Reviewed, UniProtKB/Swiss-Prot Q9BYV9 (BACH2_HUMAN)

Names and origin

Protein names

Recommended name:
    Transcription regulator protein BACH2
Alternative name(s):
    BTB and CNC homolog 2

Gene names

Name:

BACH2

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	841 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Transcriptional regulator that acts as repressor or activator. Binds to Maf recognition elements (MARE). Play important roles in coordinating transcription activation and repression by MAFK By similarity.
Subunit structure	Heterodimer of BACH2 and Maf-related transcription factors By similarity.
Subcellular location	Nucleus By similarity.
Tissue specificity	B-cell specific.
Sequence similarities	Belongs to the bZIP family. CNC subfamily. Contains 1 BTB (POZ) domain. Contains 1 bZIP domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Polymorphism
Ligand	DNA-binding
Molecular function	Activator Repressor
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	transcription Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	protein dimerization activity Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 841	841	Transcription regulator protein BACH2		PRO_0000076456
Regions
	Domain	37 – 103	67	BTB
	Domain	674 – 695	22	Leucine-zipper
	DNA binding	651 – 666	16	Basic motif
	Compositional bias	162 – 169	8	Poly-Glu
Natural variations
	Natural variant	418	1	A → T: dbSNP rs34335140.		VAR_033535
Experimental info
	Sequence conflict	75	1	V → A in BAD92126. Ref.3
	Sequence conflict	291	1	L → F in AAK48898. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q9BYV9-1 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: 4E926AC325952A93	FASTA	841	92,537
	10 20 30 40 50 60 MSVDEKPDSP MYVYESTVHC TNILLGLNDQ RKKDILCDVT LIVERKEFRA HRAVLAACSE 70 80 90 100 110 120 YFWQALVGQT KNDLVVSLPE EVTARGFGPL LQFAYTAKLL LSRENIREVI RCAEFLRMHN 130 140 150 160 170 180 LEDSCFSFLQ TQLLNSEDGL FVCRKDAACQ RPHEDCENSA GEEEDEEEET MDSETAKMAC 190 200 210 220 230 240 PRDQMLPEPI SFEAAAIPVA EKEEALLPEP DVPTDTKESS EKDALTQYPR YKKYQLACTK 250 260 270 280 290 300 NVYNASSHST SGFASTFRED NSSNSLKPGL ARGQIKSEPP SEENEEESIT LCLSGDEPDA 310 320 330 340 350 360 KDRAGDVEMD RKQPSPAPTP TAPAGAACLE RSRSVASPSC LRSLFSITKS VELSGLPSTS 370 380 390 400 410 420 QQHFARSPAC PFDKGITQGD LKTDYTPFTG NYGQPHVGQK EVSNFTMGSP LRGPGLEALC 430 440 450 460 470 480 KQEGELDRRS VIFSSSACDQ VSTSVHSYSG VSSLDKDLSE PVPKGLWVGA GQSLPSSQAY 490 500 510 520 530 540 SHGGLMADHL PGRMRPNTSC PVPIKVCPRS PPLETRTRTS SSCSSYSYAE DGSGGSPCSL 550 560 570 580 590 600 PLCEFSSSPC SQGARFLATE HQEPGLMGDG MYNQVRPQIK CEQSYGTNSS DESGSFSEAD 610 620 630 640 650 660 SESCPVQDRG QEVKLPFPVD QITDLPRNDF QMMIKMHKLT SEQLEFIHDV RRRSKNRIAA 670 680 690 700 710 720 QRCRKRKLDC IQNLECEIRK LVCEKEKLLS ERNQLKACMG ELLDNFSCLS QEVCRDIQSP 730 740 750 760 770 780 EQIQALHRYC PVLRPMDLPT ASSINPAPLG AEQNIAASQC AVGENVPCCL EPGAAPPGPP 790 800 810 820 830 840 WAPSNTSENC TSGRRLEGTD PGTFSERGPP LEPRSQTVTV DFCQEMTDKC TTDEQPRKDY T

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and expression of human B cell-specific transcription factor BACH2 mapped to chromosome 6q15." Sasaki S., Ito E., Toki T., Maekawa T., Kanezaki R., Umenai T., Muto A., Nagai H., Kinoshita T., Yamamoto M., Inazawa J., Taketo M.M., Nakahata T., Igarashi K., Yokoyama M. Oncogene 19:3739-3749(2000) [PubMed: 10949928] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Transcription factor BACH2 is transcriptionally regulated by the BCR/ABL oncogene." Vieira S.A.D., Deininger M.W.N., Sorour A., Sinclair P., Foroni L., Goldman J.M., Melo J.V. Genes Chromosomes Cancer 32:353-363(2001) [PubMed: 11746976] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F. Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[4]	"The DNA sequence and analysis of human chromosome 6." Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S. Nature 425:805-811(2003) [PubMed: 14574404] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF357835 mRNA. Translation: AAK48898.1. AJ271878 mRNA. Translation: CAC28130.1. AB208889 mRNA. Translation: BAD92126.1. Different initiation. AL353692, AL121787 Genomic DNA. Translation: CAI16237.1. AL121787, AL353692 Genomic DNA. Translation: CAI21648.1.
IPI	IPI00029178.
RefSeq	NP_068585.1.
UniGene	Hs.269764
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q9BYV9.
PTM databases
PhosphoSite	Q9BYV9.
Proteomic databases
PRIDE	Q9BYV9.
Genome annotation databases
Ensembl	ENST00000257749; ENSP00000257749; ENSG00000112182; Homo sapiens. [Genome view] ENST00000343122; ENSP00000345642; ENSG00000112182; Homo sapiens. [Genome view]
GeneID	60468.
KEGG	hsa:60468.
UCSC	uc003pnv.1. human.
Organism-specific databases
CTD	60468.
GeneCards	GC06M090692.
H-InvDB	HIX0006073.
HGNC	HGNC:14078. BACH2.
MIM	605394. gene.
PharmGKB	PA25235.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	Q9BYV9.
HOVERGEN	Q9BYV9.
OMA	ADSESCP
OrthoDB	EOG9RV5BC
Gene expression databases
ArrayExpress	Q9BYV9.
Bgee	Q9BYV9.
CleanEx	HS_BACH2.
Genevestigator	Q9BYV9.
GermOnline	ENSG00000112182. Homo sapiens.
Family and domain databases
InterPro	IPR000210. BTB/POZ-like. IPR011333. BTB/POZ_fold. IPR013069. BTB_POZ. IPR011616. bZIP_1. IPR008917. Euk_TF_DNA_bd. IPR013089. Kelch_related. IPR004827. TF_bZIP. [Graphical view]
Gene3D	G3DSA:3.30.710.10. BTB/POZ_fold. 1 hit.
PANTHER	PTHR23230. Kelch_related. 1 hit.
Pfam	PF00651. BTB. 1 hit. PF00170. bZIP_1. 1 hit. [Graphical view]
SMART	SM00338. BRLZ. 1 hit. SM00225. BTB. 1 hit. [Graphical view]
PROSITE	PS50097. BTB. 1 hit. PS50217. BZIP. 1 hit. PS00036. BZIP_BASIC. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	65347.
SOURCE	Search...

Entry information

Entry name

BACH2_HUMAN

Accession

Primary (citable) accession number: Q9BYV9
Secondary accession number(s): Q59H70, Q5T793, Q9NTS5

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 5, 2001
Last sequence update:	June 1, 2001
Last modified:	November 24, 2009
This is version 72 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.