Q9BYW3 (DB126_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Beta-defensin 126

Alternative name(s):
Beta-defensin 26
Short name=DEFB-26
Defensin, beta 126
Epididymal secretory protein 13.2
Short name=ESP13.2

Gene names

Name:	DEFB126
Synonyms:	C20orf8, DEFB26

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	111 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Has antibacterial activity Potential.
Subcellular location	Secreted.
Tissue specificity	High-level and epididymis-specific expression.
Sequence similarities	Belongs to the beta-defensin family.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Molecular function	Antibiotic Antimicrobial Defensin
PTM	Cleavage on pair of basic residues Disulfide bond
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	defense response to bacterium Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cell surface Inferred from electronic annotation. Source: Compara extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell glycocalyx Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 20	20	Potential
	Peptide	21 – 63	43	Beta-defensin 126		PRO_0000006998
	Propeptide	66 – 111	46	Potential		PRO_0000006999
Amino acid modifications
	Disulfide bond	27 ↔ 58		By similarity
	Disulfide bond	34 ↔ 52		By similarity
	Disulfide bond	38 ↔ 59		By similarity
Experimental info
	Sequence conflict	3	1	S → F in CAC27121. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q9BYW3 [UniParc]. Last modified March 15, 2005. Version 2. Checksum: 956E77CB6812A32D	FASTA	111	12,174
	10 20 30 40 50 60 MKSLLFTLAV FMLLAQLVSG NWYVKKCLND VGICKKKCKP EEMHVKNGWA MCGKQRDCCV 70 80 90 100 110 PADRRANYPV FCVQTKTTRI STVTATTATT TLMMTTASMS SMAPTPVSPT G

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The novel epididymal secretory protein ESP13.2 in Macaca fascicularis." Perry A.C.F., Jones R., Moisyadi S., Coadwell W.J., Hall L. Biol. Reprod. 61:965-972(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Epididymis.
[2]	"Distribution of new human beta-defensin genes clustered on chromosome 20 in functionally different segments of epididymis." Rodriguez-Jimenez F.-J., Krause A., Schulz S., Forssmann W.-G., Conejo-Garcia J.-R., Schreeb R., Motzkus D. Genomics 81:175-183(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Testis.
[3]	"The DNA sequence and comparative analysis of human chromosome 20." Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J. Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"Discovery of five conserved beta-defensin gene clusters using a computational search strategy." Schutte B.C., Mitros J.P., Bartlett J.A., Walters J.D., Jia H.P., Welsh M.J., Casavant T.L., McCray P.B. Jr. Proc. Natl. Acad. Sci. U.S.A. 99:2129-2133(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 3-96, IDENTIFICATION. Tissue: Testis.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ236910 mRNA. Translation: CAC27121.1. AF525928 mRNA. Translation: AAP47221.1. AL360078 Genomic DNA. Translation: CAC17684.1. AY122478 mRNA. Translation: AAM93919.1.
IPI	IPI00307734.
RefSeq	NP_112193.1. NM_030931.2.
UniGene	Hs.124211.
3D structure databases
ProteinModelPortal	Q9BYW3.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000371835.
Polymorphism databases
DMDM	61252638.
Proteomic databases
PaxDb	Q9BYW3.
PRIDE	Q9BYW3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000382398; ENSP00000371835; ENSG00000125788.
GeneID	81623.
KEGG	hsa:81623.
UCSC	uc002wcx.3. human.
Organism-specific databases
CTD	81623.
GeneCards	GC20P000071.
HGNC	HGNC:15900. DEFB126.
neXtProt	NX_Q9BYW3.
PharmGKB	PA27246.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG79563.
HOGENOM	HOG000112158.
HOVERGEN	HBG051309.
InParanoid	Q9BYW3.
OMA	ICKKKCK.
OrthoDB	EOG4933KN.
PhylomeDB	Q9BYW3.
Enzyme and pathway databases
Reactome	REACT_6900. Immune System.
Gene expression databases
Bgee	Q9BYW3.
CleanEx	HS_DEFB126.
Genevestigator	Q9BYW3.
GermOnline	ENSG00000125788. Homo sapiens.
Family and domain databases
InterPro	IPR025933. Beta_defensin. IPR020329. Beta_defensin_126. [Graphical view]
Pfam	PF13841. Defensin_beta_2. 1 hit. [Graphical view]
ProDom	PD289049. Beta_defensin_126. 1 hit. [Graphical view] [Entries sharing at least one domain]
ProtoNet	Search...
Other
GenomeRNAi	81623.
NextBio	71992.

Entry information

Entry name

DB126_HUMAN

Accession

Primary (citable) accession number: Q9BYW3
Secondary accession number(s): Q562G3, Q9H1M5

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 10, 2002
Last sequence update:	March 15, 2005
Last modified:	April 3, 2013
This is version 78 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.