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Q9BYV2 (TRI54_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 114. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tripartite motif-containing protein 54
Alternative name(s):
Muscle-specific RING finger protein
Short name=MuRF
Muscle-specific RING finger protein 3
Short name=MuRF-3
Short name=MuRF3
RING finger protein 30
Gene names
Name:TRIM54
Synonyms:MURF, MURF3, RNF30
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length358 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May bind and stabilize microtubules during myotubes formation By similarity.

Subunit structure

Homooligomer and heterooligomer. Interacts with tubulin By similarity. Interacts with TRIM63 and probably with TRIM55. Ref.1

Subcellular location

Cytoplasmcytoskeleton By similarity. CytoplasmmyofibrilsarcomereZ line By similarity. Note: Associates with microtubules. Localizes to the Z-lines in skeletal muscles By similarity.

Tissue specificity

Specifically expressed in heart and skeletal muscle. Ref.1

Sequence similarities

Contains 1 B box-type zinc finger.

Contains 1 COS domain.

Contains 1 RING-type zinc finger.

Sequence caution

The sequence AAY24296.1 differs from that shown. Reason: Erroneous initiation.

The sequence CAC32841.1 differs from that shown. Reason: Erroneous initiation.

The sequence CAC32842.1 differs from that shown. Reason: Erroneous initiation.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9BYV2-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9BYV2-2)

The sequence of this isoform differs from the canonical sequence as follows:
     171-171: K → KKQDLTLLPRLECSGTNTTYCSLDLPSSSDPPILASQNTKIID

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 358358Tripartite motif-containing protein 54
PRO_0000056282

Regions

Domain271 – 32959COS
Zinc finger26 – 8257RING-type
Zinc finger121 – 16343B box-type
Region168 – 21144Mediates microtubule-binding and homooligomerization By similarity
Coiled coil220 – 25839 Potential

Natural variations

Alternative sequence1711K → KKQDLTLLPRLECSGTNTTY CSLDLPSSSDPPILASQNTK IID in isoform 2.
VSP_016061

Experimental info

Sequence conflict1721S → N in CAC32841. Ref.1
Sequence conflict2141N → T in CAC32841. Ref.1
Sequence conflict2141N → T in CAC32842. Ref.1

Secondary structure

.............. 358
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified October 14, 2008. Version 3.
Checksum: C44B08A9871323F6

FASTA35840,301
        10         20         30         40         50         60 
MNFTVGFKPL LGDAHSMDNL EKQLICPICL EMFSKPVVIL PCQHNLCRKC ANDVFQASNP 

        70         80         90        100        110        120 
LWQSRGSTTV SSGGRFRCPS CRHEVVLDRH GVYGLQRNLL VENIIDIYKQ ESSRPLHSKA 

       130        140        150        160        170        180 
EQHLMCEEHE EEKINIYCLS CEVPTCSLCK VFGAHKDCEV APLPTIYKRQ KSELSDGIAM 

       190        200        210        220        230        240 
LVAGNDRVQA VITQMEEVCQ TIEDNSRRQK QLLNQRFESL CAVLEERKGE LLQALAREQE 

       250        260        270        280        290        300 
EKLQRVRGLI RQYGDHLEAS SKLVESAIQS MEEPQMALYL QQAKELINKV GAMSKVELAG 

       310        320        330        340        350 
RPEPGYESME QFTVRVEHVA EMLRTIDFQP GASGEEEEVA PDGEEGSAGP EEERPDGP 

« Hide

Isoform 2 [UniParc].

Checksum: D4D12B4FA81A841F
Show »

FASTA40044,833

References

« Hide 'large scale' references
[1]"Identification of muscle specific ring finger proteins as potential regulators of the titin kinase domain."
Centner T., Yano J., Kimura E., McElhinny A.S., Pelin K., Witt C.C., Bang M.-L., Trombitas K., Granzier H., Gregorio C.C., Sorimachi H., Labeit S.
J. Mol. Biol. 306:717-726(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), TISSUE SPECIFICITY, OLIGOMERIZATION, INTERACTION WITH TRIM63 AND TRIM55.
[2]"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. expand/collapse author list , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]"The B-box domain of TRIM54."
Structural genomics consortium (SGC)
Submitted (FEB-2011) to the PDB data bank
Cited for: X-RAY CRYSTALLOGRAPHY (2.15 ANGSTROMS) OF 122-168 IN COMPLEX WITH ZINC IONS.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ291714 mRNA. Translation: CAC32841.1. Different initiation.
AJ291714 mRNA. Translation: CAC32842.1. Different initiation.
AC013413 Genomic DNA. Translation: AAY24296.1. Different initiation.
CH471053 Genomic DNA. Translation: EAX00606.1.
BC141807 mRNA. Translation: AAI41808.1.
RefSeqNP_115935.3. NM_032546.3.
NP_912730.2. NM_187841.2.
UniGeneHs.516036.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3Q1DX-ray2.15A122-168[»]
ProteinModelPortalQ9BYV2.
SMRQ9BYV2. Positions 13-168.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid121415. 28 interactions.
IntActQ9BYV2. 4 interactions.
STRING9606.ENSP00000296098.

PTM databases

PhosphoSiteQ9BYV2.

Polymorphism databases

DMDM209572715.

Proteomic databases

PaxDbQ9BYV2.
PRIDEQ9BYV2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000296098; ENSP00000296098; ENSG00000138100. [Q9BYV2-2]
ENST00000380075; ENSP00000369415; ENSG00000138100. [Q9BYV2-1]
GeneID57159.
KEGGhsa:57159.
UCSCuc002rjn.3. human. [Q9BYV2-2]
uc002rjo.3. human. [Q9BYV2-1]

Organism-specific databases

CTD57159.
GeneCardsGC02P027506.
HGNCHGNC:16008. TRIM54.
HPAHPA019690.
MIM606474. gene.
neXtProtNX_Q9BYV2.
PharmGKBPA34434.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG310224.
HOGENOMHOG000231156.
HOVERGENHBG071242.
KOK10653.
OMAGYESMDQ.
OrthoDBEOG7VDXPK.
PhylomeDBQ9BYV2.
TreeFamTF331669.

Gene expression databases

BgeeQ9BYV2.
CleanExHS_TRIM54.
GenevestigatorQ9BYV2.

Family and domain databases

Gene3D3.30.40.10. 1 hit.
4.10.45.10. 1 hit.
InterProIPR017903. COS_domain.
IPR000315. Znf_B-box.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamPF00643. zf-B_box. 1 hit.
[Graphical view]
SMARTSM00336. BBOX. 1 hit.
SM00184. RING. 1 hit.
[Graphical view]
PROSITEPS51262. COS. 1 hit.
PS50119. ZF_BBOX. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSTRIM54. human.
EvolutionaryTraceQ9BYV2.
GenomeRNAi57159.
NextBio63157.
PROQ9BYV2.
SOURCESearch...

Entry information

Entry nameTRI54_HUMAN
AccessionPrimary (citable) accession number: Q9BYV2
Secondary accession number(s): A5D8T7, Q53SY4, Q9BYV3
Entry history
Integrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: October 14, 2008
Last modified: April 16, 2014
This is version 114 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 2

Human chromosome 2: entries, gene names and cross-references to MIM