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Protein

Keratin-associated protein 9-3

Gene

KRTAP9-3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000180453-MONOMER.
ReactomeiR-HSA-6805567. Keratinization.

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin-associated protein 9-3
Alternative name(s):
Keratin-associated protein 9.3
Ultrahigh sulfur keratin-associated protein 9.3
Gene namesi
Name:KRTAP9-3
Synonyms:KAP9.3, KRTAP9.3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:16927. KRTAP9-3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Keratin

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000204873.
ENSG00000262749.
PharmGKBiPA38425.

Polymorphism and mutation databases

BioMutaiKRTAP9-3.
DMDMi38372388.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001851891 – 159Keratin-associated protein 9-3Add BLAST159

Proteomic databases

PaxDbiQ9BYQ3.
PeptideAtlasiQ9BYQ3.
PRIDEiQ9BYQ3.

Expressioni

Gene expression databases

BgeeiENSG00000204873.
CleanExiHS_KRTAP9-3.
GenevisibleiQ9BYQ3. HS.

Interactioni

Subunit structurei

Interacts with hair keratins.

Binary interactionsi

WithEntry#Exp.IntActNotes
CATSPER1Q8NEC54EBI-1043191,EBI-744545
CRCT1Q9UGL94EBI-1043191,EBI-713677
CYSRT1B8A4K44EBI-1043191,EBI-11741341
HOXA1P496394EBI-1043191,EBI-740785
KRTAP5-9P263714EBI-1043191,EBI-3958099
KRTAP9-2Q9BYQ44EBI-1043191,EBI-1044640
LCE1DQ5T7524EBI-1043191,EBI-11741311
LCE1EQ5T7534EBI-1043191,EBI-11955335
LCE2CQ5TA814EBI-1043191,EBI-11973993
LCE3BQ5TA774EBI-1043191,EBI-11974495
NUFIP2Q7Z4174EBI-1043191,EBI-1210753
OTX1P322424EBI-1043191,EBI-740446
YY1P254904EBI-1043191,EBI-765538

Protein-protein interaction databases

BioGridi123811. 3 interactors.
IntActiQ9BYQ3. 90 interactors.
STRINGi9606.ENSP00000392189.

Structurei

3D structure databases

ProteinModelPortaliQ9BYQ3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati8 – 1215
Repeati13 – 1725
Repeati32 – 3635
Repeati37 – 4145
Repeati46 – 5055
Repeati51 – 5565
Repeati56 – 6075
Repeati61 – 6585
Repeati70 – 7495
Repeati75 – 79105
Repeati80 – 84115
Repeati85 – 89125
Repeati129 – 133135
Repeati134 – 138145
Repeati139 – 143155
Repeati153 – 157165

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni8 – 15716 X 5 AA repeats of C-C-[RQVSHE]-[SPTN]-[TASPI]Add BLAST150

Sequence similaritiesi

Belongs to the KRTAP type 9 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410JE2D. Eukaryota.
ENOG41118YY. LUCA.
GeneTreeiENSGT00810000125514.
HOGENOMiHOG000234030.
HOVERGENiHBG096080.
InParanoidiQ9BYQ3.
OMAiACRETTC.
PhylomeDBiQ9BYQ3.
TreeFamiTF351356.

Family and domain databases

InterProiIPR002494. KAP.
[Graphical view]
PANTHERiPTHR23262. PTHR23262. 1 hit.
PfamiPF13885. Keratin_B2_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9BYQ3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTHCCSPCCQ PTCCRTTCWQ PTTVTTCSST PCCQPSCCVS SCCQPCCHPT
60 70 80 90 100
CCQNTCCRTT CCQPICVTSC CQPSCCSTPC CQPTCCGSSC GQSSSCAPVY
110 120 130 140 150
CRRTCYHPTS VCLPGCLNQS CGSNCCQPCC RPACCETTCC RTTCFQPTCV

YSCCQPSCC
Length:159
Mass (Da):16,854
Last modified:June 1, 2001 - v1
Checksum:i375CC1E52EECDE68
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ406947 mRNA. Translation: CAC27586.1.
BC074918 mRNA. Translation: AAH74918.1.
BC074919 mRNA. Translation: AAH74919.1.
CCDSiCCDS11385.1.
RefSeqiNP_114168.1. NM_031962.2.
UniGeneiHs.307012.

Genome annotation databases

EnsembliENST00000411528; ENSP00000392189; ENSG00000204873.
ENST00000571096; ENSP00000458819; ENSG00000262749.
GeneIDi83900.
KEGGihsa:83900.
UCSCiuc021txg.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ406947 mRNA. Translation: CAC27586.1.
BC074918 mRNA. Translation: AAH74918.1.
BC074919 mRNA. Translation: AAH74919.1.
CCDSiCCDS11385.1.
RefSeqiNP_114168.1. NM_031962.2.
UniGeneiHs.307012.

3D structure databases

ProteinModelPortaliQ9BYQ3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123811. 3 interactors.
IntActiQ9BYQ3. 90 interactors.
STRINGi9606.ENSP00000392189.

Polymorphism and mutation databases

BioMutaiKRTAP9-3.
DMDMi38372388.

Proteomic databases

PaxDbiQ9BYQ3.
PeptideAtlasiQ9BYQ3.
PRIDEiQ9BYQ3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000411528; ENSP00000392189; ENSG00000204873.
ENST00000571096; ENSP00000458819; ENSG00000262749.
GeneIDi83900.
KEGGihsa:83900.
UCSCiuc021txg.1. human.

Organism-specific databases

CTDi83900.
GeneCardsiKRTAP9-3.
HGNCiHGNC:16927. KRTAP9-3.
neXtProtiNX_Q9BYQ3.
OpenTargetsiENSG00000204873.
ENSG00000262749.
PharmGKBiPA38425.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JE2D. Eukaryota.
ENOG41118YY. LUCA.
GeneTreeiENSGT00810000125514.
HOGENOMiHOG000234030.
HOVERGENiHBG096080.
InParanoidiQ9BYQ3.
OMAiACRETTC.
PhylomeDBiQ9BYQ3.
TreeFamiTF351356.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000180453-MONOMER.
ReactomeiR-HSA-6805567. Keratinization.

Miscellaneous databases

GenomeRNAii83900.
PROiQ9BYQ3.

Gene expression databases

BgeeiENSG00000204873.
CleanExiHS_KRTAP9-3.
GenevisibleiQ9BYQ3. HS.

Family and domain databases

InterProiIPR002494. KAP.
[Graphical view]
PANTHERiPTHR23262. PTHR23262. 1 hit.
PfamiPF13885. Keratin_B2_2. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKRA93_HUMAN
AccessioniPrimary (citable) accession number: Q9BYQ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 14, 2003
Last sequence update: June 1, 2001
Last modified: November 30, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.