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Protein

Leucine-rich repeat-containing protein 2

Gene

LRRC2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat-containing protein 2
Gene namesi
Name:LRRC2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000163827.12.
HGNCiHGNC:14676. LRRC2.

Pathology & Biotechi

Organism-specific databases

DisGeNETi79442.
OpenTargetsiENSG00000163827.
PharmGKBiPA30461.

Polymorphism and mutation databases

BioMutaiLRRC2.
DMDMi23821855.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000844911 – 371Leucine-rich repeat-containing protein 2Add BLAST371

Proteomic databases

EPDiQ9BYS8.
PaxDbiQ9BYS8.
PeptideAtlasiQ9BYS8.
PRIDEiQ9BYS8.

PTM databases

iPTMnetiQ9BYS8.
PhosphoSitePlusiQ9BYS8.

Expressioni

Gene expression databases

BgeeiENSG00000163827.
CleanExiHS_LRRC2.
ExpressionAtlasiQ9BYS8. baseline and differential.
GenevisibleiQ9BYS8. HS.

Organism-specific databases

HPAiHPA039138.
HPA040096.

Interactioni

Protein-protein interaction databases

BioGridi122668. 1 interactor.
IntActiQ9BYS8. 3 interactors.
STRINGi9606.ENSP00000296144.

Structurei

3D structure databases

ProteinModelPortaliQ9BYS8.
SMRiQ9BYS8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati122 – 143LRR 1Add BLAST22
Repeati145 – 166LRR 2Add BLAST22
Repeati168 – 189LRR 3Add BLAST22
Repeati191 – 214LRR 4Add BLAST24
Repeati215 – 235LRR 5Add BLAST21
Repeati238 – 260LRR 6Add BLAST23
Repeati261 – 283LRR 7Add BLAST23
Repeati284 – 305LRR 8Add BLAST22
Repeati308 – 329LRR 9Add BLAST22

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00840000129686.
HOGENOMiHOG000065739.
HOVERGENiHBG052358.
InParanoidiQ9BYS8.
OMAiPTALCDS.
OrthoDBiEOG091G0BH1.
PhylomeDBiQ9BYS8.
TreeFamiTF333627.

Family and domain databases

Gene3Di3.80.10.10. 2 hits.
InterProiView protein in InterPro
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
PfamiView protein in Pfam
PF13855. LRR_8. 1 hit.
SMARTiView protein in SMART
SM00369. LRR_TYP. 4 hits.
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiView protein in PROSITE
PS51450. LRR. 4 hits.

Sequencei

Sequence statusi: Complete.

Q9BYS8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGHKVVVFDI SVIRALWETR VKKHKAWQKK EVERLEKSAL EKIKEEWNFV
60 70 80 90 100
AECRRKGIPQ AVYCKNGFID TSVRLLDKIE RNTLTRQSSL PKDRGKRSSA
110 120 130 140 150
FVFELSGEHW TELPDSLKEQ THLREWYISN TLIQIIPTYI QLFQAMRILD
160 170 180 190 200
LPKNQISHLP AEIGCLKNLK ELNVGFNYLK SIPPELGDCE NLERLDCSGN
210 220 230 240 250
LELMELPFEL SNLKQVTFVD ISANKFSSVP ICVLRMSNLQ WLDISSNNLT
260 270 280 290 300
DLPQDIDRLE ELQSFLLYKN KLTYLPYSML NLKKLTLLVV SGDHLVELPT
310 320 330 340 350
ALCDSSTPLK FVSLMDNPID NAQCEDGNEI MESERDRQHF DKEVMKAYIE
360 370
DLKERESVPS YTTKVSFSLQ L
Length:371
Mass (Da):42,943
Last modified:October 10, 2002 - v2
Checksum:iFF67A824F26680C3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti30K → R in BAB71585 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05114032V → A1 PublicationCorresponds to variant dbSNP:rs28687398Ensembl.1
Natural variantiVAR_05114183T → A. Corresponds to variant dbSNP:rs17286758Ensembl.1
Natural variantiVAR_051142145A → E1 PublicationCorresponds to variant dbSNP:rs17078944Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ308569 mRNA. Translation: CAC33442.1.
AK057808 mRNA. Translation: BAB71585.1.
AK315636 mRNA. Translation: BAG38004.1.
BC029118 mRNA. Translation: AAH29118.1.
CCDSiCCDS2741.1.
RefSeqiNP_078788.2. NM_024512.4.
XP_011532412.1. XM_011534110.2.
UniGeneiHs.657345.

Genome annotation databases

EnsembliENST00000296144; ENSP00000296144; ENSG00000163827.
ENST00000395905; ENSP00000379241; ENSG00000163827.
GeneIDi79442.
KEGGihsa:79442.
UCSCiuc003cpu.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiLRRC2_HUMAN
AccessioniPrimary (citable) accession number: Q9BYS8
Secondary accession number(s): B2RDQ7, Q96LT5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: October 10, 2002
Last modified: September 27, 2017
This is version 137 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot