ID GTR11_HUMAN Reviewed; 496 AA. AC Q9BYW1; E9PH55; Q542Y4; Q6ICJ5; Q8WXF9; Q8WYM4; DT 16-NOV-2001, integrated into UniProtKB/Swiss-Prot. DT 01-JUN-2001, sequence version 1. DT 24-JAN-2024, entry version 181. DE RecName: Full=Solute carrier family 2, facilitated glucose transporter member 11 {ECO:0000305}; DE AltName: Full=Glucose transporter type 11 {ECO:0000303|PubMed:11741323}; DE Short=GLUT-11 {ECO:0000303|PubMed:11741323}; GN Name=SLC2A11 {ECO:0000303|PubMed:11741323, GN ECO:0000312|HGNC:HGNC:14239}; GN Synonyms=GLUT11 {ECO:0000303|PubMed:11741323}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). RC TISSUE=Heart; RA Doege H., Bocianski A., Scheepers A., Axer H., Eckel J., Joost H.-G.; RT "Two novel members of the family of sugar transport facilitators: genomic RT organization and predominant expression in lymphocytes (GLUT9) and muscle RT (GLUT10)."; RL Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases. RN [2] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS 2 AND 4), AND VARIANT GLN-232. RX PubMed=11741323; DOI=10.1006/bbrc.2001.6101; RA Sasaki T., Minoshima S., Shiohama A., Shintani A., Shimizu A., Asakawa S., RA Kawasaki K., Shimizu N.; RT "Molecular cloning of a member of the facilitative glucose transporter gene RT family GLUT11 (SLC2A11) and identification of transcription variants."; RL Biochem. Biophys. Res. Commun. 289:1218-1224(2001). RN [3] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4), ALTERNATIVE SPLICING, FUNCTION, RP TRANSPORTER ACTIVITY, SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY. RX PubMed=12175779; DOI=10.1016/s1096-7192(02)00018-5; RA Wu X., Li W., Sharma V., Godzik A., Freeze H.H.; RT "Cloning and characterization of glucose transporter 11, a novel sugar RT transporter that is alternatively spliced in various tissues."; RL Mol. Genet. Metab. 76:37-45(2002). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). RX PubMed=15461802; DOI=10.1186/gb-2004-5-10-r84; RA Collins J.E., Wright C.L., Edwards C.A., Davis M.P., Grinham J.A., RA Cole C.G., Goward M.E., Aguado B., Mallya M., Mokrab Y., Huckle E.J., RA Beare D.M., Dunham I.; RT "A genome annotation-driven approach to cloning the human ORFeome."; RL Genome Biol. 5:R84.1-R84.11(2004). RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4), AND VARIANT GLN-232. RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., RA Isogai T., Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). RN [6] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). RC TISSUE=Placenta; RX PubMed=16303743; DOI=10.1093/dnares/12.2.117; RA Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., RA Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., RA Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y., RA Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., RA Isogai T.; RT "Signal sequence and keyword trap in silico for selection of full-length RT human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA RT libraries."; RL DNA Res. 12:117-126(2005). RN [7] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=10591208; DOI=10.1038/990031; RA Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., RA Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., RA Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., RA Bridgeman A.M., Buck D., Burgess J., Burrill W.D., Burton J., Carder