Q9BYW1 (GTR11_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Solute carrier family 2, facilitated glucose transporter member 11

Alternative name(s):
Glucose transporter type 10
Short name=GLUT-10
Glucose transporter type 11
Short name=GLUT-11

Gene names

Name:	SLC2A11
Synonyms:	GLUT10, GLUT11

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	496 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Facilitative glucose transporter By similarity.
Subcellular location	Membrane; Multi-pass membrane protein.
Tissue specificity	Expressed in heart and skeletal muscle.
Sequence similarities	Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily. [View classification]
Caution	Has been described as GLUT10 in litterature, but this gene name has already been used for SLC2A10.

Ontologies

Keywords
Biological process	Sugar transport Transport
Cellular component	Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Transmembrane Transmembrane helix
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	carbohydrate transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Traceable author statement. Source: Reactome
Molecular function	substrate-specific transmembrane transporter activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9BYW1-1)

Also known as: GLUT11;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9BYW1-2)

Also known as: GLUT11-s;

The sequence of this isoform differs from the canonical sequence as follows:
     1-7: MRALRRL → MLHALLRSRM
     179-245: RELLGGPQAW...SGDLAGELEE → STTAATGLRG...SGQCHGALRE
     246-496: Missing.

Isoform 3 (identifier: Q9BYW1-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-7: MRALRRL → MLHALLRSRM

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 496	496	Solute carrier family 2, facilitated glucose transporter member 11		PRO_0000050380
Regions
	Topological domain	1 – 11	11	Cytoplasmic Potential
	Transmembrane	12 – 32	21	Helical; Name=1; Potential
	Topological domain	33 – 61	29	Extracellular Potential
	Transmembrane	62 – 82	21	Helical; Name=2; Potential
	Topological domain	83 – 97	15	Cytoplasmic Potential
	Transmembrane	98 – 118	21	Helical; Name=3; Potential
	Topological domain	119 – 128	10	Extracellular Potential
	Transmembrane	129 – 149	21	Helical; Name=4; Potential
	Topological domain	150 – 157	8	Cytoplasmic Potential
	Transmembrane	158 – 178	21	Helical; Name=5; Potential
	Topological domain	179 – 187	9	Extracellular Potential
	Transmembrane	188 – 208	21	Helical; Name=6; Potential
	Topological domain	209 – 273	65	Cytoplasmic Potential
	Transmembrane	274 – 294	21	Helical; Name=7; Potential
	Topological domain	295 – 311	17	Extracellular Potential
	Transmembrane	312 – 332	21	Helical; Name=8; Potential
	Topological domain	333 – 338	6	Cytoplasmic Potential
	Transmembrane	339 – 359	21	Helical; Name=9; Potential
	Topological domain	360 – 364	5	Extracellular Potential
	Transmembrane	365 – 385	21	Helical; Name=10; Potential
	Topological domain	386 – 408	23	Cytoplasmic Potential
	Transmembrane	409 – 429	21	Helical; Name=11; Potential
	Topological domain	430 – 435	6	Extracellular Potential
	Transmembrane	436 – 456	21	Helical; Name=12; Potential
	Topological domain	457 – 496	40	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	47	1	N-linked (GlcNAc...) Potential
Natural variations
	Alternative sequence	1 – 7	7	MRALRRL → MLHALLRSRM in isoform 2 and isoform 3.		VSP_006293
	Alternative sequence	179 – 245	67	RELLG…GELEE → STTAATGLRGLGRGAGGAGG GARCLPGLPCPAPMGAVPAS GPEETGDKPRGSGQCHGALR E in isoform 2.		VSP_006294
	Alternative sequence	246 – 496	251	Missing in isoform 2.		VSP_006295
	Natural variant	60	1	D → N. Corresponds to variant rs7292659 [ dbSNP | Ensembl ].		VAR_046704
	Natural variant	232	1	R → Q. Corresponds to variant rs9608213 [ dbSNP | Ensembl ].		VAR_046705
	Natural variant	301	1	R → Q. Corresponds to variant rs36015336 [ dbSNP | Ensembl ].		VAR_061881
	Natural variant	420	1	I → F. Corresponds to variant rs34096096 [ dbSNP | Ensembl ].		VAR_046706
	Natural variant	469	1	K → E. Corresponds to variant rs60882514 [ dbSNP | Ensembl ].		VAR_061882

