Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Dedicator of cytokinesis protein 9

Gene

DOCK9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP. Overexpression induces filopodia formation.2 Publications

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Guanine-nucleotide releasing factor

Enzyme and pathway databases

BioCyciZFISH:ENSG00000088387-MONOMER.
ReactomeiR-HSA-983231. Factors involved in megakaryocyte development and platelet production.

Names & Taxonomyi

Protein namesi
Recommended name:
Dedicator of cytokinesis protein 9
Alternative name(s):
Cdc42 guanine nucleotide exchange factor zizimin-1
Gene namesi
Name:DOCK9
Synonyms:KIAA1058
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

HGNCiHGNC:14132. DOCK9.

Subcellular locationi

GO - Cellular componenti

  • cell-cell adherens junction Source: BHF-UCL
  • cytosol Source: Reactome
  • endomembrane system Source: UniProtKB-SubCell
  • membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi23348.
OpenTargetsiENSG00000088387.
PharmGKBiPA134877754.

Polymorphism and mutation databases

BioMutaiDOCK9.
DMDMi24212635.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001899991 – 2069Dedicator of cytokinesis protein 9Add BLAST2069

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei21PhosphoserineCombined sources1
Modified residuei32PhosphoserineCombined sources1
Modified residuei167PhosphoserineCombined sources1
Modified residuei170PhosphoserineCombined sources1
Modified residuei433PhosphoserineBy similarity1
Modified residuei443PhosphoserineBy similarity1
Modified residuei927PhosphoserineCombined sources1
Modified residuei1235PhosphoserineCombined sources1
Modified residuei1241PhosphothreonineCombined sources1
Modified residuei1255PhosphoserineCombined sources1
Modified residuei1261PhosphoserineBy similarity1
Modified residuei1264PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9BZ29.
MaxQBiQ9BZ29.
PaxDbiQ9BZ29.
PeptideAtlasiQ9BZ29.
PRIDEiQ9BZ29.

PTM databases

iPTMnetiQ9BZ29.
PhosphoSitePlusiQ9BZ29.

Expressioni

Tissue specificityi

Widely expressed, with highest expression in heart and placenta. Expressed at intermediate level in kidney, brain, lung and skeletal muscle.1 Publication

Gene expression databases

BgeeiENSG00000088387.
ExpressionAtlasiQ9BZ29. baseline and differential.
GenevisibleiQ9BZ29. HS.

Organism-specific databases

HPAiCAB034061.
CAB034065.
HPA043940.

Interactioni

Subunit structurei

Homodimer (Probable). Interacts preferentially with nucleotide-depleted CDC42.Curated2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
NEBP209292EBI-2695893,EBI-1049657
SMAD2Q157963EBI-2695893,EBI-1040141
SMAD3P840223EBI-2695893,EBI-347161

GO - Molecular functioni

  • cadherin binding involved in cell-cell adhesion Source: BHF-UCL

Protein-protein interaction databases

BioGridi116930. 7 interactors.
IntActiQ9BZ29. 15 interactors.
MINTiMINT-4657670.
STRINGi9606.ENSP00000365643.

Structurei

Secondary structure

12069
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi178 – 183Combined sources6
Helixi190 – 194Combined sources5
Beta strandi198 – 206Combined sources9
Beta strandi208 – 210Combined sources3
Beta strandi212 – 220Combined sources9
Beta strandi227 – 230Combined sources4
Turni232 – 234Combined sources3
Beta strandi248 – 252Combined sources5
Beta strandi254 – 256Combined sources3
Beta strandi258 – 262Combined sources5
Helixi266 – 291Combined sources26
Helixi1610 – 1628Combined sources19
Helixi1631 – 1651Combined sources21
Beta strandi1677 – 1679Combined sources3
Helixi1682 – 1685Combined sources4
Turni1686 – 1688Combined sources3
Helixi1690 – 1695Combined sources6
Beta strandi1708 – 1710Combined sources3
Helixi1711 – 1727Combined sources17
Helixi1731 – 1733Combined sources3
Helixi1734 – 1738Combined sources5
Turni1739 – 1741Combined sources3
Helixi1742 – 1747Combined sources6
Helixi1751 – 1774Combined sources24
Beta strandi1781 – 1788Combined sources8
Helixi1804 – 1807Combined sources4
Helixi1808 – 1810Combined sources3
Beta strandi1814 – 1820Combined sources7
Helixi1825 – 1840Combined sources16
Helixi1842 – 1844Combined sources3
Beta strandi1845 – 1848Combined sources4
Helixi1856 – 1858Combined sources3
Beta strandi1863 – 1873Combined sources11
Helixi1877 – 1882Combined sources6
Helixi1887 – 1889Combined sources3
Beta strandi1890 – 1902Combined sources13
Beta strandi1904 – 1909Combined sources6
Turni1912 – 1914Combined sources3
Beta strandi1916 – 1929Combined sources14
Beta strandi1931 – 1945Combined sources15
Helixi1947 – 1967Combined sources21
Helixi1973 – 1984Combined sources12
Beta strandi1987 – 1989Combined sources3
Helixi1993 – 1999Combined sources7
Helixi2013 – 2037Combined sources25
Turni2041 – 2043Combined sources3
Helixi2044 – 2064Combined sources21

