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Protein

Pre-B-cell leukemia transcription factor 4

Gene

PBX4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi210 – 272Homeobox; TALE-typePROSITE-ProRule annotationAdd BLAST63

GO - Molecular functioni

  • sequence-specific DNA binding Source: BHF-UCL
  • transcription factor activity, sequence-specific DNA binding Source: InterPro

GO - Biological processi

  • positive regulation of transcription, DNA-templated Source: BHF-UCL
  • transcription from RNA polymerase II promoter Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000105717-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Pre-B-cell leukemia transcription factor 4
Alternative name(s):
Homeobox protein PBX4
Gene namesi
Name:PBX4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:13403. PBX4.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  • nucleus Source: BHF-UCL
  • XY body Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi80714.
OpenTargetsiENSG00000105717.
PharmGKBiPA32973.

Polymorphism and mutation databases

BioMutaiPBX4.
DMDMi122065777.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000492411 – 374Pre-B-cell leukemia transcription factor 4Add BLAST374

Proteomic databases

MaxQBiQ9BYU1.
PaxDbiQ9BYU1.
PeptideAtlasiQ9BYU1.
PRIDEiQ9BYU1.

PTM databases

iPTMnetiQ9BYU1.
PhosphoSitePlusiQ9BYU1.

Expressioni

Gene expression databases

BgeeiENSG00000105717.
CleanExiHS_PBX4.
ExpressionAtlasiQ9BYU1. baseline and differential.
GenevisibleiQ9BYU1. HS.

Organism-specific databases

HPAiHPA049859.
HPA056469.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
IPO13O948295EBI-10302990,EBI-747310
TFIP11Q9UBB95EBI-10302990,EBI-1105213

Protein-protein interaction databases

BioGridi123272. 4 interactors.
IntActiQ9BYU1. 7 interactors.
STRINGi9606.ENSP00000251203.

Structurei

3D structure databases

ProteinModelPortaliQ9BYU1.
SMRiQ9BYU1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TALE/PBX homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0774. Eukaryota.
ENOG410XRVF. LUCA.
GeneTreeiENSGT00390000016426.
HOGENOMiHOG000266972.
HOVERGENiHBG000122.
InParanoidiQ9BYU1.
KOiK15611.
OMAiFYSHLNN.
OrthoDBiEOG091G10TD.
PhylomeDBiQ9BYU1.
TreeFamiTF314340.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR005542. PBX.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF03792. PBC. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9BYU1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAPPRPAPS PPAPRRLDTS DVLQQIMAIT DQSLDEAQAR KHALNCHRMK
60 70 80 90 100
PALFSVLCEI KEKTVVSIRG IQDEDPPDAQ LLRLDNMLLA EGVCRPEKRG
110 120 130 140 150
RGGAVARAGT ATPGGCPNDN SIEHSDYRAK LSQIRQIYHS ELEKYEQACR
160 170 180 190 200
EFTTHVTNLL QEQSRMRPVS PKEIERMVGA IHGKFSAIQM QLKQSTCEAV
210 220 230 240 250
MTLRSRLLDA RRKRRNFSKQ ATEVLNEYFY SHLNNPYPSE EAKEELARKG
260 270 280 290 300
GLTISQVSNW FGNKRIRYKK NMGKFQEEAT IYTGKTAVDT TEVGVPGNHA
310 320 330 340 350
SCLSTPSSGS SGPFPLPSAG DAFLTLRTLA SLQPPPGGGC LQSQAQGSWQ
360 370
GATPQPATAS PAGDPGSINS STSN
Length:374
Mass (Da):40,854
Last modified:January 9, 2007 - v2
Checksum:iB9CE8BE93D0B7ABC
GO

Sequence cautioni

The sequence BC033067 differs from that shown. Reason: Frameshift at position 137.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti368I → T in BAG53471 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_059355169V → I.Corresponds to variant rs8108180dbSNPEnsembl.1
Natural variantiVAR_059356177M → V.Corresponds to variant rs8108981dbSNPEnsembl.1
Natural variantiVAR_036439283T → M in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant rs376647012dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK097427 mRNA. Translation: BAG53471.1.
BC033067 mRNA. No translation available.
CH471106 Genomic DNA. Translation: EAW84835.1.
BC141859 mRNA. Translation: AAI41860.1.
AJ300182 mRNA. Translation: CAC28212.1.
CCDSiCCDS12406.1.
RefSeqiNP_079521.1. NM_025245.2.
UniGeneiHs.466257.

Genome annotation databases

EnsembliENST00000251203; ENSP00000251203; ENSG00000105717.
GeneIDi80714.
KEGGihsa:80714.
UCSCiuc002nmy.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK097427 mRNA. Translation: BAG53471.1.
BC033067 mRNA. No translation available.
CH471106 Genomic DNA. Translation: EAW84835.1.
BC141859 mRNA. Translation: AAI41860.1.
AJ300182 mRNA. Translation: CAC28212.1.
CCDSiCCDS12406.1.
RefSeqiNP_079521.1. NM_025245.2.
UniGeneiHs.466257.

3D structure databases

ProteinModelPortaliQ9BYU1.
SMRiQ9BYU1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123272. 4 interactors.
IntActiQ9BYU1. 7 interactors.
STRINGi9606.ENSP00000251203.

PTM databases

iPTMnetiQ9BYU1.
PhosphoSitePlusiQ9BYU1.

Polymorphism and mutation databases

BioMutaiPBX4.
DMDMi122065777.

Proteomic databases

MaxQBiQ9BYU1.
PaxDbiQ9BYU1.
PeptideAtlasiQ9BYU1.
PRIDEiQ9BYU1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000251203; ENSP00000251203; ENSG00000105717.
GeneIDi80714.
KEGGihsa:80714.
UCSCiuc002nmy.4. human.

Organism-specific databases

CTDi80714.
DisGeNETi80714.
GeneCardsiPBX4.
HGNCiHGNC:13403. PBX4.
HPAiHPA049859.
HPA056469.
MIMi608127. gene.
neXtProtiNX_Q9BYU1.
OpenTargetsiENSG00000105717.
PharmGKBiPA32973.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0774. Eukaryota.
ENOG410XRVF. LUCA.
GeneTreeiENSGT00390000016426.
HOGENOMiHOG000266972.
HOVERGENiHBG000122.
InParanoidiQ9BYU1.
KOiK15611.
OMAiFYSHLNN.
OrthoDBiEOG091G10TD.
PhylomeDBiQ9BYU1.
TreeFamiTF314340.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000105717-MONOMER.

Miscellaneous databases

ChiTaRSiPBX4. human.
GenomeRNAii80714.
PROiQ9BYU1.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000105717.
CleanExiHS_PBX4.
ExpressionAtlasiQ9BYU1. baseline and differential.
GenevisibleiQ9BYU1. HS.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR005542. PBX.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF03792. PBC. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPBX4_HUMAN
AccessioniPrimary (citable) accession number: Q9BYU1
Secondary accession number(s): A5D8Y0, B3KUK9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 24, 2003
Last sequence update: January 9, 2007
Last modified: November 30, 2016
This is version 138 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.