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Q9BYT1 (S17A9_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 101. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Solute carrier family 17 member 9
Gene names
Name:SLC17A9
Synonyms:C20orf59
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length436 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Involved in vesicular storage and exocytosis of ATP. May accumulate ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. Ref.1

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Tissue specificity

Predominantly expressed in adrenal gland, brain and thyroid. Ref.1

Sequence similarities

Belongs to the major facilitator superfamily. Sodium/anion cotransporter family.

Sequence caution

The sequence AAH25312.1 differs from that shown. Reason: Erroneous termination at position 389. Translated as Leu.

The sequence BAB84933.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processExocytosis
Transport
   Cellular componentMembrane
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainTransmembrane
Transmembrane helix
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processexocytosis

Inferred from electronic annotation. Source: UniProtKB-KW

transmembrane transport

Inferred from electronic annotation. Source: InterPro

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functiontransporter activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9BYT1-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9BYT1-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-19: MQPPPDEARRDMAGDTQWS → MTLTSRRQDSQEA
Isoform 3 (identifier: Q9BYT1-3)

The sequence of this isoform differs from the canonical sequence as follows:
     210-216: DLILALG → GNAGRAG
     217-436: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 436436Solute carrier family 17 member 9
PRO_0000084849

Regions

Transmembrane64 – 8421Helical; Potential
Transmembrane92 – 11221Helical; Potential
Transmembrane118 – 13821Helical; Potential
Transmembrane158 – 17821Helical; Potential
Transmembrane181 – 20121Helical; Potential
Transmembrane239 – 25921Helical; Potential
Transmembrane276 – 29621Helical; Potential
Transmembrane316 – 33621Helical; Potential
Transmembrane369 – 38921Helical; Potential
Transmembrane402 – 42221Helical; Potential

Natural variations

Alternative sequence1 – 1919MQPPP…DTQWS → MTLTSRRQDSQEA in isoform 2.
VSP_010344
Alternative sequence210 – 2167DLILALG → GNAGRAG in isoform 3.
VSP_010345
Alternative sequence217 – 436220Missing in isoform 3.
VSP_010346
Natural variant2281N → S. Ref.1 Ref.3 Ref.5
Corresponds to variant rs2427463 [ dbSNP | Ensembl ].
VAR_055326
Natural variant3971T → M.
Corresponds to variant rs7271712 [ dbSNP | Ensembl ].
VAR_056128

Experimental info

Sequence conflict3951E → K Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified May 24, 2004. Version 2.
Checksum: FE9E065E0A76A94A

FASTA43647,482
        10         20         30         40         50         60 
MQPPPDEARR DMAGDTQWSR PECQAWTGTL LLGTCLLYCA RSSMPICTVS MSQDFGWNKK 

        70         80         90        100        110        120 
EAGIVLSSFF WGYCLTQVVG GHLGDRIGGE KVILLSASAW GSITAVTPLL AHLSSAHLAF 

       130        140        150        160        170        180 
MTFSRILMGL LQGVYFPALT SLLSQKVRES ERAFTYSIVG AGSQFGTLLT GAVGSLLLEW 

       190        200        210        220        230        240 
YGWQSIFYFS GGLTLLWVWY VYRYLLSEKD LILALGVLAQ SRPVSRHNRV PWRRLFRKPA 

       250        260        270        280        290        300 
VWAAVVSQLS AACSFFILLS WLPTFFEETF PDAKGWIFNV VPWLVAIPAS LFSGFLSDHL 

       310        320        330        340        350        360 
INQGYRAITV RKLMQGMGLG LSSVFALCLG HTSSFCESVV FASASIGLQT FNHSGISVNI 

       370        380        390        400        410        420 
QDLAPSCAGF LFGVANTAGA LAGVVGVCLG GYLMETTGSW TCLFNLVAII SNLGLCTFLV 

       430 
FGQAQRVDLS STHEDL 

« Hide

Isoform 2 [UniParc].

