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Protein

Keratin-associated protein 4-2

Gene

KRTAP4-2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin-associated protein 4-2
Alternative name(s):
Keratin-associated protein 4.2
Ultrahigh sulfur keratin-associated protein 4.2
Gene namesi
Name:KRTAP4-2
Synonyms:KAP4.2, KRTAP4.2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:18900. KRTAP4-2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Keratin

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38749.

Polymorphism and mutation databases

BioMutaiKRTAP4-2.
DMDMi296434557.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 136136Keratin-associated protein 4-2PRO_0000185170Add
BLAST

Proteomic databases

PaxDbiQ9BYR5.
PRIDEiQ9BYR5.

Expressioni

Gene expression databases

BgeeiQ9BYR5.
CleanExiHS_KRTAP4-2.
GenevisibleiQ9BYR5. HS.

Interactioni

Subunit structurei

Interacts with hair keratins.

Binary interactionsi

WithEntry#Exp.IntActNotes
Q5BKY63EBI-10172511,EBI-10243533
ADAMTSL4Q6UY14-33EBI-10172511,EBI-10173507
AMOTL2Q9Y2J4-43EBI-10172511,EBI-10187270
AQP1P299723EBI-10172511,EBI-745213
ATG9AQ7Z3C63EBI-10172511,EBI-727146
BYSLQ138953EBI-10172511,EBI-358049
CHIC2Q9UKJ53EBI-10172511,EBI-741528
CHRDQ9H2X03EBI-10172511,EBI-947551
CRCT1Q9UGL93EBI-10172511,EBI-713677
CREB5Q02930-33EBI-10172511,EBI-10192698
DLGAP2Q9P1A63EBI-10172511,EBI-1753397
DOCK2Q926083EBI-10172511,EBI-448771
FAM74A6Q5TZK33EBI-10172511,EBI-10247271
GLRX3O760033EBI-10172511,EBI-374781
HEL-S-182mPV9HW603EBI-10172511,EBI-10180762
HOXA1P496395EBI-10172511,EBI-740785
HPCAL1P372353EBI-10172511,EBI-749311
HSD3B7Q9H2F33EBI-10172511,EBI-3918847
KRTAP10-11P604123EBI-10172511,EBI-10217483
KRTAP10-5P603705EBI-10172511,EBI-10172150
KRTAP10-7P604093EBI-10172511,EBI-10172290
KRTAP10-8P604105EBI-10172511,EBI-10171774
KRTAP10-9P604115EBI-10172511,EBI-10172052
KRTAP26-1Q6PEX33EBI-10172511,EBI-3957672
KRTAP5-6Q6L8G93EBI-10172511,EBI-10250562
KRTAP5-9P263715EBI-10172511,EBI-3958099
KRTAP9-2Q9BYQ45EBI-10172511,EBI-1044640
KRTAP9-4Q9BYQ23EBI-10172511,EBI-10185730
LASP1Q148473EBI-10172511,EBI-742828
LCE1BQ5T7P33EBI-10172511,EBI-10245913
LCE2AQ5TA793EBI-10172511,EBI-10246607
LCE3CQ5T5A83EBI-10172511,EBI-10245291
LCE3EQ5T5B03EBI-10172511,EBI-10245456
LCE4AQ5TA783EBI-10172511,EBI-10246358
LNX1Q8TBB13EBI-10172511,EBI-739832
MEOX2A4D1273EBI-10172511,EBI-10172134
NLKQ9UBE83EBI-10172511,EBI-366978
NOTCH2NLQ7Z3S93EBI-10172511,EBI-945833
NR1D2Q6NSM03EBI-10172511,EBI-10250949
NUFIP2A1L3A73EBI-10172511,EBI-10172018
OTX1P322423EBI-10172511,EBI-740446
PDE9AO760833EBI-10172511,EBI-742764
PIN1Q135263EBI-10172511,EBI-714158
PLSCR1O151623EBI-10172511,EBI-740019
PRKAB2O437413EBI-10172511,EBI-1053424
PRKAG1P546193EBI-10172511,EBI-1181439
PSMA6P609003EBI-10172511,EBI-357793
PVRL3Q9NQS33EBI-10172511,EBI-2826725
RASSF5Q8WWW03EBI-10172511,EBI-367390
RGS20O760813EBI-10172511,EBI-1052678
RGS20O76081-63EBI-10172511,EBI-10178530
RYDENQ9NUL53EBI-10172511,EBI-10313866
SLC23A1Q9UHI73EBI-10172511,EBI-1759386
SLC25A10Q9UBX33EBI-10172511,EBI-750394
SPATA24Q86W543EBI-10172511,EBI-3916986
SPRY1O436093EBI-10172511,EBI-3866665
TCEANCQ8N8B73EBI-10172511,EBI-954696
TINAGL1Q9GZM7-33EBI-10172511,EBI-10303636
TRIM42A1L4B63EBI-10172511,EBI-10172216
TRIM42Q8IWZ53EBI-10172511,EBI-5235829
TXNDC5Q86UY03EBI-10172511,EBI-2825190
TYRO3Q064183EBI-10172511,EBI-3951628
WDYHV1Q96HA83EBI-10172511,EBI-741158
ZBTB24O431673EBI-10172511,EBI-744471
ZNF124Q159733EBI-10172511,EBI-2555767
ZNF20P170243EBI-10172511,EBI-717634
ZNF417Q8TAU33EBI-10172511,EBI-740727
ZNF559Q9BR843EBI-10172511,EBI-746605
ZNF581Q9P0T43EBI-10172511,EBI-745520

Protein-protein interaction databases

BioGridi124455. 72 interactions.
IntActiQ9BYR5. 69 interactions.
STRINGi9606.ENSP00000366955.

