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Protein

Keratin-associated protein 9-8

Gene

KRTAP9-8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-6805567. Keratinization.

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin-associated protein 9-8
Alternative name(s):
Keratin-associated protein 9.8
Ultrahigh sulfur keratin-associated protein 9.8
Gene namesi
Name:KRTAP9-8
Synonyms:KAP9.8, KRTAP9.8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000187272.5.
HGNCiHGNC:17231. KRTAP9-8.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Keratin

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38443.

Polymorphism and mutation databases

BioMutaiKRTAP9-8.
DMDMi296434559.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001851921 – 159Keratin-associated protein 9-8Add BLAST159

Proteomic databases

PaxDbiQ9BYQ0.
PeptideAtlasiQ9BYQ0.
PRIDEiQ9BYQ0.

PTM databases

iPTMnetiQ9BYQ0.
PhosphoSitePlusiQ9BYQ0.

Expressioni

Gene expression databases

BgeeiENSG00000187272.
CleanExiHS_KRTAP9-8.
GenevisibleiQ9BYQ0. HS.

Interactioni

Subunit structurei

Interacts with hair keratins.

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi123812. 1 interactor.
IntActiQ9BYQ0. 80 interactors.
STRINGi9606.ENSP00000254072.

Structurei

3D structure databases

ProteinModelPortaliQ9BYQ0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati8 – 1215
Repeati13 – 1725
Repeati32 – 3635
Repeati37 – 4145
Repeati46 – 5055
Repeati51 – 5565
Repeati56 – 6075
Repeati65 – 6985
Repeati70 – 7495
Repeati75 – 79105
Repeati80 – 84115
Repeati129 – 133125
Repeati134 – 138135
Repeati139 – 142144
Repeati153 – 157155

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni8 – 15715 X 5 AA repeats of C-C-[RQVSGE]-[SPSNQ]-[TASPI]Add BLAST150

Sequence similaritiesi

Belongs to the KRTAP type 9 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410JE2D. Eukaryota.
ENOG41118YY. LUCA.
GeneTreeiENSGT00890000139484.
HOGENOMiHOG000234030.
InParanoidiQ9BYQ0.
PhylomeDBiQ9BYQ0.
TreeFamiTF351356.

Family and domain databases

InterProiView protein in InterPro
IPR002494. KAP.
PANTHERiPTHR23262. PTHR23262. 1 hit.
PfamiView protein in Pfam
PF13885. Keratin_B2_2. 3 hits.

Sequencei

Sequence statusi: Complete.

Q9BYQ0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTHCCSPCCQ PTCCRTTCWK PTTVTTCSST PCCQPSCCVS SCCQPCCRPT
60 70 80 90 100
CCQNTCCQPI CVTSCCQPSC CSTPCCQPTC CGQTSCGSSC GQSSSCAPVY
110 120 130 140 150
CRRTCYHPTT VCLPGCLNQS CGSNCCQPCC RPACCETTCC RTTCFQPTCV

SSCCQPSCC
Length:159
Mass (Da):16,723
Last modified:May 18, 2010 - v2
Checksum:i4954E7F712A87BBE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti124N → S in CAC27589 (PubMed:11279113).Curated1
Sequence conflicti124N → S in AAH74981 (PubMed:15489334).Curated1
Sequence conflicti124N → S in AAH74982 (PubMed:15489334).Curated1
Sequence conflicti151S → Y in CAC27589 (PubMed:11279113).Curated1
Sequence conflicti151S → Y in AAH74981 (PubMed:15489334).Curated1
Sequence conflicti151S → Y in AAH74982 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ406950 mRNA. Translation: CAC27589.1.
AC006070 Genomic DNA. No translation available.
BC074981 mRNA. Translation: AAH74981.1.
BC074982 mRNA. Translation: AAH74982.1.
CCDSiCCDS42334.1.
RefSeqiNP_114169.2. NM_031963.2.
XP_016855212.1. XM_016999723.1.
UniGeneiHs.307011.

Genome annotation databases

EnsembliENST00000254072; ENSP00000254072; ENSG00000187272.
GeneIDi83901.
KEGGihsa:83901.
UCSCiuc002hwh.5. human.

Similar proteinsi

Entry informationi

Entry nameiKRA98_HUMAN
AccessioniPrimary (citable) accession number: Q9BYQ0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 14, 2003
Last sequence update: May 18, 2010
Last modified: September 27, 2017
This is version 111 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families