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Reviewed, UniProtKB/Swiss-Prot Q9BYZ2 (LDH6B_HUMAN)

Last modified June 16, 2009. Version 72. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    L-lactate dehydrogenase A-like 6B
    EC=1.1.1.27
Gene names
Name: LDHAL6B
Synonyms: LDHAL6, LDHL
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length381 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Catalytic activity

(S)-lactate + NAD+ = pyruvate + NADH.

Pathway

Fermentation; pyruvate fermentation to lactate; (S)-lactate from pyruvate: step 1/1.

Tissue specificity

Testis specific.

Developmental stage

Higher expression level in adult testis as compared to 6-week-old fetal testis.

Sequence similarities

Belongs to the LDH/MDH superfamily. LDH family.

Caution

It is uncertain whether Met-1 or Met-50 is the initiator.

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Ontologies

Keywords
   Biological processGlycolysis
   Coding sequence diversityPolymorphism
   LigandNAD
   Molecular functionOxidoreductase
Gene Ontology (GO)
   Biological processanaerobic glycolysis

Inferred from electronic annotation. Source: InterPro

oxidation reduction

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: InterPro

   Molecular functionL-lactate dehydrogenase activity

Inferred from electronic annotation. Source: EC

protein binding

Inferred from physical interaction. Source: IntAct

Complete GO annotation...

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Binary interactions

With

Entry

#Exp.

IntAct

Notes

HNRNPDQ141032EBI-1108377,EBI-299674

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 381381L-lactate dehydrogenase A-like 6B
PRO_0000168458

Regions

Nucleotide binding101 – 1066NAD By similarity

Sites

Active site2421Proton acceptor By similarity
Binding site1481NAD By similarity
Binding site1551Substrate By similarity
Binding site1871NAD or substrate By similarity
Binding site2181Substrate By similarity
Binding site2971Substrate By similarity

Natural variations

Natural variant141V → M: dbSNP rs3809530. Ref.3 Ref.4
VAR_027936
Natural variant301P → L: dbSNP rs3809529. Ref.3 Ref.4
VAR_027937
Natural variant2591P → S: dbSNP rs35212259.
VAR_049757
Natural variant3261I → T: dbSNP rs3825937. Ref.3 Ref.4
VAR_027938

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Sequences

Sequence LengthMass (Da)Tools
Q9BYZ2-1 [UniParc].

Last modified October 17, 2006. Version 3.
Checksum: F2B2D27E3ADE8A1D

FASTA38141,943
        10         20         30         40         50         60 
MSWTVPVVRA SQRVSSVGAN FLCLGMALCP RQATRIPLNG TWLFTPVSKM ATVKSELIER 

        70         80         90        100        110        120 
FTSEKPVHHS KVSIIGTGSV GMACAISILL KGLSDELALV DLDEDKLKGE TMDLQHGSPF 

       130        140        150        160        170        180 
TKMPNIVCSK DYFVTANSNL VIITAGARQE KGETRLNLVQ RNVAIFKLMI SSIVQYSPHC 

       190        200        210        220        230        240 
KLIIVSNPVD ILTYVAWKLS AFPKNRIIGS GCNLDTARFR FLIGQKLGIH SESCHGWILG 

       250        260        270        280        290        300 
EHGDSSVPVW SGVNIAGVPL KDLNSDIGTD KDPEQWKNVH KEVTATAYEI IKMKGYTSWA 

       310        320        330        340        350        360 
IGLSVADLTE SILKNLRRIH PVSTIIKGLY GIDEEVFLSI PCILGENGIT NLIKIKLTPE 

       370        380 
EEAHLKKSAK TLWEIQNKLK L

« Hide

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References

« Hide 'large scale' references
[1]"A novel intronless human testis lactate dehydrogenase gene from adult testis."
Sha J.H., Li J.M., Zhou Z.M.
Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Testis.
[2]Tang W.W.
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS MET-14; LEU-30 AND THR-326.
Tissue: Testis.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS MET-14; LEU-30 AND THR-326.
Tissue: Testis.

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Cross-references

Sequence databases

AY009108 mRNA. Translation: AAG49399.1.
AY642121 mRNA. Translation: AAT65080.1.
AK058192 mRNA. Translation: BAB71710.1.
BC022034 mRNA. Translation: AAH22034.1.
IPIIPI00016768.
RefSeqNP_149972.1.
UniGeneHs.307052

3D structure databases

HSSPHSSP built from PDB template 1I10 based on UniProtKB P00338.
SMRQ9BYZ2. Positions 51-381.
ModBaseSearch...

Protein-protein interaction databases

IntActQ9BYZ2. 1 interaction.

Proteomic databases

PeptideAtlasQ9BYZ2.
PRIDEQ9BYZ2.

Genome annotation databases

EnsemblENSG00000171989. Homo sapiens. [Contig view]
GeneID92483.
KEGGhsa:92483.
NMPDRfig|9606.3.peg.10773.

Organism-specific databases

GeneCardsGC15P057286.
H-InvDBHIX0012290.
HGNCHGNC:21481. LDHAL6B.
PharmGKBPA134943157.
GenAtlasSearch...

Phylogenomic databases

HOGENOMQ9BYZ2.
HOVERGENQ9BYZ2.
OMAQ9BYZ2. VHAYVLG.

Enzyme and pathway databases

BRENDA1.1.1.27. 247.

Gene expression databases

ArrayExpressQ9BYZ2.
BgeeQ9BYZ2.
CleanExHS_LDHAL6B.
GermOnlineENSG00000171989. Homo sapiens.

Family and domain databases

InterProIPR001557. L-lactate/malate_DH.
IPR011304. L-lactate_DH.
IPR018177. L-lactate_DH_AS.
IPR001236. Lactate/malate_DH.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
Gene3DG3DSA:3.90.110.10. lact_mal_DH. 1 hit.
G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PfamPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSPR00086. LLDHDRGNASE.
TIGRFAMsTIGR01771. L-LDH-NAD. 1 hit.
PROSITEPS00064. L_LDH. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

DrugBankDB00157. NADH.
NextBio77767.

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Entry information

Entry nameLDH6B_HUMAN
AccessionPrimary (citable) accession number: Q9BYZ2
Secondary accession number(s): Q6DUY4, Q96LI2
Entry history
Integrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: October 17, 2006
Last modified: June 16, 2009
This is version 72 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

Human chromosome 15

Human chromosome 15: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents