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Q9BZ11

- ADA33_HUMAN

UniProt

Q9BZ11 - ADA33_HUMAN

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Protein

Disintegrin and metalloproteinase domain-containing protein 33

Gene
ADAM33, C20orf153, UNQ873/PRO1891
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Cofactori

Binds 1 zinc ion per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi133 – 1331Zinc; in inhibited form By similarity
Metal bindingi345 – 3451Zinc; catalytic
Active sitei346 – 3461 By similarity
Metal bindingi349 – 3491Zinc; catalytic
Metal bindingi355 – 3551Zinc; catalytic

GO - Molecular functioni

  1. metalloendopeptidase activity Source: UniProtKB
  2. zinc ion binding Source: UniProtKB

GO - Biological processi

  1. proteolysis Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Metal-binding, Zinc

Protein family/group databases

MEROPSiM12.244.

Names & Taxonomyi

Protein namesi
Recommended name:
Disintegrin and metalloproteinase domain-containing protein 33 (EC:3.4.24.-)
Short name:
ADAM 33
Gene namesi
Name:ADAM33
Synonyms:C20orf153
ORF Names:UNQ873/PRO1891
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 20

Organism-specific databases

HGNCiHGNC:15478. ADAM33.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini30 – 701672Extracellular Reviewed predictionAdd
BLAST
Transmembranei702 – 72221Helical; Reviewed predictionAdd
BLAST
Topological domaini723 – 81391Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Involvement in diseasei

Asthma (ASTHMA) [MIM:600807]: The most common chronic disease affecting children and young adults. It is a complex genetic disorder with a heterogeneous phenotype, largely attributed to the interactions among many genes and between these genes and the environment. It is characterized by recurrent attacks of paroxysmal dyspnea, with wheezing due to spasmodic contraction of the bronchi.
Note: Disease susceptibility is associated with variations affecting the gene represented in this entry.3 Publications

Keywords - Diseasei

Asthma

Organism-specific databases

MIMi600807. phenotype.
PharmGKBiPA24526.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2929 Reviewed predictionAdd
BLAST
Propeptidei30 – 203174 By similarityPRO_0000029142Add
BLAST
Chaini204 – 813610Disintegrin and metalloproteinase domain-containing protein 33PRO_0000029143Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi109 – 1091N-linked (GlcNAc...) Reviewed prediction
Glycosylationi145 – 1451N-linked (GlcNAc...) Reviewed prediction
Glycosylationi231 – 2311N-linked (GlcNAc...)
Glycosylationi276 – 2761N-linked (GlcNAc...)
Disulfide bondi320 ↔ 404
Disulfide bondi360 ↔ 388
Disulfide bondi361 ↔ 371
Glycosylationi448 – 4481N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi475 ↔ 495 By similarity
Disulfide bondi653 ↔ 663 By similarity
Disulfide bondi657 ↔ 669 By similarity
Disulfide bondi671 ↔ 680 By similarity

Post-translational modificationi

The precursor is cleaved by a furin endopeptidase By similarity.

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

PaxDbiQ9BZ11.
PRIDEiQ9BZ11.

PTM databases

PhosphoSiteiQ9BZ11.

Expressioni

Tissue specificityi

Expressed in all tissues, except liver, with high expression in placenta, lung, spleen and veins.1 Publication

Gene expression databases

ArrayExpressiQ9BZ11.
BgeeiQ9BZ11.
CleanExiHS_ADAM33.
GenevestigatoriQ9BZ11.

Interactioni

Protein-protein interaction databases

BioGridi123243. 2 interactions.
IntActiQ9BZ11. 2 interactions.
MINTiMINT-2876745.
STRINGi9606.ENSP00000348912.

