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Q9BYT8

- NEUL_HUMAN

UniProt

Q9BYT8 - NEUL_HUMAN

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Protein
Neurolysin, mitochondrial
Gene
NLN, AGTBP, KIAA1226
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Hydrolyzes oligopeptides such as neurotensin, bradykinin and dynorphin A By similarity.

Catalytic activityi

Preferential cleavage in neurotensin: 10-Pro-|-Tyr-11.

Cofactori

Binds 1 zinc ion per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi497 – 4971Zinc; catalytic By similarity
Active sitei498 – 4981 By similarity
Metal bindingi501 – 5011Zinc; catalytic By similarity
Metal bindingi504 – 5041Zinc; catalytic By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. metalloendopeptidase activity Source: InterPro
  3. peptide binding Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Metal-binding, Zinc

Protein family/group databases

MEROPSiM03.002.

Names & Taxonomyi

Protein namesi
Recommended name:
Neurolysin, mitochondrial (EC:3.4.24.16)
Alternative name(s):
Angiotensin-binding protein
Microsomal endopeptidase
Short name:
MEP
Mitochondrial oligopeptidase M
Neurotensin endopeptidase
Gene namesi
Name:NLN
Synonyms:AGTBP, KIAA1226
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 5

Organism-specific databases

HGNCiHGNC:16058. NLN.

Subcellular locationi

Mitochondrion intermembrane space By similarity. Cytoplasm By similarity

GO - Cellular componenti

  1. mitochondrial intermembrane space Source: UniProtKB-SubCell
  2. plasma membrane Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Mitochondrion

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31651.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 3737Mitochondrion By similarity
Add
BLAST
Chaini38 – 704667Neurolysin, mitochondrial
PRO_0000028575Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei664 – 6641N6-acetyllysine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ9BYT8.
PaxDbiQ9BYT8.
PeptideAtlasiQ9BYT8.
PRIDEiQ9BYT8.

PTM databases

PhosphoSiteiQ9BYT8.

Expressioni

Gene expression databases

ArrayExpressiQ9BYT8.
BgeeiQ9BYT8.
CleanExiHS_NLN.
GenevestigatoriQ9BYT8.

Organism-specific databases

HPAiHPA031862.

Interactioni

Protein-protein interaction databases

BioGridi121555. 3 interactions.
IntActiQ9BYT8. 1 interaction.
STRINGi9606.ENSP00000370372.

Structurei

3D structure databases

ProteinModelPortaliQ9BYT8.
SMRiQ9BYT8. Positions 37-701.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M3 family.

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0339.
HOGENOMiHOG000245985.
HOVERGENiHBG000238.
InParanoidiQ9BYT8.
KOiK01393.
OMAiYENCLQV.
OrthoDBiEOG7SR4KW.
PhylomeDBiQ9BYT8.
TreeFamiTF300459.

Family and domain databases

Gene3Di1.10.1370.10. 2 hits.
1.20.1050.40. 1 hit.
3.40.390.10. 1 hit.
InterProiIPR024079. MetalloPept_cat_dom.
IPR024077. Neurolysin/TOP_dom2.
IPR024080. Neurolysin/TOP_N.
IPR001567. Pept_M3A_M3B.
[Graphical view]
PfamiPF01432. Peptidase_M3. 1 hit.
[Graphical view]
PROSITEiPS00142. ZINC_PROTEASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9BYT8-1 [UniParc]FASTAAdd to Basket

« Hide

MIARCLLAVR SLRRVGGSRI LLRMTLGREV MSPLQAMSSY TVAGRNVLRW    50
DLSPEQIKTR TEELIVQTKQ VYDAVGMLGI EEVTYENCLQ ALADVEVKYI 100
VERTMLDFPQ HVSSDKEVRA ASTEADKRLS RFDIEMSMRG DIFERIVHLQ 150
ETCDLGKIKP EARRYLEKSI KMGKRNGLHL PEQVQNEIKS MKKRMSELCI 200
DFNKNLNEDD TFLVFSKAEL GALPDDFIDS LEKTDDDKYK ITLKYPHYFP 250
VMKKCCIPET RRRMEMAFNT RCKEENTIIL QQLLPLRTKV AKLLGYSTHA 300
DFVLEMNTAK STSRVTAFLD DLSQKLKPLG EAEREFILNL KKKECKDRGF 350
EYDGKINAWD LYYYMTQTEE LKYSIDQEFL KEYFPIEVVT EGLLNTYQEL 400
LGLSFEQMTD AHVWNKSVTL YTVKDKATGE VLGQFYLDLY PREGKYNHAA 450
CFGLQPGCLL PDGSRMMAVA ALVVNFSQPV AGRPSLLRHD EVRTYFHEFG 500
HVMHQICAQT DFARFSGTNV ETDFVEVPSQ MLENWVWDVD SLRRLSKHYK 550
DGSPIADDLL EKLVASRLVN TGLLTLRQIV LSKVDQSLHT NTSLDAASEY 600
AKYCSEILGV AATPGTNMPA TFGHLAGGYD GQYYGYLWSE VFSMDMFYSC 650
FKKEGIMNPE VGMKYRNLIL KPGGSLDGMD MLHNFLKREP NQKAFLMSRG 700
LHAP 704
Length:704
Mass (Da):80,652
Last modified:June 1, 2001 - v1
Checksum:i80136688D79BBEDF
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti79 – 791G → S.
Corresponds to variant rs34339013 [ dbSNP | Ensembl ].
VAR_062224
Natural varianti323 – 3231S → G.
Corresponds to variant rs34063558 [ dbSNP | Ensembl ].
VAR_054002
Natural varianti372 – 3721K → R.
Corresponds to variant rs6863012 [ dbSNP | Ensembl ].
VAR_054003
Natural varianti417 – 4171S → G.
Corresponds to variant rs2289884 [ dbSNP | Ensembl ].
VAR_054004
Natural varianti704 – 7041P → S.
Corresponds to variant rs6860508 [ dbSNP | Ensembl ].
VAR_024594

