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Q9BYS1

- KRA15_HUMAN

UniProt

Q9BYS1 - KRA15_HUMAN

Protein

Keratin-associated protein 1-5

Gene

KRTAP1-5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 94 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Keratin-associated protein 1-5
    Alternative name(s):
    High sulfur keratin-associated protein 1.5
    Keratin-associated protein 1.5
    Gene namesi
    Name:KRTAP1-5
    Synonyms:KAP1.5, KRTAP1.5
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:16777. KRTAP1-5.

    Subcellular locationi

    GO - Cellular componenti

    1. keratin filament Source: InterPro

    Keywords - Cellular componenti

    Keratin

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA38417.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 174174Keratin-associated protein 1-5PRO_0000185161Add
    BLAST

    Proteomic databases

    PaxDbiQ9BYS1.

    Expressioni

    Tissue specificityi

    Expressed in the middle/upper portions of the hair cortex, in the region termed the keratogenous zone.1 Publication

    Gene expression databases

    BgeeiQ9BYS1.
    CleanExiHS_KRTAP1-5.
    GenevestigatoriQ9BYS1.

    Interactioni

    Subunit structurei

    Interacts with hair keratins.

    Protein-protein interaction databases

    STRINGi9606.ENSP00000355302.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9BYS1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni3 – 17217015 X 5 AA repeats of C-C-[QEPVRC]-[TPIVLE]-[SRHVP]Add
    BLAST

    Sequence similaritiesi

    Belongs to the KRTAP type 1 family.Curated

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG261513.
    HOGENOMiHOG000234033.
    HOVERGENiHBG008671.
    InParanoidiQ9BYS1.
    OMAiPRSCQTS.
    OrthoDBiEOG71P2DP.
    PhylomeDBiQ9BYS1.
    TreeFamiTF351356.

    Family and domain databases

    InterProiIPR002494. KAP.
    [Graphical view]
    PANTHERiPTHR23262. PTHR23262. 1 hit.
    PfamiPF01500. Keratin_B2. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9BYS1-1 [UniParc]FASTAAdd to Basket

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    MTCCQTSFCG YPSFSISGTC GSSCCQPSCC ETSCCQPRSC QTSFCGFPSF    50
    STSGTCSSSC CQPSCCETSC CQPSCCETSC CQPSCCQISS CGTGCGIGGG 100
    ISYGQEGSSG AVSTRIRWCR PDSRVEGTYL PPCCVVSCTP PSCCQLHHAQ 150
    ASCCRPSYCG QSCCRPVCCC EPTC 174
    Length:174
    Mass (Da):18,010
    Last modified:June 1, 2001 - v1
    Checksum:iFD8F32C958A9B291
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ406928 mRNA. Translation: CAC27567.1.
    AC007455 Genomic DNA. No translation available.
    CH471152 Genomic DNA. Translation: EAW60697.1.
    BC069533 mRNA. Translation: AAH69533.1.
    BC093841 mRNA. Translation: AAH93841.1.
    BC101555 mRNA. Translation: AAI01556.1.
    CCDSiCCDS42321.1.
    RefSeqiNP_114163.1. NM_031957.1.
    UniGeneiHs.534499.

    Genome annotation databases

    EnsembliENST00000361883; ENSP00000355302; ENSG00000221852.
    ENST00000572212; ENSP00000461651; ENSG00000261862.
    GeneIDi83895.
    KEGGihsa:83895.
    UCSCiuc002hvu.3. human.

    Polymorphism databases

    DMDMi56749988.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ406928 mRNA. Translation: CAC27567.1 .
    AC007455 Genomic DNA. No translation available.
    CH471152 Genomic DNA. Translation: EAW60697.1 .
    BC069533 mRNA. Translation: AAH69533.1 .
    BC093841 mRNA. Translation: AAH93841.1 .
    BC101555 mRNA. Translation: AAI01556.1 .
    CCDSi CCDS42321.1.
    RefSeqi NP_114163.1. NM_031957.1.
    UniGenei Hs.534499.

    3D structure databases

    ProteinModelPortali Q9BYS1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000355302.

    Polymorphism databases

    DMDMi 56749988.

    Proteomic databases

    PaxDbi Q9BYS1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000361883 ; ENSP00000355302 ; ENSG00000221852 .
    ENST00000572212 ; ENSP00000461651 ; ENSG00000261862 .
    GeneIDi 83895.
    KEGGi hsa:83895.
    UCSCi uc002hvu.3. human.

    Organism-specific databases

    CTDi 83895.
    GeneCardsi GC17M039183.
    HGNCi HGNC:16777. KRTAP1-5.
    MIMi 608822. gene.
    neXtProti NX_Q9BYS1.
    PharmGKBi PA38417.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG261513.
    HOGENOMi HOG000234033.
    HOVERGENi HBG008671.
    InParanoidi Q9BYS1.
    OMAi PRSCQTS.
    OrthoDBi EOG71P2DP.
    PhylomeDBi Q9BYS1.
    TreeFami TF351356.

    Miscellaneous databases

    GenomeRNAii 83895.
    NextBioi 72995.
    PROi Q9BYS1.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9BYS1.
    CleanExi HS_KRTAP1-5.
    Genevestigatori Q9BYS1.

    Family and domain databases

    InterProi IPR002494. KAP.
    [Graphical view ]
    PANTHERi PTHR23262. PTHR23262. 1 hit.
    Pfami PF01500. Keratin_B2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of a cluster of human high/ultrahigh sulfur keratin-associated protein genes embedded in the type I keratin gene domain on chromosome 17q12-21."
      Rogers M.A., Langbein L., Winter H., Ehmann C., Praetzel S., Korn B., Schweizer J.
      J. Biol. Chem. 276:19440-19451(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
      Tissue: Scalp.
    2. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
      Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
      , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
      Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Placenta.

    Entry informationi

    Entry nameiKRA15_HUMAN
    AccessioniPrimary (citable) accession number: Q9BYS1
    Secondary accession number(s): A6NJW6
    , A6NLZ6, B6ZDR1, Q52LP6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 25, 2004
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 94 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3