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Q9BYZ0

- Q9BYZ0_HUMAN

UniProt

Q9BYZ0 - Q9BYZ0_HUMAN

Protein
Submitted name:

Beta-2 adrenergic receptor

Gene

ADRB2

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 79 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. beta2-adrenergic receptor activity Source: Ensembl

    GO - Biological processi

    1. adenylate cyclase-activating G-protein coupled receptor signaling pathway Source: Ensembl
    2. bone resorption Source: Ensembl
    3. brown fat cell differentiation Source: Ensembl
    4. diet induced thermogenesis Source: Ensembl
    5. heat generation Source: Ensembl
    6. negative regulation of multicellular organism growth Source: Ensembl
    7. negative regulation of smooth muscle contraction Source: Ensembl
    8. positive regulation of bone mineralization Source: Ensembl
    9. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    10. regulation of sodium ion transport Source: Ensembl
    11. regulation of vasodilation Source: InterPro
    12. response to cold Source: Ensembl
    13. vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure Source: Ensembl

    Keywords - Molecular functioni

    G-protein coupled receptorUniRule annotation, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Beta-2 adrenergic receptorImported
    Gene namesi
    Name:ADRB2Imported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

    Subcellular locationi

    GO - Cellular componenti

    1. apical plasma membrane Source: Ensembl
    2. integral component of membrane Source: UniProtKB-KW
    3. nucleus Source: Ensembl

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Proteomic databases

    PRIDEiQ9BYZ0.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9BYZ0.
    BgeeiQ9BYZ0.

    Interactioni

    Structurei

    3D structure databases

    ProteinModelPortaliQ9BYZ0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.UniRule annotation

    Keywords - Domaini

    TransmembraneUniRule annotation

    Phylogenomic databases

    HOVERGENiHBG106962.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000332. ADRB2_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PANTHERiPTHR24248:SF21. PTHR24248:SF21. 1 hit.
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00562. ADRENRGCB2AR.
    PR00237. GPCRRHODOPSN.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    Q9BYZ0-1 [UniParc]FASTAAdd to Basket

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    VLVITAIAKF ERLQTVTNYF ITSLACADLV MGLAVVPFGA AHILMKMWTF    50
    GNFWCEFWTS IDVLCVTASI ETLCVIAVDR YFAITSPFKY QSLLTKNKAR 100
    VIILMVWIVS GLTSFLPIQM HWYRATHQEA INCYANETCC DFFTNQAYAI 150
    ASSIVSFYVP LVIMVFVYSR VFQEAKRQLQ KIDKSEGRFH VQNLSQVEQD 200
    GRTGHGLRRS SKFCLKEHKA LKTLGIIMGT FTLCWLPFFI VNIVHVIQDN 250
    LIRKEVYILL NWIGYVNSGF NPLIY 275
    Length:275
    Mass (Da):31,547
    Last modified:June 1, 2001 - v1
    Checksum:i5CBB37404B7ACBE7
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11Imported
    Non-terminal residuei275 – 2751Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY011291 Genomic DNA. Translation: AAG35451.1.
    UniGeneiHs.2551.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY011291 Genomic DNA. Translation: AAG35451.1 .
    UniGenei Hs.2551.

    3D structure databases

    ProteinModelPortali Q9BYZ0.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    BindingDBi Q9BYZ0.

    Protein family/group databases

    GPCRDBi Search...

    Proteomic databases

    PRIDEi Q9BYZ0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    H-InvDB HIX0164423.

    Phylogenomic databases

    HOVERGENi HBG106962.

    Gene expression databases

    ArrayExpressi Q9BYZ0.
    Bgeei Q9BYZ0.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000332. ADRB2_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    PANTHERi PTHR24248:SF21. PTHR24248:SF21. 1 hit.
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00562. ADRENRGCB2AR.
    PR00237. GPCRRHODOPSN.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular phylogenetics and the origins of placental mammals."
      Murphy W.J., Eizirik E., Johnson W.E., Zhang Y.P., Ryder O.A., O'Brien S.J.
      Nature 409:614-618(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.

    Entry informationi

    Entry nameiQ9BYZ0_HUMAN
    AccessioniPrimary (citable) accession number: Q9BYZ0
    Entry historyi
    Integrated into UniProtKB/TrEMBL: June 1, 2001
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 79 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.