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Protein

Keratin-associated protein 2-4

Gene

KRTAP2-4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins (By similarity).By similarity

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-6805567 Keratinization

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin-associated protein 2-4
Alternative name(s):
High sulfur keratin-associated protein 2.4
Keratin-associated protein 2.4
Gene namesi
Name:KRTAP2-4
Synonyms:KAP2.4, KRTAP2.4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000213417.3
HGNCiHGNC:18891 KRTAP2-4
neXtProtiNX_Q9BYR9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Keratin

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000212724
ENSG00000213417
PharmGKBiPA38743

Polymorphism and mutation databases

DMDMi78100181

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001851621 – 128Keratin-associated protein 2-4Add BLAST128

Proteomic databases

PRIDEiQ9BYR9

Expressioni

Tissue specificityi

Expressed specifically in the middle/upper portions of the hair cortex, in the region termed the keratogenous zone.1 Publication

Gene expression databases

BgeeiENSG00000213417
CleanExiHS_KRTAP2-4
GenevisibleiQ9BYR9 HS

Organism-specific databases

HPAiHPA059203

Interactioni

Subunit structurei

Interacts with hair keratins.By similarity

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi124458, 10 interactors
IntActiQ9BYR9, 89 interactors

Structurei

3D structure databases

ProteinModelPortaliQ9BYR9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni5 – 11210 X 5 AA repeats of C-C-[CDPQRW]-[ADPRS]-[CIPSTV]Add BLAST108

Sequence similaritiesi

Belongs to the KRTAP type 2 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG4726 Eukaryota
ENOG410XY8D LUCA
GeneTreeiENSGT00730000110961
HOVERGENiHBG108074
InParanoidiQ9BYR9
OrthoDBiEOG091G16MC
PhylomeDBiQ9BYR9

Family and domain databases

InterProiView protein in InterPro
IPR002494 KAP
PANTHERiPTHR23262 PTHR23262, 1 hit
PfamiView protein in Pfam
PF01500 Keratin_B2, 1 hit
PF13885 Keratin_B2_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9BYR9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTGSCCGSTL SSLSYGGGCC QPCCCRDPCC CRPVTCQTTV CRPVTCVPRC
60 70 80 90 100
TRPICEPCRR PVCCDPCSLQ EGCCRPITCC PSSCTAVVCR PCCWATTCCQ
110 120
PVSVQSPCCR PPCGQPTPCS TTCRTSSC
Length:128
Mass (Da):13,480
Last modified:June 1, 2001 - v1
Checksum:i1617AA40943D90F8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ406930 mRNA Translation: CAC27569.1
BC063625 mRNA Translation: AAH63625.1
BC101147 mRNA Translation: AAI01148.1
BC101148 mRNA Translation: AAI01149.1
BC101149 mRNA Translation: AAI01150.1
CCDSiCCDS32648.1
RefSeqiNP_001158724.1, NM_001165252.1
NP_149440.1, NM_033184.3
UniGeneiHs.406714
Hs.560502

Genome annotation databases

EnsembliENST00000394015; ENSP00000377583; ENSG00000213417
ENST00000572903; ENSP00000458927; ENSG00000263091
GeneIDi730755
85294
KEGGihsa:730755
hsa:85294
UCSCiuc002hvx.4 human

Similar proteinsi

Entry informationi

Entry nameiKRA24_HUMAN
AccessioniPrimary (citable) accession number: Q9BYR9
Secondary accession number(s): Q495J2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: June 1, 2001
Last modified: January 31, 2018
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health