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Q9BYT1

- S17A9_HUMAN

UniProt

Q9BYT1 - S17A9_HUMAN

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Protein

Solute carrier family 17 member 9

Gene
SLC17A9, C20orf59
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Involved in vesicular storage and exocytosis of ATP. May accumulate ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles.1 Publication

GO - Molecular functioni

  1. transporter activity Source: InterPro

GO - Biological processi

  1. exocytosis Source: UniProtKB-KW
  2. transmembrane transport Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Exocytosis, Transport

Protein family/group databases

TCDBi2.A.1.14.21. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 17 member 9
Gene namesi
Name:SLC17A9
Synonyms:C20orf59
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 20

Organism-specific databases

HGNCiHGNC:16192. SLC17A9.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei64 – 8421Helical; Reviewed predictionAdd
BLAST
Transmembranei92 – 11221Helical; Reviewed predictionAdd
BLAST
Transmembranei118 – 13821Helical; Reviewed predictionAdd
BLAST
Transmembranei158 – 17821Helical; Reviewed predictionAdd
BLAST
Transmembranei181 – 20121Helical; Reviewed predictionAdd
BLAST
Transmembranei239 – 25921Helical; Reviewed predictionAdd
BLAST
Transmembranei276 – 29621Helical; Reviewed predictionAdd
BLAST
Transmembranei316 – 33621Helical; Reviewed predictionAdd
BLAST
Transmembranei369 – 38921Helical; Reviewed predictionAdd
BLAST
Transmembranei402 – 42221Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164725806.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 436436Solute carrier family 17 member 9PRO_0000084849Add
BLAST

Proteomic databases

MaxQBiQ9BYT1.
PaxDbiQ9BYT1.
PRIDEiQ9BYT1.

PTM databases

PhosphoSiteiQ9BYT1.

Expressioni

Tissue specificityi

Predominantly expressed in adrenal gland, brain and thyroid.1 Publication

Gene expression databases

ArrayExpressiQ9BYT1.
BgeeiQ9BYT1.
GenevestigatoriQ9BYT1.

Organism-specific databases

HPAiHPA047470.
HPA056499.

Interactioni

Protein-protein interaction databases

BioGridi121984. 1 interaction.
IntActiQ9BYT1. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ9BYT1.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0477.
InParanoidiQ9BYT1.
KOiK12303.
OMAiPVCTVAM.
OrthoDBiEOG7JDQXB.
PhylomeDBiQ9BYT1.
TreeFamiTF313341.

Family and domain databases

InterProiIPR011701. MFS.
IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00217. SUGAR_TRANSPORT_2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9BYT1-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MQPPPDEARR DMAGDTQWSR PECQAWTGTL LLGTCLLYCA RSSMPICTVS    50
MSQDFGWNKK EAGIVLSSFF WGYCLTQVVG GHLGDRIGGE KVILLSASAW 100
GSITAVTPLL AHLSSAHLAF MTFSRILMGL LQGVYFPALT SLLSQKVRES 150
ERAFTYSIVG AGSQFGTLLT GAVGSLLLEW YGWQSIFYFS GGLTLLWVWY 200
VYRYLLSEKD LILALGVLAQ SRPVSRHNRV PWRRLFRKPA VWAAVVSQLS 250
AACSFFILLS WLPTFFEETF PDAKGWIFNV VPWLVAIPAS LFSGFLSDHL 300
INQGYRAITV RKLMQGMGLG LSSVFALCLG HTSSFCESVV FASASIGLQT 350
FNHSGISVNI QDLAPSCAGF LFGVANTAGA LAGVVGVCLG GYLMETTGSW 400
TCLFNLVAII SNLGLCTFLV FGQAQRVDLS STHEDL 436
Length:436
Mass (Da):47,482
Last modified:May 24, 2004 - v2
Checksum:iFE9E065E0A76A94A
GO
Isoform 2 (identifier: Q9BYT1-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-19: MQPPPDEARRDMAGDTQWS → MTLTSRRQDSQEA

Show »
Length:430
Mass (Da):46,816
Checksum:iBBA4CF4BF06C2221
GO
Isoform 3 (identifier: Q9BYT1-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     210-216: DLILALG → GNAGRAG
     217-436: Missing.

Note: No experimental confirmation available.

Show »
Length:216
Mass (Da):23,676
Checksum:i07AA6D8E45540E23
GO

Sequence cautioni

The sequence BAB84933.1 differs from that shown. Reason: Erroneous initiation.
The sequence AAH25312.1 differs from that shown. Reason: Erroneous termination at position 389. Translated as Leu.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti228 – 2281N → S.3 Publications
Corresponds to variant rs2427463 [ dbSNP | Ensembl ].
VAR_055326
Natural varianti397 – 3971T → M.
Corresponds to variant rs7271712 [ dbSNP | Ensembl ].
VAR_056128

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 1919MQPPP…DTQWS → MTLTSRRQDSQEA in isoform 2. VSP_010344Add
BLAST
Alternative sequencei210 – 2167DLILALG → GNAGRAG in isoform 3. VSP_010345
Alternative sequencei217 – 436220Missing in isoform 3. VSP_010346Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti395 – 3951E → K1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK074107 mRNA. Translation: BAB84933.1. Different initiation.
AK095473 mRNA. Translation: BAG53064.1.
AL121673 Genomic DNA. Translation: CAC28600.1.
AL121673 Genomic DNA. Translation: CAH72268.1.
BC025312 mRNA. Translation: AAH25312.1. Sequence problems.
BC027447 mRNA. Translation: AAH27447.1.
BC038593 mRNA. No translation available.
CCDSiCCDS42901.1. [Q9BYT1-1]
RefSeqiNP_071365.3. NM_022082.3.
XP_005260285.1. XM_005260228.1. [Q9BYT1-2]
UniGeneiHs.512686.

Genome annotation databases

EnsembliENST00000370349; ENSP00000359374; ENSG00000101194. [Q9BYT1-2]
ENST00000370351; ENSP00000359376; ENSG00000101194. [Q9BYT1-1]
GeneIDi63910.
KEGGihsa:63910.
UCSCiuc002ydz.4. human. [Q9BYT1-2]
uc002yea.4. human. [Q9BYT1-1]

Polymorphism databases

DMDMi47605540.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK074107 mRNA. Translation: BAB84933.1 . Different initiation.
AK095473 mRNA. Translation: BAG53064.1 .
AL121673 Genomic DNA. Translation: CAC28600.1 .
AL121673 Genomic DNA. Translation: CAH72268.1 .
BC025312 mRNA. Translation: AAH25312.1 . Sequence problems.
BC027447 mRNA. Translation: AAH27447.1 .
BC038593 mRNA. No translation available.
CCDSi CCDS42901.1. [Q9BYT1-1 ]
RefSeqi NP_071365.3. NM_022082.3.
XP_005260285.1. XM_005260228.1. [Q9BYT1-2 ]
UniGenei Hs.512686.

3D structure databases

ProteinModelPortali Q9BYT1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 121984. 1 interaction.
IntActi Q9BYT1. 1 interaction.

Protein family/group databases

TCDBi 2.A.1.14.21. the major facilitator superfamily (mfs).

PTM databases

PhosphoSitei Q9BYT1.

Polymorphism databases

DMDMi 47605540.

Proteomic databases

MaxQBi Q9BYT1.
PaxDbi Q9BYT1.
PRIDEi Q9BYT1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000370349 ; ENSP00000359374 ; ENSG00000101194 . [Q9BYT1-2 ]
ENST00000370351 ; ENSP00000359376 ; ENSG00000101194 . [Q9BYT1-1 ]
GeneIDi 63910.
KEGGi hsa:63910.
UCSCi uc002ydz.4. human. [Q9BYT1-2 ]
uc002yea.4. human. [Q9BYT1-1 ]

Organism-specific databases

CTDi 63910.
GeneCardsi GC20P061583.
HGNCi HGNC:16192. SLC17A9.
HPAi HPA047470.
HPA056499.
MIMi 612107. gene.
neXtProti NX_Q9BYT1.
PharmGKBi PA164725806.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0477.
InParanoidi Q9BYT1.
KOi K12303.
OMAi PVCTVAM.
OrthoDBi EOG7JDQXB.
PhylomeDBi Q9BYT1.
TreeFami TF313341.

Miscellaneous databases

GenomeRNAii 63910.
NextBioi 65626.
PROi Q9BYT1.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9BYT1.
Bgeei Q9BYT1.
Genevestigatori Q9BYT1.

Family and domain databases

InterProi IPR011701. MFS.
IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view ]
Pfami PF07690. MFS_1. 1 hit.
[Graphical view ]
SUPFAMi SSF103473. SSF103473. 1 hit.
PROSITEi PS50850. MFS. 1 hit.
PS00217. SUGAR_TRANSPORT_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION, TISSUE SPECIFICITY, VARIANT SER-228.
  2. "Characterization of long cDNA clones from human adult spleen. II. The complete sequences of 81 cDNA clones."
    Jikuya H., Takano J., Kikuno R., Hirosawa M., Nagase T., Nomura N., Ohara O.
    DNA Res. 10:49-57(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Spleen.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT SER-228.
    Tissue: Neonatal skin.
  4. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT SER-228.
    Tissue: Kidney.

Entry informationi

Entry nameiS17A9_HUMAN
AccessioniPrimary (citable) accession number: Q9BYT1
Secondary accession number(s): B3KTF2
, Q5W198, Q8TB07, Q8TBP4, Q8TEL5, Q9BYT0, Q9BYT2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: May 24, 2004
Last modified: July 9, 2014
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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