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Q9BYR8 (KRA31_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 84. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Keratin-associated protein 3-1
Alternative name(s):
High sulfur keratin-associated protein 3.1
Keratin-associated protein 3.1
Gene names
Name:KRTAP3-1
Synonyms:KAP3.1, KRTAP3.1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length98 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.

Subunit structure

Interacts with hair keratins.

Sequence similarities

Belongs to the KRTAP type 3 family.

Ontologies

Keywords
   Cellular componentKeratin
   DomainRepeat
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentkeratin filament

Inferred from electronic annotation. Source: InterPro

   Molecular_functionstructural molecule activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 9897Keratin-associated protein 3-1
PRO_0000185163

Regions

Repeat3 – 751
Repeat8 – 1252
Repeat47 – 5153
Repeat55 – 5954
Region3 – 59574 X 5 AA repeats of C-C-X(3)

Sequences

Sequence LengthMass (Da)Tools
Q9BYR8 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: 59934FD69880C797

FASTA9810,539
        10         20         30         40         50         60 
MYCCALRSCS VPTGPATTFC SFDKSCRCGV CLPSTCPHEI SLLQPICCDT CPPPCCKPDT 

        70         80         90 
YVPTCWLLNN CHPTPGLSGI NLTTYVQPGC ESPCEPRC 

« Hide

References

« Hide 'large scale' references
[1]"Characterization of a cluster of human high/ultrahigh sulfur keratin-associated protein genes embedded in the type I keratin gene domain on chromosome 17q12-21."
Rogers M.A., Langbein L., Winter H., Ehmann C., Praetzel S., Korn B., Schweizer J.
J. Biol. Chem. 276:19440-19451(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Scalp.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ406931 mRNA. Translation: CAC27570.1.
BC113077 mRNA. Translation: AAI13078.1.
BC113078 mRNA. Translation: AAI13079.1.
RefSeqNP_114164.1. NM_031958.1.
UniGeneHs.307027.

3D structure databases

ProteinModelPortalQ9BYR8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000375430.

Polymorphism databases

DMDM38372629.

Proteomic databases

PaxDbQ9BYR8.
PeptideAtlasQ9BYR8.
PRIDEQ9BYR8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000391588; ENSP00000375430; ENSG00000212901.
ENST00000571440; ENSP00000459883; ENSG00000262068.
GeneID83896.
KEGGhsa:83896.
UCSCuc002hvt.1. human.

Organism-specific databases

CTD83896.
GeneCardsGC17M039164.
HGNCHGNC:16778. KRTAP3-1.
neXtProtNX_Q9BYR8.
PharmGKBPA38418.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG280104.
HOGENOMHOG000230984.
HOVERGENHBG108073.
InParanoidQ9BYR8.
OMALQPTCCD.
OrthoDBEOG7S2218.
PhylomeDBQ9BYR8.
TreeFamTF338042.

Gene expression databases

BgeeQ9BYR8.
CleanExHS_KRTAP3-1.
GenevestigatorQ9BYR8.

Family and domain databases

InterProIPR007659. Keratin_matx.
[Graphical view]
PANTHERPTHR23260. PTHR23260. 1 hit.
PfamPF04579. Keratin_matx. 1 hit.
[Graphical view]
ProDomPD010562. Keratin_matx. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetSearch...

Other

GenomeRNAi83896.
NextBio72999.
PROQ9BYR8.

Entry information

Entry nameKRA31_HUMAN
AccessionPrimary (citable) accession number: Q9BYR8
Secondary accession number(s): Q14DM4
Entry history
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: June 1, 2001
Last modified: February 19, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM