Q9BYS1 (KRA15_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Keratin-associated protein 1-5

Alternative name(s):
High sulfur keratin-associated protein 1.5
Keratin-associated protein 1.5

Gene names

Name:	KRTAP1-5
Synonyms:	KAP1.5, KRTAP1.5

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	174 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
Subunit structure	Interacts with hair keratins.
Tissue specificity	Expressed in the middle/upper portions of the hair cortex, in the region termed the keratogenous zone. Ref.1
Sequence similarities	Belongs to the KRTAP type 1 family.

Ontologies

Keywords
Cellular component	Keratin
Domain	Repeat
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	keratin filament Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 174	174	Keratin-associated protein 1-5		PRO_0000185161
Regions
	Region	3 – 172	170	15 X 5 AA repeats of C-C-[QEPVRC]-[TPIVLE]-[SRHVP]

Sequences

	Sequence		Length	Mass (Da)
	Q9BYS1 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: FD8F32C958A9B291	FASTA	174	18,010
	10 20 30 40 50 60 MTCCQTSFCG YPSFSISGTC GSSCCQPSCC ETSCCQPRSC QTSFCGFPSF STSGTCSSSC 70 80 90 100 110 120 CQPSCCETSC CQPSCCETSC CQPSCCQISS CGTGCGIGGG ISYGQEGSSG AVSTRIRWCR 130 140 150 160 170 PDSRVEGTYL PPCCVVSCTP PSCCQLHHAQ ASCCRPSYCG QSCCRPVCCC EPTC

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Characterization of a cluster of human high/ultrahigh sulfur keratin-associated protein genes embedded in the type I keratin gene domain on chromosome 17q12-21." Rogers M.A., Langbein L., Winter H., Ehmann C., Praetzel S., Korn B., Schweizer J. J. Biol. Chem. 276:19440-19451(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY. Tissue: Scalp.
[2]	"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L. , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C. Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Placenta.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ406928 mRNA. Translation: CAC27567.1. AC007455 Genomic DNA. No translation available. CH471152 Genomic DNA. Translation: EAW60697.1. BC069533 mRNA. Translation: AAH69533.1. BC093841 mRNA. Translation: AAH93841.1. BC101555 mRNA. Translation: AAI01556.1.
IPI	IPI00011211.
RefSeq	NP_114163.1. NM_031957.1.
UniGene	Hs.534499.
3D structure databases
ProteinModelPortal	Q9BYS1.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000355302.
Polymorphism databases
DMDM	56749988.
Proteomic databases
PaxDb	Q9BYS1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000361883; ENSP00000355302; ENSG00000221852. ENST00000572212; ENSP00000461651; ENSG00000261862.
GeneID	83895.
KEGG	hsa:83895.
UCSC	uc002hvu.3. human.
Organism-specific databases
CTD	83895.
GeneCards	GC17M039183.
HGNC	HGNC:16777. KRTAP1-5.
MIM	608822. gene.
neXtProt	NX_Q9BYS1.
PharmGKB	PA38417.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG261513.
HOGENOM	HOG000234033.
HOVERGEN	HBG008671.
InParanoid	Q9BYS1.
OMA	YCETSCC.
OrthoDB	EOG412M77.
PhylomeDB	Q9BYS1.
Gene expression databases
ArrayExpress	Q9BYS1.
Bgee	Q9BYS1.
CleanEx	HS_KRTAP1-5.
Genevestigator	Q9BYS1.
GermOnline	ENSG00000204888. Homo sapiens.
Family and domain databases
InterPro	IPR002494. Keratin-assoc. [Graphical view]
PANTHER	PTHR23262. PTHR23262. 1 hit.
Pfam	PF01500. Keratin_B2. 2 hits. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	83895.
NextBio	72995.
SOURCE	Search...

Entry information

Entry name

KRA15_HUMAN

Accession

Primary (citable) accession number: Q9BYS1
Secondary accession number(s): A6NJW6 , A6NLZ6, B6ZDR1, Q52LP6

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 25, 2004
Last sequence update:	June 1, 2001
Last modified:	April 3, 2013
This is version 85 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.