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Q9BZ11

- ADA33_HUMAN

UniProt

Q9BZ11 - ADA33_HUMAN

Protein

Disintegrin and metalloproteinase domain-containing protein 33

Gene

ADAM33

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 138 (01 Oct 2014)
      Sequence version 2 (27 Mar 2002)
      Previous versions | rss
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    Functioni

    Cofactori

    Binds 1 zinc ion per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi133 – 1331Zinc; in inhibited formBy similarity
    Metal bindingi345 – 3451Zinc; catalytic
    Active sitei346 – 3461PROSITE-ProRule annotation
    Metal bindingi349 – 3491Zinc; catalytic
    Metal bindingi355 – 3551Zinc; catalytic

    GO - Molecular functioni

    1. metalloendopeptidase activity Source: UniProtKB
    2. zinc ion binding Source: UniProtKB

    GO - Biological processi

    1. proteolysis Source: UniProtKB

    Keywords - Molecular functioni

    Hydrolase, Metalloprotease, Protease

    Keywords - Ligandi

    Metal-binding, Zinc

    Protein family/group databases

    MEROPSiM12.244.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Disintegrin and metalloproteinase domain-containing protein 33 (EC:3.4.24.-)
    Short name:
    ADAM 33
    Gene namesi
    Name:ADAM33
    Synonyms:C20orf153
    ORF Names:UNQ873/PRO1891
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 20

    Organism-specific databases

    HGNCiHGNC:15478. ADAM33.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Involvement in diseasei

    Asthma (ASTHMA) [MIM:600807]: The most common chronic disease affecting children and young adults. It is a complex genetic disorder with a heterogeneous phenotype, largely attributed to the interactions among many genes and between these genes and the environment. It is characterized by recurrent attacks of paroxysmal dyspnea, with wheezing due to spasmodic contraction of the bronchi.3 Publications
    Note: Disease susceptibility is associated with variations affecting the gene represented in this entry.

    Keywords - Diseasei

    Asthma

    Organism-specific databases

    MIMi600807. phenotype.
    PharmGKBiPA24526.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2929Sequence AnalysisAdd
    BLAST
    Propeptidei30 – 203174By similarityPRO_0000029142Add
    BLAST
    Chaini204 – 813610Disintegrin and metalloproteinase domain-containing protein 33PRO_0000029143Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi109 – 1091N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi145 – 1451N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi231 – 2311N-linked (GlcNAc...)
    Glycosylationi276 – 2761N-linked (GlcNAc...)
    Disulfide bondi320 ↔ 404
    Disulfide bondi360 ↔ 388
    Disulfide bondi361 ↔ 371
    Glycosylationi448 – 4481N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi475 ↔ 495By similarity
    Disulfide bondi653 ↔ 663By similarity
    Disulfide bondi657 ↔ 669By similarity
    Disulfide bondi671 ↔ 680By similarity

    Post-translational modificationi

    The precursor is cleaved by a furin endopeptidase.By similarity

    Keywords - PTMi

    Cleavage on pair of basic residues, Disulfide bond, Glycoprotein, Zymogen

    Proteomic databases

    PaxDbiQ9BZ11.
    PRIDEiQ9BZ11.

    PTM databases

    PhosphoSiteiQ9BZ11.

    Expressioni

    Tissue specificityi

    Expressed in all tissues, except liver, with high expression in placenta, lung, spleen and veins.1 Publication

    Gene expression databases

    ArrayExpressiQ9BZ11.
    BgeeiQ9BZ11.
    CleanExiHS_ADAM33.
    GenevestigatoriQ9BZ11.

    Interactioni

    Protein-protein interaction databases

    BioGridi123243. 2 interactions.
    IntActiQ9BZ11. 2 interactions.
    MINTiMINT-2876745.
    STRINGi9606.ENSP00000348912.

    Structurei

    Secondary structure

    1
    813
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi210 – 2189
    Helixi220 – 2256
    Turni226 – 2283
    Helixi230 – 24819
    Helixi249 – 2513
    Beta strandi253 – 26210
    Beta strandi264 – 2663
    Helixi275 – 29218
    Beta strandi296 – 3038
    Helixi307 – 3093
    Turni322 – 3243
    Beta strandi326 – 3305
    Beta strandi333 – 3353
    Helixi336 – 35015
    Helixi366 – 3683
    Helixi387 – 39812
    Turni399 – 4024
    Helixi403 – 4064

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1R54X-ray1.85A204-409[»]
    1R55X-ray1.58A204-409[»]
    ProteinModelPortaliQ9BZ11.
    SMRiQ9BZ11. Positions 204-681.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9BZ11.

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini30 – 701672ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini723 – 81391CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei702 – 72221HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini210 – 409200Peptidase M12BPROSITE-ProRule annotationAdd
    BLAST
    Domaini417 – 50387DisintegrinPROSITE-ProRule annotationAdd
    BLAST
    Domaini649 – 68133EGF-likePROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi131 – 1388Cysteine switchBy similarity

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi503 – 648146Cys-richAdd
    BLAST

    Domaini

    The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.

    Sequence similaritiesi

    Contains 1 disintegrin domain.PROSITE-ProRule annotation
    Contains 1 EGF-like domain.PROSITE-ProRule annotation
    Contains 1 peptidase M12B domain.PROSITE-ProRule annotation

    Keywords - Domaini

    EGF-like domain, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG294463.
    HOGENOMiHOG000230883.
    HOVERGENiHBG006978.
    InParanoidiQ9BZ11.
    KOiK08616.
    OMAiLPCAGRD.
    OrthoDBiEOG7F7W89.
    PhylomeDBiQ9BZ11.
    TreeFamiTF314733.

    Family and domain databases

    Gene3Di3.40.390.10. 1 hit.
    4.10.70.10. 1 hit.
    InterProiIPR006586. ADAM_Cys-rich.
    IPR001762. Blood-coag_inhib_Disintegrin.
    IPR018358. Disintegrin_CS.
    IPR000742. EG-like_dom.
    IPR013032. EGF-like_CS.
    IPR024079. MetalloPept_cat_dom.
    IPR001590. Peptidase_M12B.
    IPR002870. Peptidase_M12B_N.
    [Graphical view]
    PfamiPF08516. ADAM_CR. 1 hit.
    PF00200. Disintegrin. 1 hit.
    PF01562. Pep_M12B_propep. 1 hit.
    PF01421. Reprolysin. 1 hit.
    [Graphical view]
    PRINTSiPR00289. DISINTEGRIN.
    SMARTiSM00608. ACR. 1 hit.
    SM00050. DISIN. 1 hit.
    SM00181. EGF. 1 hit.
    [Graphical view]
    SUPFAMiSSF57552. SSF57552. 1 hit.
    PROSITEiPS50215. ADAM_MEPRO. 1 hit.
    PS00427. DISINTEGRIN_1. 1 hit.
    PS50214. DISINTEGRIN_2. 1 hit.
    PS01186. EGF_2. 1 hit.
    PS50026. EGF_3. 1 hit.
    PS00142. ZINC_PROTEASE. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9BZ11-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGWRPRRARG TPLLLLLLLL LLWPVPGAGV LQGHIPGQPV TPHWVLDGQP    50
    WRTVSLEEPV SKPDMGLVAL EAEGQELLLE LEKNHRLLAP GYIETHYGPD 100
    GQPVVLAPNH TDHCHYQGRV RGFPDSWVVL CTCSGMSGLI TLSRNASYYL 150
    RPWPPRGSKD FSTHEIFRME QLLTWKGTCG HRDPGNKAGM TSLPGGPQSR 200
    GRREARRTRK YLELYIVADH TLFLTRHRNL NHTKQRLLEV ANYVDQLLRT 250
    LDIQVALTGL EVWTERDRSR VTQDANATLW AFLQWRRGLW AQRPHDSAQL 300
    LTGRAFQGAT VGLAPVEGMC RAESSGGVST DHSELPIGAA ATMAHEIGHS 350
    LGLSHDPDGC CVEAAAESGG CVMAAATGHP FPRVFSACSR RQLRAFFRKG 400
    GGACLSNAPD PGLPVPPALC GNGFVEAGEE CDCGPGQECR DLCCFAHNCS 450
    LRPGAQCAHG DCCVRCLLKP AGALCRQAMG DCDLPEFCTG TSSHCPPDVY 500
    LLDGSPCARG SGYCWDGACP TLEQQCQQLW GPGSHPAPEA CFQVVNSAGD 550
    AHGNCGQDSE GHFLPCAGRD ALCGKLQCQG GKPSLLAPHM VPVDSTVHLD 600
    GQEVTCRGAL ALPSAQLDLL GLGLVEPGTQ CGPRMVCQSR RCRKNAFQEL 650
    QRCLTACHSH GVCNSNHNCH CAPGWAPPFC DKPGFGGSMD SGPVQAENHD 700
    TFLLAMLLSV LLPLLPGAGL AWCCYRLPGA HLQRCSWGCR RDPACSGPKD 750
    GPHRDHPLGG VHPMELGPTA TGQPWPLDPE NSHEPSSHPE KPLPAVSPDP 800
    QADQVQMPRS CLW 813
    Length:813
    Mass (Da):87,739
    Last modified:March 27, 2002 - v2
    Checksum:i90713A99668D5569
    GO
    Isoform 2 (identifier: Q9BZ11-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         636-661: Missing.

