Q9BYV9 (BACH2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Transcription regulator protein BACH2

Alternative name(s):
BTB and CNC homolog 2

Gene names

Name:

BACH2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	841 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Transcriptional regulator that acts as repressor or activator. Binds to Maf recognition elements (MARE). Play important roles in coordinating transcription activation and repression by MAFK By similarity.
Subunit structure	Heterodimer of BACH2 and Maf-related transcription factors By similarity.
Subcellular location	Nucleus By similarity.
Tissue specificity	B-cell specific.
Sequence similarities	Belongs to the bZIP family. CNC subfamily. Contains 1 BTB (POZ) domain. Contains 1 bZIP (basic-leucine zipper) domain.
Sequence caution	The sequence BAD92126.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Polymorphism
Ligand	DNA-binding
Molecular function	Activator Repressor
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 841

841

Transcription regulator protein BACH2

PRO_0000076456

Regions

Domain

37 – 103

67

BTB

Domain

646 – 709

64

bZIP

Region

651 – 667

17

Basic motif By similarity

Region

671 – 678

8

Leucine-zipper By similarity

Compositional bias

162 – 169

8

Poly-Glu

Natural variations

Natural variant

418

1

A → T.
Corresponds to variant rs34335140 [ dbSNP | Ensembl ].

VAR_033535

Experimental info

Sequence conflict

75

1

V → A in BAD92126. Ref.3

Sequence conflict

291

1

L → F in AAK48898. Ref.1

Secondary structure

1

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841

Helix Strand Turn

Details...

Beta strand

12 – 15

4

Helix

19 – 33

15

Beta strand

39 – 43

5

Beta strand

46 – 50

5

Helix

52 – 58

7

Helix

60 – 66

7

Beta strand

75 – 77

3

Helix

84 – 94

11

Beta strand

97 – 101

5

Turn

103 – 105

3

Helix

106 – 116

11

Beta strand

118 – 120

3

Sequences

	Sequence		Length	Mass (Da)
	Q9BYV9 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: 4E926AC325952A93	FASTA	841	92,537
	10 20 30 40 50 60 MSVDEKPDSP MYVYESTVHC TNILLGLNDQ RKKDILCDVT LIVERKEFRA HRAVLAACSE 70 80 90 100 110 120 YFWQALVGQT KNDLVVSLPE EVTARGFGPL LQFAYTAKLL LSRENIREVI RCAEFLRMHN 130 140 150 160 170 180 LEDSCFSFLQ TQLLNSEDGL FVCRKDAACQ RPHEDCENSA GEEEDEEEET MDSETAKMAC 190 200 210 220 230 240 PRDQMLPEPI SFEAAAIPVA EKEEALLPEP DVPTDTKESS EKDALTQYPR YKKYQLACTK 250 260 270 280 290 300 NVYNASSHST SGFASTFRED NSSNSLKPGL ARGQIKSEPP SEENEEESIT LCLSGDEPDA 310 320 330 340 350 360 KDRAGDVEMD RKQPSPAPTP TAPAGAACLE RSRSVASPSC LRSLFSITKS VELSGLPSTS 370 380 390 400 410 420 QQHFARSPAC PFDKGITQGD LKTDYTPFTG NYGQPHVGQK EVSNFTMGSP LRGPGLEALC 430 440 450 460 470 480 KQEGELDRRS VIFSSSACDQ VSTSVHSYSG VSSLDKDLSE PVPKGLWVGA GQSLPSSQAY 490 500 510 520 530 540 SHGGLMADHL PGRMRPNTSC PVPIKVCPRS PPLETRTRTS SSCSSYSYAE DGSGGSPCSL 550 560 570 580 590 600 PLCEFSSSPC SQGARFLATE HQEPGLMGDG MYNQVRPQIK CEQSYGTNSS DESGSFSEAD 610 620 630 640 650 660 SESCPVQDRG QEVKLPFPVD QITDLPRNDF QMMIKMHKLT SEQLEFIHDV RRRSKNRIAA 670 680 690 700 710 720 QRCRKRKLDC IQNLECEIRK LVCEKEKLLS ERNQLKACMG ELLDNFSCLS QEVCRDIQSP 730 740 750 760 770 780 EQIQALHRYC PVLRPMDLPT ASSINPAPLG AEQNIAASQC AVGENVPCCL EPGAAPPGPP 790 800 810 820 830 840 WAPSNTSENC TSGRRLEGTD PGTFSERGPP LEPRSQTVTV DFCQEMTDKC TTDEQPRKDY T

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and expression of human B cell-specific transcription factor BACH2 mapped to chromosome 6q15." Sasaki S., Ito E., Toki T., Maekawa T., Kanezaki R., Umenai T., Muto A., Nagai H., Kinoshita T., Yamamoto M., Inazawa J., Taketo M.M., Nakahata T., Igarashi K., Yokoyama M. Oncogene 19:3739-3749(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Transcription factor BACH2 is transcriptionally regulated by the BCR/ABL oncogene." Vieira S.A.D., Deininger M.W.N., Sorour A., Sinclair P., Foroni L., Goldman J.M., Melo J.V. Genes Chromosomes Cancer 32:353-363(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F. Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[4]	"The DNA sequence and analysis of human chromosome 6." Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S. Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AF357835 mRNA. Translation: AAK48898.1.
AJ271878 mRNA. Translation: CAC28130.1.
AB208889 mRNA. Translation: BAD92126.1. Different initiation.
AL353692, AL121787 Genomic DNA. Translation: CAI16237.1.
AL121787, AL353692 Genomic DNA. Translation: CAI21648.1.
CH471051 Genomic DNA. Translation: EAW48530.1.
CH471051 Genomic DNA. Translation: EAW48531.1.
CH471051 Genomic DNA. Translation: EAW48532.1.
CH471051 Genomic DNA. Translation: EAW48533.1.
CH471051 Genomic DNA. Translation: EAW48534.1.

IPI

IPI00029178.

RefSeq

NP_001164265.1. NM_001170794.1.
NP_068585.1. NM_021813.2.

UniGene

Hs.269764.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3OHU	X-ray	2.10	A/B/C/D/E/F	9-129	[»]
3OHV	X-ray	2.20	A/B/C/D/E/F	9-129	[»]

ProteinModelPortal

Q9BYV9.

ModBase

Search...

Protein-protein interaction databases

IntAct

Q9BYV9. 2 interactions.

STRING

9606.ENSP00000257749.

PTM databases

PhosphoSite

Q9BYV9.

Polymorphism databases

DMDM

17433037.

Proteomic databases

PaxDb

Q9BYV9.

PRIDE

Q9BYV9.

Protocols and materials databases

DNASU

60468.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000257749; ENSP00000257749; ENSG00000112182.
ENST00000343122; ENSP00000345642; ENSG00000112182.
ENST00000537989; ENSP00000437473; ENSG00000112182.

GeneID

60468.

KEGG

hsa:60468.

UCSC

uc003pnw.3. human.

Organism-specific databases

CTD

60468.

GeneCards

GC06M090636.

HGNC

HGNC:14078. BACH2.

HPA

HPA051384.

MIM

605394. gene.

neXtProt

NX_Q9BYV9.

PharmGKB

PA25235.

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG276808.

HOGENOM

HOG000231712.

HOVERGEN

HBG050655.

InParanoid

Q9BYV9.

KO

K09042.

OMA

STSQQHF.

OrthoDB

EOG405S0H.

PhylomeDB

Q9BYV9.

Gene expression databases

ArrayExpress

Q9BYV9.

Bgee

Q9BYV9.

CleanEx

HS_BACH2.

Genevestigator

Q9BYV9.

GermOnline

ENSG00000112182. Homo sapiens.

Family and domain databases

Gene3D

1.10.880.10. 1 hit.
3.30.710.10. 1 hit.

InterPro

IPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR013069. BTB_POZ.
IPR004827. bZIP.
IPR008917. Euk_TF_DNA-bd.
[Graphical view]

Pfam

PF00651. BTB. 1 hit.
PF00170. bZIP_1. 1 hit.
[Graphical view]

SMART

SM00338. BRLZ. 1 hit.
SM00225. BTB. 1 hit.
[Graphical view]

SUPFAM

SSF54695. BTB/POZ_fold. 1 hit.
SSF47454. Euk_transcr_DNA. 1 hit.

PROSITE

PS50097. BTB. 1 hit.
PS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

EvolutionaryTrace

Q9BYV9.

GenomeRNAi

60468.

NextBio

65347.

SOURCE

Search...

Entry information

Entry name

BACH2_HUMAN

Accession

Primary (citable) accession number: Q9BYV9
Secondary accession number(s): E1P518 , Q59H70, Q5T793, Q9NTS5

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 5, 2001
Last sequence update:	June 1, 2001
Last modified:	May 1, 2013
This is version 105 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.