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (GLUT11) [UniParc]. Last modified June 1, 2001. Version 1. Checksum: 55FFEA82C7007D6D	FASTA	496	53,703
	10 20 30 40 50 60 MRALRRLIQG RILLLTICAA GIGGTFQFGY NLSIINAPTL HIQEFTNETW QARTGEPLPD 70 80 90 100 110 120 HLVLLMWSLI VSLYPLGGLF GALLAGPLAI TLGRKKSLLV NNIFVVSAAI LFGFSRKAGS 130 140 150 160 170 180 FEMIMLGRLL VGVNAGVSMN IQPMYLGESA PKELRGAVAM SSAIFTALGI VMGQVVGLRE 190 200 210 220 230 240 LLGGPQAWPL LLASCLVPGA LQLASLPLLP ESPRYLLIDC GDTEACLAAL RRLRGSGDLA 250 260 270 280 290 300 GELEELEEER AACQGCRARR PWELFQHRAL RRQVTSLVVL GSAMELCGND SVYAYASSVF 310 320 330 340 350 360 RKAGVPEAKI QYAIIGTGSC ELLTAVVSCV VIERVGRRVL LIGGYSLMTC WGSIFTVALC 370 380 390 400 410 420 LQSSFPWTLY LAMACIFAFI LSFGIGPAGV TGILATELFD QMARPAACMV CGALMWIMLI 430 440 450 460 470 480 LVGLGFPFIM EALSHFLYVP FLGVCVCGAI YTGLFLPETK GKTFQEISKE LHRLNFPRRA 490 QGPTWRSLEV IQSTEL
	Isoform 2 (GLUT11-s) [UniParc]. Checksum: 195731E90310ED9E	FASTA	242	25,022
	10 20 30 40 50 60 MLHALLRSRM IQGRILLLTI CAAGIGGTFQ FGYNLSIINA PTLHIQEFTN ETWQARTGEP 70 80 90 100 110 120 LPDHLVLLMW SLIVSLYPLG GLFGALLAGP LAITLGRKKS LLVNNIFVVS AAILFGFSRK 130 140 150 160 170 180 AGSFEMIMLG RLLVGVNAGV SMNIQPMYLG ESAPKELRGA VAMSSAIFTA LGIVMGQVVG 190 200 210 220 230 240 LSTTAATGLR GLGRGAGGAG GGARCLPGLP CPAPMGAVPA SGPEETGDKP RGSGQCHGAL RE
	Isoform 3 [UniParc]. Checksum: 7AFD0B6773A935AF	FASTA	499	54,015
	10 20 30 40 50 60 MLHALLRSRM IQGRILLLTI CAAGIGGTFQ FGYNLSIINA PTLHIQEFTN ETWQARTGEP 70 80 90 100 110 120 LPDHLVLLMW SLIVSLYPLG GLFGALLAGP LAITLGRKKS LLVNNIFVVS AAILFGFSRK 130 140 150 160 170 180 AGSFEMIMLG RLLVGVNAGV SMNIQPMYLG ESAPKELRGA VAMSSAIFTA LGIVMGQVVG 190 200 210 220 230 240 LRELLGGPQA WPLLLASCLV PGALQLASLP LLPESPRYLL IDCGDTEACL AALRRLRGSG 250 260 270 280 290 300 DLAGELEELE EERAACQGCR ARRPWELFQH RALRRQVTSL VVLGSAMELC GNDSVYAYAS 310 320 330 340 350 360 SVFRKAGVPE AKIQYAIIGT GSCELLTAVV SCVVIERVGR RVLLIGGYSL MTCWGSIFTV 370 380 390 400 410 420 ALCLQSSFPW TLYLAMACIF AFILSFGIGP AGVTGILATE LFDQMARPAA CMVCGALMWI 430 440 450 460 470 480 MLILVGLGFP FIMEALSHFL YVPFLGVCVC GAIYTGLFLP ETKGKTFQEI SKELHRLNFP 490 RRAQGPTWRS LEVIQSTEL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Two novel members of the family of sugar transport facilitators: genomic organization and predominant expression in lymphocytes (GLUT9) and muscle (GLUT10)." Doege H., Bocianski A., Scheepers A., Axer H., Eckel J., Joost H.-G. Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Heart.
[2]	"Molecular cloning of a member of the facilitative glucose transporter gene family GLUT11 (SLC2A11) and identification of transcription variants." Sasaki T., Minoshima S., Shiohama A., Shintani A., Shimizu A., Asakawa S., Kawasaki K., Shimizu N. Biochem. Biophys. Res. Commun. 289:1218-1224(2001) [PubMed: 11741323] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 2).