    Show »
    Length:787
    Mass (Da):84,724
    Checksum:iCBAF1B08B263A890
    GO
    Isoform 3 (identifier: Q9BZ11-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-478: Missing.
         636-661: Missing.

    Note: No experimental confirmation available. By similarity with mouse isoform.

    Show »
    Length:309
    Mass (Da):32,554
    Checksum:iA60AC04E056CF264
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti802 – 8021Missing in AAM80482. (PubMed:12110844)Curated
    Sequence conflicti802 – 8021Missing in AAM80483. (PubMed:12110844)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti109 – 1091N → S.1 Publication
    Corresponds to variant rs41467948 [ dbSNP | Ensembl ].
    VAR_030512
    Natural varianti178 – 1781T → A.1 Publication
    Corresponds to variant rs3918392 [ dbSNP | Ensembl ].
    VAR_029143
    Natural varianti272 – 2721T → M.1 Publication
    Corresponds to variant rs41534847 [ dbSNP | Ensembl ].
    VAR_030513
    Natural varianti305 – 3051A → V in a cutaneous metastatic melanoma sample; somatic mutation. 1 Publication
    VAR_066337
    Natural varianti316 – 3161V → I.1 Publication
    Corresponds to variant rs41459049 [ dbSNP | Ensembl ].
    VAR_030514
    Natural varianti336 – 3361P → S.1 Publication
    Corresponds to variant rs41483049 [ dbSNP | Ensembl ].
    VAR_030515
    Natural varianti365 – 3651A → S.1 Publication
    Corresponds to variant rs41419248 [ dbSNP | Ensembl ].
    VAR_030516
    Natural varianti441 – 4411D → E.1 Publication
    Corresponds to variant rs41382144 [ dbSNP | Ensembl ].
    VAR_030517
    Natural varianti515 – 5151W → R.1 Publication
    Corresponds to variant rs615436 [ dbSNP | Ensembl ].
    VAR_030518
    Natural varianti612 – 6121L → H.1 Publication
    Corresponds to variant rs41453444 [ dbSNP | Ensembl ].
    VAR_030519
    Natural varianti710 – 7101V → I.1 Publication
    Corresponds to variant rs3918396 [ dbSNP | Ensembl ].
    VAR_030520
    Natural varianti739 – 7391C → G.1 Publication
    Corresponds to variant rs41434648 [ dbSNP | Ensembl ].
    VAR_030521
    Natural varianti742 – 7421D → Y.1 Publication
    Corresponds to variant rs41462450 [ dbSNP | Ensembl ].
    VAR_030522
    Natural varianti764 – 7641M → T.1 Publication
    Corresponds to variant rs2280091 [ dbSNP | Ensembl ].
    VAR_021847
    Natural varianti774 – 7741P → S.1 Publication
    Corresponds to variant rs2280090 [ dbSNP | Ensembl ].
    VAR_029144