Structurei

Secondary structure

1
813
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi210 – 2189
Helixi220 – 2256
Turni226 – 2283
Helixi230 – 24819
Helixi249 – 2513
Beta strandi253 – 26210
Beta strandi264 – 2663
Helixi275 – 29218
Beta strandi296 – 3038
Helixi307 – 3093
Turni322 – 3243
Beta strandi326 – 3305
Beta strandi333 – 3353
Helixi336 – 35015
Helixi366 – 3683
Helixi387 – 39812
Turni399 – 4024
Helixi403 – 4064

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1R54X-ray1.85A204-409[»]
1R55X-ray1.58A204-409[»]
ProteinModelPortaliQ9BZ11.
SMRiQ9BZ11. Positions 204-681.

Miscellaneous databases

EvolutionaryTraceiQ9BZ11.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini210 – 409200Peptidase M12BAdd
BLAST
Domaini417 – 50387DisintegrinAdd
BLAST
Domaini649 – 68133EGF-likeAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi131 – 1388Cysteine switch By similarity

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi503 – 648146Cys-richAdd
BLAST

Domaini

The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.

Sequence similaritiesi

Contains 1 disintegrin domain.
Contains 1 EGF-like domain.

Keywords - Domaini

EGF-like domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG294463.
HOGENOMiHOG000230883.
HOVERGENiHBG006978.
InParanoidiQ9BZ11.
KOiK08616.
OMAiLPCAGRD.
OrthoDBiEOG7F7W89.
PhylomeDBiQ9BZ11.
TreeFamiTF314733.

Family and domain databases

Gene3Di3.40.390.10. 1 hit.
4.10.70.10. 1 hit.
InterProiIPR006586. ADAM_Cys-rich.
IPR001762. Blood-coag_inhib_Disintegrin.
IPR018358. Disintegrin_CS.
IPR000742. EG-like_dom.
IPR013032. EGF-like_CS.
IPR024079. MetalloPept_cat_dom.
IPR001590. Peptidase_M12B.
IPR002870. Peptidase_M12B_N.
[Graphical view]
PfamiPF08516. ADAM_CR. 1 hit.
PF00200. Disintegrin. 1 hit.
PF01562. Pep_M12B_propep. 1 hit.
PF01421. Reprolysin. 1 hit.
[Graphical view]
PRINTSiPR00289. DISINTEGRIN.
SMARTiSM00608. ACR. 1 hit.
SM00050. DISIN. 1 hit.
SM00181. EGF. 1 hit.
[Graphical view]
SUPFAMiSSF57552. SSF57552. 1 hit.
PROSITEiPS50215. ADAM_MEPRO. 1 hit.
PS00427. DISINTEGRIN_1. 1 hit.
PS50214. DISINTEGRIN_2. 1 hit.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 1 hit.
PS00142. ZINC_PROTEASE. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9BZ11-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MGWRPRRARG TPLLLLLLLL LLWPVPGAGV LQGHIPGQPV TPHWVLDGQP    50
WRTVSLEEPV SKPDMGLVAL EAEGQELLLE LEKNHRLLAP GYIETHYGPD 100
GQPVVLAPNH TDHCHYQGRV RGFPDSWVVL CTCSGMSGLI TLSRNASYYL 150
RPWPPRGSKD FSTHEIFRME QLLTWKGTCG HRDPGNKAGM TSLPGGPQSR 200
GRREARRTRK YLELYIVADH TLFLTRHRNL NHTKQRLLEV ANYVDQLLRT 250
LDIQVALTGL EVWTERDRSR VTQDANATLW AFLQWRRGLW AQRPHDSAQL 300
LTGRAFQGAT VGLAPVEGMC RAESSGGVST DHSELPIGAA ATMAHEIGHS 350
LGLSHDPDGC CVEAAAESGG CVMAAATGHP FPRVFSACSR RQLRAFFRKG 400
GGACLSNAPD PGLPVPPALC GNGFVEAGEE CDCGPGQECR DLCCFAHNCS 450
LRPGAQCAHG DCCVRCLLKP AGALCRQAMG DCDLPEFCTG TSSHCPPDVY 500
LLDGSPCARG SGYCWDGACP TLEQQCQQLW GPGSHPAPEA CFQVVNSAGD 550
AHGNCGQDSE GHFLPCAGRD ALCGKLQCQG GKPSLLAPHM VPVDSTVHLD 600
GQEVTCRGAL ALPSAQLDLL GLGLVEPGTQ CGPRMVCQSR RCRKNAFQEL 650
QRCLTACHSH GVCNSNHNCH CAPGWAPPFC DKPGFGGSMD SGPVQAENHD 700
TFLLAMLLSV LLPLLPGAGL AWCCYRLPGA HLQRCSWGCR RDPACSGPKD 750
GPHRDHPLGG VHPMELGPTA TGQPWPLDPE NSHEPSSHPE KPLPAVSPDP 800
QADQVQMPRS CLW 813
Length:813
Mass (Da):87,739
Last modified:March 27, 2002 - v2
Checksum:i90713A99668D5569
GO
Isoform 2 (identifier: Q9BZ11-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     636-661: Missing.

