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Protein

Transporter

Gene

SLC6A18

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

Keywordsi

Molecular functionIon channelImported
Biological processIon transport, SymportUniRule annotationSAAS annotation, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
TransporterUniRule annotation
Gene namesi
Name:SLC6A18Imported
ORF Names:hCG_1991125Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei27 – 45HelicalSequence analysisAdd BLAST19
Transmembranei57 – 78HelicalSequence analysisAdd BLAST22
Transmembranei99 – 127HelicalSequence analysisAdd BLAST29
Transmembranei179 – 199HelicalSequence analysisAdd BLAST21
Transmembranei208 – 228HelicalSequence analysisAdd BLAST21
Transmembranei248 – 273HelicalSequence analysisAdd BLAST26
Transmembranei294 – 318HelicalSequence analysisAdd BLAST25
Transmembranei330 – 351HelicalSequence analysisAdd BLAST22
Transmembranei372 – 394HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Membrane

Family & Domainsi

Sequence similaritiesi

Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG3659. Eukaryota.
COG0733. LUCA.
HOGENOMiHOG000116406.
HOVERGENiHBG071421.

Family and domain databases

InterProiView protein in InterPro
IPR000175. Na/ntran_symport.
IPR002438. Na/ntran_symport_orphan.
PANTHERiPTHR11616. PTHR11616. 1 hit.
PfamiView protein in Pfam
PF00209. SNF. 1 hit.
PRINTSiPR00176. NANEUSMPORT.
PR01206. ORPHTRNSPORT.
PROSITEiView protein in PROSITE
PS00610. NA_NEUROTRAN_SYMP_1. 1 hit.
PS00754. NA_NEUROTRAN_SYMP_2. 1 hit.
PS50267. NA_NEUROTRAN_SYMP_3. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9BYZ7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAHAPEPDPA ASDLGDERPK WDNKAQYLLS CIGFAVGLGN IWRFPYLCQT
60 70 80 90 100
YGGGAFLIPY VIALVFEGIP IFHVELAIGQ RLRKGSVGVW TAISPYLSGV
110 120 130 140 150
GLGCVTLSFL ISLYYNTIVA WVLWYLLNSF QHPLPWSSCP PDLNRTGFVE
160 170 180 190 200
ECQGSSAVSY FWYRQTLNIT ADINDSGSIQ WWLLICLAAS WAVVYMCVIR
210 220 230 240 250
GIETTGKVIY FTALFPYLVL TIFLIRGLTL PGATKGLIYL FTPNNPRVWL
260 270 280 290 300
DAATQIFFSL SLAFGGHIAF ASYNSPRNDC QKDAVVIALV NRMTSLYASI
310 320 330 340 350
AVFSVLGASG PGLAFVVFTE TDLHMPGAPV WAMLFFGMLF TLGLSTMFGT
360 370 380 390
VEAVITPLLD SGNYWLEIFD NFAASLNLLM LAFLEVVGVV YVYGMKR
Length:397
Mass (Da):43,784
Last modified:June 1, 2001 - v1
Checksum:iE70588E4D7FD9CF6
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei397Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY007685 Genomic DNA. Translation: AAG23290.1.
CH471102 Genomic DNA. Translation: EAX08173.1.
UniGeneiHs.213284.

Similar proteinsi

Entry informationi

Entry nameiQ9BYZ7_HUMAN
AccessioniPrimary (citable) accession number: Q9BYZ7
Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 2001
Last sequence update: June 1, 2001
Last modified: July 5, 2017
This is version 89 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.