Structurei

3D structure databases

ProteinModelPortaliQ9BYR5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati5 – 951
Repeati20 – 2452
Repeati25 – 2953
Repeati30 – 3454
Repeati35 – 3955
Repeati40 – 4456
Repeati45 – 4957
Repeati50 – 5458
Repeati55 – 5959
Repeati60 – 64510
Repeati65 – 69511
Repeati70 – 74512
Repeati75 – 79513
Repeati80 – 84514
Repeati90 – 94515
Repeati95 – 99516
Repeati100 – 104517
Repeati110 – 114518
Repeati120 – 124519
Repeati125 – 129520

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni5 – 12912520 X 5 AA repeats OF C-C-[GRQVS]-[SPT]-[VSTQ]Add
BLAST

Sequence similaritiesi

Belongs to the KRTAP type 4 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG4726. Eukaryota.
ENOG410XY8D. LUCA.
GeneTreeiENSGT00810000125453.
HOGENOMiHOG000234030.
HOVERGENiHBG108074.
InParanoidiQ9BYR5.
OMAiCGEETCC.
OrthoDBiEOG71P2DP.
PhylomeDBiQ9BYR5.
TreeFamiTF351356.

Family and domain databases

InterProiIPR002494. KAP.
[Graphical view]
PANTHERiPTHR23262. PTHR23262. 1 hit.
PfamiPF13885. Keratin_B2_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9BYR5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVNSCCGSVC SDQGCGLENC CRPSCCQTTC CRTTCCRPSC CVSSCCRPQC
60 70 80 90 100
CQSVCCQPTC CSPSCCQTTC CRTTCCRPSC CVSSCFRPQC CQSVYCQPTC
110 120 130
CRPSCGQTTC CRTTCYRPSC CVSTCCRPTC SSGSCC
Length:136
Mass (Da):14,462
Last modified:May 18, 2010 - v2
Checksum:i51F82875EB25E02E
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti95 – 951Y → C.2 Publications
Corresponds to variant rs389784 [ dbSNP | Ensembl ].
VAR_060241

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ406934 mRNA. Translation: CAC27573.1.
AC006070 Genomic DNA. No translation available.
BC127252 mRNA. Translation: AAI27253.1.
CCDSiCCDS11384.1.
RefSeqiNP_149051.1. NM_033062.3.
UniGeneiHs.380165.

Genome annotation databases

EnsembliENST00000377726; ENSP00000366955; ENSG00000244537.
GeneIDi85291.
KEGGihsa:85291.
UCSCiuc002hwd.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ406934 mRNA. Translation: CAC27573.1.
AC006070 Genomic DNA. No translation available.
BC127252 mRNA. Translation: AAI27253.1.
CCDSiCCDS11384.1.
RefSeqiNP_149051.1. NM_033062.3.
UniGeneiHs.380165.

3D structure databases

ProteinModelPortaliQ9BYR5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124455. 72 interactions.
IntActiQ9BYR5. 69 interactions.
STRINGi9606.ENSP00000366955.

Polymorphism and mutation databases

BioMutaiKRTAP4-2.
DMDMi296434557.

Proteomic databases

PaxDbiQ9BYR5.
PRIDEiQ9BYR5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000377726; ENSP00000366955; ENSG00000244537.
GeneIDi85291.
KEGGihsa:85291.
UCSCiuc002hwd.3. human.

Organism-specific databases

CTDi85291.
GeneCardsiKRTAP4-2.
H-InvDBHIX0212385.
HGNCiHGNC:18900. KRTAP4-2.
neXtProtiNX_Q9BYR5.
PharmGKBiPA38749.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4726. Eukaryota.
ENOG410XY8D. LUCA.
GeneTreeiENSGT00810000125453.
HOGENOMiHOG000234030.
HOVERGENiHBG108074.
InParanoidiQ9BYR5.
OMAiCGEETCC.
OrthoDBiEOG71P2DP.
PhylomeDBiQ9BYR5.
TreeFamiTF351356.

Miscellaneous databases

GenomeRNAii85291.
PROiQ9BYR5.

Gene expression databases

BgeeiQ9BYR5.
CleanExiHS_KRTAP4-2.
GenevisibleiQ9BYR5. HS.

Family and domain databases

InterProiIPR002494. KAP.
[Graphical view]
PANTHERiPTHR23262. PTHR23262. 1 hit.
PfamiPF13885. Keratin_B2_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of a cluster of human high/ultrahigh sulfur keratin-associated protein genes embedded in the type I keratin gene domain on chromosome 17q12-21."
    Rogers M.A., Langbein L., Winter H., Ehmann C., Praetzel S., Korn B., Schweizer J.
    J. Biol. Chem. 276:19440-19451(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT CYS-95.
    Tissue: Scalp.
  2. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT CYS-95.

Entry informationi

Entry nameiKRA42_HUMAN
AccessioniPrimary (citable) accession number: Q9BYR5
Secondary accession number(s): A0JP64
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 24, 2003
Last sequence update: May 18, 2010
Last modified: June 8, 2016
This is version 97 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.