Q9BYQ3 (KRA93_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Keratin-associated protein 9-3

Alternative name(s):
Keratin-associated protein 9.3
Ultrahigh sulfur keratin-associated protein 9.3

Gene names

Name:	KRTAP9-3
Synonyms:	KAP9.3, KRTAP9.3

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	159 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
Subunit structure	Interacts with hair keratins.
Sequence similarities	Belongs to the KRTAP type 9 family.

Ontologies

Keywords
Cellular component	Keratin
Domain	Repeat
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	keratin filament Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
CDC20	Q12834	1	EBI-1043191,EBI-367462

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 159	159	Keratin-associated protein 9-3		PRO_0000185189
Regions
	Repeat	8 – 12	5	1
	Repeat	13 – 17	5	2
	Repeat	32 – 36	5	3
	Repeat	37 – 41	5	4
	Repeat	46 – 50	5	5
	Repeat	51 – 55	5	6
	Repeat	56 – 60	5	7
	Repeat	61 – 65	5	8
	Repeat	70 – 74	5	9
	Repeat	75 – 79	5	10
	Repeat	80 – 84	5	11
	Repeat	85 – 89	5	12
	Repeat	129 – 133	5	13
	Repeat	134 – 138	5	14
	Repeat	139 – 143	5	15
	Repeat	153 – 157	5	16
	Region	8 – 157	150	16 X 5 AA repeats of C-C-[RQVSHE]-[SPTN]-[TASPI]

Sequences

	Sequence		Length	Mass (Da)
	Q9BYQ3 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: 375CC1E52EECDE68	FASTA	159	16,854
	10 20 30 40 50 60 MTHCCSPCCQ PTCCRTTCWQ PTTVTTCSST PCCQPSCCVS SCCQPCCHPT CCQNTCCRTT 70 80 90 100 110 120 CCQPICVTSC CQPSCCSTPC CQPTCCGSSC GQSSSCAPVY CRRTCYHPTS VCLPGCLNQS 130 140 150 CGSNCCQPCC RPACCETTCC RTTCFQPTCV YSCCQPSCC

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Characterization of a cluster of human high/ultrahigh sulfur keratin-associated protein genes embedded in the type I keratin gene domain on chromosome 17q12-21." Rogers M.A., Langbein L., Winter H., Ehmann C., Praetzel S., Korn B., Schweizer J. J. Biol. Chem. 276:19440-19451(2001) [PubMed: 11279113] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Scalp.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ406947 mRNA. Translation: CAC27586.1. BC074918 mRNA. Translation: AAH74918.1. BC074919 mRNA. Translation: AAH74919.1.
IPI	IPI00011222.
RefSeq	NP_114168.1. NM_031962.2.
UniGene	Hs.307012.
3D structure databases
ProteinModelPortal	Q9BYQ3.
ModBase	Search...
Protein-protein interaction databases
STRING	Q9BYQ3.
Polymorphism databases
DMDM	38372388.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000377719; ENSP00000366948; ENSG00000204873.
GeneID	83900.
KEGG	hsa:83900.
UCSC	uc002hwg.2. human.
Organism-specific databases
CTD	83900.
GeneCards	GC17P039388.
H-InvDB	HIX0039109.
HGNC	HGNC:16927. KRTAP9-3.
neXtProt	NX_Q9BYQ3.
PharmGKB	PA38425.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG21848.
GeneTree	ENSGT00590000082724.
HOVERGEN	HBG096080.
InParanoid	Q9BYQ3.
OMA	QPTCVYS.
OrthoDB	EOG4MKNJ2.
PhylomeDB	Q9BYQ3.
Gene expression databases
ArrayExpress	Q9BYQ3.
Bgee	Q9BYQ3.
CleanEx	HS_KRTAP9-3.
Genevestigator	Q9BYQ3.
GermOnline	ENSG00000204873. Homo sapiens.
Family and domain databases
InterPro	IPR002494. Keratin_B2. [Graphical view]
PANTHER	PTHR23262. Keratin_B2. 1 hit.
ProtoNet	Search...
Other
NextBio	73019.

Entry information

Entry name

KRA93_HUMAN

Accession

Primary (citable) accession number: Q9BYQ3

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 14, 2003
Last sequence update:	June 1, 2001
Last modified:	December 14, 2011
This is version 65 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.