[3]	"A genome annotation-driven approach to cloning the human ORFeome." Collins J.E., Wright C.L., Edwards C.A., Davis M.P., Grinham J.A., Cole C.G., Goward M.E., Aguado B., Mallya M., Mokrab Y., Huckle E.J., Beare D.M., Dunham I. Genome Biol. 5:R84.1-R84.11(2004) [PubMed: 15461802] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
[4]	"Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries." Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y. , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T. DNA Res. 12:117-126(2005) [PubMed: 16303743] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Placenta.
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ271290 mRNA. Translation: CAC29020.1. AB049214 Genomic DNA. Translation: BAB68410.1. CR456373 mRNA. Translation: CAG30259.1. AK075467 mRNA. Translation: BAC11637.1. BC100808 mRNA. Translation: AAI00809.1.
IPI	IPI00477596. IPI00607565. IPI00903027.
RefSeq	NP_001020109.1. NM_001024938.2. NP_001020110.1. NM_001024939.2. NP_110434.3. NM_030807.3.
UniGene	Hs.632772.
3D structure databases
ProteinModelPortal	Q9BYW1.
ModBase	Search...
Protein-protein interaction databases
STRING	Q9BYW1.
Protein family/group databases
TCDB	2.A.1.1.44. major facilitator superfamily (MFS).
Polymorphism databases
DMDM	17366685.
Proteomic databases
PRIDE	Q9BYW1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000345044; ENSP00000342542; ENSG00000133460.
GeneID	66035.
KEGG	hsa:66035.
UCSC	uc002zyn.2. human.
Organism-specific databases
CTD	66035.
GeneCards	GC22P024198.
H-InvDB	HIX0016301.
HGNC	HGNC:14239. SLC2A11.
MIM	610367. gene.
neXtProt	NX_Q9BYW1.
GenAtlas	Search...
Phylogenomic databases
GeneTree	ENSGT00600000084262.
HOVERGEN	HBG014816.
OrthoDB	EOG4T783C.
PhylomeDB	Q9BYW1.
Enzyme and pathway databases
Reactome	REACT_15518. Transmembrane transport of small molecules.
Gene expression databases
ArrayExpress	Q9BYW1.
Bgee	Q9BYW1.
CleanEx	HS_SLC2A11.
Genevestigator	Q9BYW1.
GermOnline	ENSG00000133460. Homo sapiens.
Family and domain databases
InterPro	IPR020846. MFS_dom. IPR016196. MFS_dom_general_subst_transpt. IPR005828. Sub_transporter. IPR003663. Sugar/inositol_transpt. IPR005829. Sugar_transporter_CS. [Graphical view]
KO	K08148.
Pfam	PF00083. Sugar_tr. 1 hit. [Graphical view]
PRINTS	PR00171. SUGRTRNSPORT.
SUPFAM	SSF103473. MFS_gen_substrate_transporter. 1 hit.
TIGRFAMs	TIGR00879. SP. 1 hit.
PROSITE	PS50850. MFS. 1 hit. PS00216. SUGAR_TRANSPORT_1. False negative. PS00217. SUGAR_TRANSPORT_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	67534.
SOURCE	Search...

Entry information

Entry name

GTR11_HUMAN

Accession

Primary (citable) accession number: Q9BYW1
Secondary accession number(s): Q542Y4, Q6ICJ5

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 16, 2001
Last sequence update:	June 1, 2001
Last modified:	January 25, 2012
This is version 94 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.