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Protein

Beta-defensin 126

Gene

DEFB126

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Has antibacterial activity.Curated

GO - Biological processi

  1. defense response to bacterium Source: GO_Central
  2. innate immune response Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Antibiotic, Antimicrobial, Defensin

Enzyme and pathway databases

ReactomeiREACT_115846. Defensins.
REACT_115897. Beta defensins.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-defensin 126
Alternative name(s):
Beta-defensin 26
Short name:
DEFB-26
Defensin, beta 126
Epididymal secretory protein 13.2
Short name:
ESP13.2
Gene namesi
Name:DEFB126
Synonyms:C20orf8, DEFB26
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:15900. DEFB126.

Subcellular locationi

GO - Cellular componenti

  1. cell surface Source: GO_Central
  2. extracellular region Source: UniProtKB-SubCell
  3. glycocalyx Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA27246.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence AnalysisAdd
BLAST
Peptidei21 – 6343Beta-defensin 126PRO_0000006998Add
BLAST
Propeptidei66 – 11146Sequence AnalysisPRO_0000006999Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi27 ↔ 58By similarity
Disulfide bondi34 ↔ 52By similarity
Disulfide bondi38 ↔ 59By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PaxDbiQ9BYW3.
PRIDEiQ9BYW3.

Expressioni

Tissue specificityi

High-level and epididymis-specific expression.

Gene expression databases

BgeeiQ9BYW3.
CleanExiHS_DEFB126.
GenevestigatoriQ9BYW3.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000371835.

Structurei

3D structure databases

ProteinModelPortaliQ9BYW3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the beta-defensin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG79563.
GeneTreeiENSGT00390000012226.
HOGENOMiHOG000112158.
HOVERGENiHBG051309.
InParanoidiQ9BYW3.
OMAiICKKKCK.
OrthoDBiEOG7Z69FT.
PhylomeDBiQ9BYW3.

Family and domain databases

InterProiIPR025933. Beta_defensin.
IPR020329. Beta_defensin_126.
[Graphical view]
PfamiPF13841. Defensin_beta_2. 1 hit.
[Graphical view]
ProDomiPD289049. Beta_defensin_126. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9BYW3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKSLLFTLAV FMLLAQLVSG NWYVKKCLND VGICKKKCKP EEMHVKNGWA
60 70 80 90 100
MCGKQRDCCV PADRRANYPV FCVQTKTTRI STVTATTATT TLMMTTASMS
110
SMAPTPVSPT G
Length:111
Mass (Da):12,174
Last modified:March 14, 2005 - v2
Checksum:i956E77CB6812A32D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti3 – 31S → F in CAC27121 (PubMed:10491631).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ236910 mRNA. Translation: CAC27121.1.
AF525928 mRNA. Translation: AAP47221.1.
AL360078 Genomic DNA. Translation: CAC17684.1.
AY122478 mRNA. Translation: AAM93919.1.
CCDSiCCDS12990.1.
RefSeqiNP_112193.1. NM_030931.3.
UniGeneiHs.124211.

Genome annotation databases

EnsembliENST00000382398; ENSP00000371835; ENSG00000125788.
GeneIDi81623.
KEGGihsa:81623.
UCSCiuc002wcx.3. human.

Polymorphism databases

DMDMi61252638.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ236910 mRNA. Translation: CAC27121.1.
AF525928 mRNA. Translation: AAP47221.1.
AL360078 Genomic DNA. Translation: CAC17684.1.
AY122478 mRNA. Translation: AAM93919.1.
CCDSiCCDS12990.1.
RefSeqiNP_112193.1. NM_030931.3.
UniGeneiHs.124211.

3D structure databases

ProteinModelPortaliQ9BYW3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000371835.

Polymorphism databases

DMDMi61252638.

Proteomic databases

PaxDbiQ9BYW3.
PRIDEiQ9BYW3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000382398; ENSP00000371835; ENSG00000125788.
GeneIDi81623.
KEGGihsa:81623.
UCSCiuc002wcx.3. human.

Organism-specific databases

CTDi81623.
GeneCardsiGC20P000123.
HGNCiHGNC:15900. DEFB126.
neXtProtiNX_Q9BYW3.
PharmGKBiPA27246.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG79563.
GeneTreeiENSGT00390000012226.
HOGENOMiHOG000112158.
HOVERGENiHBG051309.
InParanoidiQ9BYW3.
OMAiICKKKCK.
OrthoDBiEOG7Z69FT.
PhylomeDBiQ9BYW3.

Enzyme and pathway databases

ReactomeiREACT_115846. Defensins.
REACT_115897. Beta defensins.

Miscellaneous databases

GeneWikiiDEFB126.
GenomeRNAii81623.
NextBioi71992.
PROiQ9BYW3.

Gene expression databases

BgeeiQ9BYW3.
CleanExiHS_DEFB126.
GenevestigatoriQ9BYW3.

Family and domain databases

InterProiIPR025933. Beta_defensin.
IPR020329. Beta_defensin_126.
[Graphical view]
PfamiPF13841. Defensin_beta_2. 1 hit.
[Graphical view]
ProDomiPD289049. Beta_defensin_126. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The novel epididymal secretory protein ESP13.2 in Macaca fascicularis."
    Perry A.C.F., Jones R., Moisyadi S., Coadwell W.J., Hall L.
    Biol. Reprod. 61:965-972(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Epididymis.
  2. "Distribution of new human beta-defensin genes clustered on chromosome 20 in functionally different segments of epididymis."
    Rodriguez-Jimenez F.-J., Krause A., Schulz S., Forssmann W.-G., Conejo-Garcia J.-R., Schreeb R., Motzkus D.
    Genomics 81:175-183(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Testis.
  3. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "Discovery of five conserved beta-defensin gene clusters using a computational search strategy."
    Schutte B.C., Mitros J.P., Bartlett J.A., Walters J.D., Jia H.P., Welsh M.J., Casavant T.L., McCray P.B. Jr.
    Proc. Natl. Acad. Sci. U.S.A. 99:2129-2133(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 3-96, IDENTIFICATION.
    Tissue: Testis.

Entry informationi

Entry nameiDB126_HUMAN
AccessioniPrimary (citable) accession number: Q9BYW3
Secondary accession number(s): Q562G3, Q9H1M5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 9, 2002
Last sequence update: March 14, 2005
Last modified: February 3, 2015
This is version 88 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.