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Protein

Keratin-associated protein 4-7

Gene

KRTAP4-7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.

GO - Biological processi

  • aging Source: UniProtKB
  • hair cycle Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin-associated protein 4-7
Alternative name(s):
Keratin-associated protein 4.7
Ultrahigh sulfur keratin-associated protein 4.7
Gene namesi
Name:KRTAP4-7
Synonyms:KAP4.7, KRTAP4.7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:18898. KRTAP4-7.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Keratin

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38747.

Polymorphism and mutation databases

DMDMi322510047.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 210210Keratin-associated protein 4-7PRO_0000185174Add
BLAST

Proteomic databases

PeptideAtlasiQ9BYR0.
PRIDEiQ9BYR0.

Expressioni

Tissue specificityi

Expressed in the hair follicles.1 Publication

Gene expression databases

BgeeiENSG00000240871.
CleanExiHS_KRTAP4-7.
ExpressionAtlasiQ9BYR0. baseline and differential.
GenevisibleiQ9BYR0. HS.

Interactioni

Subunit structurei

Interacts with hair keratins.

Binary interactionsi

WithEntry#Exp.IntActNotes
CATSPER1Q8NEC53EBI-10302547,EBI-744545
FAM76BQ5HYJ33EBI-10302547,EBI-751192
GLRX3O760033EBI-10302547,EBI-374781
HOXA1P496393EBI-10302547,EBI-740785
KRTAP10-8P604103EBI-10302547,EBI-10171774
KRTAP26-1Q6PEX33EBI-10302547,EBI-3957672
KRTAP9-2Q9BYQ43EBI-10302547,EBI-1044640
MEOX2A4D1273EBI-10302547,EBI-10172134
NOTCH2NLQ7Z3S93EBI-10302547,EBI-945833
OTX1P322423EBI-10302547,EBI-740446
SMCPP499013EBI-10302547,EBI-750494
SPRY2O435973EBI-10302547,EBI-742487

Protein-protein interaction databases

IntActiQ9BYR0. 12 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ9BYR0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati5 – 951
Repeati24 – 2852
Repeati29 – 3353
Repeati34 – 3854
Repeati44 – 4855
Repeati49 – 5356
Repeati54 – 5857
Repeati59 – 6358
Repeati64 – 6859
Repeati69 – 73510
Repeati74 – 78511
Repeati79 – 83512
Repeati84 – 88513
Repeati89 – 93514
Repeati94 – 98515
Repeati99 – 103516
Repeati104 – 108517
Repeati109 – 113518
Repeati114 – 118519
Repeati119 – 123520
Repeati124 – 128521
Repeati129 – 133522
Repeati134 – 138523
Repeati139 – 143524
Repeati144 – 148525
Repeati149 – 153526
Repeati154 – 158527
Repeati159 – 163528
Repeati164 – 168529
Repeati169 – 173530
Repeati174 – 178531

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni5 – 17817431 X 5 AA repeats of C-C-[GIKRQVHEML]-[SPTRV]-[STVQRCP]Add
BLAST

Sequence similaritiesi

Belongs to the KRTAP type 4 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

HOGENOMiHOG000234030.
InParanoidiQ9BYR0.
TreeFamiTF351356.

Family and domain databases

InterProiIPR002494. KAP.
[Graphical view]
PANTHERiPTHR23262. PTHR23262. 1 hit.
PfamiPF13885. Keratin_B2_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9BYR0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVSSCCGSVC SDQGCSQDLC QETCCRPSCC QTTCCRTTCY RPSCCVSSCC
60 70 80 90 100
RPQCCQSVCC QPTCCRPTCC ETTCCHPRCC ISSCCRPSCC MSSCCKPQCC
110 120 130 140 150
QSVCCQPTCC HPSCCISSCC RPSCCVSRCC RPQCCQSVCC QPTCCRPSCC
160 170 180 190 200
ISSCCRPSCC ESSCCRPSCC RPCCCLRPVC GRVSCHTTCY RPTCVISTCP
210
RPLCCASSCC
Length:210
Mass (Da):22,535
Last modified:February 8, 2011 - v2
Checksum:iE203C21460E4C785
GO

Polymorphismi

Numerous size polymorphism are present in KRTAP4 gene family, which are mainly due to variations in the sequence encoding cysteine-rich repeat segments (PubMed:15955084).1 Publication

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti16 – 161S → G.3 Publications
VAR_064459
Natural varianti18 – 181D → V.3 Publications
VAR_064460
Natural varianti68 – 681T → S.3 Publications
VAR_064461
Natural varianti111 – 16555Missing .1 Publication
VAR_064462Add
BLAST
Natural varianti144 – 16522Missing .1 Publication
VAR_064463Add
BLAST
Natural varianti168 – 1681S → C.2 Publications
VAR_064464

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ406939 mRNA. Translation: CAC27578.1.
AC100808 Genomic DNA. No translation available.
BC126421 mRNA. Translation: AAI26422.1.
BC126423 mRNA. Translation: AAI26424.1.
RefSeqiXP_003846526.1. XM_003846478.1.

Genome annotation databases

EnsembliENST00000391417; ENSP00000375236; ENSG00000240871.
GeneIDi100996750.
KEGGihsa:100996750.
UCSCiuc010wfn.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ406939 mRNA. Translation: CAC27578.1.
AC100808 Genomic DNA. No translation available.
BC126421 mRNA. Translation: AAI26422.1.
BC126423 mRNA. Translation: AAI26424.1.
RefSeqiXP_003846526.1. XM_003846478.1.

3D structure databases

ProteinModelPortaliQ9BYR0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9BYR0. 12 interactions.

Polymorphism and mutation databases

DMDMi322510047.

Proteomic databases

PeptideAtlasiQ9BYR0.
PRIDEiQ9BYR0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000391417; ENSP00000375236; ENSG00000240871.
GeneIDi100996750.
KEGGihsa:100996750.
UCSCiuc010wfn.3. human.

Organism-specific databases

GeneCardsiKRTAP4-7.
H-InvDBHIX0212283.
HGNCiHGNC:18898. KRTAP4-7.
neXtProtiNX_Q9BYR0.
PharmGKBiPA38747.
GenAtlasiSearch...

Phylogenomic databases

HOGENOMiHOG000234030.
InParanoidiQ9BYR0.
TreeFamiTF351356.

Miscellaneous databases

PROiQ9BYR0.

Gene expression databases

BgeeiENSG00000240871.
CleanExiHS_KRTAP4-7.
ExpressionAtlasiQ9BYR0. baseline and differential.
GenevisibleiQ9BYR0. HS.

Family and domain databases

InterProiIPR002494. KAP.
[Graphical view]
PANTHERiPTHR23262. PTHR23262. 1 hit.
PfamiPF13885. Keratin_B2_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKRA47_HUMAN
AccessioniPrimary (citable) accession number: Q9BYR0
Secondary accession number(s): A0AVM6, A8MQ08, A8MTL4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2003
Last sequence update: February 8, 2011
Last modified: September 7, 2016
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.