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Q9BYW1 (GTR11_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 118. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Solute carrier family 2, facilitated glucose transporter member 11
Alternative name(s):
Glucose transporter type 10
Short name=GLUT-10
Glucose transporter type 11
Short name=GLUT-11
Gene names
Name:SLC2A11
Synonyms:GLUT10, GLUT11
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length496 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Facilitative glucose transporter. Ref.3

Subcellular location

Cell membrane; Multi-pass membrane protein Ref.3.

Tissue specificity

Expressed in heart and skeletal muscle.

Sequence similarities

Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily. [View classification]

Caution

Has been described as GLUT10 in literature, but this gene name has already been used for SLC2A10.

Ontologies

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9BYW1-1)

Also known as: GLUT11;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9BYW1-2)

Also known as: GLUT11-s;

The sequence of this isoform differs from the canonical sequence as follows:
     1-7: MRALRRL → MLHALLRSRM
     179-245: RELLGGPQAW...SGDLAGELEE → STTAATGLRG...SGQCHGALRE
     246-496: Missing.
Isoform 3 (identifier: Q9BYW1-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-7: MRALRRL → MLHALLRSRM
Isoform 4 (identifier: Q9BYW1-4)

Also known as: GLUT11-L;

The sequence of this isoform differs from the canonical sequence as follows:
     1-7: MRALRRL → MEDELEPSLRPRTQ

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 496496Solute carrier family 2, facilitated glucose transporter member 11
PRO_0000050380

Regions

Topological domain1 – 1111Cytoplasmic Potential
Transmembrane12 – 3221Helical; Name=1; Potential
Topological domain33 – 6129Extracellular Potential
Transmembrane62 – 8221Helical; Name=2; Potential
Topological domain83 – 9715Cytoplasmic Potential
Transmembrane98 – 11821Helical; Name=3; Potential
Topological domain119 – 12810Extracellular Potential
Transmembrane129 – 14921Helical; Name=4; Potential
Topological domain150 – 1578Cytoplasmic Potential
Transmembrane158 – 17821Helical; Name=5; Potential
Topological domain179 – 1879Extracellular Potential
Transmembrane188 – 20821Helical; Name=6; Potential
Topological domain209 – 27365Cytoplasmic Potential
Transmembrane274 – 29421Helical; Name=7; Potential
Topological domain295 – 31117Extracellular Potential
Transmembrane312 – 33221Helical; Name=8; Potential
Topological domain333 – 3386Cytoplasmic Potential
Transmembrane339 – 35921Helical; Name=9; Potential
Topological domain360 – 3645Extracellular Potential
Transmembrane365 – 38521Helical; Name=10; Potential
Topological domain386 – 40823Cytoplasmic Potential
Transmembrane409 – 42921Helical; Name=11; Potential
Topological domain430 – 4356Extracellular Potential
Transmembrane436 – 45621Helical; Name=12; Potential
Topological domain457 – 49640Cytoplasmic Potential

Amino acid modifications

Glycosylation471N-linked (GlcNAc...) Potential

Natural variations

Alternative sequence1 – 77MRALRRL → MLHALLRSRM in isoform 2 and isoform 3.
VSP_006293
Alternative sequence1 – 77MRALRRL → MEDELEPSLRPRTQ in isoform 4.
VSP_045650
Alternative sequence179 – 24567RELLG…GELEE → STTAATGLRGLGRGAGGAGG GARCLPGLPCPAPMGAVPAS GPEETGDKPRGSGQCHGALR E in isoform 2.
VSP_006294
Alternative sequence246 – 496251Missing in isoform 2.
VSP_006295
Natural variant601D → N.
Corresponds to variant rs7292659 [ dbSNP | Ensembl ].
VAR_046704
Natural variant2321R → Q. Ref.2 Ref.5
Corresponds to variant rs9608213 [ dbSNP | Ensembl ].
VAR_046705
Natural variant3011R → Q.
Corresponds to variant rs36015336 [ dbSNP | Ensembl ].
VAR_061881
Natural variant4201I → F.
Corresponds to variant rs34096096 [ dbSNP | Ensembl ].
VAR_046706
Natural variant4691K → E.
Corresponds to variant rs60882514 [ dbSNP | Ensembl ].
VAR_061882

