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Protein

Neurolysin, mitochondrial

Gene

NLN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Hydrolyzes oligopeptides such as neurotensin, bradykinin and dynorphin A.By similarity

Catalytic activityi

Preferential cleavage in neurotensin: 10-Pro-|-Tyr-11.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi497Zinc; catalyticPROSITE-ProRule annotation1
Active sitei498PROSITE-ProRule annotation1
Metal bindingi501Zinc; catalyticPROSITE-ProRule annotation1
Metal bindingi504Zinc; catalyticPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:HS04642-MONOMER.

Protein family/group databases

MEROPSiM03.002.

Names & Taxonomyi

Protein namesi
Recommended name:
Neurolysin, mitochondrial (EC:3.4.24.16)
Alternative name(s):
Angiotensin-binding protein
Microsomal endopeptidase
Short name:
MEP
Mitochondrial oligopeptidase M
Neurotensin endopeptidase
Gene namesi
Name:NLN
Synonyms:AGTBP, KIAA1226
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:16058. NLN.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Mitochondrion

Pathology & Biotechi

Organism-specific databases

DisGeNETi57486.
OpenTargetsiENSG00000123213.
PharmGKBiPA31651.

Polymorphism and mutation databases

BioMutaiNLN.
DMDMi20139130.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 37MitochondrionBy similarityAdd BLAST37
ChainiPRO_000002857538 – 704Neurolysin, mitochondrialAdd BLAST667

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei664N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9BYT8.
MaxQBiQ9BYT8.
PaxDbiQ9BYT8.
PeptideAtlasiQ9BYT8.
PRIDEiQ9BYT8.

PTM databases

iPTMnetiQ9BYT8.
PhosphoSitePlusiQ9BYT8.

Expressioni

Gene expression databases

BgeeiENSG00000123213.
CleanExiHS_NLN.
ExpressionAtlasiQ9BYT8. baseline and differential.
GenevisibleiQ9BYT8. HS.

Organism-specific databases

HPAiHPA031862.

Interactioni

Protein-protein interaction databases

BioGridi121555. 24 interactors.
IntActiQ9BYT8. 17 interactors.
STRINGi9606.ENSP00000370372.

Structurei

3D structure databases

ProteinModelPortaliQ9BYT8.
SMRiQ9BYT8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M3 family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG2089. Eukaryota.
COG0339. LUCA.
GeneTreeiENSGT00550000074738.
HOGENOMiHOG000245985.
HOVERGENiHBG000238.
InParanoidiQ9BYT8.
KOiK01393.
OMAiRILFRMT.
OrthoDBiEOG091G0325.
PhylomeDBiQ9BYT8.
TreeFamiTF300459.

Family and domain databases

Gene3Di1.10.1370.10. 2 hits.
1.20.1050.40. 1 hit.
3.40.390.10. 1 hit.
InterProiIPR024079. MetalloPept_cat_dom.
IPR024077. Neurolysin/TOP_dom2.
IPR024080. Neurolysin/TOP_N.
IPR001567. Pept_M3A_M3B.
[Graphical view]
PfamiPF01432. Peptidase_M3. 1 hit.
[Graphical view]
PROSITEiPS00142. ZINC_PROTEASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9BYT8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIARCLLAVR SLRRVGGSRI LLRMTLGREV MSPLQAMSSY TVAGRNVLRW
60 70 80 90 100
DLSPEQIKTR TEELIVQTKQ VYDAVGMLGI EEVTYENCLQ ALADVEVKYI
110 120 130 140 150
VERTMLDFPQ HVSSDKEVRA ASTEADKRLS RFDIEMSMRG DIFERIVHLQ
160 170 180 190 200
ETCDLGKIKP EARRYLEKSI KMGKRNGLHL PEQVQNEIKS MKKRMSELCI
210 220 230 240 250
DFNKNLNEDD TFLVFSKAEL GALPDDFIDS LEKTDDDKYK ITLKYPHYFP
260 270 280 290 300
VMKKCCIPET RRRMEMAFNT RCKEENTIIL QQLLPLRTKV AKLLGYSTHA
310 320 330 340 350
DFVLEMNTAK STSRVTAFLD DLSQKLKPLG EAEREFILNL KKKECKDRGF
360 370 380 390 400
EYDGKINAWD LYYYMTQTEE LKYSIDQEFL KEYFPIEVVT EGLLNTYQEL
410 420 430 440 450
LGLSFEQMTD AHVWNKSVTL YTVKDKATGE VLGQFYLDLY PREGKYNHAA
460 470 480 490 500
CFGLQPGCLL PDGSRMMAVA ALVVNFSQPV AGRPSLLRHD EVRTYFHEFG
510 520 530 540 550
HVMHQICAQT DFARFSGTNV ETDFVEVPSQ MLENWVWDVD SLRRLSKHYK
560 570 580 590 600
DGSPIADDLL EKLVASRLVN TGLLTLRQIV LSKVDQSLHT NTSLDAASEY
610 620 630 640 650
AKYCSEILGV AATPGTNMPA TFGHLAGGYD GQYYGYLWSE VFSMDMFYSC
660 670 680 690 700
FKKEGIMNPE VGMKYRNLIL KPGGSLDGMD MLHNFLKREP NQKAFLMSRG