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WG7NMR-A165-301[»]
2WM9X-ray2.20A1605-2067[»]
2WMNX-ray2.39A1605-2067[»]
2WMOX-ray2.20A1605-2067[»]
ProteinModelPortaliQ9BZ29.
SMRiQ9BZ29.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9BZ29.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini174 – 281PHPROSITE-ProRule annotationAdd BLAST108
Domaini640 – 818DHR-1PROSITE-ProRule annotationAdd BLAST179
Domaini1605 – 2069DHR-2PROSITE-ProRule annotationAdd BLAST465

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni75 – 135Interaction with activated CDC42By similarityAdd BLAST61

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili1948 – 1982Sequence analysisAdd BLAST35
Coiled coili2034 – 2067Sequence analysisAdd BLAST34

Domaini

The DHR-2 domain is necessary and sufficient for the GEF activity.

Sequence similaritiesi

Belongs to the DOCK family.PROSITE-ProRule annotation
Contains 1 DHR-1 domain.PROSITE-ProRule annotation
Contains 1 DHR-2 domain.PROSITE-ProRule annotation
Contains 1 PH domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiKOG1997. Eukaryota.
ENOG410XNVY. LUCA.
GeneTreeiENSGT00760000119234.
HOGENOMiHOG000231373.
HOVERGENiHBG107819.
InParanoidiQ9BZ29.
PhylomeDBiQ9BZ29.
TreeFamiTF313629.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR016024. ARM-type_fold.
IPR027007. DHR-1_domain.
IPR027357. DHR-2.
IPR026791. DOCK.
IPR026796. DOCK9.
IPR010703. DOCK_C.
IPR021816. DOCK_C/D_N.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
[Graphical view]
PANTHERiPTHR23317. PTHR23317. 3 hits.
PTHR23317:SF77. PTHR23317:SF77. 3 hits.
PfamiPF06920. DHR-2. 1 hit.
PF14429. DOCK-C2. 1 hit.
PF11878. DUF3398. 1 hit.
PF00169. PH. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 5 hits.
SSF50729. SSF50729. 1 hit.
PROSITEiPS51650. DHR_1. 1 hit.
PS51651. DHR_2. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9BZ29-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSQPPLLPAS AETRKFTRAL SKPGTAAELR QSVSEVVRGS VLLAKPKLIE
60 70 80 90 100
PLDYENVIVQ KKTQILNDCL REMLLFPYDD FQTAILRRQG RYICSTVPAK
110 120 130 140 150
AEEEAQSLFV TECIKTYNSD WHLVNYKYED YSGEFRQLPN KVVKLDKLPV
160 170 180 190 200
HVYEVDEEVD KDEDAASLGS QKGGITKHGW LYKGNMNSAI SVTMRSFKRR
210 220 230 240 250
FFHLIQLGDG SYNLNFYKDE KISKEPKGSI FLDSCMGVVQ NNKVRRFAFE
260 270 280 290 300
LKMQDKSSYL LAADSEVEME EWITILNKIL QLNFEAAMQE KRNGDSHEDD
310 320 330 340 350
EQSKLEGSGS GLDSYLPELA KSAREAEIKL KSESRVKLFY LDPDAQKLDF
360 370 380 390 400
SSAEPEVKSF EEKFGKRILV KCNDLSFNLQ CCVAENEEGP TTNVEPFFVT
410 420 430 440 450
LSLFDIKYNR KISADFHVDL NHFSVRQMLA TTSPALMNGS GQSPSVLKGI
460 470 480 490 500
LHEAAMQYPK QGIFSVTCPH PDIFLVARIE KVLQGSITHC AEPYMKSSDS
510 520 530 540 550
SKVAQKVLKN AKQACQRLGQ YRMPFAWAAR TLFKDASGNL DKNARFSAIY
560 570 580 590 600
RQDSNKLSND DMLKLLADFR KPEKMAKLPV ILGNLDITID NVSSDFPNYV
610 620 630 640 650
NSSYIPTKQF ETCSKTPITF EVEEFVPCIP KHTQPYTIYT NHLYVYPKYL
660 670 680 690 700
KYDSQKSFAK ARNIAICIEF KDSDEEDSQP LKCIYGRPGG PVFTRSAFAA
710 720 730 740 750
VLHHHQNPEF YDEIKIELPT QLHEKHHLLL TFFHVSCDNS SKGSTKKRDV
760 770 780 790 800
VETQVGYSWL PLLKDGRVVT SEQHIPVSAN LPSGYLGYQE LGMGRHYGPE
810 820 830 840 850
IKWVDGGKPL LKISTHLVST VYTQDQHLHN FFQYCQKTES GAQALGNELV
860 870 880 890 900
KYLKSLHAME GHVMIAFLPT ILNQLFRVLT RATQEEVAVN VTRVIIHVVA
910 920 930 940 950
QCHEEGLESH LRSYVKYAYK AEPYVASEYK TVHEELTKSM TTILKPSADF
960 970 980 990 1000
LTSNKLLKYS WFFFDVLIKS MAQHLIENSK VKLLRNQRFP ASYHHAVETV
1010 1020 1030 1040 1050
VNMLMPHITQ KFRDNPEASK NANHSLAVFI KRCFTFMDRG FVFKQINNYI
1060 1070 1080 1090 1100
SCFAPGDPKT LFEYKFEFLR VVCNHEHYIP LNLPMPFGKG RIQRYQDLQL
1110 1120 1130 1140 1150
DYSLTDEFCR NHFLVGLLLR EVGTALQEFR EVRLIAISVL KNLLIKHSFD
1160 1170 1180 1190 1200
DRYASRSHQA RIATLYLPLF GLLIENVQRI NVRDVSPFPV NAGMTVKDES
1210 1220 1230 1240 1250
LALPAVNPLV TPQKGSTLDN SLHKDLLGAI SGIASPYTTS TPNINSVRNA
1260 1270 1280 1290 1300
DSRGSLISTD SGNSLPERNS EKSNSLDKHQ QSSTLGNSVV RCDKLDQSEI
1310 1320 1330 1340 1350
KSLLMCFLYI LKSMSDDALF TYWNKASTSE LMDFFTISEV CLHQFQYMGK
1360 1370 1380 1390 1400
RYIARTGMMH ARLQQLGSLD NSLTFNHSYG HSDADVLHQS LLEANIATEV
1410 1420 1430 1440 1450
CLTALDTLSL FTLAFKNQLL ADHGHNPLMK KVFDVYLCFL QKHQSETALK
1460 1470 1480 1490 1500
NVFTALRSLI YKFPSTFYEG RADMCAALCY EILKCCNSKL SSIRTEASQL
1510 1520 1530 1540 1550
LYFLMRNNFD YTGKKSFVRT HLQVIISVSQ LIADVVGIGG TRFQQSLSII
1560 1570 1580 1590 1600
NNCANSDRLI KHTSFSSDVK DLTKRIRTVL MATAQMKEHE NDPEMLVDLQ
1610 1620 1630 1640 1650
YSLAKSYAST PELRKTWLDS MARIHVKNGD LSEAAMCYVH VTALVAEYLT
1660 1670 1680 1690 1700
RKEAVQWEPP LLPHSHSACL RRSRGGVFRQ GCTAFRVITP NIDEEASMME
1710 1720 1730 1740 1750
DVGMQDVHFN EDVLMELLEQ CADGLWKAER YELIADIYKL IIPIYEKRRD
1760 1770 1780 1790 1800
FERLAHLYDT LHRAYSKVTE VMHSGRRLLG TYFRVAFFGQ AAQYQFTDSE
1810 1820 1830 1840 1850
TDVEGFFEDE DGKEYIYKEP KLTPLSEISQ RLLKLYSDKF GSENVKMIQD
1860 1870 1880 1890 1900
SGKVNPKDLD SKYAYIQVTH VIPFFDEKEL QERKTEFERS HNIRRFMFEM
1910 1920 1930 1940 1950
PFTQTGKRQG GVEEQCKRRT ILTAIHCFPY VKKRIPVMYQ HHTDLNPIEV
1960 1970 1980 1990 2000
AIDEMSKKVA ELRQLCSSAE VDMIKLQLKL QGSVSVQVNA GPLAYARAFL
2010 2020 2030 2040 2050
DDTNTKRYPD NKVKLLKEVF RQFVEACGQA LAVNERLIKE DQLEYQEEMK
2060
ANYREMAKEL SEIMHEQLG
Length:2,069
Mass (Da):236,446
Last modified:October 19, 2002 - v2
Checksum:i95073CD751745AAE
GO
Isoform 2 (identifier: Q9BZ29-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-43: MSQPPLLPAS...SEVVRGSVLL → MQADKCRTSS...VEAESPGPVP

Show »
Length:2,068
Mass (Da):236,425
Checksum:iC2654DB8162F26F1
GO
Isoform 3 (identifier: Q9BZ29-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1355-1378: RTGMMHARLQQLGSLDNSLTFNHS → SVRKISSVLGISVDNG

Note: No experimental confirmation available.
Show »
Length:2,061
Mass (Da):235,361
Checksum:iDEB17F98C3573D68
GO
Isoform 4 (identifier: Q9BZ29-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1791-1804: Missing.
     2068-2069: LG → ICPLEEKTSVLPNSLHIFNAISGTPTSTMVHGMTSSSSVV

Note: Produced by exon skipping that results in a frameshift. No experimental confirmation available.
Show »
Length:2,093
Mass (Da):238,846
Checksum:iA540EC1EDDCFFDB5
GO
Isoform 5 (identifier: Q9BZ29-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-43: MSQPPLLPAS...SEVVRGSVLL → MQADKCRTSS...VEAESPGPVP
     1234-1254: ASPYTTSTPNINSVRNADSRG → GNAPCSCGLLSTITLKVSWSQ
     1255-2069: Missing.

Note: No experimental confirmation available.
Show »
Length:1,253
Mass (Da):142,650
Checksum:i7BA871F8ACA17693
GO

Sequence cautioni

The sequence BAA83010 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti170S → P in BAG54337 (PubMed:14702039).Curated1
Sequence conflicti296S → P in BAG54337 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_062000455A → T.Corresponds to variant rs56010605dbSNPEnsembl.1
Natural variantiVAR_0530671416K → E.Corresponds to variant rs16955934dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0171281 – 43MSQPP…GSVLL → MQADKCRTSSRSVKKELVIE SPLQYKDAAQGEVEAESPGP VP in isoform 2 and isoform 5. 2 PublicationsAdd BLAST43
Alternative sequenceiVSP_0456831234 – 1254ASPYT…ADSRG → GNAPCSCGLLSTITLKVSWS Q in isoform 5. 1 PublicationAdd BLAST21
Alternative sequenceiVSP_0456841255 – 2069Missing in isoform 5. 1 PublicationAdd BLAST815
Alternative sequenceiVSP_0040241355 – 1378RTGMM…TFNHS → SVRKISSVLGISVDNG in isoform 3. CuratedAdd BLAST24
Alternative sequenceiVSP_0077091791 – 1804Missing in isoform 4. 1 PublicationAdd BLAST14
Alternative sequenceiVSP_0077102068 – 2069LG → ICPLEEKTSVLPNSLHIFNA ISGTPTSTMVHGMTSSSSVV in isoform 4. 1 Publication2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF527605 mRNA. Translation: AAM90306.1.
AB028981 mRNA. Translation: BAA83010.2. Different initiation.
AK126492 mRNA. Translation: BAG54337.1.
AL139084, AL161420 Genomic DNA. Translation: CAI13370.1.
AL139084, AL161420, AL391122 Genomic DNA. Translation: CAI13372.1.
AL161420, AL139084 Genomic DNA. Translation: CAI39569.1.
AL161420 Genomic DNA. Translation: CAI39570.1.
AL161420, AL139084, AL391122 Genomic DNA. Translation: CAI39574.1.
AL161420 Genomic DNA. Translation: CAI39577.1.
AL391122, AL139084, AL161420 Genomic DNA. Translation: CAI11061.1.
BC043506 mRNA. Translation: AAH43506.1.
CCDSiCCDS45062.1. [Q9BZ29-5]
CCDS45063.1. [Q9BZ29-6]
RefSeqiNP_001123520.1. NM_001130048.1. [Q9BZ29-5]
NP_001123521.1. NM_001130049.1.
NP_001123522.1. NM_001130050.1. [Q9BZ29-6]
NP_001305778.1. NM_001318849.1.
NP_056111.1. NM_015296.2. [Q9BZ29-1]
UniGeneiHs.596105.

