FFHLIQLGDG SYNLNFYKDE KISKEPKGSI FLDSCMGVVQ 250 260 270 280 290 300 NNKVRRFAFE LKMQDKSSYL LAADSEVEME EWITILNKIL QLNFEAAMQE KRNGDSHEDD 310 320 330 340 350 360 EQSKLEGSGS GLDSYLPELA KSAREAEIKL KSESRVKLFY LDPDAQKLDF SSAEPEVKSF 370 380 390 400 410 420 EEKFGKRILV KCNDLSFNLQ CCVAENEEGP TTNVEPFFVT LSLFDIKYNR KISADFHVDL 430 440 450 460 470 480 NHFSVRQMLA TTSPALMNGS GQSPSVLKGI LHEAAMQYPK QGIFSVTCPH PDIFLVARIE 490 500 510 520 530 540 KVLQGSITHC AEPYMKSSDS SKVAQKVLKN AKQACQRLGQ YRMPFAWAAR TLFKDASGNL 550 560 570 580 590 600 DKNARFSAIY RQDSNKLSND DMLKLLADFR KPEKMAKLPV ILGNLDITID NVSSDFPNYV 610 620 630 640 650 660 NSSYIPTKQF ETCSKTPITF EVEEFVPCIP KHTQPYTIYT NHLYVYPKYL KYDSQKSFAK 670 680 690 700 710 720 ARNIAICIEF KDSDEEDSQP LKCIYGRPGG PVFTRSAFAA VLHHHQNPEF YDEIKIELPT 730 740 750 760 770 780 QLHEKHHLLL TFFHVSCDNS SKGSTKKRDV VETQVGYSWL PLLKDGRVVT SEQHIPVSAN 790 800 810 820 830 840 LPSGYLGYQE LGMGRHYGPE IKWVDGGKPL LKISTHLVST VYTQDQHLHN FFQYCQKTES 850 860 870 880 890 900 GAQALGNELV KYLKSLHAME GHVMIAFLPT ILNQLFRVLT RATQEEVAVN VTRVIIHVVA 910 920 930 940 950 960 QCHEEGLESH LRSYVKYAYK AEPYVASEYK TVHEELTKSM TTILKPSADF LTSNKLLKYS 970 980 990 1000 1010 1020 WFFFDVLIKS MAQHLIENSK VKLLRNQRFP ASYHHAVETV VNMLMPHITQ KFRDNPEASK 1030 1040 1050 1060 1070 1080 NANHSLAVFI KRCFTFMDRG FVFKQINNYI SCFAPGDPKT LFEYKFEFLR VVCNHEHYIP 1090 1100 1110 1120 1130 1140 LNLPMPFGKG RIQRYQDLQL DYSLTDEFCR NHFLVGLLLR EVGTALQEFR EVRLIAISVL 1150 1160 1170 1180 1190 1200 KNLLIKHSFD DRYASRSHQA RIATLYLPLF GLLIENVQRI NVRDVSPFPV NAGMTVKDES 1210 1220 1230 1240 1250 1260 LALPAVNPLV TPQKGSTLDN SLHKDLLGAI SGIASPYTTS TPNINSVRNA DSRGSLISTD 1270 1280 1290 1300 1310 1320 SGNSLPERNS EKSNSLDKHQ QSSTLGNSVV RCDKLDQSEI KSLLMCFLYI LKSMSDDALF 1330 1340 1350 1360 1370 1380 TYWNKASTSE LMDFFTISEV CLHQFQYMGK RYIARTGMMH ARLQQLGSLD NSLTFNHSYG 1390 1400 1410 1420 1430 1440 HSDADVLHQS LLEANIATEV CLTALDTLSL FTLAFKNQLL ADHGHNPLMK KVFDVYLCFL 1450 1460 1470 1480 1490 1500 QKHQSETALK NVFTALRSLI YKFPSTFYEG RADMCAALCY EILKCCNSKL SSIRTEASQL 1510 1520 1530 1540 1550 1560 LYFLMRNNFD YTGKKSFVRT HLQVIISVSQ LIADVVGIGG TRFQQSLSII NNCANSDRLI 1570 1580 1590 1600 1610 1620 KHTSFSSDVK DLTKRIRTVL MATAQMKEHE NDPEMLVDLQ YSLAKSYAST PELRKTWLDS 1630 1640 1650 1660 1670 1680 MARIHVKNGD LSEAAMCYVH VTALVAEYLT RKEAVQWEPP LLPHSHSACL RRSRGGVFRQ 1690 1700 1710 1720 1730 1740 GCTAFRVITP NIDEEASMME DVGMQDVHFN EDVLMELLEQ CADGLWKAER YELIADIYKL 1750 1760 1770 1780 1790 1800 IIPIYEKRRD FERLAHLYDT LHRAYSKVTE VMHSGRRLLG TYFRVAFFGQ GFFEDEDGKE 1810 1820 1830 1840 1850 1860 YIYKEPKLTP LSEISQRLLK LYSDKFGSEN VKMIQDSGKV NPKDLDSKYA YIQVTHVIPF 1870 1880 1890 1900 1910 1920 FDEKELQERK TEFERSHNIR RFMFEMPFTQ TGKRQGGVEE QCKRRTILTA IHCFPYVKKR 1930 1940 1950 1960 1970 1980 IPVMYQHHTD LNPIEVAIDE MSKKVAELRQ LCSSAEVDMI KLQLKLQGSV SVQVNAGPLA 1990 2000 2010 2020 2030 2040 YARAFLDDTN TKRYPDNKVK LLKEVFRQFV EACGQALAVN ERLIKEDQLE YQEEMKANYR 2050 2060 2070 2080 2090 EMAKELSEIM HEQICPLEEK TSVLPNSLHI FNAISGTPTS TMVHGMTSSS SVV
