Reviewed, UniProtKB/Swiss-Prot Q9BZ19 (ANR60_HUMAN)

Names and origin

Protein names

Recommended name:
    Ankyrin repeat domain-containing protein 60

Gene names

Name:	ANKRD60
Synonyms:	C20orf86

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	345 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Sequence similarities

Contains 2 ANK repeats. Contains 1 ubiquitin-like domain.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Domain	ANK repeat Repeat Signal
Technical term	Complete proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 27	27	Potential
	Chain	28 – 345	318	Ankyrin repeat domain-containing protein 60		PRO_0000066988
Regions
	Domain	96 – 172	77	Ubiquitin-like
	Repeat	219 – 249	31	ANK 1
	Repeat	252 – 281	30	ANK 2
Natural variations
	Natural variant	295	1	R → C: dbSNP rs584855.		VAR_014400

Sequences

	Sequence		Length	Mass (Da)
	Q9BZ19-1 [UniParc]. Last modified September 11, 2007. Version 3. Checksum: FB3B25F546F5A8F5	FASTA	345	37,630
	10 20 30 40 50 60 MTRGRAWGMR RAAAGAGGAR AAGPTGGASR LHPNAGRRSG ARAGAQGCGG PRVGSADSRA 70 80 90 100 110 120 LPAQPLACAR GRSQRLVCDP KAASALPDLA PDVFVLRVRL EETGEMFRVA NCRGDMTVRE 130 140 150 160 170 180 LKEELDLMVG IPFNLQRLQY LDEGVLMDDT TLKFHDVVPG GIISLCIWHH DGWTELVLAA 190 200 210 220 230 240 VEGDPSKLSC LGLTEDSFYR TANSEHFEGE KWKHWTSQRA FVALYVASHR GHFDAVQYLL 250 260 270 280 290 300 EHGASCLSRS PLGRTPLHVA AAMGRSDCII LLLQHGASIH DRDAKGETPI SIAHRLNHTL 310 320 330 340 SERQMVLLHR IAKSGIRDLN DLVMKNALQR VKSGFRSEKM TMTPH

References

[1]

"The DNA sequence and comparative analysis of human chromosome 20." Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J. Nature 414:865-871(2001) [PubMed: 11780052] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AL354776 Genomic DNA. Translation: CAI94996.3. Different initiation.
IPI	IPI00011781.
RefSeq	XP_001134442.3.
UniGene	Hs.633491
3D structure databases
ModBase	Search...
Genome annotation databases
Ensembl	ENST00000457363; ENSP00000396747; ENSG00000124227; Homo sapiens. [Genome view]
GeneID	140731.
KEGG	hsa:140731.
Organism-specific databases
CTD	140731.
GeneCards	GC20M056227.
HGNC	HGNC:16217. ANKRD60.
PharmGKB	PA25794.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	Q9BZ19.
OMA	DQGILMD
OrthoDB	EOG99363T
Enzyme and pathway databases
BioCyc	CATTLE:ENSBTAG00000013574-MON.
Gene expression databases
ArrayExpress	Q9BZ19.
Bgee	Q9BZ19.
CleanEx	HS_ANKRD60.
Genevestigator	Q9BZ19.
GermOnline	ENSG00000124227. Homo sapiens.
Family and domain databases
InterPro	IPR002110. Ankyrin_rpt. IPR020683. Ankyrin_rpt-contain_dom. IPR019955. Ubiquitin_supergroup. [Graphical view]
Gene3D	G3DSA:1.25.40.20. ANK. 1 hit.
Pfam	PF00023. Ank. 3 hits. [Graphical view]
SMART	SM00248. ANK. 2 hits. [Graphical view]
PROSITE	PS50297. ANK_REP_REGION. 1 hit. PS50088. ANK_REPEAT. 2 hits. PS00299. UBIQUITIN_1. False negative. PS50053. UBIQUITIN_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ANR60_HUMAN

Accession

Primary (citable) accession number: Q9BZ19
Secondary accession number(s): Q4VXE6

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 6, 2002
Last sequence update:	September 11, 2007
Last modified:	November 24, 2009
This is version 61 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.