UniProtKB - Q9BYS8 (LRRC2_HUMAN)
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Protein
Leucine-rich repeat-containing protein 2
Gene
LRRC2
Organism
Homo sapiens (Human)
Status
Names & Taxonomyi
Protein namesi | Recommended name: Leucine-rich repeat-containing protein 2 |
Gene namesi | Name:LRRC2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000163827.12. |
HGNCi | HGNC:14676. LRRC2. |
MIMi | 607180. gene. |
neXtProti | NX_Q9BYS8. |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 79442. |
OpenTargetsi | ENSG00000163827. |
PharmGKBi | PA30461. |
Polymorphism and mutation databases
BioMutai | LRRC2. |
DMDMi | 23821855. |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000084491 | 1 – 371 | Leucine-rich repeat-containing protein 2Add BLAST | 371 |
Proteomic databases
PaxDbi | Q9BYS8. |
PeptideAtlasi | Q9BYS8. |
PRIDEi | Q9BYS8. |
PTM databases
iPTMneti | Q9BYS8. |
PhosphoSitePlusi | Q9BYS8. |
Expressioni
Gene expression databases
Bgeei | ENSG00000163827. |
CleanExi | HS_LRRC2. |
ExpressionAtlasi | Q9BYS8. baseline and differential. |
Genevisiblei | Q9BYS8. HS. |
Organism-specific databases
HPAi | HPA039138. HPA040096. |
Interactioni
Protein-protein interaction databases
BioGridi | 122668. 1 interactor. |
IntActi | Q9BYS8. 3 interactors. |
STRINGi | 9606.ENSP00000296144. |
Structurei
3D structure databases
ProteinModelPortali | Q9BYS8. |
SMRi | Q9BYS8. |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 122 – 143 | LRR 1Add BLAST | 22 | |
Repeati | 145 – 166 | LRR 2Add BLAST | 22 | |
Repeati | 168 – 189 | LRR 3Add BLAST | 22 | |
Repeati | 191 – 214 | LRR 4Add BLAST | 24 | |
Repeati | 215 – 235 | LRR 5Add BLAST | 21 | |
Repeati | 238 – 260 | LRR 6Add BLAST | 23 | |
Repeati | 261 – 283 | LRR 7Add BLAST | 23 | |
Repeati | 284 – 305 | LRR 8Add BLAST | 22 | |
Repeati | 308 – 329 | LRR 9Add BLAST | 22 |
Keywords - Domaini
Leucine-rich repeat, RepeatPhylogenomic databases
eggNOGi | KOG0619. Eukaryota. COG4886. LUCA. |
GeneTreei | ENSGT00840000129686. |
HOGENOMi | HOG000065739. |
HOVERGENi | HBG052358. |
InParanoidi | Q9BYS8. |
OMAi | PTALCDS. |
OrthoDBi | EOG091G0BH1. |
PhylomeDBi | Q9BYS8. |
TreeFami | TF333627. |
Family and domain databases
Gene3Di | 3.80.10.10. 2 hits. |
InterProi | View protein in InterPro IPR001611. Leu-rich_rpt. IPR003591. Leu-rich_rpt_typical-subtyp. IPR032675. LRR_dom_sf. |
Pfami | View protein in Pfam PF13855. LRR_8. 1 hit. |
SMARTi | View protein in SMART SM00369. LRR_TYP. 4 hits. |
PROSITEi | View protein in PROSITE PS51450. LRR. 4 hits. |
i Sequence
Sequence statusi: Complete.
Q9BYS8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGHKVVVFDI SVIRALWETR VKKHKAWQKK EVERLEKSAL EKIKEEWNFV
60 70 80 90 100
AECRRKGIPQ AVYCKNGFID TSVRLLDKIE RNTLTRQSSL PKDRGKRSSA
110 120 130 140 150
FVFELSGEHW TELPDSLKEQ THLREWYISN TLIQIIPTYI QLFQAMRILD
160 170 180 190 200
LPKNQISHLP AEIGCLKNLK ELNVGFNYLK SIPPELGDCE NLERLDCSGN
210 220 230 240 250
LELMELPFEL SNLKQVTFVD ISANKFSSVP ICVLRMSNLQ WLDISSNNLT
260 270 280 290 300
DLPQDIDRLE ELQSFLLYKN KLTYLPYSML NLKKLTLLVV SGDHLVELPT
310 320 330 340 350
ALCDSSTPLK FVSLMDNPID NAQCEDGNEI MESERDRQHF DKEVMKAYIE
360 370
DLKERESVPS YTTKVSFSLQ L
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 30 | K → R in BAB71585 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_051140 | 32 | V → A1 PublicationCorresponds to variant dbSNP:rs28687398Ensembl. | 1 | |
Natural variantiVAR_051141 | 83 | T → A. Corresponds to variant dbSNP:rs17286758Ensembl. | 1 | |
Natural variantiVAR_051142 | 145 | A → E1 PublicationCorresponds to variant dbSNP:rs17078944Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ308569 mRNA. Translation: CAC33442.1. AK057808 mRNA. Translation: BAB71585.1. AK315636 mRNA. Translation: BAG38004.1. BC029118 mRNA. Translation: AAH29118.1. |
CCDSi | CCDS2741.1. |
RefSeqi | NP_078788.2. NM_024512.4. XP_011532412.1. XM_011534110.2. |
UniGenei | Hs.657345. |
Genome annotation databases
Ensembli | ENST00000296144; ENSP00000296144; ENSG00000163827. ENST00000395905; ENSP00000379241; ENSG00000163827. |
GeneIDi | 79442. |
KEGGi | hsa:79442. |
UCSCi | uc003cpu.5. human. |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Entry informationi
Entry namei | LRRC2_HUMAN | |
Accessioni | Q9BYS8Primary (citable) accession number: Q9BYS8 Secondary accession number(s): B2RDQ7, Q96LT5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 10, 2002 |
Last sequence update: | October 10, 2002 | |
Last modified: | February 28, 2018 | |
This is version 140 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |