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Protein

L-lactate dehydrogenase A-like 6B

Gene

LDHAL6B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

(S)-lactate + NAD+ = pyruvate + NADH.

Pathwayi: pyruvate fermentation to lactate

This protein is involved in step 1 of the subpathway that synthesizes (S)-lactate from pyruvate.
Proteins known to be involved in this subpathway in this organism are:
  1. L-lactate dehydrogenase A-like 6A (LDHAL6A), L-lactate dehydrogenase (LDHC), L-lactate dehydrogenase (LDHC), L-lactate dehydrogenase (LDHC), L-lactate dehydrogenase, L-lactate dehydrogenase (LDHC), L-lactate dehydrogenase, L-lactate dehydrogenase A-like 6B (LDHAL6B), L-lactate dehydrogenase (HEL-S-133P), L-lactate dehydrogenase (LDHAL6A), L-lactate dehydrogenase (LDHAL6A), L-lactate dehydrogenase (LDHC), L-lactate dehydrogenase (LDHB), L-lactate dehydrogenase A chain (LDHA), L-lactate dehydrogenase B chain (LDHB), L-lactate dehydrogenase (LDHB), L-lactate dehydrogenase (LDHC), L-lactate dehydrogenase, L-lactate dehydrogenase (LDHC), L-lactate dehydrogenase C chain (LDHC)
This subpathway is part of the pathway pyruvate fermentation to lactate, which is itself part of Fermentation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (S)-lactate from pyruvate, the pathway pyruvate fermentation to lactate and in Fermentation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei148NADBy similarity1
Binding sitei155SubstrateBy similarity1
Binding sitei187NAD or substrateBy similarity1
Binding sitei218SubstrateBy similarity1
Active sitei242Proton acceptorBy similarity1
Binding sitei297SubstrateBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi101 – 106NADBy similarity6

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciZFISH:HS10427-MONOMER.
ReactomeiR-HSA-70268. Pyruvate metabolism.
UniPathwayiUPA00554; UER00611.

Names & Taxonomyi

Protein namesi
Recommended name:
L-lactate dehydrogenase A-like 6B (EC:1.1.1.27)
Gene namesi
Name:LDHAL6B
Synonyms:LDHAL6, LDHL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:21481. LDHAL6B.

Subcellular locationi

GO - Cellular componenti

  • mitochondrial matrix Source: Reactome
  • nucleus Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi92483.
OpenTargetsiENSG00000171989.
PharmGKBiPA134943157.

Polymorphism and mutation databases

BioMutaiLDHAL6B.
DMDMi116242616.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001684581 – 381L-lactate dehydrogenase A-like 6BAdd BLAST381

Proteomic databases

EPDiQ9BYZ2.
MaxQBiQ9BYZ2.
PaxDbiQ9BYZ2.
PeptideAtlasiQ9BYZ2.
PRIDEiQ9BYZ2.

PTM databases

iPTMnetiQ9BYZ2.
PhosphoSitePlusiQ9BYZ2.

Expressioni

Tissue specificityi

Testis specific.

Developmental stagei

Higher expression level in adult testis as compared to 6-week-old fetal testis.

Gene expression databases

BgeeiENSG00000171989.
CleanExiHS_LDHAL6B.
ExpressionAtlasiQ9BYZ2. baseline and differential.
GenevisibleiQ9BYZ2. HS.

Organism-specific databases

HPAiHPA053962.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
HNRNPDQ141032EBI-1108377,EBI-299674

Protein-protein interaction databases

BioGridi124950. 35 interactors.
IntActiQ9BYZ2. 7 interactors.
MINTiMINT-4776595.
STRINGi9606.ENSP00000302393.

Structurei

3D structure databases

ProteinModelPortaliQ9BYZ2.
SMRiQ9BYZ2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. LDH family.Curated

