Q9BZ19 (ANR60_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ankyrin repeat domain-containing protein 60

Gene names

Name:	ANKRD60
Synonyms:	C20orf86

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	345 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities	Contains 2 ANK repeats. Contains 1 ubiquitin-like domain.
Sequence caution	The sequence CAI94996.3 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Domain	ANK repeat Repeat
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 345	345	Ankyrin repeat domain-containing protein 60		PRO_0000414175
Regions
	Domain	96 – 172	77	Ubiquitin-like
	Repeat	219 – 249	31	ANK 1
	Repeat	252 – 281	30	ANK 2
Natural variations
	Natural variant	295	1	R → C. Corresponds to variant rs584855 [ dbSNP | Ensembl ].		VAR_014400

Sequences

	Sequence		Length	Mass (Da)
	Q9BZ19 [UniParc]. Last modified September 11, 2007. Version 3. Checksum: FB3B25F546F5A8F5	FASTA	345	37,630
	10 20 30 40 50 60 MTRGRAWGMR RAAAGAGGAR AAGPTGGASR LHPNAGRRSG ARAGAQGCGG PRVGSADSRA 70 80 90 100 110 120 LPAQPLACAR GRSQRLVCDP KAASALPDLA PDVFVLRVRL EETGEMFRVA NCRGDMTVRE 130 140 150 160 170 180 LKEELDLMVG IPFNLQRLQY LDEGVLMDDT TLKFHDVVPG GIISLCIWHH DGWTELVLAA 190 200 210 220 230 240 VEGDPSKLSC LGLTEDSFYR TANSEHFEGE KWKHWTSQRA FVALYVASHR GHFDAVQYLL 250 260 270 280 290 300 EHGASCLSRS PLGRTPLHVA AAMGRSDCII LLLQHGASIH DRDAKGETPI SIAHRLNHTL 310 320 330 340 SERQMVLLHR IAKSGIRDLN DLVMKNALQR VKSGFRSEKM TMTPH

References

[1]

"The DNA sequence and comparative analysis of human chromosome 20." Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J. Nature 414:865-871(2001) [PubMed: 11780052] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL354776 Genomic DNA. Translation: CAI94996.3. Different initiation.
IPI	IPI00011781.
3D structure databases
ProteinModelPortal	Q9BZ19.
SMR	Q9BZ19. Positions 103-309.
ModBase	Search...
Protein-protein interaction databases
STRING	Q9BZ19.
Polymorphism databases
DMDM	158520015.
Proteomic databases
PRIDE	Q9BZ19.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000457363; ENSP00000396747; ENSG00000124227.
Organism-specific databases
GeneCards	GC20M056793.
HGNC	HGNC:16217. ANKRD60.
neXtProt	NX_Q9BZ19.
PharmGKB	PA162376674.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG18234.
GeneTree	ENSGT00390000015137.
HOGENOM	HBG506210.
HOVERGEN	HBG100447.
InParanoid	Q9BZ19.
OMA	RRMFLFY.
PhylomeDB	Q9BZ19.
Gene expression databases
ArrayExpress	Q9BZ19.
CleanEx	HS_ANKRD60.
Genevestigator	Q9BZ19.
GermOnline	ENSG00000124227. Homo sapiens.
Family and domain databases
InterPro	IPR002110. Ankyrin_rpt. IPR020683. Ankyrin_rpt-contain_dom. IPR019955. Ubiquitin_supergroup. [Graphical view]
Gene3D	G3DSA:1.25.40.20. ANK. 1 hit.
Pfam	PF12796. Ank_2. 1 hit. [Graphical view]
SMART	SM00248. ANK. 2 hits. [Graphical view]
SUPFAM	SSF48403. ANK. 1 hit.
PROSITE	PS50297. ANK_REP_REGION. 1 hit. PS50088. ANK_REPEAT. 2 hits. PS00299. UBIQUITIN_1. False negative. PS50053. UBIQUITIN_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ANR60_HUMAN

Accession

Primary (citable) accession number: Q9BZ19
Secondary accession number(s): Q4VXE6

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 6, 2002
Last sequence update:	September 11, 2007
Last modified:	January 25, 2012
This is version 78 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.