Experimental info

Sequence conflict2291A → E in AAL39061. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (GLUT11) [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: 55FFEA82C7007D6D

FASTA49653,703
        10         20         30         40         50         60 
MRALRRLIQG RILLLTICAA GIGGTFQFGY NLSIINAPTL HIQEFTNETW QARTGEPLPD 

        70         80         90        100        110        120 
HLVLLMWSLI VSLYPLGGLF GALLAGPLAI TLGRKKSLLV NNIFVVSAAI LFGFSRKAGS 

       130        140        150        160        170        180 
FEMIMLGRLL VGVNAGVSMN IQPMYLGESA PKELRGAVAM SSAIFTALGI VMGQVVGLRE 

       190        200        210        220        230        240 
LLGGPQAWPL LLASCLVPGA LQLASLPLLP ESPRYLLIDC GDTEACLAAL RRLRGSGDLA 

       250        260        270        280        290        300 
GELEELEEER AACQGCRARR PWELFQHRAL RRQVTSLVVL GSAMELCGND SVYAYASSVF 

       310        320        330        340        350        360 
RKAGVPEAKI QYAIIGTGSC ELLTAVVSCV VIERVGRRVL LIGGYSLMTC WGSIFTVALC 

       370        380        390        400        410        420 
LQSSFPWTLY LAMACIFAFI LSFGIGPAGV TGILATELFD QMARPAACMV CGALMWIMLI 

       430        440        450        460        470        480 
LVGLGFPFIM EALSHFLYVP FLGVCVCGAI YTGLFLPETK GKTFQEISKE LHRLNFPRRA 

       490 
QGPTWRSLEV IQSTEL 

« Hide

Isoform 2 (GLUT11-s) [UniParc].

Checksum: 195731E90310ED9E
Show »

FASTA24225,022
Isoform 3 [UniParc].

Checksum: 7AFD0B6773A935AF
Show »

FASTA49954,015
Isoform 4 (GLUT11-L) [UniParc].

Checksum: 61EC2EAB693FB88B
Show »

FASTA50354,488

References

« Hide 'large scale' references
[1]"Two novel members of the family of sugar transport facilitators: genomic organization and predominant expression in lymphocytes (GLUT9) and muscle (GLUT10)."
Doege H., Bocianski A., Scheepers A., Axer H., Eckel J., Joost H.-G.
Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Tissue: Heart.
[2]"Molecular cloning of a member of the facilitative glucose transporter gene family GLUT11 (SLC2A11) and identification of transcription variants."
Sasaki T., Minoshima S., Shiohama A., Shintani A., Shimizu A., Asakawa S., Kawasaki K., Shimizu N.
Biochem. Biophys. Res. Commun. 289:1218-1224(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS 2 AND 4), VARIANT GLN-232.
[3]"Cloning and characterization of glucose transporter 11, a novel sugar transporter that is alternatively spliced in various tissues."
Wu X., Li W., Sharma V., Godzik A., Freeze H.H.
Mol. Genet. Metab. 76:37-45(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4), ALTERNATIVE SPLICING, FUNCTION, SUBCELLULAR LOCATION.
[4]"A genome annotation-driven approach to cloning the human ORFeome."
Collins J.E., Wright C.L., Edwards C.A., Davis M.P., Grinham J.A., Cole C.G., Goward M.E., Aguado B., Mallya M., Mokrab Y., Huckle E.J., Beare D.M., Dunham I.
Genome Biol. 5:R84.1-R84.11(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
[5]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4), VARIANT GLN-232.
[6]"Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries."
Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y. expand/collapse author list , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T.
DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Placenta.
[7]"The DNA sequence of human chromosome 22."
Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M. expand/collapse author list , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[9]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ271290 mRNA. Translation: CAC29020.1.
AB049214 Genomic DNA. Translation: BAB68410.1.
AB067443 Genomic DNA. Translation: BAB83505.1.
AF443201 mRNA. Translation: AAL39061.1.
CR456373 mRNA. Translation: CAG30259.1.
AK075467 mRNA. Translation: BAC11637.1.
AK314502 mRNA. Translation: BAG37102.1.
AP000350 Genomic DNA. No translation available.
CH471095 Genomic DNA. Translation: EAW59618.1.
BC100808 mRNA. Translation: AAI00809.1.
CCDSCCDS13818.1. [Q9BYW1-4]
CCDS33616.1. [Q9BYW1-3]
CCDS46673.1. [Q9BYW1-1]
RefSeqNP_001020109.1. NM_001024938.3. [Q9BYW1-1]
NP_001020110.1. NM_001024939.3. [Q9BYW1-3]
NP_110434.3. NM_030807.4. [Q9BYW1-4]
UniGeneHs.661910.
Hs.743282.