Show »
Length:787
Mass (Da):84,724
Checksum:iCBAF1B08B263A890
GO
Isoform 3 (identifier: Q9BZ11-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-478: Missing.
     636-661: Missing.

Note: No experimental confirmation available. By similarity with mouse isoform.

Show »
Length:309
Mass (Da):32,554
Checksum:iA60AC04E056CF264
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti109 – 1091N → S.1 Publication
Corresponds to variant rs41467948 [ dbSNP | Ensembl ].
VAR_030512
Natural varianti178 – 1781T → A.1 Publication
Corresponds to variant rs3918392 [ dbSNP | Ensembl ].
VAR_029143
Natural varianti272 – 2721T → M.1 Publication
Corresponds to variant rs41534847 [ dbSNP | Ensembl ].
VAR_030513
Natural varianti305 – 3051A → V in a cutaneous metastatic melanoma sample; somatic mutation. 1 Publication
VAR_066337
Natural varianti316 – 3161V → I.1 Publication
Corresponds to variant rs41459049 [ dbSNP | Ensembl ].
VAR_030514
Natural varianti336 – 3361P → S.1 Publication
Corresponds to variant rs41483049 [ dbSNP | Ensembl ].
VAR_030515
Natural varianti365 – 3651A → S.1 Publication
Corresponds to variant rs41419248 [ dbSNP | Ensembl ].
VAR_030516
Natural varianti441 – 4411D → E.1 Publication
Corresponds to variant rs41382144 [ dbSNP | Ensembl ].
VAR_030517
Natural varianti515 – 5151W → R.1 Publication
Corresponds to variant rs615436 [ dbSNP | Ensembl ].
VAR_030518
Natural varianti612 – 6121L → H.1 Publication
Corresponds to variant rs41453444 [ dbSNP | Ensembl ].
VAR_030519
Natural varianti710 – 7101V → I.1 Publication
Corresponds to variant rs3918396 [ dbSNP | Ensembl ].
VAR_030520
Natural varianti739 – 7391C → G.1 Publication
Corresponds to variant rs41434648 [ dbSNP | Ensembl ].
VAR_030521
Natural varianti742 – 7421D → Y.1 Publication
Corresponds to variant rs41462450 [ dbSNP | Ensembl ].
VAR_030522
Natural varianti764 – 7641M → T.1 Publication
Corresponds to variant rs2280091 [ dbSNP | Ensembl ].
VAR_021847
Natural varianti774 – 7741P → S.1 Publication
Corresponds to variant rs2280090 [ dbSNP | Ensembl ].
VAR_029144