	Isoform 5 [UniParc]. Checksum: 7BA871F8ACA17693	FASTA	1,253	142,650
	10 20 30 40 50 60 MQADKCRTSS RSVKKELVIE SPLQYKDAAQ GEVEAESPGP VPAKPKLIEP LDYENVIVQK 70 80 90 100 110 120 KTQILNDCLR EMLLFPYDDF QTAILRRQGR YICSTVPAKA EEEAQSLFVT ECIKTYNSDW 130 140 150 160 170 180 HLVNYKYEDY SGEFRQLPNK VVKLDKLPVH VYEVDEEVDK DEDAASLGSQ KGGITKHGWL 190 200 210 220 230 240 YKGNMNSAIS VTMRSFKRRF FHLIQLGDGS YNLNFYKDEK ISKEPKGSIF LDSCMGVVQN 250 260 270 280 290 300 NKVRRFAFEL KMQDKSSYLL AADSEVEMEE WITILNKILQ LNFEAAMQEK RNGDSHEDDE 310 320 330 340 350 360 QSKLEGSGSG LDSYLPELAK SAREAEIKLK SESRVKLFYL DPDAQKLDFS SAEPEVKSFE 370 380 390 400 410 420 EKFGKRILVK CNDLSFNLQC CVAENEEGPT TNVEPFFVTL SLFDIKYNRK ISADFHVDLN 430 440 450 460 470 480 HFSVRQMLAT TSPALMNGSG QSPSVLKGIL HEAAMQYPKQ GIFSVTCPHP DIFLVARIEK 490 500 510 520 530 540 VLQGSITHCA EPYMKSSDSS KVAQKVLKNA KQACQRLGQY RMPFAWAART LFKDASGNLD 550 560 570 580 590 600 KNARFSAIYR QDSNKLSNDD MLKLLADFRK PEKMAKLPVI LGNLDITIDN VSSDFPNYVN 610 620 630 640 650 660 SSYIPTKQFE TCSKTPITFE VEEFVPCIPK HTQPYTIYTN HLYVYPKYLK YDSQKSFAKA 670 680 690 700 710 720 RNIAICIEFK DSDEEDSQPL KCIYGRPGGP VFTRSAFAAV LHHHQNPEFY DEIKIELPTQ 730 740 750 760 770 780 LHEKHHLLLT FFHVSCDNSS KGSTKKRDVV ETQVGYSWLP LLKDGRVVTS EQHIPVSANL 790 800 810 820 830 840 PSGYLGYQEL GMGRHYGPEI KWVDGGKPLL KISTHLVSTV YTQDQHLHNF FQYCQKTESG 850 860 870 880 890 900 AQALGNELVK YLKSLHAMEG HVMIAFLPTI LNQLFRVLTR ATQEEVAVNV TRVIIHVVAQ 910 920 930 940 950 960 CHEEGLESHL RSYVKYAYKA EPYVASEYKT VHEELTKSMT TILKPSADFL TSNKLLKYSW 970 980 990 1000 1010 1020 FFFDVLIKSM AQHLIENSKV KLLRNQRFPA SYHHAVETVV NMLMPHITQK FRDNPEASKN 1030 1040 1050 1060 1070 1080 ANHSLAVFIK RCFTFMDRGF VFKQINNYIS CFAPGDPKTL FEYKFEFLRV VCNHEHYIPL 1090 1100 1110 1120 1130 1140 NLPMPFGKGR IQRYQDLQLD YSLTDEFCRN HFLVGLLLRE VGTALQEFRE VRLIAISVLK 1150 1160 1170 1180 1190 1200 NLLIKHSFDD RYASRSHQAR IATLYLPLFG LLIENVQRIN VRDVSPFPVN AGMTVKDESL 1210 1220 1230 1240 1250 ALPAVNPLVT PQKGSTLDNS LHKDLLGAIS GIGNAPCSCG LLSTITLKVS WSQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Zizimin1, a novel Cdc42 activator, reveals a new GEF domain for Rho proteins." Meller N., Irani-Tehrani M., Kiosses W.B., Del Pozo M.A., Schwartz M.A. Nat. Cell Biol. 4:639-647(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE (ISOFORM 1), FUNCTION, INTERACTION WITH CDC42, GEF ACTIVITY, TISSUE SPECIFICITY.