3D structure databases

ProteinModelPortalQ9BYW1.
SMRQ9BYW1. Positions 14-467.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid122454. 1 interaction.
STRING9606.ENSP00000381399.

Protein family/group databases

TCDB2.A.1.1.44. the major facilitator superfamily (mfs).

PTM databases

PhosphoSiteQ9BYW1.

Polymorphism databases

DMDM17366685.

Proteomic databases

PaxDbQ9BYW1.
PRIDEQ9BYW1.

Protocols and materials databases

DNASU66035.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000316185; ENSP00000326748; ENSG00000133460. [Q9BYW1-3]
ENST00000345044; ENSP00000342542; ENSG00000133460. [Q9BYW1-1]
ENST00000398356; ENSP00000381399; ENSG00000133460. [Q9BYW1-4]
GeneID66035.
KEGGhsa:66035.
UCSCuc002zyn.4. human. [Q9BYW1-1]
uc002zyp.4. human. [Q9BYW1-3]

Organism-specific databases

CTD66035.
GeneCardsGC22P024198.
HGNCHGNC:14239. SLC2A11.
HPAHPA042960.
MIM610367. gene.
neXtProtNX_Q9BYW1.
PharmGKBPA37861.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0477.
HOGENOMHOG000202871.
HOVERGENHBG014816.
KOK08148.
OMAIFTVALC.
OrthoDBEOG7PVWP9.
PhylomeDBQ9BYW1.
TreeFamTF313762.

Enzyme and pathway databases

ReactomeREACT_15518. Transmembrane transport of small molecules.

Gene expression databases

ArrayExpressQ9BYW1.
BgeeQ9BYW1.
CleanExHS_SLC2A11.
GenevestigatorQ9BYW1.

Family and domain databases

InterProIPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR005828. Sub_transporter.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamPF00083. Sugar_tr. 1 hit.
[Graphical view]
PRINTSPR00171. SUGRTRNSPORT.
SUPFAMSSF103473. SSF103473. 1 hit.
TIGRFAMsTIGR00879. SP. 1 hit.
PROSITEPS50850. MFS. 1 hit.
PS00217. SUGAR_TRANSPORT_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSSLC2A11. human.
GeneWikiSLC2A11.
GenomeRNAi66035.
NextBio67534.
PROQ9BYW1.
SOURCESearch...

Entry information

Entry nameGTR11_HUMAN
AccessionPrimary (citable) accession number: Q9BYW1
Secondary accession number(s): E9PH55 expand/collapse secondary AC list , Q542Y4, Q6ICJ5, Q8WXF9, Q8WYM4
Entry history
Integrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: June 1, 2001
Last modified: July 9, 2014
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 22

Human chromosome 22: entries, gene names and cross-references to MIM