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Protein

Keratin-associated protein 3-2

Gene

KRTAP3-2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin-associated protein 3-2
Alternative name(s):
High sulfur keratin-associated protein 3.2
Keratin-associated protein 3.2
Gene namesi
Name:KRTAP3-2
Synonyms:KAP3.2, KRTAP3.2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:16779. KRTAP3-2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Keratin

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38419.

Polymorphism and mutation databases

BioMutaiKRTAP3-2.
DMDMi38372628.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 9897Keratin-associated protein 3-2PRO_0000185166Add
BLAST

Proteomic databases

PaxDbiQ9BYR7.
PeptideAtlasiQ9BYR7.
PRIDEiQ9BYR7.

Expressioni

Gene expression databases

BgeeiQ9BYR7.
CleanExiHS_KRTAP3-2.
GenevisibleiQ9BYR7. HS.

Organism-specific databases

HPAiHPA042992.

Interactioni

Subunit structurei

Interacts with hair keratins.

Binary interactionsi

WithEntry#Exp.IntActNotes
Q9NWL93EBI-751260,EBI-10315054
ARFGAP1Q8N6T33EBI-751260,EBI-716933
C5orf60A6NFR6-43EBI-751260,EBI-10173955
CNNM3Q8NE01-33EBI-751260,EBI-10269984
CREB5Q02930-33EBI-751260,EBI-10192698
DHRS1Q96LJ73EBI-751260,EBI-746300
HOXA1P496395EBI-751260,EBI-740785
Hoxa1P090224EBI-751260,EBI-3957603From a different organism.
HYAL2Q128913EBI-751260,EBI-2806068
KIF25-AS1Q9Y6Z43EBI-751260,EBI-10329963
KRTAP10-5P603703EBI-751260,EBI-10172150
KRTAP12-2P599913EBI-751260,EBI-10176379
KRTAP26-1Q6PEX33EBI-751260,EBI-3957672
KRTAP9-2Q9BYQ43EBI-751260,EBI-1044640
LCE1BQ5T7P33EBI-751260,EBI-10245913
LCE2AQ5TA793EBI-751260,EBI-10246607
LCE3CQ5T5A83EBI-751260,EBI-10245291
LCE3EQ5T5B03EBI-751260,EBI-10245456
LCE4AQ5TA783EBI-751260,EBI-10246358
MAPKBP1O603363EBI-751260,EBI-947402
NTMQ9P1213EBI-751260,EBI-4315078
NUFIP2A1L3A73EBI-751260,EBI-10172018
OTX1P322423EBI-751260,EBI-740446
R3HDM2Q9Y2K5-23EBI-751260,EBI-10326419
TRIM42Q8IWZ53EBI-751260,EBI-5235829
YIPF3Q9GZM53EBI-751260,EBI-743787

Protein-protein interaction databases

BioGridi123808. 30 interactions.
IntActiQ9BYR7. 29 interactions.
MINTiMINT-1441027.
STRINGi9606.ENSP00000375429.

Structurei

3D structure databases

ProteinModelPortaliQ9BYR7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati3 – 751
Repeati47 – 5152
Repeati89 – 9353

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni3 – 59573 X 5 AA repeats of C-C-X(3)Add
BLAST

Sequence similaritiesi

Belongs to the KRTAP type 3 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG4726. Eukaryota.
ENOG410XY8D. LUCA.
GeneTreeiENSGT00390000001157.
HOGENOMiHOG000230984.
HOVERGENiHBG108073.
InParanoidiQ9BYR7.
OMAiLLEPICC.
OrthoDBiEOG7S2218.
PhylomeDBiQ9BYR7.
TreeFamiTF338042.

