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Q9BYV9 (BACH2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 114. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Transcription regulator protein BACH2
Alternative name(s):
BTB and CNC homolog 2
Gene names
Name:BACH2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length841 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Transcriptional regulator that acts as repressor or activator. Binds to Maf recognition elements (MARE). Play important roles in coordinating transcription activation and repression by MAFK By similarity. Induces apoptosis in response to oxidative stress through repression of the antiapoptotic factor HMOX1. Ref.6

Subunit structure

Heterodimer of BACH2 and Maf-related transcription factors By similarity. Homodimer; disulfide-linked. Ref.7

Subcellular location

Cytoplasm. Nucleus. Note: Nucleocytoplasmic shuttling is controlled by phosphorylation. Ref.6

Tissue specificity

B-cell specific.

Post-translational modification

Phosphorylation at Ser-521 downstream of the PI-3K pathway promotes nuclear export.

The reversible disulfide bond may provide mechanism to regulate the activity in oxidative stress responses.

Sequence similarities

Belongs to the bZIP family. CNC subfamily.

Contains 1 BTB (POZ) domain.

Contains 1 bZIP (basic-leucine zipper) domain.

Sequence caution

The sequence BAD92126.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentCytoplasm
Nucleus
   Coding sequence diversityPolymorphism
   LigandDNA-binding
   Molecular functionActivator
Repressor
   PTMDisulfide bond
Phosphoprotein
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processtranscription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

nucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionsequence-specific DNA binding

Inferred from electronic annotation. Source: InterPro

sequence-specific DNA binding transcription factor activity

Inferred from electronic annotation. Source: Ensembl

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 841841Transcription regulator protein BACH2
PRO_0000076456

Regions

Domain37 – 10367BTB
Domain646 – 70964bZIP
Region651 – 66717Basic motif By similarity
Region671 – 6788Leucine-zipper By similarity
Motif821 – 84121Nuclear export signal By similarity
Compositional bias162 – 1698Poly-Glu

Amino acid modifications

Modified residue5211Phosphoserine; by RPS6KB1 Ref.6
Disulfide bond20Interchain; redox-active Ref.7

Natural variations

Natural variant4181A → T.
Corresponds to variant rs34335140 [ dbSNP | Ensembl ].
VAR_033535

Experimental info

Mutagenesis5211S → A: Leads to nuclear accumulation. Ref.6
Sequence conflict751V → A in BAD92126. Ref.3
Sequence conflict2911L → F in AAK48898. Ref.1

Secondary structure

........................ 841
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q9BYV9 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: 4E926AC325952A93

FASTA84192,537
        10         20         30         40         50         60 
MSVDEKPDSP MYVYESTVHC TNILLGLNDQ RKKDILCDVT LIVERKEFRA HRAVLAACSE 

        70         80         90        100        110        120 
YFWQALVGQT KNDLVVSLPE EVTARGFGPL LQFAYTAKLL LSRENIREVI RCAEFLRMHN 

       130        140        150        160        170        180 
LEDSCFSFLQ TQLLNSEDGL FVCRKDAACQ RPHEDCENSA GEEEDEEEET MDSETAKMAC 

       190        200        210        220        230        240 
PRDQMLPEPI SFEAAAIPVA EKEEALLPEP DVPTDTKESS EKDALTQYPR YKKYQLACTK 

       250        260        270        280        290        300 
NVYNASSHST SGFASTFRED NSSNSLKPGL ARGQIKSEPP SEENEEESIT LCLSGDEPDA 

       310        320        330        340        350        360 
KDRAGDVEMD RKQPSPAPTP TAPAGAACLE RSRSVASPSC LRSLFSITKS VELSGLPSTS 

       370        380        390        400        410        420 
QQHFARSPAC PFDKGITQGD LKTDYTPFTG NYGQPHVGQK EVSNFTMGSP LRGPGLEALC 

       430        440        450        460        470        480 
KQEGELDRRS VIFSSSACDQ VSTSVHSYSG VSSLDKDLSE PVPKGLWVGA GQSLPSSQAY 

       490        500        510        520        530        540 
SHGGLMADHL PGRMRPNTSC PVPIKVCPRS PPLETRTRTS SSCSSYSYAE DGSGGSPCSL 

       550        560        570        580        590        600 
PLCEFSSSPC SQGARFLATE HQEPGLMGDG MYNQVRPQIK CEQSYGTNSS DESGSFSEAD 

       610        620        630        640        650        660 
SESCPVQDRG QEVKLPFPVD QITDLPRNDF QMMIKMHKLT SEQLEFIHDV RRRSKNRIAA 

       670        680        690        700        710        720 
QRCRKRKLDC IQNLECEIRK LVCEKEKLLS ERNQLKACMG ELLDNFSCLS QEVCRDIQSP 

       730        740        750        760        770        780 
EQIQALHRYC PVLRPMDLPT ASSINPAPLG AEQNIAASQC AVGENVPCCL EPGAAPPGPP 

       790        800        810        820        830        840 
WAPSNTSENC TSGRRLEGTD PGTFSERGPP LEPRSQTVTV DFCQEMTDKC TTDEQPRKDY 


T 

« Hide

References

« Hide 'large scale' references
[1]"Cloning and expression of human B cell-specific transcription factor BACH2 mapped to chromosome 6q15."
Sasaki S., Ito E., Toki T., Maekawa T., Kanezaki R., Umenai T., Muto A., Nagai H., Kinoshita T., Yamamoto M., Inazawa J., Taketo M.M., Nakahata T., Igarashi K., Yokoyama M.
Oncogene 19:3739-3749(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Transcription factor BACH2 is transcriptionally regulated by the BCR/ABL oncogene."
Vieira S.A.D., Deininger M.W.N., Sorour A., Sinclair P., Foroni L., Goldman J.M., Melo J.V.
Genes Chromosomes Cancer 32:353-363(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F.
Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[4]"The DNA sequence and analysis of human chromosome 6."
Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. expand/collapse author list , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"Bcr-Abl signaling through the PI-3/S6 kinase pathway inhibits nuclear translocation of the transcription factor Bach2, which represses the antiapoptotic factor heme oxygenase-1."
Yoshida C., Yoshida F., Sears D.E., Hart S.M., Ikebe D., Muto A., Basu S., Igarashi K., Melo J.V.
Blood 109:1211-1219(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION, PHOSPHORYLATION AT SER-521, MUTAGENESIS OF SER-521.
[7]"The structure of the Bach2 POZ-domain dimer reveals an intersubunit disulfide bond."
Rosbrook G.O., Stead M.A., Carr S.B., Wright S.C.
Acta Crystallogr. D 68:26-34(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 9-129, SUBUNIT, INTERCHAIN DISULFIDE BOND.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF357835 mRNA. Translation: AAK48898.1.
AJ271878 mRNA. Translation: CAC28130.1.
AB208889 mRNA. Translation: BAD92126.1. Different initiation.
AL353692, AL121787 Genomic DNA. Translation: CAI16237.1.
AL121787, AL353692 Genomic DNA. Translation: CAI21648.1.
CH471051 Genomic DNA. Translation: EAW48530.1.
CH471051 Genomic DNA. Translation: EAW48531.1.
CH471051 Genomic DNA. Translation: EAW48532.1.
CH471051 Genomic DNA. Translation: EAW48533.1.
CH471051 Genomic DNA. Translation: EAW48534.1.
RefSeqNP_001164265.1. NM_001170794.1.
NP_068585.1. NM_021813.2.
XP_005248816.1. XM_005248759.2.
UniGeneHs.269764.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3OHUX-ray2.10A/B/C/D/E/F9-129[»]
3OHVX-ray2.20A/B/C/D/E/F9-129[»]
ProteinModelPortalQ9BYV9.
SMRQ9BYV9. Positions 10-129, 609-703.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid121913. 14 interactions.
IntActQ9BYV9. 2 interactions.
STRING9606.ENSP00000257749.

PTM databases

PhosphoSiteQ9BYV9.

Polymorphism databases

DMDM17433037.

Proteomic databases

PaxDbQ9BYV9.
PRIDEQ9BYV9.

Protocols and materials databases

DNASU60468.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000257749; ENSP00000257749; ENSG00000112182.
ENST00000343122; ENSP00000345642; ENSG00000112182.
ENST00000537989; ENSP00000437473; ENSG00000112182.
GeneID60468.
KEGGhsa:60468.
UCSCuc003pnw.3. human.

Organism-specific databases

CTD60468.
GeneCardsGC06M090636.
HGNCHGNC:14078. BACH2.
HPAHPA051384.
MIM605394. gene.
neXtProtNX_Q9BYV9.
PharmGKBPA25235.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG276808.
HOGENOMHOG000231712.
HOVERGENHBG050655.
InParanoidQ9BYV9.
KOK09042.
OMALHRYCPV.
OrthoDBEOG7WMCHX.
PhylomeDBQ9BYV9.
TreeFamTF326681.

Enzyme and pathway databases

SignaLinkQ9BYV9.

Gene expression databases

ArrayExpressQ9BYV9.
BgeeQ9BYV9.
CleanExHS_BACH2.
GenevestigatorQ9BYV9.

Family and domain databases

Gene3D1.10.880.10. 1 hit.
3.30.710.10. 1 hit.
InterProIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR013069. BTB_POZ.
IPR004827. bZIP.
IPR004826. bZIP_Maf.
IPR008917. TF_DNA-bd.
[Graphical view]
PfamPF00651. BTB. 1 hit.
PF03131. bZIP_Maf. 1 hit.
[Graphical view]
SMARTSM00338. BRLZ. 1 hit.
SM00225. BTB. 1 hit.
[Graphical view]
SUPFAMSSF47454. SSF47454. 1 hit.
SSF54695. SSF54695. 1 hit.
PROSITEPS50097. BTB. 1 hit.
PS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceQ9BYV9.
GeneWikiBACH2.
GenomeRNAi60468.
NextBio65347.
PROQ9BYV9.
SOURCESearch...

Entry information

Entry nameBACH2_HUMAN
AccessionPrimary (citable) accession number: Q9BYV9
Secondary accession number(s): E1P518 expand/collapse secondary AC list , Q59H70, Q5T793, Q9NTS5
Entry history
Integrated into UniProtKB/Swiss-Prot: December 5, 2001
Last sequence update: June 1, 2001
Last modified: April 16, 2014
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 6

Human chromosome 6: entries, gene names and cross-references to MIM