Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9BYT1

- S17A9_HUMAN

UniProt

Q9BYT1 - S17A9_HUMAN

Protein

Solute carrier family 17 member 9

Gene

SLC17A9

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 2 (24 May 2004)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Involved in vesicular storage and exocytosis of ATP. May accumulate ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles.1 Publication

    GO - Molecular functioni

    1. transporter activity Source: InterPro

    GO - Biological processi

    1. exocytosis Source: UniProtKB-KW
    2. transmembrane transport Source: InterPro

    Keywords - Biological processi

    Exocytosis, Transport

    Protein family/group databases

    TCDBi2.A.1.14.21. the major facilitator superfamily (mfs).

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Solute carrier family 17 member 9
    Gene namesi
    Name:SLC17A9
    Synonyms:C20orf59
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 20

    Organism-specific databases

    HGNCiHGNC:16192. SLC17A9.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA164725806.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 436436Solute carrier family 17 member 9PRO_0000084849Add
    BLAST

    Proteomic databases

    MaxQBiQ9BYT1.
    PaxDbiQ9BYT1.
    PRIDEiQ9BYT1.

    PTM databases

    PhosphoSiteiQ9BYT1.

    Expressioni

    Tissue specificityi

    Predominantly expressed in adrenal gland, brain and thyroid.1 Publication

    Gene expression databases

    ArrayExpressiQ9BYT1.
    BgeeiQ9BYT1.
    GenevestigatoriQ9BYT1.

    Organism-specific databases

    HPAiHPA047470.
    HPA056499.

    Interactioni

    Protein-protein interaction databases

    BioGridi121984. 1 interaction.
    IntActiQ9BYT1. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9BYT1.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei64 – 8421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei92 – 11221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei118 – 13821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei158 – 17821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei181 – 20121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei239 – 25921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei276 – 29621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei316 – 33621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei369 – 38921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei402 – 42221HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0477.
    InParanoidiQ9BYT1.
    KOiK12303.
    OMAiPVCTVAM.
    OrthoDBiEOG7JDQXB.
    PhylomeDBiQ9BYT1.
    TreeFamiTF313341.

    Family and domain databases

    InterProiIPR011701. MFS.
    IPR020846. MFS_dom.
    IPR016196. MFS_dom_general_subst_transpt.
    IPR005829. Sugar_transporter_CS.
    [Graphical view]
    PfamiPF07690. MFS_1. 1 hit.
    [Graphical view]
    SUPFAMiSSF103473. SSF103473. 1 hit.
    PROSITEiPS50850. MFS. 1 hit.
    PS00217. SUGAR_TRANSPORT_2. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9BYT1-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MQPPPDEARR DMAGDTQWSR PECQAWTGTL LLGTCLLYCA RSSMPICTVS    50
    MSQDFGWNKK EAGIVLSSFF WGYCLTQVVG GHLGDRIGGE KVILLSASAW 100
    GSITAVTPLL AHLSSAHLAF MTFSRILMGL LQGVYFPALT SLLSQKVRES 150
    ERAFTYSIVG AGSQFGTLLT GAVGSLLLEW YGWQSIFYFS GGLTLLWVWY 200
    VYRYLLSEKD LILALGVLAQ SRPVSRHNRV PWRRLFRKPA VWAAVVSQLS 250
    AACSFFILLS WLPTFFEETF PDAKGWIFNV VPWLVAIPAS LFSGFLSDHL 300
    INQGYRAITV RKLMQGMGLG LSSVFALCLG HTSSFCESVV FASASIGLQT 350
    FNHSGISVNI QDLAPSCAGF LFGVANTAGA LAGVVGVCLG GYLMETTGSW 400
    TCLFNLVAII SNLGLCTFLV FGQAQRVDLS STHEDL 436
    Length:436
    Mass (Da):47,482
    Last modified:May 24, 2004 - v2
    Checksum:iFE9E065E0A76A94A
    GO
    Isoform 2 (identifier: Q9BYT1-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-19: MQPPPDEARRDMAGDTQWS → MTLTSRRQDSQEA

    Show »
    Length:430
    Mass (Da):46,816
    Checksum:iBBA4CF4BF06C2221
    GO
    Isoform 3 (identifier: Q9BYT1-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         210-216: DLILALG → GNAGRAG
         217-436: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:216
    Mass (Da):23,676
    Checksum:i07AA6D8E45540E23
    GO

    Sequence cautioni

    The sequence BAB84933.1 differs from that shown. Reason: Erroneous initiation.
    The sequence AAH25312.1 differs from that shown. Reason: Erroneous termination at position 389. Translated as Leu.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti395 – 3951E → K(PubMed:18375752)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti228 – 2281N → S.3 Publications
    Corresponds to variant rs2427463 [ dbSNP | Ensembl ].
    VAR_055326
    Natural varianti397 – 3971T → M.
    Corresponds to variant rs7271712 [ dbSNP | Ensembl ].
    VAR_056128

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 1919MQPPP…DTQWS → MTLTSRRQDSQEA in isoform 2. 2 PublicationsVSP_010344Add
    BLAST
    Alternative sequencei210 – 2167DLILALG → GNAGRAG in isoform 3. 1 PublicationVSP_010345
    Alternative sequencei217 – 436220Missing in isoform 3. 1 PublicationVSP_010346Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK074107 mRNA. Translation: BAB84933.1. Different initiation.
    AK095473 mRNA. Translation: BAG53064.1.
    AL121673 Genomic DNA. Translation: CAC28600.1.
    AL121673 Genomic DNA. Translation: CAH72268.1.
    BC025312 mRNA. Translation: AAH25312.1. Sequence problems.
    BC027447 mRNA. Translation: AAH27447.1.
    BC038593 mRNA. No translation available.
    CCDSiCCDS42901.1. [Q9BYT1-1]
    RefSeqiNP_071365.3. NM_022082.3.
    XP_005260285.1. XM_005260228.1. [Q9BYT1-2]
    UniGeneiHs.512686.

    Genome annotation databases

    EnsembliENST00000370349; ENSP00000359374; ENSG00000101194. [Q9BYT1-2]
    ENST00000370351; ENSP00000359376; ENSG00000101194. [Q9BYT1-1]
    GeneIDi63910.
    KEGGihsa:63910.
    UCSCiuc002ydz.4. human. [Q9BYT1-2]
    uc002yea.4. human. [Q9BYT1-1]

    Polymorphism databases

    DMDMi47605540.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK074107 mRNA. Translation: BAB84933.1 . Different initiation.
    AK095473 mRNA. Translation: BAG53064.1 .
    AL121673 Genomic DNA. Translation: CAC28600.1 .
    AL121673 Genomic DNA. Translation: CAH72268.1 .
    BC025312 mRNA. Translation: AAH25312.1 . Sequence problems.
    BC027447 mRNA. Translation: AAH27447.1 .
    BC038593 mRNA. No translation available.
    CCDSi CCDS42901.1. [Q9BYT1-1 ]
    RefSeqi NP_071365.3. NM_022082.3.
    XP_005260285.1. XM_005260228.1. [Q9BYT1-2 ]
    UniGenei Hs.512686.

    3D structure databases

    ProteinModelPortali Q9BYT1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 121984. 1 interaction.
    IntActi Q9BYT1. 1 interaction.

    Protein family/group databases

    TCDBi 2.A.1.14.21. the major facilitator superfamily (mfs).

    PTM databases

    PhosphoSitei Q9BYT1.

    Polymorphism databases

    DMDMi 47605540.

    Proteomic databases

    MaxQBi Q9BYT1.
    PaxDbi Q9BYT1.
    PRIDEi Q9BYT1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000370349 ; ENSP00000359374 ; ENSG00000101194 . [Q9BYT1-2 ]
    ENST00000370351 ; ENSP00000359376 ; ENSG00000101194 . [Q9BYT1-1 ]
    GeneIDi 63910.
    KEGGi hsa:63910.
    UCSCi uc002ydz.4. human. [Q9BYT1-2 ]
    uc002yea.4. human. [Q9BYT1-1 ]

    Organism-specific databases

    CTDi 63910.
    GeneCardsi GC20P061583.
    HGNCi HGNC:16192. SLC17A9.
    HPAi HPA047470.
    HPA056499.
    MIMi 612107. gene.
    neXtProti NX_Q9BYT1.
    PharmGKBi PA164725806.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0477.
    InParanoidi Q9BYT1.
    KOi K12303.
    OMAi PVCTVAM.
    OrthoDBi EOG7JDQXB.
    PhylomeDBi Q9BYT1.
    TreeFami TF313341.

    Miscellaneous databases

    GenomeRNAii 63910.
    NextBioi 65626.
    PROi Q9BYT1.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9BYT1.
    Bgeei Q9BYT1.
    Genevestigatori Q9BYT1.

    Family and domain databases

    InterProi IPR011701. MFS.
    IPR020846. MFS_dom.
    IPR016196. MFS_dom_general_subst_transpt.
    IPR005829. Sugar_transporter_CS.
    [Graphical view ]
    Pfami PF07690. MFS_1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF103473. SSF103473. 1 hit.
    PROSITEi PS50850. MFS. 1 hit.
    PS00217. SUGAR_TRANSPORT_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION, TISSUE SPECIFICITY, VARIANT SER-228.
    2. "Characterization of long cDNA clones from human adult spleen. II. The complete sequences of 81 cDNA clones."
      Jikuya H., Takano J., Kikuno R., Hirosawa M., Nagase T., Nomura N., Ohara O.
      DNA Res. 10:49-57(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
      Tissue: Spleen.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT SER-228.
      Tissue: Neonatal skin.
    4. "The DNA sequence and comparative analysis of human chromosome 20."
      Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
      , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
      Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT SER-228.
      Tissue: Kidney.

    Entry informationi

    Entry nameiS17A9_HUMAN
    AccessioniPrimary (citable) accession number: Q9BYT1
    Secondary accession number(s): B3KTF2
    , Q5W198, Q8TB07, Q8TBP4, Q8TEL5, Q9BYT0, Q9BYT2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 24, 2004
    Last sequence update: May 24, 2004
    Last modified: October 1, 2014
    This is version 102 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 20
      Human chromosome 20: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3