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Q9BYW3 (DB126_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 83. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Beta-defensin 126
Alternative name(s):
Beta-defensin 26
Short name=DEFB-26
Defensin, beta 126
Epididymal secretory protein 13.2
Short name=ESP13.2
Gene names
Name:DEFB126
Synonyms:C20orf8, DEFB26
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length111 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Has antibacterial activity Potential.

Subcellular location

Secreted.

Tissue specificity

High-level and epididymis-specific expression.

Sequence similarities

Belongs to the beta-defensin family.

Ontologies

Keywords
   Cellular componentSecreted
   DomainSignal
   Molecular functionAntibiotic
Antimicrobial
Defensin
   PTMCleavage on pair of basic residues
Disulfide bond
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processdefense response to bacterium

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentcell surface

Inferred from electronic annotation. Source: Ensembl

extracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

glycocalyx

Inferred from electronic annotation. Source: Ensembl

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020 Potential
Peptide21 – 6343Beta-defensin 126
PRO_0000006998
Propeptide66 – 11146 Potential
PRO_0000006999

Amino acid modifications

Disulfide bond27 ↔ 58 By similarity
Disulfide bond34 ↔ 52 By similarity
Disulfide bond38 ↔ 59 By similarity

Experimental info

Sequence conflict31S → F in CAC27121. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q9BYW3 [UniParc].

Last modified March 15, 2005. Version 2.
Checksum: 956E77CB6812A32D

FASTA11112,174
        10         20         30         40         50         60 
MKSLLFTLAV FMLLAQLVSG NWYVKKCLND VGICKKKCKP EEMHVKNGWA MCGKQRDCCV 

        70         80         90        100        110 
PADRRANYPV FCVQTKTTRI STVTATTATT TLMMTTASMS SMAPTPVSPT G 

« Hide

References

« Hide 'large scale' references
[1]"The novel epididymal secretory protein ESP13.2 in Macaca fascicularis."
Perry A.C.F., Jones R., Moisyadi S., Coadwell W.J., Hall L.
Biol. Reprod. 61:965-972(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Epididymis.
[2]"Distribution of new human beta-defensin genes clustered on chromosome 20 in functionally different segments of epididymis."
Rodriguez-Jimenez F.-J., Krause A., Schulz S., Forssmann W.-G., Conejo-Garcia J.-R., Schreeb R., Motzkus D.
Genomics 81:175-183(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Testis.
[3]"The DNA sequence and comparative analysis of human chromosome 20."
Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. expand/collapse author list , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"Discovery of five conserved beta-defensin gene clusters using a computational search strategy."
Schutte B.C., Mitros J.P., Bartlett J.A., Walters J.D., Jia H.P., Welsh M.J., Casavant T.L., McCray P.B. Jr.
Proc. Natl. Acad. Sci. U.S.A. 99:2129-2133(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 3-96, IDENTIFICATION.
Tissue: Testis.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ236910 mRNA. Translation: CAC27121.1.
AF525928 mRNA. Translation: AAP47221.1.
AL360078 Genomic DNA. Translation: CAC17684.1.
AY122478 mRNA. Translation: AAM93919.1.
CCDSCCDS12990.1.
RefSeqNP_112193.1. NM_030931.3.
UniGeneHs.124211.

3D structure databases

ProteinModelPortalQ9BYW3.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000371835.

Polymorphism databases

DMDM61252638.

Proteomic databases

PaxDbQ9BYW3.
PRIDEQ9BYW3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000382398; ENSP00000371835; ENSG00000125788.
GeneID81623.
KEGGhsa:81623.
UCSCuc002wcx.3. human.

Organism-specific databases

CTD81623.
GeneCardsGC20P000071.
HGNCHGNC:15900. DEFB126.
neXtProtNX_Q9BYW3.
PharmGKBPA27246.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG79563.
HOGENOMHOG000112158.
HOVERGENHBG051309.
InParanoidQ9BYW3.
OMAICKKKCK.
OrthoDBEOG7Z69FT.
PhylomeDBQ9BYW3.

Enzyme and pathway databases

ReactomeREACT_6900. Immune System.

Gene expression databases

BgeeQ9BYW3.
CleanExHS_DEFB126.
GenevestigatorQ9BYW3.

Family and domain databases

InterProIPR025933. Beta_defensin.
IPR020329. Beta_defensin_126.
[Graphical view]
PfamPF13841. Defensin_beta_2. 1 hit.
[Graphical view]
ProDomPD289049. Beta_defensin_126. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetSearch...

Other

GeneWikiDEFB126.
GenomeRNAi81623.
NextBio71992.
PROQ9BYW3.

Entry information

Entry nameDB126_HUMAN
AccessionPrimary (citable) accession number: Q9BYW3
Secondary accession number(s): Q562G3, Q9H1M5
Entry history
Integrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: March 15, 2005
Last modified: July 9, 2014
This is version 83 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 20

Human chromosome 20: entries, gene names and cross-references to MIM