[2]	"Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Kikuno R., Nagase T., Ishikawa K., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 6:197-205(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Brain.
[3]	"Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones." Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T. DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract] Cited for: SEQUENCE REVISION.
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5). Tissue: Uterus.
[5]	"The DNA sequence and analysis of human chromosome 13." Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T. Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ISOFORMS 1; 2; 3 AND 4).
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1551-2069 (ISOFORM 4). Tissue: Eye.
[7]	"Identification of an evolutionarily conserved superfamily of DOCK180-related proteins with guanine nucleotide exchange activity." Cote J.-F., Vuori K. J. Cell Sci. 115:4901-4913(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NOMENCLATURE, GEF ACTIVITY.
[8]	"A probability-based approach for high-throughput protein phosphorylation analysis and site localization." Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P. Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1241, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[9]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-21, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[10]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1235 AND THR-1241, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[11]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[12]	"Solution structure of pleckstrin homology domain from human KIAA1058 protein." RIKEN structural genomics initiative (RSGI) Submitted (NOV-2004) to the PDB data bank Cited for: STRUCTURE BY NMR OF 165-301.
[13]	"Activation of Rho GTPases by DOCK exchange factors is mediated by a nucleotide sensor." Yang J., Zhang Z., Roe S.M., Marshall C.J., Barford D. Science 325:1398-1402(2009) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 1605-2069 IN COMPLEX WITH CDC42, FUNCTION, SUBUNIT.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AF527605 mRNA. Translation: AAM90306.1.
AB028981 mRNA. Translation: BAA83010.2. Different initiation.
AK126492 mRNA. Translation: BAG54337.1.
AL139084, AL161420 Genomic DNA. Translation: CAI13370.1.
AL139084, AL161420, AL391122 Genomic DNA. Translation: CAI13372.1.
AL161420, AL139084 Genomic DNA. Translation: CAI39569.1.
AL161420 Genomic DNA. Translation: CAI39570.1.
AL161420, AL139084, AL391122 Genomic DNA. Translation: CAI39574.1.
AL161420 Genomic DNA. Translation: CAI39577.1.
AL391122, AL139084, AL161420 Genomic DNA. Translation: CAI11061.1.
BC043506 mRNA. Translation: AAH43506.1.