C., RA Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., RA Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., RA Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., RA Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., RA Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., RA Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., RA Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., RA Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., RA Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., RA Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., RA Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., RA Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., RA Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., RA Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., RA Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., RA Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., RA Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., RA Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., RA Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., RA Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., RA Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., RA Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., RA Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., RA Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., RA Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., RA Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., RA Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., RA Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., RA Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., RA McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., RA Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., RA Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., RA Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., RA Wright H.; RT "The DNA sequence of human chromosome 22."; RL Nature 402:489-495(1999). RN [8] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., RA Hunkapiller M.W., Myers E.W., Venter J.C.; RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases. RN [9] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). CC -!- FUNCTION: Facilitative glucose transporter. CC {ECO:0000269|PubMed:12175779}. CC -!- CATALYTIC ACTIVITY: CC Reaction=D-glucose(out) = D-glucose(in); Xref=Rhea:RHEA:60376, CC ChEBI:CHEBI:4167; Evidence={ECO:0000269|PubMed:12175779}; CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12175779}; CC Multi-pass membrane protein {ECO:0000255}. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=4; CC Name=1; CC IsoId=Q9BYW1-1; Sequence=Displayed; CC Name=2; Synonyms=GLUT11-s {ECO:0000303|PubMed:12175779}; CC IsoId=Q9BYW1-2; Sequence=VSP_006293, VSP_006294, VSP_006295; CC Name=3; CC IsoId=Q9BYW1-3; Sequence=VSP_006293; CC Name=4; Synonyms=GLUT11-L {ECO:0000303|PubMed:12175779}; CC IsoId=Q9BYW1-4; Sequence=VSP_045650; CC -!- TISSUE SPECIFICITY: Expressed in heart and skeletal muscle. CC {ECO:0000269|PubMed:12175779}. CC -!- SIMILARITY: Belongs to the major facilitator superfamily. Sugar CC transporter (TC 2.A.1.1) family. Glucose transporter subfamily. CC {ECO:0000305}. CC -!- CAUTION: Has been described as GLUT10 in literature, but this gene name CC has already been used for SLC2A10. {ECO:0000305|Ref.1}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AJ271290; CAC29020.1; -; mRNA. DR EMBL; AB049214; BAB68410.1; -; Genomic_DNA. DR EMBL; AB067443; BAB83505.1; -; Genomic_DNA. DR EMBL; AF443201; AAL39061.1; -; mRNA. DR EMBL; CR456373; CAG30259.1; -; mRNA. DR EMBL; AK075467; BAC11637.1; -; mRNA. DR EMBL; AK314502; BAG37102.1; -; mRNA. DR EMBL; AP000350; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CH471095; EAW59618.1; -; Genomic_DNA. DR EMBL; BC100808; AAI00809.1; -; mRNA. DR CCDS; CCDS13818.1; -. [Q9BYW1-4] DR CCDS; CCDS33616.1; -. [Q9BYW1-3] DR CCDS; CCDS46673.1; -. [Q9BYW1-1] DR RefSeq; NP_001020109.1; NM_001024938.3. [Q9BYW1-1] DR RefSeq; NP_001020110.1; NM_001024939.3. [Q9BYW1-3] DR RefSeq; NP_110434.3; NM_030807.4. [Q9BYW1-4] DR AlphaFoldDB; Q9BYW1; -. DR SMR; Q9BYW1; -. DR BioGRID; 122454; 1. DR STRING; 9606.ENSP00000483038; -. DR DrugBank; DB01914; D-glucose. DR DrugBank; DB09341; Dextrose, unspecified form. DR DrugBank; DB09502; Fludeoxyglucose (18F). DR TCDB; 2.A.1.1.44; the major facilitator superfamily (mfs). DR GlyCosmos; Q9BYW1; 1 site, No reported glycans. DR GlyGen; Q9BYW1; 1 site. DR iPTMnet; Q9BYW1; -. DR PhosphoSitePlus; Q9BYW1; -. DR BioMuta; SLC2A11; -. DR DMDM; 17366685; -. DR MassIVE; Q9BYW1; -. DR PaxDb; 9606-ENSP00000483038; -. DR PeptideAtlas; Q9BYW1; -. DR ProteomicsDB; 20459; -. DR ProteomicsDB; 79727; -. [Q9BYW1-1] DR ProteomicsDB; 79728; -. [Q9BYW1-2] DR ProteomicsDB; 79729; -. [Q9BYW1-3] DR Antibodypedia; 45145; 34 antibodies from 12 providers. DR DNASU; 66035; -. DR Ensembl; ENST00000316185.9; ENSP00000326748.8; ENSG00000133460.20. [Q9BYW1-3] DR Ensembl; ENST00000345044.10; ENSP00000342542.5; ENSG00000133460.20. [Q9BYW1-1] DR Ensembl; ENST00000398356.6; ENSP00000381399.2; ENSG00000133460.20. [Q9BYW1-4] DR Ensembl; ENST00000618502.4; ENSP00000482495.1; ENSG00000275744.4. [Q9BYW1-1] DR Ensembl; ENST00000619254.4; ENSP00000480839.1; ENSG00000275744.4. [Q9BYW1-4] DR Ensembl; ENST00000620942.4; ENSP00000483163.2; ENSG00000275744.4. [Q9BYW1-3] DR GeneID; 66035; -. DR KEGG; hsa:66035; -. DR MANE-Select; ENST00000316185.9; ENSP00000326748.8; NM_001024939.4; NP_001020110.1. [Q9BYW1-3] DR UCSC; uc002zym.6; human. [Q9BYW1-1] DR AGR; HGNC:14239; -. DR CTD; 66035; -. DR DisGeNET; 66035; -. DR GeneCards; SLC2A11; -. DR HGNC; HGNC:14239; SLC2A11. DR HPA; ENSG00000133460; Low tissue specificity. DR MIM; 610367; gene. DR neXtProt; NX_Q9BYW1; -. DR OpenTargets; ENSG00000133460; -. DR PharmGKB; PA37861; -. DR VEuPathDB; HostDB:ENSG00000133460; -. DR eggNOG; KOG0569; Eukaryota. DR GeneTree; ENSGT00940000161061; -. DR HOGENOM; CLU_001265_30_11_1; -. DR InParanoid; Q9BYW1; -. DR OMA; VFFMYPE; -. DR OrthoDB; 1899001at2759; -. DR PhylomeDB; Q9BYW1; -. DR TreeFam; TF313762; -. DR PathwayCommons; Q9BYW1; -. DR Reactome; R-HSA-189200; Cellular hexose transport. DR SignaLink; Q9BYW1; -. DR BioGRID-ORCS; 66035; 13 hits in 1134 CRISPR screens. DR ChiTaRS; SLC2A11; human. DR GeneWiki; SLC2A11; -. DR GenomeRNAi; 66035; -. DR Pharos; Q9BYW1; Tbio. DR PRO; PR:Q9BYW1; -. DR Proteomes; UP000005640; Chromosome 22. DR RNAct; Q9BYW1; Protein. DR Bgee; ENSG00000133460; Expressed in right hemisphere of cerebellum and 98 other cell types or tissues. DR ExpressionAtlas; Q9BYW1; baseline and differential. DR GO; GO:0030054; C:cell junction; IDA:HPA. DR GO; GO:0016020; C:membrane; IBA:GO_Central. DR GO; GO:0005654; C:nucleoplasm; IDA:HPA. DR GO; GO:0005886; C:plasma membrane; IDA:UniProtKB. DR GO; GO:0005353; F:fructose transmembrane transporter activity; IDA:UniProtKB. DR GO; GO:0005355; F:glucose transmembrane transporter activity; IDA:UniProtKB. DR GO; GO:0015149; F:hexose transmembrane transporter activity; IBA:GO_Central. DR GO; GO:0051119; F:sugar transmembrane transporter activity; TAS:Reactome. DR GO; GO:0015755; P:fructose transmembrane transport; IDA:UniProtKB. DR GO; GO:1904659; P:glucose transmembrane transport; IDA:UniProtKB. DR GO; GO:0008645; P:hexose transmembrane transport; TAS:Reactome. DR GO; GO:0015749; P:monosaccharide transmembrane transport; IBA:GO_Central. DR CDD; cd17432; MFS_GLUT_Class2; 1. DR Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 1. DR InterPro; IPR045263; GLUT. DR InterPro; IPR020846; MFS_dom. DR InterPro; IPR005828; MFS_sugar_transport-like. DR InterPro; IPR036259; MFS_trans_sf. DR InterPro; IPR003663; Sugar/inositol_transpt. DR InterPro; IPR005829; Sugar_transporter_CS. DR NCBIfam; TIGR00879; SP; 1. DR PANTHER; PTHR23503; SOLUTE CARRIER FAMILY 2; 1. DR PANTHER; PTHR23503:SF22; SOLUTE CARRIER FAMILY 2, FACILITATED GLUCOSE TRANSPORTER MEMBER 11; 1. DR Pfam; PF00083; Sugar_tr; 1. DR PRINTS; PR00171; SUGRTRNSPORT. DR SUPFAM; SSF103473; MFS general substrate transporter; 1. DR PROSITE; PS50850; MFS; 1. DR PROSITE; PS00217; SUGAR_TRANSPORT_2; 1. DR Genevisible; Q9BYW1; HS. PE 2: Evidence at transcript