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Protein

Solute carrier family 2, facilitated glucose transporter member 11

Gene

SLC2A11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Facilitative glucose transporter.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processSugar transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-189200. Cellular hexose transport.

Protein family/group databases

TCDBi2.A.1.1.44. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 2, facilitated glucose transporter member 11
Alternative name(s):
Glucose transporter type 10
Short name:
GLUT-10
Glucose transporter type 11
Short name:
GLUT-11
Gene namesi
Name:SLC2A11
Synonyms:GLUT10, GLUT11
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

EuPathDBiHostDB:ENSG00000133460.19.
HGNCiHGNC:14239. SLC2A11.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 11CytoplasmicSequence analysisAdd BLAST11
Transmembranei12 – 32Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini33 – 61ExtracellularSequence analysisAdd BLAST29
Transmembranei62 – 82Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini83 – 97CytoplasmicSequence analysisAdd BLAST15
Transmembranei98 – 118Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini119 – 128ExtracellularSequence analysis10
Transmembranei129 – 149Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini150 – 157CytoplasmicSequence analysis8
Transmembranei158 – 178Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini179 – 187ExtracellularSequence analysis9
Transmembranei188 – 208Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini209 – 273CytoplasmicSequence analysisAdd BLAST65
Transmembranei274 – 294Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini295 – 311ExtracellularSequence analysisAdd BLAST17
Transmembranei312 – 332Helical; Name=8Sequence analysisAdd BLAST21
Topological domaini333 – 338CytoplasmicSequence analysis6
Transmembranei339 – 359Helical; Name=9Sequence analysisAdd BLAST21
Topological domaini360 – 364ExtracellularSequence analysis5
Transmembranei365 – 385Helical; Name=10Sequence analysisAdd BLAST21
Topological domaini386 – 408CytoplasmicSequence analysisAdd BLAST23
Transmembranei409 – 429Helical; Name=11Sequence analysisAdd BLAST21
Topological domaini430 – 435ExtracellularSequence analysis6
Transmembranei436 – 456Helical; Name=12Sequence analysisAdd BLAST21
Topological domaini457 – 496CytoplasmicSequence analysisAdd BLAST40

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi66035.
OpenTargetsiENSG00000133460.
PharmGKBiPA37861.

Chemistry databases

DrugBankiDB09502. Fludeoxyglucose F-18.

Polymorphism and mutation databases

BioMutaiSLC2A11.
DMDMi17366685.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000503801 – 496Solute carrier family 2, facilitated glucose transporter member 11Add BLAST496

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi47N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9BYW1.
PeptideAtlasiQ9BYW1.
PRIDEiQ9BYW1.

PTM databases

iPTMnetiQ9BYW1.
PhosphoSitePlusiQ9BYW1.

Expressioni

Tissue specificityi

Expressed in heart and skeletal muscle.

Gene expression databases

BgeeiENSG00000133460.
CleanExiHS_SLC2A11.
ExpressionAtlasiQ9BYW1. baseline and differential.
GenevisibleiQ9BYW1. HS.

Organism-specific databases

HPAiHPA042960.
HPA071184.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000381399.

Structurei

3D structure databases

ProteinModelPortaliQ9BYW1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0569. Eukaryota.
COG0477. LUCA.
GeneTreeiENSGT00760000119022.
HOGENOMiHOG000202871.
HOVERGENiHBG014816.
InParanoidiQ9BYW1.
KOiK08148.
PhylomeDBiQ9BYW1.
TreeFamiTF313762.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiView protein in InterPro
IPR020846. MFS_dom.
IPR005828. MFS_sugar_transport-like.
IPR036259. MFS_trans_sf.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
PfamiView protein in Pfam
PF00083. Sugar_tr. 1 hit.
PRINTSiPR00171. SUGRTRNSPORT.
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00879. SP. 1 hit.
PROSITEiView protein in PROSITE
PS50850. MFS. 1 hit.
PS00217. SUGAR_TRANSPORT_2. 1 hit.

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9BYW1-1) [UniParc]FASTAAdd to basket
Also known as: GLUT11

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRALRRLIQG RILLLTICAA GIGGTFQFGY NLSIINAPTL HIQEFTNETW
60 70 80 90 100
QARTGEPLPD HLVLLMWSLI VSLYPLGGLF GALLAGPLAI TLGRKKSLLV
110 120 130 140 150
NNIFVVSAAI LFGFSRKAGS FEMIMLGRLL VGVNAGVSMN IQPMYLGESA
160 170 180 190 200
PKELRGAVAM SSAIFTALGI VMGQVVGLRE LLGGPQAWPL LLASCLVPGA
210 220 230 240 250
LQLASLPLLP ESPRYLLIDC GDTEACLAAL RRLRGSGDLA GELEELEEER
260 270 280 290 300
AACQGCRARR PWELFQHRAL RRQVTSLVVL GSAMELCGND SVYAYASSVF
310 320 330 340 350
RKAGVPEAKI QYAIIGTGSC ELLTAVVSCV VIERVGRRVL LIGGYSLMTC
360 370 380 390 400
WGSIFTVALC LQSSFPWTLY LAMACIFAFI LSFGIGPAGV TGILATELFD
410 420 430 440 450
QMARPAACMV CGALMWIMLI LVGLGFPFIM EALSHFLYVP FLGVCVCGAI
460 470 480 490
YTGLFLPETK GKTFQEISKE LHRLNFPRRA QGPTWRSLEV IQSTEL
Length:496
Mass (Da):53,703
Last modified:June 1, 2001 - v1
Checksum:i55FFEA82C7007D6D
GO
Isoform 2 (identifier: Q9BYW1-2) [UniParc]FASTAAdd to basket
Also known as: GLUT11-s

