Q9BYZ6 (RHBT2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Rho-related BTB domain-containing protein 2

Alternative name(s):
Deleted in breast cancer 2 gene protein
p83

Gene names

Name:	RHOBTB2
Synonyms:	DBC2, KIAA0717

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	727 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Tissue specificity	Ubiquitous, with highest levels in neural tissues. Expression is also detected in fetal lung, heart, and brain. Ref.1
Sequence similarities	Belongs to the small GTPase superfamily. Rho family. Contains 2 BTB (POZ) domains.
Sequence caution	The sequence BAA34437.2 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Domain	Repeat
Ligand	GTP-binding Nucleotide-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	regulation of small GTPase mediated signal transduction Traceable author statement. Source: Reactome small GTPase mediated signal transduction Traceable author statement. Source: Reactome
Cellular_component	cytosol Traceable author statement. Source: Reactome plasma membrane Traceable author statement. Source: Reactome
Molecular_function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 727	727	Rho-related BTB domain-containing protein 2		PRO_0000198962
Regions
	Domain	266 – 442	177	BTB 1
	Domain	500 – 567	68	BTB 2
	Nucleotide binding	21 – 28	8	GTP Potential
	Nucleotide binding	84 – 88	5	GTP Potential
	Nucleotide binding	140 – 143	4	GTP Potential
	Region	1 – 210	210	Rho-like
Experimental info
	Sequence conflict	255	1	C → G in AAG61157. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q9BYZ6 [UniParc]. Last modified November 28, 2002. Version 2. Checksum: 25C7493B2894A1B3	FASTA	727	82,626
	10 20 30 40 50 60 MDSDMDYERP NVETIKCVVV GDNAVGKTRL ICARACNATL TQYQLLATHV PTVWAIDQYR 70 80 90 100 110 120 VCQEVLERSR DVVDDVSVSL RLWDTFGDHH KDRRFAYGRS DVVVLCFSIA NPNSLHHVKT 130 140 150 160 170 180 MWYPEIKHFC PRAPVILVGC QLDLRYADLE AVNRARRPLA RPIKPNEILP PEKGREVAKE 190 200 210 220 230 240 LGIPYYETSV VAQFGIKDVF DNAIRAALIS RRHLQFWKSH LRNVQRPLLQ APFLPPKPPP 250 260 270 280 290 300 PIIVVPDPPS SSEECPAHLL EDPLCADVIL VLQERVRIFA HKIYLSTSSS KFYDLFLMDL 310 320 330 340 350 360 SEGELGGPSE PGGTHPEDHQ GHSDQHHHHH HHHHGRDFLL RAASFDVCES VDEAGGSGPA 370 380 390 400 410 420 GLRASTSDGI LRGNGTGYLP GRGRVLSSWS RAFVSIQEEM AEDPLTYKSR LMVVVKMDSS 430 440 450 460 470 480 IQPGPFRAVL KYLYTGELDE NERDLMHIAH IAELLEVFDL RMMVANILNN EAFMNQEITK 490 500 510 520 530 540 AFHVRRTNRV KECLAKGTFS DVTFILDDGT ISAHKPLLIS SCDWMAAMFG GPFVESSTRE 550 560 570 580 590 600 VVFPYTSKSC MRAVLEYLYT GMFTSSPDLD DMKLIILANR LCLPHLVALT EQYTVTGLME 610 620 630 640 650 660 ATQMMVDIDG DVLVFLELAQ FHCAYQLADW CLHHICTNYN NVCRKFPRDM KAMSPENQEY 670 680 690 700 710 720 FEKHRWPPVW YLKEEDHYQR ARKEREKEDY LHLKRQPKRR WLFWNSPSSP SSSAASSSSP SSSSAVV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Genomic organization and expression profile of the small GTPases of the RhoBTB family in human and mouse." Ramos S., Khademi F., Somesh B.P., Rivero F. Gene 298:147-157(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY.
[2]	"Homozygously deleted genes in breast cancer." Hamaguchi M., King D., Meth J., Odawara T., Wigler M. Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"Genomic sequence for DBC2." Hamaguchi M., Meth J., Odawara T. Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]	"Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Ishikawa K., Suyama M., Kikuno R., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 5:277-286(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[5]	"Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones." Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T. DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract] Cited for: SEQUENCE REVISION.
[6]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Eye.
+	Additional computationally mapped references.

Web resources

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY009093 mRNA. Translation: AAG61157.1. AF315385 Genomic DNA. Translation: AAK07562.1. AB018260 mRNA. Translation: BAA34437.2. Different initiation. CH471080 Genomic DNA. Translation: EAW63644.1. CH471080 Genomic DNA. Translation: EAW63646.1. BC034917 mRNA. Translation: AAH34917.1.
IPI	IPI00171950.
RefSeq	NP_001153508.1. NM_001160036.1. NP_001153509.1. NM_001160037.1. NP_055993.2. NM_015178.2.
UniGene	Hs.372688.
3D structure databases
ProteinModelPortal	Q9BYZ6.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000251822.
PTM databases
PhosphoSite	Q9BYZ6.
Polymorphism databases
DMDM	26006845.
Proteomic databases
PaxDb	Q9BYZ6.
PRIDE	Q9BYZ6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000251822; ENSP00000251822; ENSG00000008853.
GeneID	23221.
KEGG	hsa:23221.
UCSC	uc003xcq.2. human.
Organism-specific databases
CTD	23221.
GeneCards	GC08P022844.
H-InvDB	HIX0034584.
HGNC	HGNC:18756. RHOBTB2.
MIM	607352. gene.
neXtProt	NX_Q9BYZ6.
PharmGKB	PA38678.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG1100.
HOGENOM	HOG000007723.
HOVERGEN	HBG054987.
InParanoid	Q9BYZ6.
KO	K07868.
OrthoDB	EOG479F6M.
PhylomeDB	Q9BYZ6.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction.
Gene expression databases
ArrayExpress	Q9BYZ6.
Bgee	Q9BYZ6.
CleanEx	HS_RHOBTB2.
Genevestigator	Q9BYZ6.
GermOnline	ENSG00000008853. Homo sapiens.
Family and domain databases
Gene3D	3.30.710.10. 3 hits.
InterPro	IPR000210. BTB/POZ-like. IPR011333. BTB/POZ_fold. IPR013069. BTB_POZ. IPR001806. Small_GTPase. IPR003578. Small_GTPase_Rho. [Graphical view]
Pfam	PF00651. BTB. 2 hits. PF00071. Ras. 1 hit. [Graphical view]
PRINTS	PR00449. RASTRNSFRMNG.
SMART	SM00225. BTB. 2 hits. SM00174. RHO. 1 hit. [Graphical view]
SUPFAM	SSF54695. BTB/POZ_fold. 2 hits.
PROSITE	PS50097. BTB. 2 hits. PS51420. RHO. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	RHOBTB2. human.
GenomeRNAi	23221.
NextBio	44815.
SOURCE	Search...

Entry information

Entry name

RHBT2_HUMAN

Accession

Primary (citable) accession number: Q9BYZ6
Secondary accession number(s): D3DSR8 , O94825, Q8N4A8, Q9BZK6

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 28, 2002
Last sequence update:	November 28, 2002
Last modified:	May 1, 2013
This is version 108 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.