Genome annotation databases

EnsembliENST00000376460; ENSP00000365643; ENSG00000088387. [Q9BZ29-5]
ENST00000627024; ENSP00000487551; ENSG00000088387. [Q9BZ29-6]
GeneIDi23348.
KEGGihsa:23348.
UCSCiuc058xyj.1. human. [Q9BZ29-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF527605 mRNA. Translation: AAM90306.1.
AB028981 mRNA. Translation: BAA83010.2. Different initiation.
AK126492 mRNA. Translation: BAG54337.1.
AL139084, AL161420 Genomic DNA. Translation: CAI13370.1.
AL139084, AL161420, AL391122 Genomic DNA. Translation: CAI13372.1.
AL161420, AL139084 Genomic DNA. Translation: CAI39569.1.
AL161420 Genomic DNA. Translation: CAI39570.1.
AL161420, AL139084, AL391122 Genomic DNA. Translation: CAI39574.1.
AL161420 Genomic DNA. Translation: CAI39577.1.
AL391122, AL139084, AL161420 Genomic DNA. Translation: CAI11061.1.
BC043506 mRNA. Translation: AAH43506.1.
CCDSiCCDS45062.1. [Q9BZ29-5]
CCDS45063.1. [Q9BZ29-6]
RefSeqiNP_001123520.1. NM_001130048.1. [Q9BZ29-5]
NP_001123521.1. NM_001130049.1.
NP_001123522.1. NM_001130050.1. [Q9BZ29-6]
NP_001305778.1. NM_001318849.1.
NP_056111.1. NM_015296.2. [Q9BZ29-1]
UniGeneiHs.596105.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WG7NMR-A165-301[»]
2WM9X-ray2.20A1605-2067[»]
2WMNX-ray2.39A1605-2067[»]
2WMOX-ray2.20A1605-2067[»]
ProteinModelPortaliQ9BZ29.
SMRiQ9BZ29.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116930. 7 interactors.
IntActiQ9BZ29. 15 interactors.
MINTiMINT-4657670.
STRINGi9606.ENSP00000365643.

PTM databases

iPTMnetiQ9BZ29.
PhosphoSitePlusiQ9BZ29.

Polymorphism and mutation databases

BioMutaiDOCK9.
DMDMi24212635.

Proteomic databases

EPDiQ9BZ29.
MaxQBiQ9BZ29.
PaxDbiQ9BZ29.
PeptideAtlasiQ9BZ29.
PRIDEiQ9BZ29.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000376460; ENSP00000365643; ENSG00000088387. [Q9BZ29-5]
ENST00000627024; ENSP00000487551; ENSG00000088387. [Q9BZ29-6]
GeneIDi23348.
KEGGihsa:23348.
UCSCiuc058xyj.1. human. [Q9BZ29-1]

Organism-specific databases

CTDi23348.
DisGeNETi23348.
GeneCardsiDOCK9.
HGNCiHGNC:14132. DOCK9.
HPAiCAB034061.
CAB034065.
HPA043940.
MIMi607325. gene.
neXtProtiNX_Q9BZ29.
OpenTargetsiENSG00000088387.
PharmGKBiPA134877754.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1997. Eukaryota.
ENOG410XNVY. LUCA.
GeneTreeiENSGT00760000119234.
HOGENOMiHOG000231373.
HOVERGENiHBG107819.
InParanoidiQ9BZ29.
PhylomeDBiQ9BZ29.
TreeFamiTF313629.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000088387-MONOMER.
ReactomeiR-HSA-983231. Factors involved in megakaryocyte development and platelet production.

Miscellaneous databases

ChiTaRSiDOCK9. human.
EvolutionaryTraceiQ9BZ29.
GeneWikiiDock9.
GenomeRNAii23348.
PROiQ9BZ29.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000088387.
ExpressionAtlasiQ9BZ29. baseline and differential.
GenevisibleiQ9BZ29. HS.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR016024. ARM-type_fold.
IPR027007. DHR-1_domain.
IPR027357. DHR-2.
IPR026791. DOCK.
IPR026796. DOCK9.
IPR010703. DOCK_C.
IPR021816. DOCK_C/D_N.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
[Graphical view]
PANTHERiPTHR23317. PTHR23317. 3 hits.
PTHR23317:SF77. PTHR23317:SF77. 3 hits.
PfamiPF06920. DHR-2. 1 hit.
PF14429. DOCK-C2. 1 hit.
PF11878. DUF3398. 1 hit.
PF00169. PH. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 5 hits.
SSF50729. SSF50729. 1 hit.
PROSITEiPS51650. DHR_1. 1 hit.
PS51651. DHR_2. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDOCK9_HUMAN
AccessioniPrimary (citable) accession number: Q9BZ29
Secondary accession number(s): B3KX25
, E9PFM9, Q5JUD4, Q5JUD6, Q5T2Q1, Q5TAN8, Q9BZ25, Q9BZ26, Q9BZ27, Q9BZ28, Q9UPU4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: October 19, 2002
Last modified: November 2, 2016
This is version 144 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

'Zizim' means 'spike' in Hebrew.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.