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 478478Missing in isoform 3. VSP_015421Add
BLAST
Alternative sequencei636 – 66126Missing in isoform 2 and isoform 3. VSP_005495Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti802 – 8021Missing in AAM80482. 1 Publication
Sequence conflicti802 – 8021Missing in AAM80483. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB055891 mRNA. Translation: BAB83092.1.
AF466287 mRNA. Translation: AAM80482.1.
AF466288 Genomic DNA. Translation: AAM80483.1.
AY358314 mRNA. Translation: AAQ88680.1.
DQ995342 Genomic DNA. Translation: ABI97387.1.
AL109804, AL356755 Genomic DNA. Translation: CAI18840.1.
CCDSiCCDS13058.1. [Q9BZ11-1]
RefSeqiNP_001269376.1. NM_001282447.1.
NP_079496.1. NM_025220.3. [Q9BZ11-1]
NP_694882.1. NM_153202.2. [Q9BZ11-2]
UniGeneiHs.173716.

Genome annotation databases

EnsembliENST00000350009; ENSP00000322550; ENSG00000149451. [Q9BZ11-2]
ENST00000356518; ENSP00000348912; ENSG00000149451. [Q9BZ11-1]
GeneIDi80332.
KEGGihsa:80332.
UCSCiuc002wis.3. human. [Q9BZ11-3]
uc002wit.3. human. [Q9BZ11-1]
uc002wiu.3. human. [Q9BZ11-2]

Polymorphism databases

DMDMi20137458.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB055891 mRNA. Translation: BAB83092.1 .
AF466287 mRNA. Translation: AAM80482.1 .
AF466288 Genomic DNA. Translation: AAM80483.1 .
AY358314 mRNA. Translation: AAQ88680.1 .
DQ995342 Genomic DNA. Translation: ABI97387.1 .
AL109804 , AL356755 Genomic DNA. Translation: CAI18840.1 .
CCDSi CCDS13058.1. [Q9BZ11-1 ]
RefSeqi NP_001269376.1. NM_001282447.1.
NP_079496.1. NM_025220.3. [Q9BZ11-1 ]
NP_694882.1. NM_153202.2. [Q9BZ11-2 ]
UniGenei Hs.173716.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1R54 X-ray 1.85 A 204-409 [» ]
1R55 X-ray 1.58 A 204-409 [» ]
ProteinModelPortali Q9BZ11.
SMRi Q9BZ11. Positions 204-681.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 123243. 2 interactions.
IntActi Q9BZ11. 2 interactions.
MINTi MINT-2876745.
STRINGi 9606.ENSP00000348912.

Chemistry

BindingDBi Q9BZ11.
ChEMBLi CHEMBL6121.

Protein family/group databases

MEROPSi M12.244.

PTM databases

PhosphoSitei Q9BZ11.

Polymorphism databases

DMDMi 20137458.

Proteomic databases

PaxDbi Q9BZ11.
PRIDEi Q9BZ11.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000350009 ; ENSP00000322550 ; ENSG00000149451 . [Q9BZ11-2 ]
ENST00000356518 ; ENSP00000348912 ; ENSG00000149451 . [Q9BZ11-1 ]
GeneIDi 80332.
KEGGi hsa:80332.
UCSCi uc002wis.3. human. [Q9BZ11-3 ]
uc002wit.3. human. [Q9BZ11-1 ]
uc002wiu.3. human. [Q9BZ11-2 ]

Organism-specific databases

CTDi 80332.
GeneCardsi GC20M003596.
HGNCi HGNC:15478. ADAM33.
MIMi 600807. phenotype.
607114. gene.
neXtProti NX_Q9BZ11.
PharmGKBi PA24526.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG294463.
HOGENOMi HOG000230883.
HOVERGENi HBG006978.
InParanoidi Q9BZ11.
KOi K08616.
OMAi LPCAGRD.
OrthoDBi EOG7F7W89.
PhylomeDBi Q9BZ11.
TreeFami TF314733.

Miscellaneous databases

EvolutionaryTracei Q9BZ11.
GeneWikii ADAM33.
GenomeRNAii 80332.
NextBioi 70880.
PROi Q9BZ11.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9BZ11.
Bgeei Q9BZ11.
CleanExi HS_ADAM33.
Genevestigatori Q9BZ11.

