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Reviewed, UniProtKB/Swiss-Prot Q9BYT9 (ANO3_HUMAN)

Last modified November 24, 2009. Version 54. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Anoctamin-3
Alternative name(s):
    Transmembrane protein 16C
Gene names
Name: ANO3
Synonyms: C11orf25, TMEM16C
ORF Names: GENX-3947
OrganismHomo sapiens (Human) [Complete proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length981 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Function

May act as a calcium-activated chloride channel.

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Sequence similarities

Belongs to the anoctamin family.

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Ontologies

Keywords
   Biological processIon transport
Transport
   Cellular componentMembrane
   Coding sequence diversityPolymorphism
   DomainTransmembrane
   LigandCalcium
Chloride
   Molecular functionChloride channel
Ionic channel
   PTMGlycoprotein
   Technical termComplete proteome
Gene Ontology (GO)
   Biological procession transport

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentchloride channel complex

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functioncalcium ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

chloride channel activity

Inferred from electronic annotation. Source: UniProtKB-KW

chloride ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 981981Anoctamin-3
PRO_0000072565

Regions

Topological domain1 – 403403Cytoplasmic Potential
Transmembrane404 – 42421 Potential
Topological domain425 – 46945Extracellular Potential
Transmembrane470 – 49021 Potential
Topological domain491 – 55060Cytoplasmic Potential
Transmembrane551 – 57121 Potential
Topological domain572 – 59221Extracellular Potential
Transmembrane593 – 61321 Potential
Topological domain614 – 64027Cytoplasmic Potential
Transmembrane641 – 66121 Potential
Topological domain662 – 761100Extracellular Potential
Transmembrane762 – 78221 Potential
Topological domain783 – 81028Cytoplasmic Potential
Transmembrane811 – 83121 Potential
Topological domain832 – 91483Extracellular Potential
Transmembrane915 – 93521 Potential
Topological domain936 – 98146Cytoplasmic Potential

Amino acid modifications

Glycosylation4251N-linked (GlcNAc...) Potential
Glycosylation4481N-linked (GlcNAc...) Potential
Glycosylation4551N-linked (GlcNAc...) Potential
Glycosylation8661N-linked (GlcNAc...) Potential

Natural variations

Natural variant7811L → V: dbSNP rs11825056.
VAR_057287

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Sequences

Sequence LengthMass (Da)Tools
Q9BYT9-1 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: 15A3276420912393

FASTA981114,655
        10         20         30         40         50         60 
MVHHSGSIQS FKQQKGMNIS KSEITKETSL KPSRRSLPCL AQSYAYSKSL SQSTSLFQST 

        70         80         90        100        110        120 
ESESQAPTSI TLISTDKAEQ VNTEENKNDS VLRCSFADLS DFCLALGKDK DYTDESEHAT 

       130        140        150        160        170        180 
YDRSRLINDF VIKDKSEFKT KLSKNDMNYI ASSGPLFKDG KRRIDYILVY RKTNIPYDKR 

       190        200        210        220        230        240 
NTFEKNLRAE GLMLEKEPAI ASPDIMFIKI HIPWDTLCKY AERLNIRMPF RKKCYYTDGR 

       250        260        270        280        290        300 
SKSMGRMQTY FRRIKDWMAQ NPMVLDKSAF PDLEESDCYT GPFSRARIHH FIINNKDTFF 

       310        320        330        340        350        360 
SNATRSRIVY HMLERTKYEN GISKVGIRKL INNGSYIAAF PPHEGAYKSS QPIKTHGPQN 

       370        380        390        400        410        420 
NRHLLYERWA RWGMWYKHQP LDLIRLYFGE KIGLYFAWLG WYTGMLIPAA IVGLCVFFYG 

       430        440        450        460        470        480 
LFTMNNSQVS QEICKATEVF MCPLCDKNCS LQRLNDSCIY AKVTYLFDNG GTVFFAIFMA 

       490        500        510        520        530        540 
IWATVFLEFW KRRRSILTYT WDLIEWEEEE ETLRPQFEAK YYKMEIVNPI TGKPEPHQPS 

       550        560        570        580        590        600 
SDKVTRLLVS VSGIFFMISL VITAVFGVVV YRLVVMEQFA SFKWNFIKQY WQFATSAAAV 

       610        620        630        640        650        660 
CINFIIIMLL NLAYEKIAYL LTNLEYPRTE SEWENSFALK MFLFQFVNLN SSIFYIAFFL 

       670        680        690        700        710        720 
GRFVGHPGKY NKLFDRWRLE ECHPSGCLID LCLQMGVIMF LKQIWNNFME LGYPLIQNWW 

       730        740        750        760        770        780 
SRHKIKRGIH DASIPQWEND WNLQPMNLHG LMDEYLEMVL QFGFTTIFVA AFPLAPLLAL 

       790        800        810        820        830        840 
LNNIIEIRLD AYKFVTQWRR PLPARATDIG IWLGILEGIG ILAVITNAFV IAITSDYIPR 

       850        860        870        880        890        900 
FVYEYKYGPC ANHVEPSENC LKGYVNNSLS FFDLSELGMG KSGYCRYRDY RGPPWSSKPY 

       910        920        930        940        950        960 
EFTLQYWHIL AARLAFIIVF EHLVFGIKSF IAYLIPDVPK GLHDRIRREK YLVQEMMYEA 

       970        980 
ELEHLQQQRR KSGQPVHHEW P

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References

[1]"Predominant brain expression and full-length characterization of a novel human 6.6-Kb transcript mapping at 11p14 in the telomeric part of WAGR locus."
Rosier M.F., Toselli E., Segurens-Soury B., Auffray C., Devignes M.D.
Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"TMEM16A confers receptor-activated calcium-dependent chloride conductance."
Yang Y.D., Cho H., Koo J.Y., Tak M.H., Cho Y., Shim W.-S., Park S.P., Lee J., Lee B., Kim B.-M., Raouf R., Shin Y.K., Oh U.
Nature 455:1210-1215(2008) [PubMed: 18724360] [Abstract]
Cited for: IDENTIFICATION AS PUTATIVE CHLORIDE CHANNEL.
+Additional computationally mapped references.

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Cross-references

Sequence databases

AJ300461 mRNA. Translation: CAC32454.1.
IPIIPI00185058.
RefSeqNP_113606.2.
UniGeneHs.91791

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGQ9BYT9.

Proteomic databases

PRIDEQ9BYT9.

Genome annotation databases

EnsemblENST00000256737; ENSP00000256737; ENSG00000134343; Homo sapiens. [Genome view]
GeneID63982.
KEGGhsa:63982.
UCSCuc001mqt.2. human.

Organism-specific databases

CTD63982.
GeneCardsGC11P026310.
HGNCHGNC:14004. ANO3.
MIM610110. gene.
PharmGKBPA25489.
GenAtlasSearch...

Phylogenomic databases

HOGENOMQ9BYT9.
HOVERGENQ9BYT9.

Enzyme and pathway databases

BioCycCATTLE:ENSBTAG00000021855-MON.

Gene expression databases

ArrayExpressQ9BYT9.
BgeeQ9BYT9.
CleanExHS_ANO3.
GenevestigatorQ9BYT9.

Family and domain databases

InterProIPR007632. DUF590.
[Graphical view]
PANTHERPTHR12308. DUF590. 1 hit.
PfamPF04547. DUF590. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio65800.
SOURCESearch...

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Entry information

Entry nameANO3_HUMAN
AccessionPrimary (citable) accession number: Q9BYT9
Entry history
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: June 1, 2001
Last modified: November 24, 2009
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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Relevant documents

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents