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Protein

Keratin-associated protein 4-7

Gene

KRTAP4-7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.

GO - Biological processi

  • aging Source: UniProtKB
  • hair cycle Source: UniProtKB
  • keratinization Source: Reactome

Enzyme and pathway databases

ReactomeiR-HSA-6805567. Keratinization.

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin-associated protein 4-7
Alternative name(s):
Keratin-associated protein 4.7
Ultrahigh sulfur keratin-associated protein 4.7
Gene namesi
Name:KRTAP4-7
Synonyms:KAP4.7, KRTAP4.7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:18898. KRTAP4-7.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Keratin

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38747.

Polymorphism and mutation databases

DMDMi322510047.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001851741 – 210Keratin-associated protein 4-7Add BLAST210

Proteomic databases

PeptideAtlasiQ9BYR0.
PRIDEiQ9BYR0.

Expressioni

Tissue specificityi

Expressed in the hair follicles.1 Publication

Gene expression databases

BgeeiENSG00000240871.
CleanExiHS_KRTAP4-7.
ExpressionAtlasiQ9BYR0. baseline and differential.
GenevisibleiQ9BYR0. HS.

Interactioni

Subunit structurei

Interacts with hair keratins.

Binary interactionsi

Show more details

Protein-protein interaction databases

IntActiQ9BYR0. 12 interactors.

Structurei

3D structure databases

ProteinModelPortaliQ9BYR0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati5 – 915
Repeati24 – 2825
Repeati29 – 3335
Repeati34 – 3845
Repeati44 – 4855
Repeati49 – 5365
Repeati54 – 5875
Repeati59 – 6385
Repeati64 – 6895
Repeati69 – 73105
Repeati74 – 78115
Repeati79 – 83125
Repeati84 – 88135
Repeati89 – 93145
Repeati94 – 98155
Repeati99 – 103165
Repeati104 – 108175
Repeati109 – 113185
Repeati114 – 118195
Repeati119 – 123205
Repeati124 – 128215
Repeati129 – 133225
Repeati134 – 138235
Repeati139 – 143245
Repeati144 – 148255
Repeati149 – 153265
Repeati154 – 158275
Repeati159 – 163285
Repeati164 – 168295
Repeati169 – 173305
Repeati174 – 178315

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni5 – 17831 X 5 AA repeats of C-C-[GIKRQVHEML]-[SPTRV]-[STVQRCP]Add BLAST174

Sequence similaritiesi

Belongs to the KRTAP type 4 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

HOGENOMiHOG000234030.
InParanoidiQ9BYR0.
TreeFamiTF351356.

Family and domain databases

InterProiView protein in InterPro
IPR002494. KAP.
PANTHERiPTHR23262. PTHR23262. 1 hit.
PfamiView protein in Pfam
PF13885. Keratin_B2_2. 2 hits.

Sequencei

Sequence statusi: Complete.

Q9BYR0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVSSCCGSVC SDQGCSQDLC QETCCRPSCC QTTCCRTTCY RPSCCVSSCC
60 70 80 90 100
RPQCCQSVCC QPTCCRPTCC ETTCCHPRCC ISSCCRPSCC MSSCCKPQCC
110 120 130 140 150
QSVCCQPTCC HPSCCISSCC RPSCCVSRCC RPQCCQSVCC QPTCCRPSCC
160 170 180 190 200
ISSCCRPSCC ESSCCRPSCC RPCCCLRPVC GRVSCHTTCY RPTCVISTCP
210
RPLCCASSCC
Length:210
Mass (Da):22,535
Last modified:February 8, 2011 - v2
Checksum:iE203C21460E4C785
GO

Polymorphismi

Numerous size polymorphism are present in KRTAP4 gene family, which are mainly due to variations in the sequence encoding cysteine-rich repeat segments (PubMed:15955084).1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06445916S → G3 Publications1
Natural variantiVAR_06446018D → V3 Publications1
Natural variantiVAR_06446168T → S3 Publications1
Natural variantiVAR_064462111 – 165Missing 1 PublicationAdd BLAST55
Natural variantiVAR_064463144 – 165Missing 1 PublicationAdd BLAST22
Natural variantiVAR_064464168S → C2 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ406939 mRNA. Translation: CAC27578.1.
AC100808 Genomic DNA. No translation available.
BC126421 mRNA. Translation: AAI26422.1.
BC126423 mRNA. Translation: AAI26424.1.
RefSeqiXP_003846526.1. XM_003846478.1.

Genome annotation databases

EnsembliENST00000391417; ENSP00000375236; ENSG00000240871.
GeneIDi100996750.
KEGGihsa:100996750.
UCSCiuc010wfn.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiKRA47_HUMAN
AccessioniPrimary (citable) accession number: Q9BYR0
Secondary accession number(s): A0AVM6, A8MQ08, A8MTL4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2003
Last sequence update: February 8, 2011
Last modified: March 15, 2017
This is version 107 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families