Family and domain databases

Gene3Di 3.40.390.10. 1 hit.
4.10.70.10. 1 hit.
InterProi IPR006586. ADAM_Cys-rich.
IPR001762. Blood-coag_inhib_Disintegrin.
IPR018358. Disintegrin_CS.
IPR000742. EG-like_dom.
IPR013032. EGF-like_CS.
IPR024079. MetalloPept_cat_dom.
IPR001590. Peptidase_M12B.
IPR002870. Peptidase_M12B_N.
[Graphical view ]
Pfami PF08516. ADAM_CR. 1 hit.
PF00200. Disintegrin. 1 hit.
PF01562. Pep_M12B_propep. 1 hit.
PF01421. Reprolysin. 1 hit.
[Graphical view ]
PRINTSi PR00289. DISINTEGRIN.
SMARTi SM00608. ACR. 1 hit.
SM00050. DISIN. 1 hit.
SM00181. EGF. 1 hit.
[Graphical view ]
SUPFAMi SSF57552. SSF57552. 1 hit.
PROSITEi PS50215. ADAM_MEPRO. 1 hit.
PS00427. DISINTEGRIN_1. 1 hit.
PS50214. DISINTEGRIN_2. 1 hit.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 1 hit.
PS00142. ZINC_PROTEASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and characterization of novel mouse and human ADAM33s with potential metalloprotease activity."
    Yoshinaka T., Nishii K., Yamada K., Sawada H., Nishiwaki E., Smith K., Yoshino K., Ishiguro H., Higashiyama S.
    Gene 282:227-236(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), TISSUE SPECIFICITY.
    Tissue: Testis.
  2. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1), INVOLVEMENT IN ASTHMA.
    Tissue: Uterus.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  4. NIEHS SNPs program
    Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS SER-109; ALA-178; MET-272; ILE-316; SER-336; SER-365; GLU-441; ARG-515; HIS-612; ILE-710; GLY-739; TYR-742; THR-764 AND SER-774.
  5. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "ADAM33 haplotypes are associated with asthma in a large Australian population."
    Kedda M.A., Duffy D.L., Bradley B., O'Hehir R.E., Thompson P.J.
    Eur. J. Hum. Genet. 14:1027-1036(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INVOLVEMENT IN SUSCEPTIBILITY TO ASTHMA.
  7. "Positionally cloned asthma susceptibility gene polymorphisms and disease risk in the British 1958 Birth Cohort."
    Blakey J.D., Sayers I., Ring S.M., Strachan D.P., Hall I.P.
    Thorax 64:381-387(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: INVOLVEMENT IN SUSCEPTIBILITY TO ASTHMA.
  8. Cited for: X-RAY CRYSTALLOGRAPHY (1.58 ANGSTROMS) OF 204-410 IN COMPLEX WITH METALLOPROTEASE INHIBITOR MARIMASTAT, X-RAY CRYSTALLOGRAPHY (1.85 ANGSTROMS) OF 204-410.
  9. "Analysis of the disintegrin-metalloproteinases family reveals ADAM29 and ADAM7 are often mutated in melanoma."
    Wei X., Moncada-Pazos A., Cal S., Soria-Valles C., Gartner J., Rudloff U., Lin J.C., Rosenberg S.A., Lopez-Otin C., Samuels Y.
    Hum. Mutat. 32:E2148-E2175(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT VAL-305.

Entry informationi

Entry nameiADA33_HUMAN
AccessioniPrimary (citable) accession number: Q9BZ11
Secondary accession number(s): A0A1K6
, Q5JT75, Q5JT76, Q8N0W6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: March 27, 2002
Last modified: July 9, 2014
This is version 137 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Peptidase families
    Classification of peptidase families and list of entries
  7. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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