Reviewed, UniProtKB/Swiss-Prot Q9BYX7 (ACTBM_HUMAN)

Names and origin

Protein names

Recommended name:
    Beta-actin-like protein 3
Alternative name(s):
    Kappa-actin

Gene names

Name:	ACTBL3
ORF Names:	FKSG30

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	375 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Subunit structure	Interacts with PFN1 and PFDN1. Does not interact with PFN2. Ref.2
Subcellular location	Cytoplasm › cytoskeleton By similarity.
Tissue specificity	Expressed in some hepatocellular carcinomas. Ref.2
Sequence similarities	Belongs to the actin family.

Ontologies

Keywords
Cellular component	Cytoplasm Cytoskeleton
Ligand	ATP-binding Nucleotide-binding
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	cytoskeleton Inferred from electronic annotation. Source: UniProtKB-SubCell cytosol Inferred from Experiment. Source: Reactome extracellular region Inferred from Experiment. Source: Reactome
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW protein binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 375	375	Beta-actin-like protein 3		PRO_0000307865
Experimental info
	Sequence conflict	159	1	F → V in AAX82286. Ref.2
	Sequence conflict	177	1	R → P in AAX82286. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q9BYX7-1 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: 98127B88A9983B7D	FASTA	375	42,016
	10 20 30 40 50 60 MDDDTAVLVI DNGSGMCKAG FAGDDAPQAV FPSIVGRPRH QGMMEGMHQK ESYVGKEAQS 70 80 90 100 110 120 KRGMLTLKYP MEHGIITNWD DMEKIWHHTF YNELRVAPEE HPILLTEAPL NPKANREKMT 130 140 150 160 170 180 QIMFETFNTP AMYVAIQAVL SLYTSGRTTG IVMDSGDGFT HTVPIYEGNA LPHATLRLDL 190 200 210 220 230 240 AGRELTDYLM KILTERGYRF TTTAEQEIVR DIKEKLCYVA LDSEQEMAMA ASSSSVEKSY 250 260 270 280 290 300 ELPDGQVITI GNERFRCPEA LFQPCFLGME SCGIHKTTFN SIVKSDVDIR KDLYTNTVLS 310 320 330 340 350 360 GGTTMYPGIA HRMQKEITAL APSIMKIKII APPKRKYSVW VGGSILASLS TFQQMWISKQ 370 EYDESGPSIV HRKCF

References

[1]	"Cloning and characterization of FKSG30, a novel gene encoding a protein similar to ACTG1." Wang Y.-G., Gong L. Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Identification of a novel actin isoform in hepatocellular carcinoma." Chang K.-W., Yang P.-Y., Lai H.-Y., Yeh T.-S., Chen T.-C., Yeh C.-T. Hepatol. Res. 36:33-39(2006) [PubMed: 16824795] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 84-186, INTERACTION WITH PFN1 AND PFDN1, TISSUE SPECIFICITY. Tissue: Liver.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AY014272 mRNA. Translation: AAG50355.1. AY970480 Genomic DNA. Translation: AAX82286.1.
IPI	IPI00888712.
UniGene	Hs.631267 Hs.654289
3D structure databases
HSSP	HSSP built from PDB template 2BTF based on UniProtKB P60712.
SMR	Q9BYX7. Positions 5-375.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9BYX7. 3 interactions.
STRING	Q9BYX7.
PTM databases
PhosphoSite	Q9BYX7.
Proteomic databases
PRIDE	Q9BYX7.
Genome annotation databases
Ensembl	ENST00000451531; ENSP00000392718; ENSG00000196834; Homo sapiens. [Genome view]
UCSC	uc010fmg.1. human.
Organism-specific databases
GeneCards	GC02P132068.
HGNC	HGNC:30182. ACTBL3.
MIM	611266. gene.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	HBG506345.
HOVERGEN	Q9BYX7.
Enzyme and pathway databases
Reactome	REACT_604. Hemostasis.
Gene expression databases
Bgee	Q9BYX7.
Genevestigator	Q9BYX7.
Family and domain databases
InterPro	IPR004000. Actin-like. IPR004001. Actin_CS. [Graphical view]
PANTHER	PTHR11937. Actin_like. 1 hit.
Pfam	PF00022. Actin. 1 hit. [Graphical view]
PRINTS	PR00190. ACTIN.
SMART	SM00268. ACTIN. 1 hit. [Graphical view]
PROSITE	PS00432. ACTINS_2. 1 hit. PS01132. ACTINS_ACT_LIKE. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
SOURCE	Search...

Entry information

Entry name

ACTBM_HUMAN

Accession

Primary (citable) accession number: Q9BYX7
Secondary accession number(s): Q562N5

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 23, 2007
Last sequence update:	June 1, 2001
Last modified:	December 15, 2009
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.