level; KW Alternative splicing; Cell membrane; Glycoprotein; Membrane; KW Reference proteome; Sugar transport; Transmembrane; Transmembrane helix; KW Transport. FT CHAIN 1..496 FT /note="Solute carrier family 2, facilitated glucose FT transporter member 11" FT /id="PRO_0000050380" FT TOPO_DOM 1..11 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 12..32 FT /note="Helical; Name=1" FT /evidence="ECO:0000255" FT TOPO_DOM 33..61 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 62..82 FT /note="Helical; Name=2" FT /evidence="ECO:0000255" FT TOPO_DOM 83..97 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 98..118 FT /note="Helical; Name=3" FT /evidence="ECO:0000255" FT TOPO_DOM 119..128 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 129..149 FT /note="Helical; Name=4" FT /evidence="ECO:0000255" FT TOPO_DOM 150..157 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 158..178 FT /note="Helical; Name=5" FT /evidence="ECO:0000255" FT TOPO_DOM 179..187 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 188..208 FT /note="Helical; Name=6" FT /evidence="ECO:0000255" FT TOPO_DOM 209..273 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 274..294 FT /note="Helical; Name=7" FT /evidence="ECO:0000255" FT TOPO_DOM 295..311 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 312..332 FT /note="Helical; Name=8" FT /evidence="ECO:0000255" FT TOPO_DOM 333..338 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 339..359 FT /note="Helical; Name=9" FT /evidence="ECO:0000255" FT TOPO_DOM 360..364 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 365..385 FT /note="Helical; Name=10" FT /evidence="ECO:0000255" FT TOPO_DOM 386..408 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 409..429 FT /note="Helical; Name=11" FT /evidence="ECO:0000255" FT TOPO_DOM 430..435 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 436..456 FT /note="Helical; Name=12" FT /evidence="ECO:0000255" FT TOPO_DOM 457..496 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT CARBOHYD 47 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT VAR_SEQ 1..7 FT /note="MRALRRL -> MLHALLRSRM (in isoform 2 and isoform 3)" FT /evidence="ECO:0000303|PubMed:15461802" FT /id="VSP_006293" FT VAR_SEQ 1..7 FT /note="MRALRRL -> MEDELEPSLRPRTQ (in isoform 4)" FT /evidence="ECO:0000303|PubMed:12175779, FT ECO:0000303|PubMed:14702039" FT /id="VSP_045650" FT VAR_SEQ 179..245 FT /note="RELLGGPQAWPLLLASCLVPGALQLASLPLLPESPRYLLIDCGDTEACLAAL FT RRLRGSGDLAGELEE -> STTAATGLRGLGRGAGGAGGGARCLPGLPCPAPMGAVPAS FT GPEETGDKPRGSGQCHGALRE (in isoform 2)" FT /evidence="ECO:0000305" FT /id="VSP_006294" FT VAR_SEQ 246..496 FT /note="Missing (in isoform 2)" FT /evidence="ECO:0000305" FT /id="VSP_006295" FT VARIANT 60 FT /note="D -> N (in dbSNP:rs7292659)" FT /id="VAR_046704" FT VARIANT 232 FT /note="R -> Q (in dbSNP:rs9608213)" FT /evidence="ECO:0000269|PubMed:11741323, FT ECO:0000269|PubMed:14702039" FT /id="VAR_046705" FT VARIANT 301 FT /note="R -> Q (in dbSNP:rs36015336)" FT /id="VAR_061881" FT VARIANT 420 FT /note="I -> F (in dbSNP:rs34096096)" FT /id="VAR_046706" FT VARIANT 469 FT /note="K -> E (in dbSNP:rs60882514)" FT /id="VAR_061882" FT CONFLICT 229 FT /note="A -> E (in Ref. 3; AAL39061)" FT /evidence="ECO:0000305" SQ SEQUENCE 496 AA; 53703 MW; 55FFEA82C7007D6D CRC64; MRALRRLIQG RILLLTICAA GIGGTFQFGY NLSIINAPTL HIQEFTNETW QARTGEPLPD HLVLLMWSLI VSLYPLGGLF GALLAGPLAI TLGRKKSLLV NNIFVVSAAI LFGFSRKAGS FEMIMLGRLL VGVNAGVSMN IQPMYLGESA PKELRGAVAM SSAIFTALGI VMGQVVGLRE LLGGPQAWPL LLASCLVPGA LQLASLPLLP ESPRYLLIDC GDTEACLAAL RRLRGSGDLA GELEELEEER AACQGCRARR PWELFQHRAL RRQVTSLVVL GSAMELCGND SVYAYASSVF RKAGVPEAKI QYAIIGTGSC ELLTAVVSCV VIERVGRRVL LIGGYSLMTC WGSIFTVALC LQSSFPWTLY LAMACIFAFI LSFGIGPAGV TGILATELFD QMARPAACMV CGALMWIMLI LVGLGFPFIM EALSHFLYVP FLGVCVCGAI YTGLFLPETK GKTFQEISKE LHRLNFPRRA QGPTWRSLEV IQSTEL //