The sequence of this isoform differs from the canonical sequence as follows:
     1-7: MRALRRL → MLHALLRSRM
     179-245: RELLGGPQAW...SGDLAGELEE → STTAATGLRG...SGQCHGALRE
     246-496: Missing.

Show »
Length:242
Mass (Da):25,022
Checksum:i195731E90310ED9E
GO
Isoform 3 (identifier: Q9BYW1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-7: MRALRRL → MLHALLRSRM

Show »
Length:499
Mass (Da):54,015
Checksum:i7AFD0B6773A935AF
GO
Isoform 4 (identifier: Q9BYW1-4) [UniParc]FASTAAdd to basket
Also known as: GLUT11-L

The sequence of this isoform differs from the canonical sequence as follows:
     1-7: MRALRRL → MEDELEPSLRPRTQ

Show »
Length:503
Mass (Da):54,488
Checksum:i61EC2EAB693FB88B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti229A → E in AAL39061 (PubMed:12175779).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04670460D → N. Corresponds to variant dbSNP:rs7292659Ensembl.1
Natural variantiVAR_046705232R → Q2 PublicationsCorresponds to variant dbSNP:rs9608213Ensembl.1
Natural variantiVAR_061881301R → Q. Corresponds to variant dbSNP:rs36015336Ensembl.1
Natural variantiVAR_046706420I → F. Corresponds to variant dbSNP:rs34096096Ensembl.1
Natural variantiVAR_061882469K → E. Corresponds to variant dbSNP:rs60882514Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0062931 – 7MRALRRL → MLHALLRSRM in isoform 2 and isoform 3. 1 Publication7
Alternative sequenceiVSP_0456501 – 7MRALRRL → MEDELEPSLRPRTQ in isoform 4. 2 Publications7
Alternative sequenceiVSP_006294179 – 245RELLG…GELEE → STTAATGLRGLGRGAGGAGG GARCLPGLPCPAPMGAVPAS GPEETGDKPRGSGQCHGALR E in isoform 2. CuratedAdd BLAST67
Alternative sequenceiVSP_006295246 – 496Missing in isoform 2. CuratedAdd BLAST251

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ271290 mRNA. Translation: CAC29020.1.
AB049214 Genomic DNA. Translation: BAB68410.1.
AB067443 Genomic DNA. Translation: BAB83505.1.
AF443201 mRNA. Translation: AAL39061.1.
CR456373 mRNA. Translation: CAG30259.1.
AK075467 mRNA. Translation: BAC11637.1.
AK314502 mRNA. Translation: BAG37102.1.
AP000350 Genomic DNA. No translation available.
CH471095 Genomic DNA. Translation: EAW59618.1.
BC100808 mRNA. Translation: AAI00809.1.
CCDSiCCDS13818.1. [Q9BYW1-4]
CCDS33616.1. [Q9BYW1-3]
CCDS46673.1. [Q9BYW1-1]
RefSeqiNP_001020109.1. NM_001024938.3. [Q9BYW1-1]
NP_001020110.1. NM_001024939.3. [Q9BYW1-3]
NP_110434.3. NM_030807.4. [Q9BYW1-4]
UniGeneiHs.661910.
Hs.743282.

Genome annotation databases

EnsembliENST00000316185; ENSP00000326748; ENSG00000133460. [Q9BYW1-3]
ENST00000345044; ENSP00000342542; ENSG00000133460. [Q9BYW1-1]
ENST00000398356; ENSP00000381399; ENSG00000133460. [Q9BYW1-4]
ENST00000618502; ENSP00000482495; ENSG00000275744. [Q9BYW1-1]
ENST00000619254; ENSP00000480839; ENSG00000275744. [Q9BYW1-4]
ENST00000620942; ENSP00000483163; ENSG00000275744. [Q9BYW1-3]
GeneIDi66035.
KEGGihsa:66035.
UCSCiuc002zym.6. human. [Q9BYW1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiGTR11_HUMAN
AccessioniPrimary (citable) accession number: Q9BYW1
Secondary accession number(s): E9PH55
, Q542Y4, Q6ICJ5, Q8WXF9, Q8WYM4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: June 1, 2001
Last modified: October 25, 2017
This is version 145 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Has been described as GLUT10 in literature, but this gene name has already been used for SLC2A10.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families