IPI

IPI00216408.
IPI00332567.
IPI00743652.
IPI00911071.
IPI01012860.

RefSeq

NP_001123520.1. NM_001130048.1.
NP_001123521.1. NM_001130049.1.
NP_001123522.1. NM_001130050.1.
NP_056111.1. NM_015296.2.

UniGene

Hs.596105.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1WG7	NMR	-	A	165-301	[»]
2WM9	X-ray	2.20	A	1605-2069	[»]
2WMN	X-ray	2.39	A	1605-2069	[»]
2WMO	X-ray	2.20	A	1605-2069	[»]

ProteinModelPortal

Q9BZ29.

ModBase

Search...

Protein-protein interaction databases

IntAct

Q9BZ29. 12 interactions.

PTM databases

PhosphoSite

Q9BZ29.

Polymorphism databases

DMDM

24212635.

Proteomic databases

PaxDb

Q9BZ29.

PRIDE

Q9BZ29.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000339416; ENSP00000341086; ENSG00000088387.
ENST00000376460; ENSP00000365643; ENSG00000088387.
ENST00000427887; ENSP00000413781; ENSG00000088387.
ENST00000442173; ENSP00000406883; ENSG00000088387.
ENST00000449796; ENSP00000403528; ENSG00000088387.

GeneID

23348.

KEGG

hsa:23348.

UCSC

uc001vnt.2. human.
uc001vnw.2. human.

Organism-specific databases

CTD

23348.

GeneCards

GC13M099445.

HGNC

HGNC:14132. DOCK9.

HPA

CAB034061.

MIM

607325. gene.

neXtProt

NX_Q9BZ29.

PharmGKB

PA134877754.

HUGE

Search...

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG242127.

HOVERGEN

HBG107819.

InParanoid

Q9BZ29.

Enzyme and pathway databases

Reactome

REACT_604. Hemostasis.

Gene expression databases

ArrayExpress

Q9BZ29.

Bgee

Q9BZ29.

Genevestigator

Q9BZ29.

GermOnline

ENSG00000088387. Homo sapiens.

Family and domain databases

Gene3D

2.30.29.30. 1 hit.

InterPro

IPR027007. DHR-1_domain.
IPR027357. DHR-2.
IPR026791. DOCK.
IPR010703. DOCK_C.
IPR021816. DOCK_C/D_N.
IPR026796. DOCK_D.
IPR011993. PH_like_dom.
IPR001849. Pleckstrin_homology.
[Graphical view]

PANTHER

PTHR23317. PTHR23317. 1 hit.
PTHR23317:SF26. PTHR23317:SF26. 1 hit.

Pfam

PF06920. Ded_cyto. 1 hit.
PF14429. DOCK-C2. 1 hit.
PF11878. DUF3398. 1 hit.
PF00169. PH. 1 hit.
[Graphical view]

SMART

SM00233. PH. 1 hit.
[Graphical view]

PROSITE

PS51650. DHR_1. 1 hit.
PS51651. DHR_2. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
[Graphical view]

ProtoNet

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Other

ChiTaRS

DOCK9. human.

EvolutionaryTrace

Q9BZ29.

GenomeRNAi

23348.

NextBio

45323.

SOURCE

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Entry information

Entry name

DOCK9_HUMAN

Accession

Primary (citable) accession number: Q9BZ29
Secondary accession number(s): B3KX25 , E9PFM9, Q5JUD4, Q5JUD6, Q5T2Q1, Q5TAN8, Q9BZ25, Q9BZ26, Q9BZ27, Q9BZ28, Q9UPU4

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 19, 2002
Last sequence update:	October 19, 2002
Last modified:	May 1, 2013
This is version 111 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.