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Protein

Ankyrin repeat domain-containing protein 60

Gene

ANKRD60

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Names & Taxonomyi

Protein namesi
Recommended name:
Ankyrin repeat domain-containing protein 60
Gene namesi
Name:ANKRD60
Synonyms:C20orf86
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:16217. ANKRD60.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162376674.

Polymorphism and mutation databases

DMDMi158520015.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 345345Ankyrin repeat domain-containing protein 60PRO_0000414175Add
BLAST

Proteomic databases

EPDiQ9BZ19.
PaxDbiQ9BZ19.
PRIDEiQ9BZ19.

PTM databases

iPTMnetiQ9BZ19.
PhosphoSiteiQ9BZ19.

Expressioni

Gene expression databases

BgeeiQ9BZ19.
CleanExiHS_ANKRD60.
GenevisibleiQ9BZ19. HS.

Organism-specific databases

HPAiHPA060561.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000396747.

Structurei

3D structure databases

ProteinModelPortaliQ9BZ19.
SMRiQ9BZ19. Positions 104-167, 172-320.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini96 – 17277Ubiquitin-likePROSITE-ProRule annotationAdd
BLAST
Repeati219 – 24931ANK 1Add
BLAST
Repeati252 – 28130ANK 2Add
BLAST

Sequence similaritiesi

Contains 2 ANK repeats.PROSITE-ProRule annotation
Contains 1 ubiquitin-like domain.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiKOG4177. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00390000015137.
HOGENOMiHOG000231652.
HOVERGENiHBG100447.
InParanoidiQ9BZ19.
OMAiRMFLFYW.
PhylomeDBiQ9BZ19.
TreeFamiTF351265.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR029071. Ubiquitin-rel_dom.
IPR000626. Ubiquitin_dom.
[Graphical view]
PfamiPF12796. Ank_2. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 2 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.
PS50053. UBIQUITIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9BZ19-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTRGRAWGMR RAAAGAGGAR AAGPTGGASR LHPNAGRRSG ARAGAQGCGG
60 70 80 90 100
PRVGSADSRA LPAQPLACAR GRSQRLVCDP KAASALPDLA PDVFVLRVRL
110 120 130 140 150
EETGEMFRVA NCRGDMTVRE LKEELDLMVG IPFNLQRLQY LDEGVLMDDT
160 170 180 190 200
TLKFHDVVPG GIISLCIWHH DGWTELVLAA VEGDPSKLSC LGLTEDSFYR
210 220 230 240 250
TANSEHFEGE KWKHWTSQRA FVALYVASHR GHFDAVQYLL EHGASCLSRS
260 270 280 290 300
PLGRTPLHVA AAMGRSDCII LLLQHGASIH DRDAKGETPI SIAHRLNHTL
310 320 330 340
SERQMVLLHR IAKSGIRDLN DLVMKNALQR VKSGFRSEKM TMTPH
Length:345
Mass (Da):37,630
Last modified:September 11, 2007 - v3
Checksum:iFB3B25F546F5A8F5
GO

Sequence cautioni

The sequence CAI94996.3 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti295 – 2951R → C.
Corresponds to variant rs584855 [ dbSNP | Ensembl ].
VAR_014400

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL354776 Genomic DNA. Translation: CAI94996.3. Different initiation.
CCDSiCCDS77596.1.
RefSeqiNP_001291298.1. NM_001304369.1.
UniGeneiHs.266571.

Genome annotation databases

EnsembliENST00000457363; ENSP00000396747; ENSG00000124227.
GeneIDi140731.
KEGGihsa:140731.
UCSCiuc061xzo.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL354776 Genomic DNA. Translation: CAI94996.3. Different initiation.
CCDSiCCDS77596.1.
RefSeqiNP_001291298.1. NM_001304369.1.
UniGeneiHs.266571.

3D structure databases

ProteinModelPortaliQ9BZ19.
SMRiQ9BZ19. Positions 104-167, 172-320.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000396747.

PTM databases

iPTMnetiQ9BZ19.
PhosphoSiteiQ9BZ19.

Polymorphism and mutation databases

DMDMi158520015.

Proteomic databases

EPDiQ9BZ19.
PaxDbiQ9BZ19.
PRIDEiQ9BZ19.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000457363; ENSP00000396747; ENSG00000124227.
GeneIDi140731.
KEGGihsa:140731.
UCSCiuc061xzo.1. human.

Organism-specific databases

CTDi140731.
GeneCardsiANKRD60.
HGNCiHGNC:16217. ANKRD60.
HPAiHPA060561.
neXtProtiNX_Q9BZ19.
PharmGKBiPA162376674.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4177. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00390000015137.
HOGENOMiHOG000231652.
HOVERGENiHBG100447.
InParanoidiQ9BZ19.
OMAiRMFLFYW.
PhylomeDBiQ9BZ19.
TreeFamiTF351265.

Miscellaneous databases

GenomeRNAii140731.
PROiQ9BZ19.

Gene expression databases

BgeeiQ9BZ19.
CleanExiHS_ANKRD60.
GenevisibleiQ9BZ19. HS.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR029071. Ubiquitin-rel_dom.
IPR000626. Ubiquitin_dom.
[Graphical view]
PfamiPF12796. Ank_2. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 2 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.
PS50053. UBIQUITIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiANR60_HUMAN
AccessioniPrimary (citable) accession number: Q9BZ19
Secondary accession number(s): Q4VXE6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2002
Last sequence update: September 11, 2007
Last modified: July 6, 2016
This is version 113 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.