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Protein
Submitted name:

Beta-2 adrenergic receptor

Gene

ADRB2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptorUniRule annotation, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Submitted name:
Beta-2 adrenergic receptorImported
Gene namesi
Name:ADRB2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei19 – 45HelicalSequence analysisAdd BLAST27
Transmembranei57 – 78HelicalSequence analysisAdd BLAST22
Transmembranei99 – 118HelicalSequence analysisAdd BLAST20
Transmembranei147 – 168HelicalSequence analysisAdd BLAST22
Transmembranei224 – 244HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PaxDbiQ9BYZ0.
PeptideAtlasiQ9BYZ0.
PRIDEiQ9BYZ0.

Expressioni

Gene expression databases

BgeeiENSG00000169252.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000305372.

Structurei

3D structure databases

ProteinModelPortaliQ9BYZ0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 275G_PROTEIN_RECEP_F1_2InterPro annotationAdd BLAST275

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOVERGENiHBG106962.

Family and domain databases

InterProiIPR000332. ADRB2_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24248:SF21. PTHR24248:SF21. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00562. ADRENRGCB2AR.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q9BYZ0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
VLVITAIAKF ERLQTVTNYF ITSLACADLV MGLAVVPFGA AHILMKMWTF
60 70 80 90 100
GNFWCEFWTS IDVLCVTASI ETLCVIAVDR YFAITSPFKY QSLLTKNKAR
110 120 130 140 150
VIILMVWIVS GLTSFLPIQM HWYRATHQEA INCYANETCC DFFTNQAYAI
160 170 180 190 200
ASSIVSFYVP LVIMVFVYSR VFQEAKRQLQ KIDKSEGRFH VQNLSQVEQD
210 220 230 240 250
GRTGHGLRRS SKFCLKEHKA LKTLGIIMGT FTLCWLPFFI VNIVHVIQDN
260 270
LIRKEVYILL NWIGYVNSGF NPLIY
Length:275
Mass (Da):31,547
Last modified:June 1, 2001 - v1
Checksum:i5CBB37404B7ACBE7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1
Non-terminal residuei275Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY011291 Genomic DNA. Translation: AAG35451.1.
UniGeneiHs.2551.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY011291 Genomic DNA. Translation: AAG35451.1.
UniGeneiHs.2551.

3D structure databases

ProteinModelPortaliQ9BYZ0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000305372.

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PaxDbiQ9BYZ0.
PeptideAtlasiQ9BYZ0.
PRIDEiQ9BYZ0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

H-InvDBHIX0164423.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOVERGENiHBG106962.

Gene expression databases

BgeeiENSG00000169252.

Family and domain databases

InterProiIPR000332. ADRB2_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24248:SF21. PTHR24248:SF21. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00562. ADRENRGCB2AR.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ9BYZ0_HUMAN
AccessioniPrimary (citable) accession number: Q9BYZ0
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2001
Last sequence update: June 1, 2001
Last modified: September 7, 2016
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.