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Q9BYX7 (ACTBM_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 83. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Putative beta-actin-like protein 3
Alternative name(s):
Kappa-actin
POTE ankyrin domain family member K
Gene names
Name:POTEKP
Synonyms:ACTBL3
ORF Names:FKSG30
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length375 AA.
Sequence statusComplete.
Protein existenceUncertain

General annotation (Comments)

Subunit structure

Interacts with PFN1 and PFDN1. Does not interact with PFN2. Ref.2

Subcellular location

Cytoplasmcytoskeleton By similarity.

Tissue specificity

Expressed in some hepatocellular carcinomas. Ref.2

Post-translational modification

Oxidation of Met-44 and Met-47 by MICALs (MICAL1, MICAL2 or MICAL3) to form methionine sulfoxide promotes actin filament depolymerization. MICAL1 and MICAL2 produce the (R)-S-oxide form. The (R)-S-oxide form is reverted by MSRB1 and MSRB2, which promote actin repolymerization By similarity.

Monomethylation at Lys-84 (K84me1) regulates actin-myosin interaction and actomyosin-dependent processes. Demethylation by ALKBH4 is required for maintaining actomyosin dynamics supporting normal cleavage furrow ingression during cytokinesis and cell migration.

Sequence similarities

Belongs to the actin family.

Caution

Could be the product of a pseudogene.

Ontologies

Keywords
   Cellular componentCytoplasm
Cytoskeleton
   LigandATP-binding
Nucleotide-binding
   PTMMethylation
Oxidation
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processblood coagulation

Traceable author statement. Source: Reactome

platelet activation

Traceable author statement. Source: Reactome

platelet degranulation

Traceable author statement. Source: Reactome

   Cellular_componentcytoskeleton

Inferred from electronic annotation. Source: UniProtKB-SubCell

cytosol

Traceable author statement. Source: Reactome

extracellular region

Traceable author statement. Source: Reactome

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 375375Putative beta-actin-like protein 3
PRO_0000307865

Amino acid modifications

Modified residue441Methionine (R)-sulfoxide By similarity
Modified residue471Methionine (R)-sulfoxide By similarity
Modified residue841N6-methyllysine Ref.3

Experimental info

Sequence conflict1591F → V in AAX82286. Ref.2
Sequence conflict1771R → P in AAX82286. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q9BYX7 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: 98127B88A9983B7D

FASTA37542,016
        10         20         30         40         50         60 
MDDDTAVLVI DNGSGMCKAG FAGDDAPQAV FPSIVGRPRH QGMMEGMHQK ESYVGKEAQS 

        70         80         90        100        110        120 
KRGMLTLKYP MEHGIITNWD DMEKIWHHTF YNELRVAPEE HPILLTEAPL NPKANREKMT 

       130        140        150        160        170        180 
QIMFETFNTP AMYVAIQAVL SLYTSGRTTG IVMDSGDGFT HTVPIYEGNA LPHATLRLDL 

       190        200        210        220        230        240 
AGRELTDYLM KILTERGYRF TTTAEQEIVR DIKEKLCYVA LDSEQEMAMA ASSSSVEKSY 

       250        260        270        280        290        300 
ELPDGQVITI GNERFRCPEA LFQPCFLGME SCGIHKTTFN SIVKSDVDIR KDLYTNTVLS 

       310        320        330        340        350        360 
GGTTMYPGIA HRMQKEITAL APSIMKIKII APPKRKYSVW VGGSILASLS TFQQMWISKQ 

       370 
EYDESGPSIV HRKCF 

« Hide

References

[1]"Cloning and characterization of FKSG30, a novel gene encoding a protein similar to ACTG1."
Wang Y.-G., Gong L.
Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Identification of a novel actin isoform in hepatocellular carcinoma."
Chang K.-W., Yang P.-Y., Lai H.-Y., Yeh T.-S., Chen T.-C., Yeh C.-T.
Hepatol. Res. 36:33-39(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 84-186, INTERACTION WITH PFN1 AND PFDN1, TISSUE SPECIFICITY.
Tissue: Liver.
[3]"ALKBH4-dependent demethylation of actin regulates actomyosin dynamics."
Li M.M., Nilsen A., Shi Y., Fusser M., Ding Y.H., Fu Y., Liu B., Niu Y., Wu Y.S., Huang C.M., Olofsson M., Jin K.X., Lv Y., Xu X.Z., He C., Dong M.Q., Rendtlew Danielsen J.M., Klungland A., Yang Y.G.
Nat. Commun. 4:1832-1832(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: METHYLATION AT LYS-84, DEMETHYLATION BY ALKBH4.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY014272 mRNA. Translation: AAG50355.1.
AY970480 Genomic DNA. Translation: AAX82286.1.
UniGeneHs.631267.
Hs.654289.

3D structure databases

ProteinModelPortalQ9BYX7.
SMRQ9BYX7. Positions 6-375.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ9BYX7. 5 interactions.
MINTMINT-1141007.

PTM databases

PhosphoSiteQ9BYX7.

Polymorphism databases

DMDM74739412.

Proteomic databases

PaxDbQ9BYX7.
PRIDEQ9BYX7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

GeneCardsGC02P132350.
HGNCHGNC:30182. POTEKP.
HPAHPA041264.
MIM611266. gene.
neXtProtNX_Q9BYX7.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0666.

Enzyme and pathway databases

ReactomeREACT_604. Hemostasis.
SignaLinkQ9BYX7.

Gene expression databases

GenevestigatorQ9BYX7.

Family and domain databases

InterProIPR004000. Actin-related.
IPR020902. Actin/actin-like_CS.
IPR004001. Actin_CS.
[Graphical view]
PANTHERPTHR11937. PTHR11937. 1 hit.
PfamPF00022. Actin. 1 hit.
[Graphical view]
PRINTSPR00190. ACTIN.
SMARTSM00268. ACTIN. 1 hit.
[Graphical view]
PROSITEPS00432. ACTINS_2. 1 hit.
PS01132. ACTINS_ACT_LIKE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

PROQ9BYX7.
SOURCESearch...

Entry information

Entry nameACTBM_HUMAN
AccessionPrimary (citable) accession number: Q9BYX7
Secondary accession number(s): Q562N5
Entry history
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: June 1, 2001
Last modified: April 16, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 2

Human chromosome 2: entries, gene names and cross-references to MIM