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Q9BYV2

- TRI54_HUMAN

UniProt

Q9BYV2 - TRI54_HUMAN

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Protein

Tripartite motif-containing protein 54

Gene

TRIM54

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

May bind and stabilize microtubules during myotubes formation.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri26 – 8257RING-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri121 – 16343B box-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. signal transducer activity Source: UniProtKB
  2. zinc ion binding Source: UniProtKB

GO - Biological processi

  1. cell differentiation Source: UniProtKB-KW
  2. microtubule-based process Source: UniProtKB
  3. multicellular organismal development Source: UniProtKB-KW
  4. negative regulation of microtubule depolymerization Source: UniProtKB
  5. signal transduction Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Tripartite motif-containing protein 54
Alternative name(s):
Muscle-specific RING finger protein
Short name:
MuRF
Muscle-specific RING finger protein 3
Short name:
MuRF-3
Short name:
MuRF3
RING finger protein 30
Gene namesi
Name:TRIM54
Synonyms:MURF, MURF3, RNF30
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:16008. TRIM54.

Subcellular locationi

Cytoplasmcytoskeleton By similarity. CytoplasmmyofibrilsarcomereZ line By similarity
Note: Associates with microtubules. Localizes to the Z-lines in skeletal muscles (By similarity).By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. microtubule Source: UniProtKB
  3. microtubule associated complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA34434.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 358358Tripartite motif-containing protein 54PRO_0000056282Add
BLAST

Proteomic databases

MaxQBiQ9BYV2.
PaxDbiQ9BYV2.
PRIDEiQ9BYV2.

PTM databases

PhosphoSiteiQ9BYV2.

Expressioni

Tissue specificityi

Specifically expressed in heart and skeletal muscle.1 Publication

Gene expression databases

BgeeiQ9BYV2.
CleanExiHS_TRIM54.
GenevestigatoriQ9BYV2.

Organism-specific databases

HPAiHPA019690.

Interactioni

Subunit structurei

Homooligomer and heterooligomer. Interacts with tubulin (By similarity). Interacts with TRIM63 and probably with TRIM55.By similarity2 Publications

Protein-protein interaction databases

BioGridi121415. 29 interactions.
IntActiQ9BYV2. 4 interactions.
STRINGi9606.ENSP00000296098.

Structurei

Secondary structure

1
358
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi127 – 1293
Beta strandi132 – 1387
Turni139 – 1424
Beta strandi143 – 1464
Helixi147 – 1515
Turni154 – 1574
Beta strandi160 – 1623
Helixi164 – 1663

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3Q1DX-ray2.15A122-168[»]
ProteinModelPortaliQ9BYV2.
SMRiQ9BYV2. Positions 17-85, 122-168, 218-274.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9BYV2.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini271 – 32959COSPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni168 – 21144Mediates microtubule-binding and homooligomerizationBy similarityAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili220 – 25839Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Contains 1 B box-type zinc finger.PROSITE-ProRule annotation
Contains 1 COS domain.PROSITE-ProRule annotation
Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri26 – 8257RING-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri121 – 16343B box-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiNOG310224.
GeneTreeiENSGT00760000118878.
HOGENOMiHOG000231156.
HOVERGENiHBG071242.
InParanoidiQ9BYV2.
KOiK10653.
OMAiGYESMDQ.
OrthoDBiEOG7VDXPK.
PhylomeDBiQ9BYV2.
TreeFamiTF331669.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
4.10.45.10. 1 hit.
InterProiIPR017903. COS_domain.
IPR000315. Znf_B-box.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamiPF00643. zf-B_box. 1 hit.
[Graphical view]
SMARTiSM00336. BBOX. 1 hit.
SM00184. RING. 1 hit.
[Graphical view]
PROSITEiPS51262. COS. 1 hit.
PS50119. ZF_BBOX. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9BYV2) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNFTVGFKPL LGDAHSMDNL EKQLICPICL EMFSKPVVIL PCQHNLCRKC
60 70 80 90 100
ANDVFQASNP LWQSRGSTTV SSGGRFRCPS CRHEVVLDRH GVYGLQRNLL
110 120 130 140 150
VENIIDIYKQ ESSRPLHSKA EQHLMCEEHE EEKINIYCLS CEVPTCSLCK
160 170 180 190 200
VFGAHKDCEV APLPTIYKRQ KSELSDGIAM LVAGNDRVQA VITQMEEVCQ
210 220 230 240 250
TIEDNSRRQK QLLNQRFESL CAVLEERKGE LLQALAREQE EKLQRVRGLI
260 270 280 290 300
RQYGDHLEAS SKLVESAIQS MEEPQMALYL QQAKELINKV GAMSKVELAG
310 320 330 340 350
RPEPGYESME QFTVRVEHVA EMLRTIDFQP GASGEEEEVA PDGEEGSAGP

EEERPDGP
Length:358
Mass (Da):40,301
Last modified:October 14, 2008 - v3
Checksum:iC44B08A9871323F6
GO
Isoform 2 (identifier: Q9BYV2-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     171-171: K → KKQDLTLLPRLECSGTNTTYCSLDLPSSSDPPILASQNTKIID

Show »
Length:400
Mass (Da):44,833
Checksum:iD4D12B4FA81A841F
GO

Sequence cautioni

The sequence AAY24296.1 differs from that shown. Reason: Erroneous initiation.
The sequence CAC32841.1 differs from that shown. Reason: Erroneous initiation.
The sequence CAC32842.1 differs from that shown. Reason: Erroneous initiation.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti172 – 1721S → N in CAC32841. (PubMed:11243782)Curated
Sequence conflicti214 – 2141N → T in CAC32841. (PubMed:11243782)Curated
Sequence conflicti214 – 2141N → T in CAC32842. (PubMed:11243782)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei171 – 1711K → KKQDLTLLPRLECSGTNTTY CSLDLPSSSDPPILASQNTK IID in isoform 2. 1 PublicationVSP_016061