Phylogenomic databases

eggNOGiKOG1495. Eukaryota.
COG0039. LUCA.
GeneTreeiENSGT00550000074541.
HOGENOMiHOG000213793.
HOVERGENiHBG000462.
InParanoidiQ9BYZ2.
KOiK00016.
OMAiVCSKDYF.
OrthoDBiEOG091G0HME.
PhylomeDBiQ9BYZ2.
TreeFamiTF314963.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPiMF_00488. Lactate_dehydrog. 1 hit.
InterProiIPR001557. L-lactate/malate_DH.
IPR011304. L-lactate_DH.
IPR018177. L-lactate_DH_AS.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11540. PTHR11540. 1 hit.
PfamiPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSiPR00086. LLDHDRGNASE.
SUPFAMiSSF51735. SSF51735. 1 hit.
SSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01771. L-LDH-NAD. 1 hit.
PROSITEiPS00064. L_LDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9BYZ2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSWTVPVVRA SQRVSSVGAN FLCLGMALCP RQATRIPLNG TWLFTPVSKM
60 70 80 90 100
ATVKSELIER FTSEKPVHHS KVSIIGTGSV GMACAISILL KGLSDELALV
110 120 130 140 150
DLDEDKLKGE TMDLQHGSPF TKMPNIVCSK DYFVTANSNL VIITAGARQE
160 170 180 190 200
KGETRLNLVQ RNVAIFKLMI SSIVQYSPHC KLIIVSNPVD ILTYVAWKLS
210 220 230 240 250
AFPKNRIIGS GCNLDTARFR FLIGQKLGIH SESCHGWILG EHGDSSVPVW
260 270 280 290 300
SGVNIAGVPL KDLNSDIGTD KDPEQWKNVH KEVTATAYEI IKMKGYTSWA
310 320 330 340 350
IGLSVADLTE SILKNLRRIH PVSTIIKGLY GIDEEVFLSI PCILGENGIT
360 370 380
NLIKIKLTPE EEAHLKKSAK TLWEIQNKLK L
Length:381
Mass (Da):41,943
Last modified:October 17, 2006 - v3
Checksum:iF2B2D27E3ADE8A1D
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02793614V → M.2 PublicationsCorresponds to variant rs3809530dbSNPEnsembl.1
Natural variantiVAR_02793730P → L.2 PublicationsCorresponds to variant rs3809529dbSNPEnsembl.1
Natural variantiVAR_049757259P → S.Corresponds to variant rs35212259dbSNPEnsembl.1
Natural variantiVAR_027938326I → T.2 PublicationsCorresponds to variant rs3825937dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY009108 mRNA. Translation: AAG49399.1.
AY642121 mRNA. Translation: AAT65080.1.
AK058192 mRNA. Translation: BAB71710.1.
BC022034 mRNA. Translation: AAH22034.1.
CCDSiCCDS10171.1.
RefSeqiNP_149972.1. NM_033195.2.
UniGeneiHs.307052.

Genome annotation databases

EnsembliENST00000307144; ENSP00000302393; ENSG00000171989.
GeneIDi92483.
KEGGihsa:92483.
UCSCiuc002agb.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY009108 mRNA. Translation: AAG49399.1.
AY642121 mRNA. Translation: AAT65080.1.
AK058192 mRNA. Translation: BAB71710.1.
BC022034 mRNA. Translation: AAH22034.1.
CCDSiCCDS10171.1.
RefSeqiNP_149972.1. NM_033195.2.
UniGeneiHs.307052.

3D structure databases

ProteinModelPortaliQ9BYZ2.
SMRiQ9BYZ2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124950. 35 interactors.
IntActiQ9BYZ2. 7 interactors.
MINTiMINT-4776595.
STRINGi9606.ENSP00000302393.

PTM databases

iPTMnetiQ9BYZ2.
PhosphoSitePlusiQ9BYZ2.

Polymorphism and mutation databases

BioMutaiLDHAL6B.
DMDMi116242616.

Proteomic databases

EPDiQ9BYZ2.
MaxQBiQ9BYZ2.
PaxDbiQ9BYZ2.
PeptideAtlasiQ9BYZ2.
PRIDEiQ9BYZ2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000307144; ENSP00000302393; ENSG00000171989.
GeneIDi92483.
KEGGihsa:92483.
UCSCiuc002agb.5. human.

Organism-specific databases

CTDi92483.
DisGeNETi92483.
GeneCardsiLDHAL6B.
HGNCiHGNC:21481. LDHAL6B.
HPAiHPA053962.
neXtProtiNX_Q9BYZ2.
OpenTargetsiENSG00000171989.
PharmGKBiPA134943157.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1495. Eukaryota.
COG0039. LUCA.
GeneTreeiENSGT00550000074541.
HOGENOMiHOG000213793.
HOVERGENiHBG000462.
InParanoidiQ9BYZ2.
KOiK00016.
OMAiVCSKDYF.
OrthoDBiEOG091G0HME.
PhylomeDBiQ9BYZ2.
TreeFamiTF314963.

Enzyme and pathway databases

UniPathwayiUPA00554; UER00611.
BioCyciZFISH:HS10427-MONOMER.
ReactomeiR-HSA-70268. Pyruvate metabolism.

Miscellaneous databases

GenomeRNAii92483.
PROiQ9BYZ2.

Gene expression databases

BgeeiENSG00000171989.
CleanExiHS_LDHAL6B.
ExpressionAtlasiQ9BYZ2. baseline and differential.
GenevisibleiQ9BYZ2. HS.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPiMF_00488. Lactate_dehydrog. 1 hit.
InterProiIPR001557. L-lactate/malate_DH.
IPR011304. L-lactate_DH.
IPR018177. L-lactate_DH_AS.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11540. PTHR11540. 1 hit.
PfamiPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSiPR00086. LLDHDRGNASE.
SUPFAMiSSF51735. SSF51735. 1 hit.
SSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01771. L-LDH-NAD. 1 hit.
PROSITEiPS00064. L_LDH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLDH6B_HUMAN
AccessioniPrimary (citable) accession number: Q9BYZ2
Secondary accession number(s): Q6DUY4, Q96LI2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: October 17, 2006
Last modified: November 30, 2016
This is version 142 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-50 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.