LHAP
Length:704
Mass (Da):80,652
Last modified:June 1, 2001 - v1
Checksum:i80136688D79BBEDF
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06222479G → S.Corresponds to variant rs34339013dbSNPEnsembl.1
Natural variantiVAR_054002323S → G.Corresponds to variant rs34063558dbSNPEnsembl.1
Natural variantiVAR_054003372K → R.Corresponds to variant rs6863012dbSNPEnsembl.1
Natural variantiVAR_054004417S → G.Corresponds to variant rs2289884dbSNPEnsembl.1
Natural variantiVAR_024594704P → S.Corresponds to variant rs6860508dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ300837 mRNA. Translation: CAC27329.1.
AB033052 mRNA. Translation: BAA86540.2.
CCDSiCCDS3989.1.
RefSeqiNP_065777.1. NM_020726.4.
UniGeneiHs.247460.

Genome annotation databases

EnsembliENST00000380985; ENSP00000370372; ENSG00000123213.
GeneIDi57486.
KEGGihsa:57486.
UCSCiuc003juf.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ300837 mRNA. Translation: CAC27329.1.
AB033052 mRNA. Translation: BAA86540.2.
CCDSiCCDS3989.1.
RefSeqiNP_065777.1. NM_020726.4.
UniGeneiHs.247460.

3D structure databases

ProteinModelPortaliQ9BYT8.
SMRiQ9BYT8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121555. 24 interactors.
IntActiQ9BYT8. 17 interactors.
STRINGi9606.ENSP00000370372.

Protein family/group databases

MEROPSiM03.002.

PTM databases

iPTMnetiQ9BYT8.
PhosphoSitePlusiQ9BYT8.

Polymorphism and mutation databases

BioMutaiNLN.
DMDMi20139130.

Proteomic databases

EPDiQ9BYT8.
MaxQBiQ9BYT8.
PaxDbiQ9BYT8.
PeptideAtlasiQ9BYT8.
PRIDEiQ9BYT8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000380985; ENSP00000370372; ENSG00000123213.
GeneIDi57486.
KEGGihsa:57486.
UCSCiuc003juf.3. human.

Organism-specific databases

CTDi57486.
DisGeNETi57486.
GeneCardsiNLN.
HGNCiHGNC:16058. NLN.
HPAiHPA031862.
MIMi611530. gene.
neXtProtiNX_Q9BYT8.
OpenTargetsiENSG00000123213.
PharmGKBiPA31651.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2089. Eukaryota.
COG0339. LUCA.
GeneTreeiENSGT00550000074738.
HOGENOMiHOG000245985.
HOVERGENiHBG000238.
InParanoidiQ9BYT8.
KOiK01393.
OMAiRILFRMT.
OrthoDBiEOG091G0325.
PhylomeDBiQ9BYT8.
TreeFamiTF300459.

Enzyme and pathway databases

BioCyciZFISH:HS04642-MONOMER.

Miscellaneous databases

GeneWikiiNLN_(gene).
GenomeRNAii57486.
PROiQ9BYT8.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000123213.
CleanExiHS_NLN.
ExpressionAtlasiQ9BYT8. baseline and differential.
GenevisibleiQ9BYT8. HS.

Family and domain databases

Gene3Di1.10.1370.10. 2 hits.
1.20.1050.40. 1 hit.
3.40.390.10. 1 hit.
InterProiIPR024079. MetalloPept_cat_dom.
IPR024077. Neurolysin/TOP_dom2.
IPR024080. Neurolysin/TOP_N.
IPR001567. Pept_M3A_M3B.
[Graphical view]
PfamiPF01432. Peptidase_M3. 1 hit.
[Graphical view]
PROSITEiPS00142. ZINC_PROTEASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNEUL_HUMAN
AccessioniPrimary (citable) accession number: Q9BYT8
Secondary accession number(s): Q9ULJ4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: June 1, 2001
Last modified: November 2, 2016
This is version 136 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Peptidase families
    Classification of peptidase families and list of entries
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.