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Protein

Keratin-associated protein 9-2

Gene

KRTAP9-2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin-associated protein 9-2
Alternative name(s):
Keratin-associated protein 9.2
Ultrahigh sulfur keratin-associated protein 9.2
Gene namesi
Name:KRTAP9-2
Synonyms:KAP9.2, KRTAP9.2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:16926. KRTAP9-2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Keratin

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38424.

Polymorphism and mutation databases

BioMutaiKRTAP9-2.
DMDMi209572642.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 174174Keratin-associated protein 9-2PRO_0000185188Add
BLAST

Proteomic databases

PaxDbiQ9BYQ4.
PeptideAtlasiQ9BYQ4.
PRIDEiQ9BYQ4.

PTM databases

iPTMnetiQ9BYQ4.
PhosphoSiteiQ9BYQ4.

Expressioni

Gene expression databases

CleanExiHS_KRTAP9-2.
GenevisibleiQ9BYQ4. HS.

Interactioni

Subunit structurei

Interacts with hair keratins.

Binary interactionsi

WithEntry#Exp.IntActNotes
G2XKQ03EBI-1044640,EBI-10175576
ADAMTSL4Q6UY14-33EBI-1044640,EBI-10173507
AQP1P299723EBI-1044640,EBI-745213
ARFGAP1Q8N6T33EBI-1044640,EBI-716933
CATSPER1Q8NEC55EBI-1044640,EBI-744545
CCDC28AQ8IWP93EBI-1044640,EBI-355471
CHRDQ9H2X03EBI-1044640,EBI-947551
COL8A1P276583EBI-1044640,EBI-747133
CREB5Q02930-35EBI-1044640,EBI-10192698
DOCK2Q926083EBI-1044640,EBI-448771
FAM76BQ5HYJ33EBI-1044640,EBI-751192
GATA1P159763EBI-1044640,EBI-3909284
GLRX3O760033EBI-1044640,EBI-374781
GNEQ9Y2233EBI-1044640,EBI-4291090
HOXA1P496395EBI-1044640,EBI-740785
JOSD1Q150403EBI-1044640,EBI-2510602
KRTAP10-11P604123EBI-1044640,EBI-10217483
KRTAP10-5P603705EBI-1044640,EBI-10172150
KRTAP10-7P604093EBI-1044640,EBI-10172290
KRTAP10-8P604103EBI-1044640,EBI-10171774
KRTAP10-9P604116EBI-1044640,EBI-10172052
KRTAP26-1Q6PEX33EBI-1044640,EBI-3957672
KRTAP3-2Q9BYR73EBI-1044640,EBI-751260
KRTAP4-12Q9BQ663EBI-1044640,EBI-739863
KRTAP4-2Q9BYR55EBI-1044640,EBI-10172511
KRTAP4-7Q9BYR03EBI-1044640,EBI-10302547
KRTAP5-6Q6L8G93EBI-1044640,EBI-10250562
KRTAP5-9P263713EBI-1044640,EBI-3958099
KRTAP9-4Q9BYQ23EBI-1044640,EBI-10185730
LCE1BQ5T7P33EBI-1044640,EBI-10245913
LCE2AQ5TA793EBI-1044640,EBI-10246607
LCE3EQ5T5B03EBI-1044640,EBI-10245456
LCE4AQ5TA783EBI-1044640,EBI-10246358
LNX1Q8TBB13EBI-1044640,EBI-739832
MAPKBP1O603363EBI-1044640,EBI-947402
MEOX2A4D1273EBI-1044640,EBI-10172134
NOTCH2NLQ7Z3S93EBI-1044640,EBI-945833
NUFIP2A1L3A73EBI-1044640,EBI-10172018
OTX1P322423EBI-1044640,EBI-740446
PDE9AO760833EBI-1044640,EBI-742764
PLSCR1O151623EBI-1044640,EBI-740019
PRKAB2O437413EBI-1044640,EBI-1053424
PTPMT1Q8WUK03EBI-1044640,EBI-7199479
RCHY1Q96PM53EBI-1044640,EBI-947779
RNF31Q96EP0-33EBI-1044640,EBI-10225152
RYDENQ9NUL53EBI-1044640,EBI-10313866
SMCPP499013EBI-1044640,EBI-750494
SPATA8Q6RVD63EBI-1044640,EBI-8635958
SPRY2O435973EBI-1044640,EBI-742487
TMSB10P633133EBI-1044640,EBI-2688673
WDYHV1Q96HA83EBI-1044640,EBI-741158

Protein-protein interaction databases

BioGridi123810. 57 interactions.
IntActiQ9BYQ4. 52 interactions.
STRINGi9606.ENSP00000366950.