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ291714 mRNA. Translation: CAC32841.1. Different initiation.
AJ291714 mRNA. Translation: CAC32842.1. Different initiation.
AC013413 Genomic DNA. Translation: AAY24296.1. Different initiation.
CH471053 Genomic DNA. Translation: EAX00606.1.
BC141807 mRNA. Translation: AAI41808.1.
CCDSiCCDS1745.2. [Q9BYV2-2]
CCDS1746.2. [Q9BYV2-1]
RefSeqiNP_115935.3. NM_032546.3. [Q9BYV2-2]
NP_912730.2. NM_187841.2. [Q9BYV2-1]
UniGeneiHs.516036.

Genome annotation databases

EnsembliENST00000296098; ENSP00000296098; ENSG00000138100. [Q9BYV2-2]
ENST00000380075; ENSP00000369415; ENSG00000138100. [Q9BYV2-1]
GeneIDi57159.
KEGGihsa:57159.
UCSCiuc002rjn.3. human. [Q9BYV2-2]
uc002rjo.3. human. [Q9BYV2-1]

Polymorphism databases

DMDMi209572715.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ291714 mRNA. Translation: CAC32841.1 . Different initiation.
AJ291714 mRNA. Translation: CAC32842.1 . Different initiation.
AC013413 Genomic DNA. Translation: AAY24296.1 . Different initiation.
CH471053 Genomic DNA. Translation: EAX00606.1 .
BC141807 mRNA. Translation: AAI41808.1 .
CCDSi CCDS1745.2. [Q9BYV2-2 ]
CCDS1746.2. [Q9BYV2-1 ]
RefSeqi NP_115935.3. NM_032546.3. [Q9BYV2-2 ]
NP_912730.2. NM_187841.2. [Q9BYV2-1 ]
UniGenei Hs.516036.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3Q1D X-ray 2.15 A 122-168 [» ]
ProteinModelPortali Q9BYV2.
SMRi Q9BYV2. Positions 17-85, 122-168, 218-274.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 121415. 29 interactions.
IntActi Q9BYV2. 4 interactions.
STRINGi 9606.ENSP00000296098.

PTM databases

PhosphoSitei Q9BYV2.

Polymorphism databases

DMDMi 209572715.

Proteomic databases

MaxQBi Q9BYV2.
PaxDbi Q9BYV2.
PRIDEi Q9BYV2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000296098 ; ENSP00000296098 ; ENSG00000138100 . [Q9BYV2-2 ]
ENST00000380075 ; ENSP00000369415 ; ENSG00000138100 . [Q9BYV2-1 ]
GeneIDi 57159.
KEGGi hsa:57159.
UCSCi uc002rjn.3. human. [Q9BYV2-2 ]
uc002rjo.3. human. [Q9BYV2-1 ]

Organism-specific databases

CTDi 57159.
GeneCardsi GC02P027506.
HGNCi HGNC:16008. TRIM54.
HPAi HPA019690.
MIMi 606474. gene.
neXtProti NX_Q9BYV2.
PharmGKBi PA34434.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG310224.
GeneTreei ENSGT00760000118878.
HOGENOMi HOG000231156.
HOVERGENi HBG071242.
InParanoidi Q9BYV2.
KOi K10653.
OMAi GYESMDQ.
OrthoDBi EOG7VDXPK.
PhylomeDBi Q9BYV2.
TreeFami TF331669.

Miscellaneous databases

ChiTaRSi TRIM54. human.
EvolutionaryTracei Q9BYV2.
GenomeRNAii 57159.
NextBioi 63157.
PROi Q9BYV2.
SOURCEi Search...

Gene expression databases

Bgeei Q9BYV2.
CleanExi HS_TRIM54.
Genevestigatori Q9BYV2.

Family and domain databases

Gene3Di 3.30.40.10. 1 hit.
4.10.45.10. 1 hit.
InterProi IPR017903. COS_domain.
IPR000315. Znf_B-box.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view ]
Pfami PF00643. zf-B_box. 1 hit.
[Graphical view ]
SMARTi SM00336. BBOX. 1 hit.
SM00184. RING. 1 hit.
[Graphical view ]
PROSITEi PS51262. COS. 1 hit.
PS50119. ZF_BBOX. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of muscle specific ring finger proteins as potential regulators of the titin kinase domain."
    Centner T., Yano J., Kimura E., McElhinny A.S., Pelin K., Witt C.C., Bang M.-L., Trombitas K., Granzier H., Gregorio C.C., Sorimachi H., Labeit S.
    J. Mol. Biol. 306:717-726(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), TISSUE SPECIFICITY, OLIGOMERIZATION, INTERACTION WITH TRIM63 AND TRIM55.
  2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "The B-box domain of TRIM54."
    Structural genomics consortium (SGC)
    Submitted (FEB-2011) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.15 ANGSTROMS) OF 122-168 IN COMPLEX WITH ZINC IONS.

Entry informationi

Entry nameiTRI54_HUMAN
AccessioniPrimary (citable) accession number: Q9BYV2
Secondary accession number(s): A5D8T7, Q53SY4, Q9BYV3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: October 14, 2008
Last modified: October 29, 2014
This is version 119 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3