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Protein

Transcription regulator protein BACH2

Gene

BACH2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcriptional regulator that acts as repressor or activator (By similarity). Binds to Maf recognition elements (MARE) (By similarity). Plays an important role in coordinating transcription activation and repression by MAFK (By similarity). Induces apoptosis in response to oxidative stress through repression of the antiapoptotic factor HMOX1 (PubMed:17018862). Positively regulates the nuclear import of actin (By similarity).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding, Repressor
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

SignaLinkiQ9BYV9.
SIGNORiQ9BYV9.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription regulator protein BACH2
Alternative name(s):
BTB and CNC homolog 2
Gene namesi
Name:BACH2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000112182.14.
HGNCiHGNC:14078. BACH2.
MIMi605394. gene.
neXtProtiNX_Q9BYV9.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi521S → A: Leads to nuclear accumulation. 1 Publication1

Organism-specific databases

DisGeNETi60468.
OpenTargetsiENSG00000112182.
PharmGKBiPA25235.

Polymorphism and mutation databases

BioMutaiBACH2.
DMDMi17433037.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000764561 – 841Transcription regulator protein BACH2Add BLAST841

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi20Interchain; redox-active1 Publication
Modified residuei315PhosphoserineBy similarity1
Cross-linki382Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki421Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei521Phosphoserine; by RPS6KB11 Publication1

Post-translational modificationi

Phosphorylation at Ser-521 downstream of the PI-3K pathway promotes nuclear export.1 Publication
The reversible disulfide bond may provide a mechanism to regulate the activity in oxidative stress responses.1 Publication

Keywords - PTMi

Disulfide bond, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ9BYV9.
PaxDbiQ9BYV9.
PeptideAtlasiQ9BYV9.
PRIDEiQ9BYV9.

PTM databases

iPTMnetiQ9BYV9.
PhosphoSitePlusiQ9BYV9.

Expressioni

Tissue specificityi

B-cell specific.

Gene expression databases

BgeeiENSG00000112182.
CleanExiHS_BACH2.
ExpressionAtlasiQ9BYV9. baseline and differential.
GenevisibleiQ9BYV9. HS.

Organism-specific databases

HPAiHPA051384.
HPA058384.

Interactioni

Subunit structurei

Homodimer; disulfide-linked (PubMed:22194330). Heterodimer of BACH2 and Maf-related transcription factors (By similarity).By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
NXF1Q9UBU94EBI-1642333,EBI-398874

Protein-protein interaction databases

BioGridi121913. 15 interactors.
IntActiQ9BYV9. 43 interactors.
STRINGi9606.ENSP00000257749.

Structurei

Secondary structure

1841
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi12 – 15Combined sources4
Helixi19 – 33Combined sources15
Beta strandi39 – 43Combined sources5
Beta strandi46 – 50Combined sources5
Helixi52 – 58Combined sources7
Helixi60 – 66Combined sources7
Beta strandi75 – 77Combined sources3
Helixi84 – 94Combined sources11
Beta strandi97 – 101Combined sources5
Turni103 – 105Combined sources3
Helixi106 – 116Combined sources11
Beta strandi118 – 120Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3OHUX-ray2.10A/B/C/D/E/F9-129[»]
3OHVX-ray2.20A/B/C/D/E/F9-129[»]
ProteinModelPortaliQ9BYV9.
SMRiQ9BYV9.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9BYV9.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini37 – 103BTBPROSITE-ProRule annotationAdd BLAST67
Domaini646 – 709bZIPPROSITE-ProRule annotationAdd BLAST64

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni651 – 667Basic motifPROSITE-ProRule annotationAdd BLAST17
Regioni671 – 678Leucine-zipperPROSITE-ProRule annotation8

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi821 – 841Nuclear export signalBy similarityAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi162 – 169Poly-Glu8

Sequence similaritiesi

Belongs to the bZIP family. CNC subfamily.Curated

Phylogenomic databases

eggNOGiENOG410ISV4. Eukaryota.
ENOG410ZDVB. LUCA.
GeneTreeiENSGT00850000132251.
HOGENOMiHOG000231712.
HOVERGENiHBG050655.
InParanoidiQ9BYV9.
KOiK09042.
OMAiIKVCPRS.
OrthoDBiEOG091G02EB.
PhylomeDBiQ9BYV9.
TreeFamiTF326681.

Family and domain databases

InterProiView protein in InterPro
IPR000210. BTB/POZ_dom.
IPR004827. bZIP.
IPR004826. bZIP_Maf.
IPR011333. SKP1/BTB/POZ_sf.
IPR008917. TF_DNA-bd_sf.
PfamiView protein in Pfam
PF00651. BTB. 1 hit.
PF03131. bZIP_Maf. 1 hit.
SMARTiView protein in SMART
SM00338. BRLZ. 1 hit.
SM00225. BTB. 1 hit.
SUPFAMiSSF47454. SSF47454. 1 hit.
SSF54695. SSF54695. 1 hit.
PROSITEiView protein in PROSITE
PS50097. BTB. 1 hit.
PS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9BYV9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVDEKPDSP MYVYESTVHC TNILLGLNDQ RKKDILCDVT LIVERKEFRA
60 70 80 90 100
HRAVLAACSE YFWQALVGQT KNDLVVSLPE EVTARGFGPL LQFAYTAKLL
110 120 130 140 150
LSRENIREVI RCAEFLRMHN LEDSCFSFLQ TQLLNSEDGL FVCRKDAACQ
160 170 180 190 200
RPHEDCENSA GEEEDEEEET MDSETAKMAC PRDQMLPEPI SFEAAAIPVA
210 220 230 240 250
EKEEALLPEP DVPTDTKESS EKDALTQYPR YKKYQLACTK NVYNASSHST
260 270 280 290 300
SGFASTFRED NSSNSLKPGL ARGQIKSEPP SEENEEESIT LCLSGDEPDA
310 320 330 340 350
KDRAGDVEMD RKQPSPAPTP TAPAGAACLE RSRSVASPSC LRSLFSITKS
360 370 380 390 400
VELSGLPSTS QQHFARSPAC PFDKGITQGD LKTDYTPFTG NYGQPHVGQK
410 420 430 440 450
EVSNFTMGSP LRGPGLEALC KQEGELDRRS VIFSSSACDQ VSTSVHSYSG
460 470 480 490 500
VSSLDKDLSE PVPKGLWVGA GQSLPSSQAY SHGGLMADHL PGRMRPNTSC
510 520 530 540 550
PVPIKVCPRS PPLETRTRTS SSCSSYSYAE DGSGGSPCSL PLCEFSSSPC
560 570 580 590 600
SQGARFLATE HQEPGLMGDG MYNQVRPQIK CEQSYGTNSS DESGSFSEAD
610 620 630 640 650
SESCPVQDRG QEVKLPFPVD QITDLPRNDF QMMIKMHKLT SEQLEFIHDV
660 670 680 690 700
RRRSKNRIAA QRCRKRKLDC IQNLECEIRK LVCEKEKLLS ERNQLKACMG
710 720 730 740 750
ELLDNFSCLS QEVCRDIQSP EQIQALHRYC PVLRPMDLPT ASSINPAPLG
760 770 780 790 800
AEQNIAASQC AVGENVPCCL EPGAAPPGPP WAPSNTSENC TSGRRLEGTD
810 820 830 840
PGTFSERGPP LEPRSQTVTV DFCQEMTDKC TTDEQPRKDY T
Length:841
Mass (Da):92,537
Last modified:June 1, 2001 - v1
Checksum:i4E926AC325952A93
GO

Sequence cautioni

The sequence BAD92126 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti75V → A in BAD92126 (Ref. 3) Curated1
Sequence conflicti291L → F in AAK48898 (PubMed:10949928).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_033535418A → T. Corresponds to variant dbSNP:rs34335140Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF357835 mRNA. Translation: AAK48898.1.
AJ271878 mRNA. Translation: CAC28130.1.
AB208889 mRNA. Translation: BAD92126.1. Different initiation.
AL353692 Genomic DNA. No translation available.
AL121787 Genomic DNA. No translation available.
CH471051 Genomic DNA. Translation: EAW48530.1.
CH471051 Genomic DNA. Translation: EAW48531.1.
CH471051 Genomic DNA. Translation: EAW48532.1.
CH471051 Genomic DNA. Translation: EAW48533.1.
CH471051 Genomic DNA. Translation: EAW48534.1.
CCDSiCCDS5026.1.
RefSeqiNP_001164265.1. NM_001170794.1.
NP_068585.1. NM_021813.3.
XP_005248816.1. XM_005248759.4.
XP_011534341.1. XM_011536039.2.
XP_011534342.1. XM_011536040.2.
XP_016866654.1. XM_017011165.1.
XP_016866655.1. XM_017011166.1.
UniGeneiHs.269764.

Genome annotation databases

EnsembliENST00000257749; ENSP00000257749; ENSG00000112182.
ENST00000343122; ENSP00000345642; ENSG00000112182.
ENST00000537989; ENSP00000437473; ENSG00000112182.
GeneIDi60468.
KEGGihsa:60468.
UCSCiuc003pnw.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiBACH2_HUMAN
AccessioniPrimary (citable) accession number: Q9BYV9
Secondary accession number(s): E1P518
, Q59H70, Q5T793, Q9NTS5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 5, 2001
Last sequence update: June 1, 2001
Last modified: March 28, 2018
This is version 150 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome