LRRC2

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Leucine-rich repeat-containing protein 2
Gene namesⁱ	Name:LRRC2
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 3

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000163827.12.
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:14676. LRRC2.
MIMⁱ	607180. gene.
neXtProtⁱ	NX_Q9BYS8.

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	79442.
Open Targets More...OpenTargetsⁱ	ENSG00000163827.
PharmGKBⁱ	PA30461.

Polymorphism and mutation databases

BioMutaⁱ	LRRC2.
DMDMⁱ	23821855.

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000084491	1 – 371	Leucine-rich repeat-containing protein 2Add BLAST		371

Proteomic databases

PaxDbⁱ	Q9BYS8.
PeptideAtlas More...PeptideAtlasⁱ	Q9BYS8.
PRIDEⁱ	Q9BYS8.

PTM databases

iPTMnetⁱ	Q9BYS8.
PhosphoSitePlusⁱ	Q9BYS8.

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000163827.
CleanExⁱ	HS_LRRC2.
ExpressionAtlasⁱ	Q9BYS8. baseline and differential.
Genevisibleⁱ	Q9BYS8. HS.

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA039138. HPA040096.

HPAⁱ

HPA039138.
HPA040096.

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	122668. 1 interactor.
IntActⁱ	Q9BYS8. 3 interactors.
STRINGⁱ	9606.ENSP00000296144.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9BYS8.
SMRⁱ	Q9BYS8.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Repeatⁱ	122 – 143	LRR 1Add BLAST	22
Repeatⁱ	145 – 166	LRR 2Add BLAST	22
Repeatⁱ	168 – 189	LRR 3Add BLAST	22
Repeatⁱ	191 – 214	LRR 4Add BLAST	24
Repeatⁱ	215 – 235	LRR 5Add BLAST	21
Repeatⁱ	238 – 260	LRR 6Add BLAST	23
Repeatⁱ	261 – 283	LRR 7Add BLAST	23
Repeatⁱ	284 – 305	LRR 8Add BLAST	22
Repeatⁱ	308 – 329	LRR 9Add BLAST	22

Keywords - Domainⁱ

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGⁱ	KOG0619. Eukaryota. COG4886. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00840000129686.
HOGENOMⁱ	HOG000065739.
HOVERGENⁱ	HBG052358.
InParanoidⁱ	Q9BYS8.
OMAⁱ	PTALCDS.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0BH1.
PhylomeDBⁱ	Q9BYS8.
TreeFamⁱ	TF333627.

Family and domain databases

Gene3Dⁱ	3.80.10.10. 2 hits.
InterProⁱ	View protein in InterPro IPR001611. Leu-rich_rpt. IPR003591. Leu-rich_rpt_typical-subtyp. IPR032675. LRR_dom_sf.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF13855. LRR_8. 1 hit.
SMARTⁱ	View protein in SMART SM00369. LRR_TYP. 4 hits.
PROSITEⁱ	View protein in PROSITE PS51450. LRR. 4 hits.

Sequenceⁱ

Sequence statusⁱ: Complete.

Q9BYS8-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MGHKVVVFDI SVIRALWETR VKKHKAWQKK EVERLEKSAL EKIKEEWNFV 
        60         70         80         90        100
AECRRKGIPQ AVYCKNGFID TSVRLLDKIE RNTLTRQSSL PKDRGKRSSA 
       110        120        130        140        150
FVFELSGEHW TELPDSLKEQ THLREWYISN TLIQIIPTYI QLFQAMRILD 
       160        170        180        190        200
LPKNQISHLP AEIGCLKNLK ELNVGFNYLK SIPPELGDCE NLERLDCSGN 
       210        220        230        240        250
LELMELPFEL SNLKQVTFVD ISANKFSSVP ICVLRMSNLQ WLDISSNNLT 
       260        270        280        290        300
DLPQDIDRLE ELQSFLLYKN KLTYLPYSML NLKKLTLLVV SGDHLVELPT 
       310        320        330        340        350
ALCDSSTPLK FVSLMDNPID NAQCEDGNEI MESERDRQHF DKEVMKAYIE 
       360        370 
DLKERESVPS YTTKVSFSLQ L

Length:371

Mass (Da):42,943

Last modified:October 10, 2002 - v2

Checksum:ⁱFF67A824F26680C3

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	30	K → R in BAB71585 (PubMed:14702039).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_051140	32	V → A1 PublicationCorresponds to variant dbSNP:rs28687398Ensembl.	1
Natural variantⁱVAR_051141	83	T → A. Corresponds to variant dbSNP:rs17286758Ensembl.	1
Natural variantⁱVAR_051142	145	A → E1 PublicationCorresponds to variant dbSNP:rs17078944Ensembl.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AJ308569 mRNA. Translation: CAC33442.1. AK057808 mRNA. Translation: BAB71585.1. AK315636 mRNA. Translation: BAG38004.1. BC029118 mRNA. Translation: AAH29118.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS2741.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_078788.2. NM_024512.4. XP_011532412.1. XM_011534110.2.
UniGeneⁱ	Hs.657345.

Genome annotation databases

Ensemblⁱ	ENST00000296144; ENSP00000296144; ENSG00000163827. ENST00000395905; ENSP00000379241; ENSG00000163827.
GeneIDⁱ	79442.
KEGGⁱ	hsa:79442.
UCSC genome browser More...UCSCⁱ	uc003cpu.5. human.

Keywords - Coding sequence diversityⁱ

Polymorphism

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q9BYS8	A0A024R2R5 UPI0007DC80F9	Homo sapiens (Human)	371	UniRef100_Q9BYS8	Cluster: Leucine-rich repeat-containing protein 2	3

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q9BYS8	A0A024R2R5 UPI0007DC80F9 A0A096N3I6 UPI000B7B55EC A0A2K5HAF3 F7GG53 A0A2K5MHX8 G7NY29 A0A2K6BR67 G1R2M6 +19	Homo sapiens (Human) Papio anubis (Olive baboon) Colobus angolensis palliatus (Peters' Angolan colobus) Callithrix jacchus (White-tufted-ear marmoset) Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys) Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) Macaca nemestrina (Pig-tailed macaque) Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys) Gorilla gorilla gorilla (Western lowland gorilla) Saimiri boliviensis boliviensis (Bolivian squirrel monkey) And more	371	UniRef90_Q9BYS8	Cluster: Leucine-rich repeat-containing protein 2	30

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q9BYS8	A0A024R2R5 UPI0007DC80F9 A0A096N3I6 UPI000B7B55EC F7GG53 A0A2K6MMR3 A0A2K6PPJ5 B2RBH0 Q5RB20 Q53F49 +180	Homo sapiens (Human) Papio anubis (Olive baboon) Callithrix jacchus (White-tufted-ear marmoset) Rhinopithecus bieti (Black snub-nosed monkey) (Pygathrix bieti) Rhinopithecus roxellana (Golden snub-nosed monkey) (Pygathrix roxellana) Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) Macaca mulatta (Rhesus macaque) Macaca nemestrina (Pig-tailed macaque) Cebus capucinus imitator Aotus nancymaae (Ma's night monkey) And more	371	UniRef50_Q9BYS8	Cluster: Leucine-rich repeat-containing protein 2	191

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AJ308569 mRNA. Translation: CAC33442.1. AK057808 mRNA. Translation: BAB71585.1. AK315636 mRNA. Translation: BAG38004.1. BC029118 mRNA. Translation: AAH29118.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS2741.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_078788.2. NM_024512.4. XP_011532412.1. XM_011534110.2.
UniGeneⁱ	Hs.657345.

3D structure databases

ProteinModelPortalⁱ	Q9BYS8.
SMRⁱ	Q9BYS8.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	122668. 1 interactor.
IntActⁱ	Q9BYS8. 3 interactors.
STRINGⁱ	9606.ENSP00000296144.

PTM databases

iPTMnetⁱ	Q9BYS8.
PhosphoSitePlusⁱ	Q9BYS8.

Polymorphism and mutation databases

BioMutaⁱ	LRRC2.
DMDMⁱ	23821855.

Proteomic databases

PaxDbⁱ	Q9BYS8.
PeptideAtlas More...PeptideAtlasⁱ	Q9BYS8.
PRIDEⁱ	Q9BYS8.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000296144; ENSP00000296144; ENSG00000163827. ENST00000395905; ENSP00000379241; ENSG00000163827.
GeneIDⁱ	79442.
KEGGⁱ	hsa:79442.
UCSC genome browser More...UCSCⁱ	uc003cpu.5. human.

Organism-specific databases

CTDⁱ	79442.
DisGeNET More...DisGeNETⁱ	79442.
EuPathDBⁱ	HostDB:ENSG00000163827.12.
GeneCardsⁱ	LRRC2.
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:14676. LRRC2.
Human Protein Atlas More...HPAⁱ	HPA039138. HPA040096.
MIMⁱ	607180. gene.
neXtProtⁱ	NX_Q9BYS8.
Open Targets More...OpenTargetsⁱ	ENSG00000163827.
PharmGKBⁱ	PA30461.
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0619. Eukaryota. COG4886. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00840000129686.
HOGENOMⁱ	HOG000065739.
HOVERGENⁱ	HBG052358.
InParanoidⁱ	Q9BYS8.
OMAⁱ	PTALCDS.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0BH1.
PhylomeDBⁱ	Q9BYS8.
TreeFamⁱ	TF333627.

Miscellaneous databases

ChiTaRSⁱ	LRRC2. human.
GenomeRNAiⁱ	79442.
Protein Ontology More...PROⁱ	PR:Q9BYS8.
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000163827.
CleanExⁱ	HS_LRRC2.
ExpressionAtlasⁱ	Q9BYS8. baseline and differential.
Genevisibleⁱ	Q9BYS8. HS.

Family and domain databases

Gene3Dⁱ	3.80.10.10. 2 hits.
InterProⁱ	View protein in InterPro IPR001611. Leu-rich_rpt. IPR003591. Leu-rich_rpt_typical-subtyp. IPR032675. LRR_dom_sf.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF13855. LRR_8. 1 hit.
SMARTⁱ	View protein in SMART SM00369. LRR_TYP. 4 hits.
PROSITEⁱ	View protein in PROSITE PS51450. LRR. 4 hits.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	LRRC2_HUMAN
Accessionⁱ	Q9BYS8Primary (citable) accession number: Q9BYS8 Secondary accession number(s): B2RDQ7, Q96LT5
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 10, 2002
	Last sequence update:	October 10, 2002
	Last modified:	February 28, 2018
	This is version 140 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9BYS8 (LRRC2_HUMAN)

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Leucine-rich repeat-containing protein 2

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<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

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Names & Taxonomyⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