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Protein

Keratin-associated protein 1-5

Gene

KRTAP1-5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin-associated protein 1-5
Alternative name(s):
High sulfur keratin-associated protein 1.5
Keratin-associated protein 1.5
Gene namesi
Name:KRTAP1-5
Synonyms:KAP1.5, KRTAP1.5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componentsi: Chromosome 17, Unplaced

Organism-specific databases

HGNCiHGNC:16777. KRTAP1-5.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Keratin

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38417.

Polymorphism and mutation databases

BioMutaiKRTAP1-5.
DMDMi56749988.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 174174Keratin-associated protein 1-5PRO_0000185161Add
BLAST

Proteomic databases

PaxDbiQ9BYS1.

Expressioni

Tissue specificityi

Expressed in the middle/upper portions of the hair cortex, in the region termed the keratogenous zone.1 Publication

Gene expression databases

BgeeiQ9BYS1.
CleanExiHS_KRTAP1-5.
GenevisibleiQ9BYS1. HS.

Interactioni

Subunit structurei

Interacts with hair keratins.

Structurei

3D structure databases

ProteinModelPortaliQ9BYS1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni3 – 17217015 X 5 AA repeats of C-C-[QEPVRC]-[TPIVLE]-[SRHVP]Add
BLAST

Sequence similaritiesi

Belongs to the KRTAP type 1 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG261513.
GeneTreeiENSGT00730000111060.
HOGENOMiHOG000234033.
HOVERGENiHBG008671.
InParanoidiQ9BYS1.
OMAiPRSCQTS.
OrthoDBiEOG71P2DP.
PhylomeDBiQ9BYS1.
TreeFamiTF351356.

Family and domain databases

InterProiIPR002494. KAP.
[Graphical view]
PANTHERiPTHR23262. PTHR23262. 1 hit.
PfamiPF01500. Keratin_B2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9BYS1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTCCQTSFCG YPSFSISGTC GSSCCQPSCC ETSCCQPRSC QTSFCGFPSF
60 70 80 90 100
STSGTCSSSC CQPSCCETSC CQPSCCETSC CQPSCCQISS CGTGCGIGGG
110 120 130 140 150
ISYGQEGSSG AVSTRIRWCR PDSRVEGTYL PPCCVVSCTP PSCCQLHHAQ
160 170
ASCCRPSYCG QSCCRPVCCC EPTC
Length:174
Mass (Da):18,010
Last modified:June 1, 2001 - v1
Checksum:iFD8F32C958A9B291
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ406928 mRNA. Translation: CAC27567.1.
AC007455 Genomic DNA. No translation available.
CH471152 Genomic DNA. Translation: EAW60697.1.
BC069533 mRNA. Translation: AAH69533.1.
BC093841 mRNA. Translation: AAH93841.1.
BC101555 mRNA. Translation: AAI01556.1.
CCDSiCCDS42321.1.
RefSeqiNP_114163.1. NM_031957.1.
UniGeneiHs.534499.

Genome annotation databases

EnsembliENST00000361883; ENSP00000355302; ENSG00000221852.
ENST00000572212; ENSP00000461651; ENSG00000261862.
GeneIDi83895.
KEGGihsa:83895.
UCSCiuc002hvu.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ406928 mRNA. Translation: CAC27567.1.
AC007455 Genomic DNA. No translation available.
CH471152 Genomic DNA. Translation: EAW60697.1.
BC069533 mRNA. Translation: AAH69533.1.
BC093841 mRNA. Translation: AAH93841.1.
BC101555 mRNA. Translation: AAI01556.1.
CCDSiCCDS42321.1.
RefSeqiNP_114163.1. NM_031957.1.
UniGeneiHs.534499.

3D structure databases

ProteinModelPortaliQ9BYS1.
ModBaseiSearch...
MobiDBiSearch...

Polymorphism and mutation databases

BioMutaiKRTAP1-5.
DMDMi56749988.

Proteomic databases

PaxDbiQ9BYS1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000361883; ENSP00000355302; ENSG00000221852.
ENST00000572212; ENSP00000461651; ENSG00000261862.
GeneIDi83895.
KEGGihsa:83895.
UCSCiuc002hvu.3. human.

Organism-specific databases

CTDi83895.
GeneCardsiGC17M039183.
HGNCiHGNC:16777. KRTAP1-5.
MIMi608822. gene.
neXtProtiNX_Q9BYS1.
PharmGKBiPA38417.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG261513.
GeneTreeiENSGT00730000111060.
HOGENOMiHOG000234033.
HOVERGENiHBG008671.
InParanoidiQ9BYS1.
OMAiPRSCQTS.
OrthoDBiEOG71P2DP.
PhylomeDBiQ9BYS1.
TreeFamiTF351356.

Miscellaneous databases

GenomeRNAii83895.
NextBioi72995.
PROiQ9BYS1.
SOURCEiSearch...

Gene expression databases

BgeeiQ9BYS1.
CleanExiHS_KRTAP1-5.
GenevisibleiQ9BYS1. HS.

Family and domain databases

InterProiIPR002494. KAP.
[Graphical view]
PANTHERiPTHR23262. PTHR23262. 1 hit.
PfamiPF01500. Keratin_B2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of a cluster of human high/ultrahigh sulfur keratin-associated protein genes embedded in the type I keratin gene domain on chromosome 17q12-21."
    Rogers M.A., Langbein L., Winter H., Ehmann C., Praetzel S., Korn B., Schweizer J.
    J. Biol. Chem. 276:19440-19451(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Tissue: Scalp.
  2. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.

Entry informationi

Entry nameiKRA15_HUMAN
AccessioniPrimary (citable) accession number: Q9BYS1
Secondary accession number(s): A6NJW6
, A6NLZ6, B6ZDR1, Q52LP6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2004
Last sequence update: June 1, 2001
Last modified: June 24, 2015
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.