Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9BYX7

- ACTBM_HUMAN

UniProt

Q9BYX7 - ACTBM_HUMAN

Protein

Putative beta-actin-like protein 3

Gene

POTEKP

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Protein uncertaini
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 86 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW

    GO - Biological processi

    1. blood coagulation Source: Reactome
    2. platelet activation Source: Reactome
    3. platelet degranulation Source: Reactome

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    SignaLinkiQ9BYX7.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative beta-actin-like protein 3
    Alternative name(s):
    Kappa-actin
    POTE ankyrin domain family member K
    Gene namesi
    Name:POTEKP
    Synonyms:ACTBL3
    ORF Names:FKSG30
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Unplaced

    Organism-specific databases

    HGNCiHGNC:30182. POTEKP.

    Subcellular locationi

    Cytoplasmcytoskeleton By similarity

    GO - Cellular componenti

    1. cytoskeleton Source: UniProtKB-SubCell
    2. cytosol Source: Reactome
    3. extracellular region Source: Reactome

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 375375Putative beta-actin-like protein 3PRO_0000307865Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei44 – 441Methionine (R)-sulfoxideBy similarity
    Modified residuei47 – 471Methionine (R)-sulfoxideBy similarity
    Modified residuei84 – 841N6-methyllysine1 Publication

    Post-translational modificationi

    Oxidation of Met-44 and Met-47 by MICALs (MICAL1, MICAL2 or MICAL3) to form methionine sulfoxide promotes actin filament depolymerization. MICAL1 and MICAL2 produce the (R)-S-oxide form. The (R)-S-oxide form is reverted by MSRB1 and MSRB2, which promote actin repolymerization By similarity.By similarity
    Monomethylation at Lys-84 (K84me1) regulates actin-myosin interaction and actomyosin-dependent processes. Demethylation by ALKBH4 is required for maintaining actomyosin dynamics supporting normal cleavage furrow ingression during cytokinesis and cell migration.

    Keywords - PTMi

    Methylation, Oxidation

    Proteomic databases

    MaxQBiQ9BYX7.
    PaxDbiQ9BYX7.
    PRIDEiQ9BYX7.

    PTM databases

    PhosphoSiteiQ9BYX7.

    Expressioni

    Tissue specificityi

    Expressed in some hepatocellular carcinomas.1 Publication

    Gene expression databases

    GenevestigatoriQ9BYX7.

    Organism-specific databases

    HPAiHPA041264.

    Interactioni

    Subunit structurei

    Interacts with PFN1 and PFDN1. Does not interact with PFN2.1 Publication

    Protein-protein interaction databases

    IntActiQ9BYX7. 5 interactions.
    MINTiMINT-1141007.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9BYX7.
    SMRiQ9BYX7. Positions 6-375.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the actin family.Curated

    Phylogenomic databases

    eggNOGiCOG0666.

    Family and domain databases

    InterProiIPR004000. Actin-related.
    IPR020902. Actin/actin-like_CS.
    IPR004001. Actin_CS.
    [Graphical view]
    PANTHERiPTHR11937. PTHR11937. 1 hit.
    PfamiPF00022. Actin. 1 hit.
    [Graphical view]
    PRINTSiPR00190. ACTIN.
    SMARTiSM00268. ACTIN. 1 hit.
    [Graphical view]
    PROSITEiPS00432. ACTINS_2. 1 hit.
    PS01132. ACTINS_ACT_LIKE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9BYX7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDDDTAVLVI DNGSGMCKAG FAGDDAPQAV FPSIVGRPRH QGMMEGMHQK    50
    ESYVGKEAQS KRGMLTLKYP MEHGIITNWD DMEKIWHHTF YNELRVAPEE 100
    HPILLTEAPL NPKANREKMT QIMFETFNTP AMYVAIQAVL SLYTSGRTTG 150
    IVMDSGDGFT HTVPIYEGNA LPHATLRLDL AGRELTDYLM KILTERGYRF 200
    TTTAEQEIVR DIKEKLCYVA LDSEQEMAMA ASSSSVEKSY ELPDGQVITI 250
    GNERFRCPEA LFQPCFLGME SCGIHKTTFN SIVKSDVDIR KDLYTNTVLS 300
    GGTTMYPGIA HRMQKEITAL APSIMKIKII APPKRKYSVW VGGSILASLS 350
    TFQQMWISKQ EYDESGPSIV HRKCF 375
    Length:375
    Mass (Da):42,016
    Last modified:June 1, 2001 - v1
    Checksum:i98127B88A9983B7D
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti159 – 1591F → V in AAX82286. (PubMed:16824795)Curated
    Sequence conflicti177 – 1771R → P in AAX82286. (PubMed:16824795)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY014272 mRNA. Translation: AAG50355.1.
    AY970480 Genomic DNA. Translation: AAX82286.1.
    UniGeneiHs.631267.
    Hs.654289.

    Polymorphism databases

    DMDMi74739412.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY014272 mRNA. Translation: AAG50355.1 .
    AY970480 Genomic DNA. Translation: AAX82286.1 .
    UniGenei Hs.631267.
    Hs.654289.

    3D structure databases

    ProteinModelPortali Q9BYX7.
    SMRi Q9BYX7. Positions 6-375.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q9BYX7. 5 interactions.
    MINTi MINT-1141007.

    PTM databases

    PhosphoSitei Q9BYX7.

    Polymorphism databases

    DMDMi 74739412.

    Proteomic databases

    MaxQBi Q9BYX7.
    PaxDbi Q9BYX7.
    PRIDEi Q9BYX7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    GeneCardsi GC02P132350.
    HGNCi HGNC:30182. POTEKP.
    HPAi HPA041264.
    MIMi 611266. gene.
    neXtProti NX_Q9BYX7.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0666.

    Enzyme and pathway databases

    SignaLinki Q9BYX7.

    Miscellaneous databases

    PROi Q9BYX7.
    SOURCEi Search...

    Gene expression databases

    Genevestigatori Q9BYX7.

    Family and domain databases

    InterProi IPR004000. Actin-related.
    IPR020902. Actin/actin-like_CS.
    IPR004001. Actin_CS.
    [Graphical view ]
    PANTHERi PTHR11937. PTHR11937. 1 hit.
    Pfami PF00022. Actin. 1 hit.
    [Graphical view ]
    PRINTSi PR00190. ACTIN.
    SMARTi SM00268. ACTIN. 1 hit.
    [Graphical view ]
    PROSITEi PS00432. ACTINS_2. 1 hit.
    PS01132. ACTINS_ACT_LIKE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of FKSG30, a novel gene encoding a protein similar to ACTG1."
      Wang Y.-G., Gong L.
      Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Identification of a novel actin isoform in hepatocellular carcinoma."
      Chang K.-W., Yang P.-Y., Lai H.-Y., Yeh T.-S., Chen T.-C., Yeh C.-T.
      Hepatol. Res. 36:33-39(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 84-186, INTERACTION WITH PFN1 AND PFDN1, TISSUE SPECIFICITY.
      Tissue: Liver.
    3. Cited for: METHYLATION AT LYS-84, DEMETHYLATION BY ALKBH4.

    Entry informationi

    Entry nameiACTBM_HUMAN
    AccessioniPrimary (citable) accession number: Q9BYX7
    Secondary accession number(s): Q562N5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 23, 2007
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 86 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    Could be the product of a pseudogene.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3