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ300837 mRNA. Translation: CAC27329.1.
AB033052 mRNA. Translation: BAA86540.2.
CCDSiCCDS3989.1.
RefSeqiNP_065777.1. NM_020726.4.
UniGeneiHs.247460.

Genome annotation databases

EnsembliENST00000380985; ENSP00000370372; ENSG00000123213.
GeneIDi57486.
KEGGihsa:57486.
UCSCiuc003juf.3. human.

Polymorphism databases

DMDMi20139130.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ300837 mRNA. Translation: CAC27329.1 .
AB033052 mRNA. Translation: BAA86540.2 .
CCDSi CCDS3989.1.
RefSeqi NP_065777.1. NM_020726.4.
UniGenei Hs.247460.

3D structure databases

ProteinModelPortali Q9BYT8.
SMRi Q9BYT8. Positions 37-701.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 121555. 3 interactions.
IntActi Q9BYT8. 1 interaction.
STRINGi 9606.ENSP00000370372.

Protein family/group databases

MEROPSi M03.002.

PTM databases

PhosphoSitei Q9BYT8.

Polymorphism databases

DMDMi 20139130.

Proteomic databases

MaxQBi Q9BYT8.
PaxDbi Q9BYT8.
PeptideAtlasi Q9BYT8.
PRIDEi Q9BYT8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000380985 ; ENSP00000370372 ; ENSG00000123213 .
GeneIDi 57486.
KEGGi hsa:57486.
UCSCi uc003juf.3. human.

Organism-specific databases

CTDi 57486.
GeneCardsi GC05P065018.
HGNCi HGNC:16058. NLN.
HPAi HPA031862.
MIMi 611530. gene.
neXtProti NX_Q9BYT8.
PharmGKBi PA31651.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0339.
HOGENOMi HOG000245985.
HOVERGENi HBG000238.
InParanoidi Q9BYT8.
KOi K01393.
OMAi YENCLQV.
OrthoDBi EOG7SR4KW.
PhylomeDBi Q9BYT8.
TreeFami TF300459.

Miscellaneous databases

GeneWikii NLN_(gene).
GenomeRNAii 57486.
NextBioi 63764.
PROi Q9BYT8.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9BYT8.
Bgeei Q9BYT8.
CleanExi HS_NLN.
Genevestigatori Q9BYT8.

Family and domain databases

Gene3Di 1.10.1370.10. 2 hits.
1.20.1050.40. 1 hit.
3.40.390.10. 1 hit.
InterProi IPR024079. MetalloPept_cat_dom.
IPR024077. Neurolysin/TOP_dom2.
IPR024080. Neurolysin/TOP_N.
IPR001567. Pept_M3A_M3B.
[Graphical view ]
Pfami PF01432. Peptidase_M3. 1 hit.
[Graphical view ]
PROSITEi PS00142. ZINC_PROTEASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and sequencing of human neurolysin, an oligopeptidase of family M3."
    Chen J.M., Rawlings N.D., Barrett A.J.
    Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Ishikawa K., Kikuno R., Hirosawa M., Nomura N., Ohara O.
    DNA Res. 6:337-345(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  3. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
    Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
    DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: SEQUENCE REVISION.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  5. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-664, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiNEUL_HUMAN
AccessioniPrimary (citable) accession number: Q9BYT8
Secondary accession number(s): Q9ULJ4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: June 1, 2001
Last modified: July 9, 2014
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Peptidase families
    Classification of peptidase families and list of entries
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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