Q9BYX7 (ACTBM_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative beta-actin-like protein 3

Alternative name(s):
Kappa-actin
POTE ankyrin domain family member K

Gene names

Name:	POTEKP
Synonyms:	ACTBL3
ORF Names:	FKSG30

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	375 AA.
Sequence status	Complete.
Protein existence	Uncertain

General annotation (Comments)

Subunit structure	Interacts with PFN1 and PFDN1. Does not interact with PFN2. Ref.2
Subcellular location	Cytoplasm › cytoskeleton By similarity.
Tissue specificity	Expressed in some hepatocellular carcinomas. Ref.2
Post-translational modification	Oxidation of Met-44 by MICALs (MICAL1, MICAL2 or MICAL3) to form methionine sulfoxide promotes actin filament depolymerization. Methionine sulfoxide is produced stereospecifically, but it is not known whether the (S)-S-oxide or the (R)-S-oxide is produced By similarity.
Sequence similarities	Belongs to the actin family.
Caution	Could be the product of a pseudogene.

Ontologies

Keywords
Cellular component	Cytoplasm Cytoskeleton
Ligand	ATP-binding Nucleotide-binding
PTM	Oxidation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	platelet activation Traceable author statement. Source: Reactome platelet degranulation Traceable author statement. Source: Reactome
Cellular_component	cytoskeleton Inferred from electronic annotation. Source: UniProtKB-SubCell cytosol Traceable author statement. Source: Reactome extracellular region Traceable author statement. Source: Reactome
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 375	375	Putative beta-actin-like protein 3		PRO_0000307865
Amino acid modifications
	Modified residue	44	1	Methionine sulfoxide By similarity
Experimental info
	Sequence conflict	159	1	F → V in AAX82286. Ref.2
	Sequence conflict	177	1	R → P in AAX82286. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q9BYX7 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: 98127B88A9983B7D	FASTA	375	42,016
	10 20 30 40 50 60 MDDDTAVLVI DNGSGMCKAG FAGDDAPQAV FPSIVGRPRH QGMMEGMHQK ESYVGKEAQS 70 80 90 100 110 120 KRGMLTLKYP MEHGIITNWD DMEKIWHHTF YNELRVAPEE HPILLTEAPL NPKANREKMT 130 140 150 160 170 180 QIMFETFNTP AMYVAIQAVL SLYTSGRTTG IVMDSGDGFT HTVPIYEGNA LPHATLRLDL 190 200 210 220 230 240 AGRELTDYLM KILTERGYRF TTTAEQEIVR DIKEKLCYVA LDSEQEMAMA ASSSSVEKSY 250 260 270 280 290 300 ELPDGQVITI GNERFRCPEA LFQPCFLGME SCGIHKTTFN SIVKSDVDIR KDLYTNTVLS 310 320 330 340 350 360 GGTTMYPGIA HRMQKEITAL APSIMKIKII APPKRKYSVW VGGSILASLS TFQQMWISKQ 370 EYDESGPSIV HRKCF

References

[1]	"Cloning and characterization of FKSG30, a novel gene encoding a protein similar to ACTG1." Wang Y.-G., Gong L. Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Identification of a novel actin isoform in hepatocellular carcinoma." Chang K.-W., Yang P.-Y., Lai H.-Y., Yeh T.-S., Chen T.-C., Yeh C.-T. Hepatol. Res. 36:33-39(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 84-186, INTERACTION WITH PFN1 AND PFDN1, TISSUE SPECIFICITY. Tissue: Liver.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY014272 mRNA. Translation: AAG50355.1. AY970480 Genomic DNA. Translation: AAX82286.1.
IPI	IPI00888712.
UniGene	Hs.631267. Hs.654289.
3D structure databases
ProteinModelPortal	Q9BYX7.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9BYX7. 3 interactions.
MINT	MINT-1141007.
PTM databases
PhosphoSite	Q9BYX7.
Polymorphism databases
DMDM	74739412.
Proteomic databases
PaxDb	Q9BYX7.
PRIDE	Q9BYX7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
GeneCards	GC02P132350.
HGNC	HGNC:30182. POTEKP.
HPA	HPA041264.
MIM	611266. gene.
neXtProt	NX_Q9BYX7.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG0666.
OrthoDB	EOG4SN1NB.
Enzyme and pathway databases
Reactome	REACT_604. Hemostasis.
SignaLink	Q9BYX7.
Gene expression databases
Genevestigator	Q9BYX7.
Family and domain databases
InterPro	IPR004000. Actin-related. IPR020902. Actin/actin-like_CS. IPR004001. Actin_CS. [Graphical view]
PANTHER	PTHR11937. PTHR11937. 1 hit.
Pfam	PF00022. Actin. 1 hit. [Graphical view]
PRINTS	PR00190. ACTIN.
SMART	SM00268. ACTIN. 1 hit. [Graphical view]
PROSITE	PS00432. ACTINS_2. 1 hit. PS01132. ACTINS_ACT_LIKE. 1 hit. [Graphical view]
ProtoNet	Search...
Other
SOURCE	Search...

Entry information

Entry name

ACTBM_HUMAN

Accession

Primary (citable) accession number: Q9BYX7
Secondary accession number(s): Q562N5

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 23, 2007
Last sequence update:	June 1, 2001
Last modified:	May 29, 2013
This is version 76 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.