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Protein

Keratin-associated protein 9-3

Gene

KRTAP9-3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin-associated protein 9-3
Alternative name(s):
Keratin-associated protein 9.3
Ultrahigh sulfur keratin-associated protein 9.3
Gene namesi
Name:KRTAP9-3
Synonyms:KAP9.3, KRTAP9.3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:16927. KRTAP9-3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Keratin

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38425.

Polymorphism and mutation databases

BioMutaiKRTAP9-3.
DMDMi38372388.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 159159Keratin-associated protein 9-3PRO_0000185189Add
BLAST

Proteomic databases

PaxDbiQ9BYQ3.
PRIDEiQ9BYQ3.

Expressioni

Gene expression databases

BgeeiQ9BYQ3.
CleanExiHS_KRTAP9-3.
GenevisibleiQ9BYQ3. HS.

Organism-specific databases

HPAiHPA042482.

Interactioni

Subunit structurei

Interacts with hair keratins.

Protein-protein interaction databases

BioGridi123811. 2 interactions.
STRINGi9606.ENSP00000392189.

Structurei

3D structure databases

ProteinModelPortaliQ9BYQ3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati8 – 1251
Repeati13 – 1752
Repeati32 – 3653
Repeati37 – 4154
Repeati46 – 5055
Repeati51 – 5556
Repeati56 – 6057
Repeati61 – 6558
Repeati70 – 7459
Repeati75 – 79510
Repeati80 – 84511
Repeati85 – 89512
Repeati129 – 133513
Repeati134 – 138514
Repeati139 – 143515
Repeati153 – 157516

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni8 – 15715016 X 5 AA repeats of C-C-[RQVSHE]-[SPTN]-[TASPI]Add
BLAST

Sequence similaritiesi

Belongs to the KRTAP type 9 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410JE2D. Eukaryota.
ENOG41118YY. LUCA.
GeneTreeiENSGT00810000125514.
HOGENOMiHOG000234030.
HOVERGENiHBG096080.
InParanoidiQ9BYQ3.
OMAiACRETTC.
OrthoDBiEOG7WMCNT.
PhylomeDBiQ9BYQ3.
TreeFamiTF351356.

Family and domain databases

InterProiIPR002494. KAP.
[Graphical view]
PANTHERiPTHR23262. PTHR23262. 1 hit.
PfamiPF13885. Keratin_B2_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9BYQ3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTHCCSPCCQ PTCCRTTCWQ PTTVTTCSST PCCQPSCCVS SCCQPCCHPT
60 70 80 90 100
CCQNTCCRTT CCQPICVTSC CQPSCCSTPC CQPTCCGSSC GQSSSCAPVY
110 120 130 140 150
CRRTCYHPTS VCLPGCLNQS CGSNCCQPCC RPACCETTCC RTTCFQPTCV

YSCCQPSCC
Length:159
Mass (Da):16,854
Last modified:June 1, 2001 - v1
Checksum:i375CC1E52EECDE68
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ406947 mRNA. Translation: CAC27586.1.
BC074918 mRNA. Translation: AAH74918.1.
BC074919 mRNA. Translation: AAH74919.1.
CCDSiCCDS11385.1.
RefSeqiNP_114168.1. NM_031962.2.
UniGeneiHs.307012.

Genome annotation databases

EnsembliENST00000411528; ENSP00000392189; ENSG00000204873.
ENST00000571096; ENSP00000458819; ENSG00000262749.
GeneIDi83900.
KEGGihsa:83900.
UCSCiuc021txg.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ406947 mRNA. Translation: CAC27586.1.
BC074918 mRNA. Translation: AAH74918.1.
BC074919 mRNA. Translation: AAH74919.1.
CCDSiCCDS11385.1.
RefSeqiNP_114168.1. NM_031962.2.
UniGeneiHs.307012.

3D structure databases

ProteinModelPortaliQ9BYQ3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123811. 2 interactions.
STRINGi9606.ENSP00000392189.

Polymorphism and mutation databases

BioMutaiKRTAP9-3.
DMDMi38372388.

Proteomic databases

PaxDbiQ9BYQ3.
PRIDEiQ9BYQ3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000411528; ENSP00000392189; ENSG00000204873.
ENST00000571096; ENSP00000458819; ENSG00000262749.
GeneIDi83900.
KEGGihsa:83900.
UCSCiuc021txg.1. human.

Organism-specific databases

CTDi83900.
GeneCardsiKRTAP9-3.
HGNCiHGNC:16927. KRTAP9-3.
HPAiHPA042482.
neXtProtiNX_Q9BYQ3.
PharmGKBiPA38425.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JE2D. Eukaryota.
ENOG41118YY. LUCA.
GeneTreeiENSGT00810000125514.
HOGENOMiHOG000234030.
HOVERGENiHBG096080.
InParanoidiQ9BYQ3.
OMAiACRETTC.
OrthoDBiEOG7WMCNT.
PhylomeDBiQ9BYQ3.
TreeFamiTF351356.

Miscellaneous databases

GenomeRNAii83900.
NextBioi73019.
PROiQ9BYQ3.

Gene expression databases

BgeeiQ9BYQ3.
CleanExiHS_KRTAP9-3.
GenevisibleiQ9BYQ3. HS.

Family and domain databases

InterProiIPR002494. KAP.
[Graphical view]
PANTHERiPTHR23262. PTHR23262. 1 hit.
PfamiPF13885. Keratin_B2_2. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of a cluster of human high/ultrahigh sulfur keratin-associated protein genes embedded in the type I keratin gene domain on chromosome 17q12-21."
    Rogers M.A., Langbein L., Winter H., Ehmann C., Praetzel S., Korn B., Schweizer J.
    J. Biol. Chem. 276:19440-19451(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Scalp.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiKRA93_HUMAN
AccessioniPrimary (citable) accession number: Q9BYQ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 14, 2003
Last sequence update: June 1, 2001
Last modified: May 11, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.