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 478478Missing in isoform 3. CuratedVSP_015421Add
    BLAST
    Alternative sequencei636 – 66126Missing in isoform 2 and isoform 3. 1 PublicationVSP_005495Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB055891 mRNA. Translation: BAB83092.1.
    AF466287 mRNA. Translation: AAM80482.1.
    AF466288 Genomic DNA. Translation: AAM80483.1.
    AY358314 mRNA. Translation: AAQ88680.1.
    DQ995342 Genomic DNA. Translation: ABI97387.1.
    AL109804, AL356755 Genomic DNA. Translation: CAI18840.1.
    CCDSiCCDS13058.1. [Q9BZ11-1]
    RefSeqiNP_001269376.1. NM_001282447.1.
    NP_079496.1. NM_025220.3. [Q9BZ11-1]
    NP_694882.1. NM_153202.2. [Q9BZ11-2]
    UniGeneiHs.173716.

    Genome annotation databases

    EnsembliENST00000350009; ENSP00000322550; ENSG00000149451. [Q9BZ11-2]
    ENST00000356518; ENSP00000348912; ENSG00000149451. [Q9BZ11-1]
    GeneIDi80332.
    KEGGihsa:80332.
    UCSCiuc002wis.3. human. [Q9BZ11-3]
    uc002wit.3. human. [Q9BZ11-1]
    uc002wiu.3. human. [Q9BZ11-2]

    Polymorphism databases

    DMDMi20137458.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    NIEHS-SNPs

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB055891 mRNA. Translation: BAB83092.1 .
    AF466287 mRNA. Translation: AAM80482.1 .
    AF466288 Genomic DNA. Translation: AAM80483.1 .
    AY358314 mRNA. Translation: AAQ88680.1 .
    DQ995342 Genomic DNA. Translation: ABI97387.1 .
    AL109804 , AL356755 Genomic DNA. Translation: CAI18840.1 .
    CCDSi CCDS13058.1. [Q9BZ11-1 ]
    RefSeqi NP_001269376.1. NM_001282447.1.
    NP_079496.1. NM_025220.3. [Q9BZ11-1 ]
    NP_694882.1. NM_153202.2. [Q9BZ11-2 ]
    UniGenei Hs.173716.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1R54 X-ray 1.85 A 204-409 [» ]
    1R55 X-ray 1.58 A 204-409 [» ]
    ProteinModelPortali Q9BZ11.
    SMRi Q9BZ11. Positions 204-681.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 123243. 2 interactions.
    IntActi Q9BZ11. 2 interactions.
    MINTi MINT-2876745.
    STRINGi 9606.ENSP00000348912.

    Chemistry

    BindingDBi Q9BZ11.
    ChEMBLi CHEMBL6121.

    Protein family/group databases

    MEROPSi M12.244.

    PTM databases

    PhosphoSitei Q9BZ11.

    Polymorphism databases

    DMDMi 20137458.

    Proteomic databases

    PaxDbi Q9BZ11.
    PRIDEi Q9BZ11.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000350009 ; ENSP00000322550 ; ENSG00000149451 . [Q9BZ11-2 ]
    ENST00000356518 ; ENSP00000348912 ; ENSG00000149451 . [Q9BZ11-1 ]
    GeneIDi 80332.
    KEGGi hsa:80332.
    UCSCi uc002wis.3. human. [Q9BZ11-3 ]
    uc002wit.3. human. [Q9BZ11-1 ]
    uc002wiu.3. human. [Q9BZ11-2 ]

    Organism-specific databases

    CTDi 80332.
    GeneCardsi GC20M003596.
    HGNCi HGNC:15478. ADAM33.
    MIMi 600807. phenotype.
    607114. gene.
    neXtProti NX_Q9BZ11.
    PharmGKBi PA24526.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG294463.
    HOGENOMi HOG000230883.
    HOVERGENi HBG006978.
    InParanoidi Q9BZ11.
    KOi K08616.
    OMAi LPCAGRD.
    OrthoDBi EOG7F7W89.
    PhylomeDBi Q9BZ11.
    TreeFami TF314733.

    Miscellaneous databases

    EvolutionaryTracei Q9BZ11.
    GeneWikii ADAM33.
    GenomeRNAii 80332.
    NextBioi 70880.
    PROi Q9BZ11.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9BZ11.
    Bgeei Q9BZ11.
    CleanExi HS_ADAM33.
    Genevestigatori Q9BZ11.

