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Q9BYX7

- ACTBM_HUMAN

UniProt

Q9BYX7 - ACTBM_HUMAN

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Protein

Putative beta-actin-like protein 3

Gene

POTEKP

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Protein uncertaini

Functioni

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW

GO - Biological processi

  1. blood coagulation Source: Reactome
  2. platelet activation Source: Reactome
  3. platelet degranulation Source: Reactome
Complete GO annotation...

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiQ9BYX7.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative beta-actin-like protein 3
Alternative name(s):
Kappa-actin
POTE ankyrin domain family member K
Gene namesi
Name:POTEKP
Synonyms:ACTBL3
ORF Names:FKSG30
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Unplaced

Organism-specific databases

HGNCiHGNC:30182. POTEKP.

Subcellular locationi

Cytoplasmcytoskeleton By similarity

GO - Cellular componenti

  1. cytoskeleton Source: UniProtKB-KW
  2. cytosol Source: Reactome
  3. extracellular region Source: Reactome
  4. extracellular vesicular exosome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 375375Putative beta-actin-like protein 3PRO_0000307865Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei44 – 441Methionine (R)-sulfoxideBy similarity
Modified residuei47 – 471Methionine (R)-sulfoxideBy similarity
Modified residuei84 – 841N6-methyllysine1 Publication

Post-translational modificationi

Oxidation of Met-44 and Met-47 by MICALs (MICAL1, MICAL2 or MICAL3) to form methionine sulfoxide promotes actin filament depolymerization. MICAL1 and MICAL2 produce the (R)-S-oxide form. The (R)-S-oxide form is reverted by MSRB1 and MSRB2, which promote actin repolymerization (By similarity).By similarity
Monomethylation at Lys-84 (K84me1) regulates actin-myosin interaction and actomyosin-dependent processes. Demethylation by ALKBH4 is required for maintaining actomyosin dynamics supporting normal cleavage furrow ingression during cytokinesis and cell migration.

Keywords - PTMi

Methylation, Oxidation

Proteomic databases

MaxQBiQ9BYX7.
PaxDbiQ9BYX7.
PRIDEiQ9BYX7.

PTM databases

PhosphoSiteiQ9BYX7.

Expressioni

Tissue specificityi

Expressed in some hepatocellular carcinomas.1 Publication

Gene expression databases

GenevestigatoriQ9BYX7.

Organism-specific databases

HPAiHPA041264.

Interactioni

Subunit structurei

Interacts with PFN1 and PFDN1. Does not interact with PFN2.1 Publication

Protein-protein interaction databases

IntActiQ9BYX7. 5 interactions.
MINTiMINT-1141007.

Structurei

3D structure databases

ProteinModelPortaliQ9BYX7.
SMRiQ9BYX7. Positions 6-375.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the actin family.Curated

Phylogenomic databases

eggNOGiCOG0666.
InParanoidiQ9BYX7.

Family and domain databases

InterProiIPR004000. Actin-related.
IPR020902. Actin/actin-like_CS.
IPR004001. Actin_CS.
[Graphical view]
PANTHERiPTHR11937. PTHR11937. 1 hit.
PfamiPF00022. Actin. 1 hit.
[Graphical view]
PRINTSiPR00190. ACTIN.
SMARTiSM00268. ACTIN. 1 hit.
[Graphical view]
PROSITEiPS00432. ACTINS_2. 1 hit.
PS01132. ACTINS_ACT_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9BYX7 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDDDTAVLVI DNGSGMCKAG FAGDDAPQAV FPSIVGRPRH QGMMEGMHQK
60 70 80 90 100
ESYVGKEAQS KRGMLTLKYP MEHGIITNWD DMEKIWHHTF YNELRVAPEE
110 120 130 140 150
HPILLTEAPL NPKANREKMT QIMFETFNTP AMYVAIQAVL SLYTSGRTTG
160 170 180 190 200
IVMDSGDGFT HTVPIYEGNA LPHATLRLDL AGRELTDYLM KILTERGYRF
210 220 230 240 250
TTTAEQEIVR DIKEKLCYVA LDSEQEMAMA ASSSSVEKSY ELPDGQVITI
260 270 280 290 300
GNERFRCPEA LFQPCFLGME SCGIHKTTFN SIVKSDVDIR KDLYTNTVLS
310 320 330 340 350
GGTTMYPGIA HRMQKEITAL APSIMKIKII APPKRKYSVW VGGSILASLS
360 370
TFQQMWISKQ EYDESGPSIV HRKCF
Length:375
Mass (Da):42,016
Last modified:June 1, 2001 - v1
Checksum:i98127B88A9983B7D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti159 – 1591F → V in AAX82286. (PubMed:16824795)Curated
Sequence conflicti177 – 1771R → P in AAX82286. (PubMed:16824795)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY014272 mRNA. Translation: AAG50355.1.
AY970480 Genomic DNA. Translation: AAX82286.1.
UniGeneiHs.631267.
Hs.654289.

Polymorphism databases

DMDMi74739412.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY014272 mRNA. Translation: AAG50355.1 .
AY970480 Genomic DNA. Translation: AAX82286.1 .
UniGenei Hs.631267.
Hs.654289.

3D structure databases

ProteinModelPortali Q9BYX7.
SMRi Q9BYX7. Positions 6-375.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q9BYX7. 5 interactions.
MINTi MINT-1141007.

PTM databases

PhosphoSitei Q9BYX7.

Polymorphism databases

DMDMi 74739412.

Proteomic databases

MaxQBi Q9BYX7.
PaxDbi Q9BYX7.
PRIDEi Q9BYX7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

GeneCardsi GC02P132350.
HGNCi HGNC:30182. POTEKP.
HPAi HPA041264.
MIMi 611266. gene.
neXtProti NX_Q9BYX7.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0666.
InParanoidi Q9BYX7.

Enzyme and pathway databases

SignaLinki Q9BYX7.

Miscellaneous databases

PROi Q9BYX7.
SOURCEi Search...

Gene expression databases

Genevestigatori Q9BYX7.

Family and domain databases

InterProi IPR004000. Actin-related.
IPR020902. Actin/actin-like_CS.
IPR004001. Actin_CS.
[Graphical view ]
PANTHERi PTHR11937. PTHR11937. 1 hit.
Pfami PF00022. Actin. 1 hit.
[Graphical view ]
PRINTSi PR00190. ACTIN.
SMARTi SM00268. ACTIN. 1 hit.
[Graphical view ]
PROSITEi PS00432. ACTINS_2. 1 hit.
PS01132. ACTINS_ACT_LIKE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning and characterization of FKSG30, a novel gene encoding a protein similar to ACTG1."
    Wang Y.-G., Gong L.
    Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Identification of a novel actin isoform in hepatocellular carcinoma."
    Chang K.-W., Yang P.-Y., Lai H.-Y., Yeh T.-S., Chen T.-C., Yeh C.-T.
    Hepatol. Res. 36:33-39(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 84-186, INTERACTION WITH PFN1 AND PFDN1, TISSUE SPECIFICITY.
    Tissue: Liver.
  3. Cited for: METHYLATION AT LYS-84, DEMETHYLATION BY ALKBH4.

Entry informationi

Entry nameiACTBM_HUMAN
AccessioniPrimary (citable) accession number: Q9BYX7
Secondary accession number(s): Q562N5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: June 1, 2001
Last modified: October 29, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Could be the product of a pseudogene.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3