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Q9BYW3

- DB126_HUMAN

UniProt

Q9BYW3 - DB126_HUMAN

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Protein
Beta-defensin 126
Gene
DEFB126, C20orf8, DEFB26
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Has antibacterial activity Reviewed prediction.

GO - Biological processi

  1. defense response to bacterium Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Antibiotic, Antimicrobial, Defensin

Enzyme and pathway databases

ReactomeiREACT_115846. Defensins.
REACT_115897. Beta defensins.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-defensin 126
Alternative name(s):
Beta-defensin 26
Short name:
DEFB-26
Defensin, beta 126
Epididymal secretory protein 13.2
Short name:
ESP13.2
Gene namesi
Name:DEFB126
Synonyms:C20orf8, DEFB26
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 20

Organism-specific databases

HGNCiHGNC:15900. DEFB126.

Subcellular locationi

GO - Cellular componenti

  1. cell surface Source: Ensembl
  2. extracellular region Source: UniProtKB-SubCell
  3. glycocalyx Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA27246.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020 Reviewed prediction
Add
BLAST
Peptidei21 – 6343Beta-defensin 126
PRO_0000006998Add
BLAST
Propeptidei66 – 11146 Reviewed prediction
PRO_0000006999Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi27 ↔ 58 By similarity
Disulfide bondi34 ↔ 52 By similarity
Disulfide bondi38 ↔ 59 By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PaxDbiQ9BYW3.
PRIDEiQ9BYW3.

Expressioni

Tissue specificityi

High-level and epididymis-specific expression.

Gene expression databases

BgeeiQ9BYW3.
CleanExiHS_DEFB126.
GenevestigatoriQ9BYW3.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000371835.

Structurei

3D structure databases

ProteinModelPortaliQ9BYW3.

Family & Domainsi

Sequence similaritiesi

Belongs to the beta-defensin family.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG79563.
HOGENOMiHOG000112158.
HOVERGENiHBG051309.
InParanoidiQ9BYW3.
OMAiICKKKCK.
OrthoDBiEOG7Z69FT.
PhylomeDBiQ9BYW3.

Family and domain databases

InterProiIPR025933. Beta_defensin.
IPR020329. Beta_defensin_126.
[Graphical view]
PfamiPF13841. Defensin_beta_2. 1 hit.
[Graphical view]
ProDomiPD289049. Beta_defensin_126. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9BYW3-1 [UniParc]FASTAAdd to Basket

« Hide

MKSLLFTLAV FMLLAQLVSG NWYVKKCLND VGICKKKCKP EEMHVKNGWA    50
MCGKQRDCCV PADRRANYPV FCVQTKTTRI STVTATTATT TLMMTTASMS 100
SMAPTPVSPT G 111
Length:111
Mass (Da):12,174
Last modified:March 15, 2005 - v2
Checksum:i956E77CB6812A32D
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti3 – 31S → F in CAC27121. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ236910 mRNA. Translation: CAC27121.1.
AF525928 mRNA. Translation: AAP47221.1.
AL360078 Genomic DNA. Translation: CAC17684.1.
AY122478 mRNA. Translation: AAM93919.1.
CCDSiCCDS12990.1.
RefSeqiNP_112193.1. NM_030931.3.
UniGeneiHs.124211.

Genome annotation databases

EnsembliENST00000382398; ENSP00000371835; ENSG00000125788.
GeneIDi81623.
KEGGihsa:81623.
UCSCiuc002wcx.3. human.

Polymorphism databases

DMDMi61252638.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ236910 mRNA. Translation: CAC27121.1 .
AF525928 mRNA. Translation: AAP47221.1 .
AL360078 Genomic DNA. Translation: CAC17684.1 .
AY122478 mRNA. Translation: AAM93919.1 .
CCDSi CCDS12990.1.
RefSeqi NP_112193.1. NM_030931.3.
UniGenei Hs.124211.

3D structure databases

ProteinModelPortali Q9BYW3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000371835.

Polymorphism databases

DMDMi 61252638.

Proteomic databases

PaxDbi Q9BYW3.
PRIDEi Q9BYW3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000382398 ; ENSP00000371835 ; ENSG00000125788 .
GeneIDi 81623.
KEGGi hsa:81623.
UCSCi uc002wcx.3. human.

Organism-specific databases

CTDi 81623.
GeneCardsi GC20P000071.
HGNCi HGNC:15900. DEFB126.
neXtProti NX_Q9BYW3.
PharmGKBi PA27246.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG79563.
HOGENOMi HOG000112158.
HOVERGENi HBG051309.
InParanoidi Q9BYW3.
OMAi ICKKKCK.
OrthoDBi EOG7Z69FT.
PhylomeDBi Q9BYW3.

Enzyme and pathway databases

Reactomei REACT_115846. Defensins.
REACT_115897. Beta defensins.

Miscellaneous databases

GeneWikii DEFB126.
GenomeRNAii 81623.
NextBioi 71992.
PROi Q9BYW3.

Gene expression databases

Bgeei Q9BYW3.
CleanExi HS_DEFB126.
Genevestigatori Q9BYW3.

Family and domain databases

InterProi IPR025933. Beta_defensin.
IPR020329. Beta_defensin_126.
[Graphical view ]
Pfami PF13841. Defensin_beta_2. 1 hit.
[Graphical view ]
ProDomi PD289049. Beta_defensin_126. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The novel epididymal secretory protein ESP13.2 in Macaca fascicularis."
    Perry A.C.F., Jones R., Moisyadi S., Coadwell W.J., Hall L.
    Biol. Reprod. 61:965-972(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Epididymis.
  2. "Distribution of new human beta-defensin genes clustered on chromosome 20 in functionally different segments of epididymis."
    Rodriguez-Jimenez F.-J., Krause A., Schulz S., Forssmann W.-G., Conejo-Garcia J.-R., Schreeb R., Motzkus D.
    Genomics 81:175-183(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Testis.
  3. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "Discovery of five conserved beta-defensin gene clusters using a computational search strategy."
    Schutte B.C., Mitros J.P., Bartlett J.A., Walters J.D., Jia H.P., Welsh M.J., Casavant T.L., McCray P.B. Jr.
    Proc. Natl. Acad. Sci. U.S.A. 99:2129-2133(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 3-96, IDENTIFICATION.
    Tissue: Testis.

Entry informationi

Entry nameiDB126_HUMAN
AccessioniPrimary (citable) accession number: Q9BYW3
Secondary accession number(s): Q562G3, Q9H1M5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: March 15, 2005
Last modified: September 3, 2014
This is version 84 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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