Family and domain databases

InterProiIPR007659. Keratin_matx.
[Graphical view]
PANTHERiPTHR23260. PTHR23260. 1 hit.
PfamiPF04579. Keratin_matx. 1 hit.
[Graphical view]
ProDomiPD010562. Keratin_matx. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9BYR7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDCCASRSCS VPTGPATTIC SSDKSCRCGV CLPSTCPHTV WLLEPICCDN
60 70 80 90
CPPPCHIPQP CVPTCFLLNS CQPTPGLETL NLTTFTQPCC EPCLPRGC
Length:98
Mass (Da):10,407
Last modified:June 1, 2001 - v1
Checksum:iC4C7C90DB6E016C7
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti8 – 81S → G.
Corresponds to variant rs9897046 [ dbSNP | Ensembl ].
VAR_053454
Natural varianti27 – 271R → C.
Corresponds to variant rs3829598 [ dbSNP | Ensembl ].
VAR_053455
Natural varianti46 – 461I → T.
Corresponds to variant rs3813050 [ dbSNP | Ensembl ].
VAR_053456

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ406932 mRNA. Translation: CAC27571.1.
BC034582 mRNA. Translation: AAH34582.1.
CCDSiCCDS32644.1.
RefSeqiNP_114165.1. NM_031959.2.
UniGeneiHs.307026.

Genome annotation databases

EnsembliENST00000391587; ENSP00000375429; ENSG00000212900.
ENST00000575409; ENSP00000459215; ENSG00000263296.
GeneIDi83897.
KEGGihsa:83897.
UCSCiuc002hvs.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ406932 mRNA. Translation: CAC27571.1.
BC034582 mRNA. Translation: AAH34582.1.
CCDSiCCDS32644.1.
RefSeqiNP_114165.1. NM_031959.2.
UniGeneiHs.307026.

3D structure databases

ProteinModelPortaliQ9BYR7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123808. 30 interactions.
IntActiQ9BYR7. 29 interactions.
MINTiMINT-1441027.
STRINGi9606.ENSP00000375429.

Polymorphism and mutation databases

BioMutaiKRTAP3-2.
DMDMi38372628.

Proteomic databases

PaxDbiQ9BYR7.
PeptideAtlasiQ9BYR7.
PRIDEiQ9BYR7.

Protocols and materials databases

DNASUi83897.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000391587; ENSP00000375429; ENSG00000212900.
ENST00000575409; ENSP00000459215; ENSG00000263296.
GeneIDi83897.
KEGGihsa:83897.
UCSCiuc002hvs.4. human.

Organism-specific databases

CTDi83897.
GeneCardsiKRTAP3-2.
HGNCiHGNC:16779. KRTAP3-2.
HPAiHPA042992.
neXtProtiNX_Q9BYR7.
PharmGKBiPA38419.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4726. Eukaryota.
ENOG410XY8D. LUCA.
GeneTreeiENSGT00390000001157.
HOGENOMiHOG000230984.
HOVERGENiHBG108073.
InParanoidiQ9BYR7.
OMAiLLEPICC.
OrthoDBiEOG7S2218.
PhylomeDBiQ9BYR7.
TreeFamiTF338042.

Miscellaneous databases

GenomeRNAii83897.
NextBioi73003.
PROiQ9BYR7.

Gene expression databases

BgeeiQ9BYR7.
CleanExiHS_KRTAP3-2.
GenevisibleiQ9BYR7. HS.

Family and domain databases

InterProiIPR007659. Keratin_matx.
[Graphical view]
PANTHERiPTHR23260. PTHR23260. 1 hit.
PfamiPF04579. Keratin_matx. 1 hit.
[Graphical view]
ProDomiPD010562. Keratin_matx. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of a cluster of human high/ultrahigh sulfur keratin-associated protein genes embedded in the type I keratin gene domain on chromosome 17q12-21."
    Rogers M.A., Langbein L., Winter H., Ehmann C., Praetzel S., Korn B., Schweizer J.
    J. Biol. Chem. 276:19440-19451(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Scalp.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Uterus.

Entry informationi

Entry nameiKRA32_HUMAN
AccessioniPrimary (citable) accession number: Q9BYR7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: June 1, 2001
Last modified: March 16, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.