Q9BYT1 (S17A9_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Solute carrier family 17 member 9

Gene names

Name:	SLC17A9
Synonyms:	C20orf59

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	436 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Involved in vesicular storage and exocytosis of ATP. May accumulate ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. Ref.1
Subcellular location	Membrane; Multi-pass membrane protein Potential.
Tissue specificity	Predominantly expressed in adrenal gland, brain and thyroid. Ref.1
Sequence similarities	Belongs to the major facilitator superfamily. Sodium/anion cotransporter family.
Sequence caution	The sequence AAH25312.1 differs from that shown. Reason: Erroneous termination at position 389. Translated as Leu. The sequence BAB84933.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Exocytosis Transport
Cellular component	Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	exocytosis Inferred from electronic annotation. Source: UniProtKB-KW transmembrane transport Inferred from electronic annotation. Source: InterPro
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	transporter activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9BYT1-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9BYT1-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-19: MQPPPDEARRDMAGDTQWS → MTLTSRRQDSQEA

Isoform 3 (identifier: Q9BYT1-3)

The sequence of this isoform differs from the canonical sequence as follows:
     210-216: DLILALG → GNAGRAG
     217-436: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 436	436	Solute carrier family 17 member 9		PRO_0000084849
Regions
	Transmembrane	64 – 84	21	Helical; Potential
	Transmembrane	92 – 112	21	Helical; Potential
	Transmembrane	118 – 138	21	Helical; Potential
	Transmembrane	158 – 178	21	Helical; Potential
	Transmembrane	181 – 201	21	Helical; Potential
	Transmembrane	239 – 259	21	Helical; Potential
	Transmembrane	276 – 296	21	Helical; Potential
	Transmembrane	316 – 336	21	Helical; Potential
	Transmembrane	369 – 389	21	Helical; Potential
	Transmembrane	402 – 422	21	Helical; Potential
Natural variations
	Alternative sequence	1 – 19	19	MQPPP…DTQWS → MTLTSRRQDSQEA in isoform 2.		VSP_010344
	Alternative sequence	210 – 216	7	DLILALG → GNAGRAG in isoform 3.		VSP_010345
	Alternative sequence	217 – 436	220	Missing in isoform 3.		VSP_010346
	Natural variant	228	1	N → S. Ref.1 Ref.3 Ref.5 Corresponds to variant rs2427463 [ dbSNP | Ensembl ].		VAR_055326
	Natural variant	397	1	T → M. Corresponds to variant rs7271712 [ dbSNP | Ensembl ].		VAR_056128
Experimental info
	Sequence conflict	395	1	E → K Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified May 24, 2004. Version 2. Checksum: FE9E065E0A76A94A	FASTA	436	47,482
	10 20 30 40 50 60 MQPPPDEARR DMAGDTQWSR PECQAWTGTL LLGTCLLYCA RSSMPICTVS MSQDFGWNKK 70 80 90 100 110 120 EAGIVLSSFF WGYCLTQVVG GHLGDRIGGE KVILLSASAW GSITAVTPLL AHLSSAHLAF 130 140 150 160 170 180 MTFSRILMGL LQGVYFPALT SLLSQKVRES ERAFTYSIVG AGSQFGTLLT GAVGSLLLEW 190 200 210 220 230 240 YGWQSIFYFS GGLTLLWVWY VYRYLLSEKD LILALGVLAQ SRPVSRHNRV PWRRLFRKPA 250 260 270 280 290 300 VWAAVVSQLS AACSFFILLS WLPTFFEETF PDAKGWIFNV VPWLVAIPAS LFSGFLSDHL 310 320 330 340 350 360 INQGYRAITV RKLMQGMGLG LSSVFALCLG HTSSFCESVV FASASIGLQT FNHSGISVNI 370 380 390 400 410 420 QDLAPSCAGF LFGVANTAGA LAGVVGVCLG GYLMETTGSW TCLFNLVAII SNLGLCTFLV 430 FGQAQRVDLS STHEDL
	Isoform 2 [UniParc]. Checksum: BBA4CF4BF06C2221	FASTA	430	46,816
	10 20 30 40 50 60 MTLTSRRQDS QEARPECQAW TGTLLLGTCL LYCARSSMPI CTVSMSQDFG WNKKEAGIVL 70 80 90 100 110 120 SSFFWGYCLT QVVGGHLGDR IGGEKVILLS ASAWGSITAV TPLLAHLSSA HLAFMTFSRI 130 140 150 160 170 180 LMGLLQGVYF PALTSLLSQK VRESERAFTY SIVGAGSQFG TLLTGAVGSL LLEWYGWQSI 190 200 210 220 230 240 FYFSGGLTLL WVWYVYRYLL SEKDLILALG VLAQSRPVSR HNRVPWRRLF RKPAVWAAVV 250 260 270 280 290 300 SQLSAACSFF ILLSWLPTFF EETFPDAKGW IFNVVPWLVA IPASLFSGFL SDHLINQGYR 310 320 330 340 350 360 AITVRKLMQG MGLGLSSVFA LCLGHTSSFC ESVVFASASI GLQTFNHSGI SVNIQDLAPS 370 380 390 400 410 420 CAGFLFGVAN TAGALAGVVG VCLGGYLMET TGSWTCLFNL VAIISNLGLC TFLVFGQAQR 430 VDLSSTHEDL
	Isoform 3 [UniParc]. Checksum: 07AA6D8E45540E23	FASTA	216	23,676
	10 20 30 40 50 60 MQPPPDEARR DMAGDTQWSR PECQAWTGTL LLGTCLLYCA RSSMPICTVS MSQDFGWNKK 70 80 90 100 110 120 EAGIVLSSFF WGYCLTQVVG GHLGDRIGGE KVILLSASAW GSITAVTPLL AHLSSAHLAF 130 140 150 160 170 180 MTFSRILMGL LQGVYFPALT SLLSQKVRES ERAFTYSIVG AGSQFGTLLT GAVGSLLLEW 190 200 210 YGWQSIFYFS GGLTLLWVWY VYRYLLSEKG NAGRAG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of a vesicular nucleotide transporter." Sawada K., Echigo N., Juge N., Miyaji T., Otsuka M., Omote H., Yamamoto A., Moriyama Y. Proc. Natl. Acad. Sci. U.S.A. 105:5683-5686(2008) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION, TISSUE SPECIFICITY, VARIANT SER-228.
[2]	"Characterization of long cDNA clones from human adult spleen. II. The complete sequences of 81 cDNA clones." Jikuya H., Takano J., Kikuno R., Hirosawa M., Nagase T., Nomura N., Ohara O. DNA Res. 10:49-57(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). Tissue: Spleen.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT SER-228. Tissue: Neonatal skin.
[4]	"The DNA sequence and comparative analysis of human chromosome 20." Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J. Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT SER-228. Tissue: Kidney.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK074107 mRNA. Translation: BAB84933.1. Different initiation. AK095473 mRNA. Translation: BAG53064.1. AL121673 Genomic DNA. Translation: CAC28600.1. AL121673 Genomic DNA. Translation: CAH72268.1. BC025312 mRNA. Translation: AAH25312.1. Sequence problems. BC027447 mRNA. Translation: AAH27447.1. BC038593 mRNA. No translation available.
IPI	IPI00001151. IPI00152768. IPI00413481.
RefSeq	NP_071365.3. NM_022082.3.
UniGene	Hs.512686.
3D structure databases
ProteinModelPortal	Q9BYT1.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9BYT1. 1 interaction.
Protein family/group databases
TCDB	2.A.1.14.21. major facilitator superfamily (MFS).
PTM databases
PhosphoSite	Q9BYT1.
Polymorphism databases
DMDM	47605540.
Proteomic databases
PaxDb	Q9BYT1.
PRIDE	Q9BYT1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000370349; ENSP00000359374; ENSG00000101194. ENST00000370351; ENSP00000359376; ENSG00000101194.
GeneID	63910.
KEGG	hsa:63910.
UCSC	uc002ydz.4. human. uc002yea.4. human.
Organism-specific databases
CTD	63910.
GeneCards	GC20P061583.
HGNC	HGNC:16192. SLC17A9.
HPA	HPA056499.
MIM	612107. gene.
neXtProt	NX_Q9BYT1.
PharmGKB	PA164725806.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG0477.
InParanoid	Q9BYT1.
KO	K12303.
OMA	YCARVAM.
OrthoDB	EOG479F74.
PhylomeDB	Q9BYT1.
Gene expression databases
ArrayExpress	Q9BYT1.
Bgee	Q9BYT1.
Genevestigator	Q9BYT1.
GermOnline	ENSG00000101194. Homo sapiens.
Family and domain databases
InterPro	IPR011701. MFS. IPR020846. MFS_dom. IPR016196. MFS_dom_general_subst_transpt. IPR005829. Sugar_transporter_CS. [Graphical view]
Pfam	PF07690. MFS_1. 1 hit. [Graphical view]
SUPFAM	SSF103473. MFS_gen_substrate_transporter. 1 hit.
PROSITE	PS50850. MFS. 1 hit. PS00217. SUGAR_TRANSPORT_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	63910.
NextBio	65626.
SOURCE	Search...

Entry information

Entry name

S17A9_HUMAN

Accession

Primary (citable) accession number: Q9BYT1
Secondary accession number(s): B3KTF2 , Q5W198, Q8TB07, Q8TBP4, Q8TEL5, Q9BYT0, Q9BYT2

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 24, 2004
Last sequence update:	May 24, 2004
Last modified:	May 1, 2013
This is version 92 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.