Checksum: BBA4CF4BF06C2221
Show »

FASTA43046,816
Isoform 3 [UniParc].

Checksum: 07AA6D8E45540E23
Show »

FASTA21623,676

References

« Hide 'large scale' references
[1]"Identification of a vesicular nucleotide transporter."
Sawada K., Echigo N., Juge N., Miyaji T., Otsuka M., Omote H., Yamamoto A., Moriyama Y.
Proc. Natl. Acad. Sci. U.S.A. 105:5683-5686(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION, TISSUE SPECIFICITY, VARIANT SER-228.
[2]"Characterization of long cDNA clones from human adult spleen. II. The complete sequences of 81 cDNA clones."
Jikuya H., Takano J., Kikuno R., Hirosawa M., Nagase T., Nomura N., Ohara O.
DNA Res. 10:49-57(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
Tissue: Spleen.
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT SER-228.
Tissue: Neonatal skin.
[4]"The DNA sequence and comparative analysis of human chromosome 20."
Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. expand/collapse author list , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT SER-228.
Tissue: Kidney.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK074107 mRNA. Translation: BAB84933.1. Different initiation.
AK095473 mRNA. Translation: BAG53064.1.
AL121673 Genomic DNA. Translation: CAC28600.1.
AL121673 Genomic DNA. Translation: CAH72268.1.
BC025312 mRNA. Translation: AAH25312.1. Sequence problems.
BC027447 mRNA. Translation: AAH27447.1.
BC038593 mRNA. No translation available.
CCDSCCDS42901.1. [Q9BYT1-1]
RefSeqNP_071365.3. NM_022082.3.
XP_005260285.1. XM_005260228.1. [Q9BYT1-2]
UniGeneHs.512686.

3D structure databases

ProteinModelPortalQ9BYT1.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid121984. 1 interaction.
IntActQ9BYT1. 1 interaction.

Protein family/group databases

TCDB2.A.1.14.21. the major facilitator superfamily (mfs).

PTM databases

PhosphoSiteQ9BYT1.

Polymorphism databases

DMDM47605540.

Proteomic databases

MaxQBQ9BYT1.
PaxDbQ9BYT1.
PRIDEQ9BYT1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000370349; ENSP00000359374; ENSG00000101194. [Q9BYT1-2]
ENST00000370351; ENSP00000359376; ENSG00000101194. [Q9BYT1-1]
GeneID63910.
KEGGhsa:63910.
UCSCuc002ydz.4. human. [Q9BYT1-2]
uc002yea.4. human. [Q9BYT1-1]

Organism-specific databases

CTD63910.
GeneCardsGC20P061583.
HGNCHGNC:16192. SLC17A9.
HPAHPA047470.
HPA056499.
MIM612107. gene.
neXtProtNX_Q9BYT1.
PharmGKBPA164725806.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0477.
InParanoidQ9BYT1.
KOK12303.
OMAPVCTVAM.
OrthoDBEOG7JDQXB.
PhylomeDBQ9BYT1.
TreeFamTF313341.

Gene expression databases

ArrayExpressQ9BYT1.
BgeeQ9BYT1.
GenevestigatorQ9BYT1.

Family and domain databases

InterProIPR011701. MFS.
IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMSSF103473. SSF103473. 1 hit.
PROSITEPS50850. MFS. 1 hit.
PS00217. SUGAR_TRANSPORT_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi63910.
NextBio65626.
PROQ9BYT1.
SOURCESearch...

Entry information

Entry nameS17A9_HUMAN
AccessionPrimary (citable) accession number: Q9BYT1
Secondary accession number(s): B3KTF2 expand/collapse secondary AC list , Q5W198, Q8TB07, Q8TBP4, Q8TEL5, Q9BYT0, Q9BYT2
Entry history
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: May 24, 2004
Last modified: July 9, 2014
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 20

Human chromosome 20: entries, gene names and cross-references to MIM