Structurei

3D structure databases

ProteinModelPortaliQ9BYQ4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati8 – 1251
Repeati13 – 1752
Repeati18 – 2253
Repeati37 – 4154
Repeati42 – 4655
Repeati51 – 5556
Repeati61 – 6557
Repeati66 – 7058
Repeati75 – 7959
Repeati80 – 84510
Repeati85 – 89511
Repeati90 – 94512
Repeati95 – 99513
Repeati144 – 148514
Repeati149 – 153515
Repeati154 – 158516
Repeati168 – 172517

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni8 – 17216517 X 5 AA repeats of C-C-[RQVSGE]-[SPTQ]-[TASP]Add
BLAST

Sequence similaritiesi

Belongs to the KRTAP type 9 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410JE2D. Eukaryota.
ENOG41118YY. LUCA.
GeneTreeiENSGT00810000125514.
HOGENOMiHOG000234030.
InParanoidiQ9BYQ4.
OMAiDPCCVTR.
PhylomeDBiQ9BYQ4.
TreeFamiTF351356.

Family and domain databases

InterProiIPR002494. KAP.
[Graphical view]
PANTHERiPTHR23262. PTHR23262. 1 hit.
PfamiPF13885. Keratin_B2_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9BYQ4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTHCCSPCCQ PTCCRTTCCR TTCWKPTTVT TCSSTPCCQP ACCVSSCCQP
60 70 80 90 100
CCRPTCCQNT CCRTTCCQPT CVTSCCQPSC CSTPCCQPTC CGSSCCGQTS
110 120 130 140 150
CGSSCGQSSS CAPVYCRRTC YYPTTVCLPG CLNQSCGSNC CQPCCRPACC
160 170
ETTCCRTTCF QPTCVSSCCQ PSCC
Length:174
Mass (Da):18,287
Last modified:October 14, 2008 - v2
Checksum:i8E5A1D598966FE3C
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti36 – 361P → S.2 Publications
Corresponds to variant rs9903833 [ dbSNP | Ensembl ].
VAR_046702
Natural varianti56 – 561C → S.2 Publications
Corresponds to variant rs9902235 [ dbSNP | Ensembl ].
VAR_046703

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ406946 mRNA. Translation: CAC27585.1.
CH471152 Genomic DNA. Translation: EAW60718.1.
BC069560 mRNA. Translation: AAH69560.1.
BC110619 mRNA. Translation: AAI10620.1.
BC117287 mRNA. Translation: AAI17288.1.
CCDSiCCDS32651.1.
RefSeqiNP_114167.2. NM_031961.2.
UniGeneiHs.307013.

Genome annotation databases

EnsembliENST00000377721; ENSP00000366950; ENSG00000239886.
ENST00000572513; ENSP00000458594; ENSG00000263090.
GeneIDi83899.
KEGGihsa:83899.
UCSCiuc002hwf.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ406946 mRNA. Translation: CAC27585.1.
CH471152 Genomic DNA. Translation: EAW60718.1.
BC069560 mRNA. Translation: AAH69560.1.
BC110619 mRNA. Translation: AAI10620.1.
BC117287 mRNA. Translation: AAI17288.1.
CCDSiCCDS32651.1.
RefSeqiNP_114167.2. NM_031961.2.
UniGeneiHs.307013.

3D structure databases

ProteinModelPortaliQ9BYQ4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123810. 57 interactions.
IntActiQ9BYQ4. 52 interactions.
STRINGi9606.ENSP00000366950.

PTM databases

iPTMnetiQ9BYQ4.
PhosphoSiteiQ9BYQ4.

Polymorphism and mutation databases

BioMutaiKRTAP9-2.
DMDMi209572642.

Proteomic databases

PaxDbiQ9BYQ4.
PeptideAtlasiQ9BYQ4.
PRIDEiQ9BYQ4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000377721; ENSP00000366950; ENSG00000239886.
ENST00000572513; ENSP00000458594; ENSG00000263090.
GeneIDi83899.
KEGGihsa:83899.
UCSCiuc002hwf.3. human.

Organism-specific databases

CTDi83899.
GeneCardsiKRTAP9-2.
H-InvDBHIX0135347.
HGNCiHGNC:16926. KRTAP9-2.
neXtProtiNX_Q9BYQ4.
PharmGKBiPA38424.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JE2D. Eukaryota.
ENOG41118YY. LUCA.
GeneTreeiENSGT00810000125514.
HOGENOMiHOG000234030.
InParanoidiQ9BYQ4.
OMAiDPCCVTR.
PhylomeDBiQ9BYQ4.
TreeFamiTF351356.

Miscellaneous databases

GenomeRNAii83899.
PROiQ9BYQ4.

Gene expression databases

CleanExiHS_KRTAP9-2.
GenevisibleiQ9BYQ4. HS.

Family and domain databases

InterProiIPR002494. KAP.
[Graphical view]
PANTHERiPTHR23262. PTHR23262. 1 hit.
PfamiPF13885. Keratin_B2_2. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKRA92_HUMAN
AccessioniPrimary (citable) accession number: Q9BYQ4
Secondary accession number(s): Q17RK8, Q2TB15, Q6ISF6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 14, 2003
Last sequence update: October 14, 2008
Last modified: September 7, 2016
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.