Q9BYQ4 (KRA92_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Keratin-associated protein 9-2

Alternative name(s):
Keratin-associated protein 9.2
Ultrahigh sulfur keratin-associated protein 9.2

Gene names

Name:	KRTAP9-2
Synonyms:	KAP9.2, KRTAP9.2

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	174 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
Subunit structure	Interacts with hair keratins.
Sequence similarities	Belongs to the KRTAP type 9 family.

Ontologies

Keywords
Cellular component	Keratin
Coding sequence diversity	Polymorphism
Domain	Repeat
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	keratin filament Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
CDC20	Q12834	1	EBI-1044640,EBI-367462

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 174	174	Keratin-associated protein 9-2		PRO_0000185188
Regions
	Repeat	8 – 12	5	1
	Repeat	13 – 17	5	2
	Repeat	18 – 22	5	3
	Repeat	37 – 41	5	4
	Repeat	42 – 46	5	5
	Repeat	51 – 55	5	6
	Repeat	61 – 65	5	7
	Repeat	66 – 70	5	8
	Repeat	75 – 79	5	9
	Repeat	80 – 84	5	10
	Repeat	85 – 89	5	11
	Repeat	90 – 94	5	12
	Repeat	95 – 99	5	13
	Repeat	144 – 148	5	14
	Repeat	149 – 153	5	15
	Repeat	154 – 158	5	16
	Repeat	168 – 172	5	17
	Region	8 – 172	165	17 X 5 AA repeats of C-C-[RQVSGE]-[SPTQ]-[TASP]
Natural variations
	Natural variant	36	1	P → S. Ref.1 Ref.3 Corresponds to variant rs9903833 [ dbSNP | Ensembl ].		VAR_046702
	Natural variant	56	1	C → S. Ref.1 Ref.3 Corresponds to variant rs9902235 [ dbSNP | Ensembl ].		VAR_046703

Sequences

	Sequence		Length	Mass (Da)
	Q9BYQ4 [UniParc]. Last modified October 14, 2008. Version 2. Checksum: 8E5A1D598966FE3C	FASTA	174	18,287
	10 20 30 40 50 60 MTHCCSPCCQ PTCCRTTCCR TTCWKPTTVT TCSSTPCCQP ACCVSSCCQP CCRPTCCQNT 70 80 90 100 110 120 CCRTTCCQPT CVTSCCQPSC CSTPCCQPTC CGSSCCGQTS CGSSCGQSSS CAPVYCRRTC 130 140 150 160 170 YYPTTVCLPG CLNQSCGSNC CQPCCRPACC ETTCCRTTCF QPTCVSSCCQ PSCC

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Characterization of a cluster of human high/ultrahigh sulfur keratin-associated protein genes embedded in the type I keratin gene domain on chromosome 17q12-21." Rogers M.A., Langbein L., Winter H., Ehmann C., Praetzel S., Korn B., Schweizer J. J. Biol. Chem. 276:19440-19451(2001) [PubMed: 11279113] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS SER-36 AND SER-56. Tissue: Scalp.
[2]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS SER-36 AND SER-56.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ406946 mRNA. Translation: CAC27585.1. CH471152 Genomic DNA. Translation: EAW60718.1. BC110619 mRNA. Translation: AAI10620.1. BC117287 mRNA. Translation: AAI17288.1.
IPI	IPI00260816.
RefSeq	NP_114167.2. NM_031961.2.
UniGene	Hs.307013.
3D structure databases
ProteinModelPortal	Q9BYQ4.
ModBase	Search...
Polymorphism databases
DMDM	209572642.
Proteomic databases
PRIDE	Q9BYQ4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000377721; ENSP00000366950; ENSG00000239886.
GeneID	83899.
KEGG	hsa:83899.
Organism-specific databases
CTD	83899.
GeneCards	GC17P039383.
H-InvDB	HIX0135347.
HGNC	HGNC:16926. KRTAP9-2.
neXtProt	NX_Q9BYQ4.
GenAtlas	Search...
Phylogenomic databases
eggNOG	maNOG21003.
GeneTree	ENSGT00590000082724.
InParanoid	Q9BYQ4.
OrthoDB	EOG4MKNJ2.
Gene expression databases
ArrayExpress	Q9BYQ4.
Bgee	Q9BYQ4.
CleanEx	HS_KRTAP9-2.
Genevestigator	Q9BYQ4.
GermOnline	ENSG00000204875. Homo sapiens.
Family and domain databases
InterPro	IPR002494. Keratin_B2. [Graphical view]
PANTHER	PTHR23262. Keratin_B2. 1 hit.
ProtoNet	Search...
Other
NextBio	73015.

Entry information

Entry name

KRA92_HUMAN

Accession

Primary (citable) accession number: Q9BYQ4
Secondary accession number(s): Q17RK8, Q2TB15

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 14, 2003
Last sequence update:	October 14, 2008
Last modified:	January 25, 2012
This is version 70 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.