Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q9BYS1 (KRA15_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Keratin-associated protein 1-5
Alternative name(s):
High sulfur keratin-associated protein 1.5
Keratin-associated protein 1.5
Gene names
Name:KRTAP1-5
Synonyms:KAP1.5, KRTAP1.5
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length174 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.

Subunit structure

Interacts with hair keratins.

Tissue specificity

Expressed in the middle/upper portions of the hair cortex, in the region termed the keratogenous zone. Ref.1

Sequence similarities

Belongs to the KRTAP type 1 family.

Ontologies

Keywords
   Cellular componentKeratin
   DomainRepeat
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentkeratin filament

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 174174Keratin-associated protein 1-5
PRO_0000185161

Regions

Region3 – 17217015 X 5 AA repeats of C-C-[QEPVRC]-[TPIVLE]-[SRHVP]

Sequences

Sequence LengthMass (Da)Tools
Q9BYS1 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: FD8F32C958A9B291

FASTA17418,010
        10         20         30         40         50         60 
MTCCQTSFCG YPSFSISGTC GSSCCQPSCC ETSCCQPRSC QTSFCGFPSF STSGTCSSSC 

        70         80         90        100        110        120 
CQPSCCETSC CQPSCCETSC CQPSCCQISS CGTGCGIGGG ISYGQEGSSG AVSTRIRWCR 

       130        140        150        160        170 
PDSRVEGTYL PPCCVVSCTP PSCCQLHHAQ ASCCRPSYCG QSCCRPVCCC EPTC 

« Hide

References

« Hide 'large scale' references
[1]"Characterization of a cluster of human high/ultrahigh sulfur keratin-associated protein genes embedded in the type I keratin gene domain on chromosome 17q12-21."
Rogers M.A., Langbein L., Winter H., Ehmann C., Praetzel S., Korn B., Schweizer J.
J. Biol. Chem. 276:19440-19451(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
Tissue: Scalp.
[2]"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L. expand/collapse author list , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Placenta.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ406928 mRNA. Translation: CAC27567.1.
AC007455 Genomic DNA. No translation available.
CH471152 Genomic DNA. Translation: EAW60697.1.
BC069533 mRNA. Translation: AAH69533.1.
BC093841 mRNA. Translation: AAH93841.1.
BC101555 mRNA. Translation: AAI01556.1.
RefSeqNP_114163.1. NM_031957.1.
UniGeneHs.534499.

3D structure databases

ProteinModelPortalQ9BYS1.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000355302.

Polymorphism databases

DMDM56749988.

Proteomic databases

PaxDbQ9BYS1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000361883; ENSP00000355302; ENSG00000221852.
ENST00000572212; ENSP00000461651; ENSG00000261862.
GeneID83895.
KEGGhsa:83895.
UCSCuc002hvu.3. human.

Organism-specific databases

CTD83895.
GeneCardsGC17M039183.
HGNCHGNC:16777. KRTAP1-5.
MIM608822. gene.
neXtProtNX_Q9BYS1.
PharmGKBPA38417.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG261513.
HOGENOMHOG000234033.
HOVERGENHBG008671.
InParanoidQ9BYS1.
OMANCCEPTC.
OrthoDBEOG71P2DP.
PhylomeDBQ9BYS1.
TreeFamTF351356.

Gene expression databases

BgeeQ9BYS1.
CleanExHS_KRTAP1-5.
GenevestigatorQ9BYS1.

Family and domain databases

InterProIPR002494. Keratin-assoc.
[Graphical view]
PANTHERPTHR23262. PTHR23262. 1 hit.
PfamPF01500. Keratin_B2. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi83895.
NextBio72995.
PROQ9BYS1.
SOURCESearch...

Entry information

Entry nameKRA15_HUMAN
AccessionPrimary (citable) accession number: Q9BYS1
Secondary accession number(s): A6NJW6 expand/collapse secondary AC list , A6NLZ6, B6ZDR1, Q52LP6
Entry history
Integrated into UniProtKB/Swiss-Prot: October 25, 2004
Last sequence update: June 1, 2001
Last modified: February 19, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM