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Q9BYW3

- DB126_HUMAN

UniProt

Q9BYW3 - DB126_HUMAN

Protein

Beta-defensin 126

Gene

DEFB126

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Has antibacterial activity.Curated

    GO - Biological processi

    1. defense response to bacterium Source: UniProtKB-KW

    Keywords - Molecular functioni

    Antibiotic, Antimicrobial, Defensin

    Enzyme and pathway databases

    ReactomeiREACT_115846. Defensins.
    REACT_115897. Beta defensins.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Beta-defensin 126
    Alternative name(s):
    Beta-defensin 26
    Short name:
    DEFB-26
    Defensin, beta 126
    Epididymal secretory protein 13.2
    Short name:
    ESP13.2
    Gene namesi
    Name:DEFB126
    Synonyms:C20orf8, DEFB26
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 20

    Organism-specific databases

    HGNCiHGNC:15900. DEFB126.

    Subcellular locationi

    GO - Cellular componenti

    1. cell surface Source: Ensembl
    2. extracellular region Source: UniProtKB-SubCell
    3. glycocalyx Source: Ensembl

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA27246.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020Sequence AnalysisAdd
    BLAST
    Peptidei21 – 6343Beta-defensin 126PRO_0000006998Add
    BLAST
    Propeptidei66 – 11146Sequence AnalysisPRO_0000006999Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi27 ↔ 58By similarity
    Disulfide bondi34 ↔ 52By similarity
    Disulfide bondi38 ↔ 59By similarity

    Keywords - PTMi

    Cleavage on pair of basic residues, Disulfide bond

    Proteomic databases

    PaxDbiQ9BYW3.
    PRIDEiQ9BYW3.

    Expressioni

    Tissue specificityi

    High-level and epididymis-specific expression.

    Gene expression databases

    BgeeiQ9BYW3.
    CleanExiHS_DEFB126.
    GenevestigatoriQ9BYW3.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000371835.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9BYW3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the beta-defensin family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG79563.
    HOGENOMiHOG000112158.
    HOVERGENiHBG051309.
    InParanoidiQ9BYW3.
    OMAiICKKKCK.
    OrthoDBiEOG7Z69FT.
    PhylomeDBiQ9BYW3.

    Family and domain databases

    InterProiIPR025933. Beta_defensin.
    IPR020329. Beta_defensin_126.
    [Graphical view]
    PfamiPF13841. Defensin_beta_2. 1 hit.
    [Graphical view]
    ProDomiPD289049. Beta_defensin_126. 1 hit.
    [Graphical view] [Entries sharing at least one domain]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9BYW3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKSLLFTLAV FMLLAQLVSG NWYVKKCLND VGICKKKCKP EEMHVKNGWA    50
    MCGKQRDCCV PADRRANYPV FCVQTKTTRI STVTATTATT TLMMTTASMS 100
    SMAPTPVSPT G 111
    Length:111
    Mass (Da):12,174
    Last modified:March 15, 2005 - v2
    Checksum:i956E77CB6812A32D
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti3 – 31S → F in CAC27121. (PubMed:10491631)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ236910 mRNA. Translation: CAC27121.1.
    AF525928 mRNA. Translation: AAP47221.1.
    AL360078 Genomic DNA. Translation: CAC17684.1.
    AY122478 mRNA. Translation: AAM93919.1.
    CCDSiCCDS12990.1.
    RefSeqiNP_112193.1. NM_030931.3.
    UniGeneiHs.124211.

    Genome annotation databases

    EnsembliENST00000382398; ENSP00000371835; ENSG00000125788.
    GeneIDi81623.
    KEGGihsa:81623.
    UCSCiuc002wcx.3. human.

    Polymorphism databases

    DMDMi61252638.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ236910 mRNA. Translation: CAC27121.1 .
    AF525928 mRNA. Translation: AAP47221.1 .
    AL360078 Genomic DNA. Translation: CAC17684.1 .
    AY122478 mRNA. Translation: AAM93919.1 .
    CCDSi CCDS12990.1.
    RefSeqi NP_112193.1. NM_030931.3.
    UniGenei Hs.124211.

    3D structure databases

    ProteinModelPortali Q9BYW3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000371835.

    Polymorphism databases

    DMDMi 61252638.

    Proteomic databases

    PaxDbi Q9BYW3.
    PRIDEi Q9BYW3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000382398 ; ENSP00000371835 ; ENSG00000125788 .
    GeneIDi 81623.
    KEGGi hsa:81623.
    UCSCi uc002wcx.3. human.

    Organism-specific databases

    CTDi 81623.
    GeneCardsi GC20P000071.
    HGNCi HGNC:15900. DEFB126.
    neXtProti NX_Q9BYW3.
    PharmGKBi PA27246.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG79563.
    HOGENOMi HOG000112158.
    HOVERGENi HBG051309.
    InParanoidi Q9BYW3.
    OMAi ICKKKCK.
    OrthoDBi EOG7Z69FT.
    PhylomeDBi Q9BYW3.

    Enzyme and pathway databases

    Reactomei REACT_115846. Defensins.
    REACT_115897. Beta defensins.

    Miscellaneous databases

    GeneWikii DEFB126.
    GenomeRNAii 81623.
    NextBioi 71992.
    PROi Q9BYW3.

    Gene expression databases

    Bgeei Q9BYW3.
    CleanExi HS_DEFB126.
    Genevestigatori Q9BYW3.

    Family and domain databases

    InterProi IPR025933. Beta_defensin.
    IPR020329. Beta_defensin_126.
    [Graphical view ]
    Pfami PF13841. Defensin_beta_2. 1 hit.
    [Graphical view ]
    ProDomi PD289049. Beta_defensin_126. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    ProtoNeti Search...

    Publicationsi

    1. "The novel epididymal secretory protein ESP13.2 in Macaca fascicularis."
      Perry A.C.F., Jones R., Moisyadi S., Coadwell W.J., Hall L.
      Biol. Reprod. 61:965-972(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Epididymis.
    2. "Distribution of new human beta-defensin genes clustered on chromosome 20 in functionally different segments of epididymis."
      Rodriguez-Jimenez F.-J., Krause A., Schulz S., Forssmann W.-G., Conejo-Garcia J.-R., Schreeb R., Motzkus D.
      Genomics 81:175-183(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Testis.
    3. "The DNA sequence and comparative analysis of human chromosome 20."
      Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
      , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
      Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "Discovery of five conserved beta-defensin gene clusters using a computational search strategy."
      Schutte B.C., Mitros J.P., Bartlett J.A., Walters J.D., Jia H.P., Welsh M.J., Casavant T.L., McCray P.B. Jr.
      Proc. Natl. Acad. Sci. U.S.A. 99:2129-2133(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 3-96, IDENTIFICATION.
      Tissue: Testis.

    Entry informationi

    Entry nameiDB126_HUMAN
    AccessioniPrimary (citable) accession number: Q9BYW3
    Secondary accession number(s): Q562G3, Q9H1M5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 10, 2002
    Last sequence update: March 15, 2005
    Last modified: October 1, 2014
    This is version 85 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 20
      Human chromosome 20: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3