    Family and domain databases

    Gene3Di 3.40.390.10. 1 hit.
    4.10.70.10. 1 hit.
    InterProi IPR006586. ADAM_Cys-rich.
    IPR001762. Blood-coag_inhib_Disintegrin.
    IPR018358. Disintegrin_CS.
    IPR000742. EG-like_dom.
    IPR013032. EGF-like_CS.
    IPR024079. MetalloPept_cat_dom.
    IPR001590. Peptidase_M12B.
    IPR002870. Peptidase_M12B_N.
    [Graphical view ]
    Pfami PF08516. ADAM_CR. 1 hit.
    PF00200. Disintegrin. 1 hit.
    PF01562. Pep_M12B_propep. 1 hit.
    PF01421. Reprolysin. 1 hit.
    [Graphical view ]
    PRINTSi PR00289. DISINTEGRIN.
    SMARTi SM00608. ACR. 1 hit.
    SM00050. DISIN. 1 hit.
    SM00181. EGF. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57552. SSF57552. 1 hit.
    PROSITEi PS50215. ADAM_MEPRO. 1 hit.
    PS00427. DISINTEGRIN_1. 1 hit.
    PS50214. DISINTEGRIN_2. 1 hit.
    PS01186. EGF_2. 1 hit.
    PS50026. EGF_3. 1 hit.
    PS00142. ZINC_PROTEASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification and characterization of novel mouse and human ADAM33s with potential metalloprotease activity."
      Yoshinaka T., Nishii K., Yamada K., Sawada H., Nishiwaki E., Smith K., Yoshino K., Ishiguro H., Higashiyama S.
      Gene 282:227-236(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), TISSUE SPECIFICITY.
      Tissue: Testis.
    2. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1), INVOLVEMENT IN ASTHMA.
      Tissue: Uterus.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    4. NIEHS SNPs program
      Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS SER-109; ALA-178; MET-272; ILE-316; SER-336; SER-365; GLU-441; ARG-515; HIS-612; ILE-710; GLY-739; TYR-742; THR-764 AND SER-774.
    5. "The DNA sequence and comparative analysis of human chromosome 20."
      Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
      , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
      Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "ADAM33 haplotypes are associated with asthma in a large Australian population."
      Kedda M.A., Duffy D.L., Bradley B., O'Hehir R.E., Thompson P.J.
      Eur. J. Hum. Genet. 14:1027-1036(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: INVOLVEMENT IN SUSCEPTIBILITY TO ASTHMA.
    7. "Positionally cloned asthma susceptibility gene polymorphisms and disease risk in the British 1958 Birth Cohort."
      Blakey J.D., Sayers I., Ring S.M., Strachan D.P., Hall I.P.
      Thorax 64:381-387(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: INVOLVEMENT IN SUSCEPTIBILITY TO ASTHMA.
    8. Cited for: X-RAY CRYSTALLOGRAPHY (1.58 ANGSTROMS) OF 204-410 IN COMPLEX WITH METALLOPROTEASE INHIBITOR MARIMASTAT, X-RAY CRYSTALLOGRAPHY (1.85 ANGSTROMS) OF 204-410.
    9. "Analysis of the disintegrin-metalloproteinases family reveals ADAM29 and ADAM7 are often mutated in melanoma."
      Wei X., Moncada-Pazos A., Cal S., Soria-Valles C., Gartner J., Rudloff U., Lin J.C., Rosenberg S.A., Lopez-Otin C., Samuels Y.
      Hum. Mutat. 32:E2148-E2175(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT VAL-305.

    Entry informationi

    Entry nameiADA33_HUMAN
    AccessioniPrimary (citable) accession number: Q9BZ11
    Secondary accession number(s): A0A1K6
    , Q5JT75, Q5JT76, Q8N0W6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 27, 2002
    Last sequence update: March 27, 2002
    Last modified: October 1, 2014
    This is version 138 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 20
      Human chromosome 20: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. Peptidase families
      Classification of peptidase families and list of entries
    7. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3