Reviewed, UniProtKB/Swiss-Prot Q9BYP7 (WNK3_HUMAN)

Names and origin

Protein names

Recommended name:
    Serine/threonine-protein kinase WNK3
    EC=2.7.11.1
Alternative name(s):
    Protein kinase with no lysine 3
    Protein kinase lysine-deficient 3

Gene names

Name:	WNK3
Synonyms:	KIAA1566, PRKWNK3

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	1743 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level.

General annotation (Comments)

Catalytic activity	ATP + a protein = ADP + a phosphoprotein. UniProtKB Q9H4A3
Cofactor	Magnesium By similarity. UniProtKB Q9H4A3
Enzyme regulation	Activation requires autophosphorylation of Ser-308. Phosphorylation of Ser-304 also promotes increased activity By similarity. UniProtKB Q9JIH7
Tissue specificity	Expressed in brain, lung, kidney, liver and pancreas, and in fetal tissues including placenta, fetal brain, lung and kidney. Very low levels of expression were also detected in fetal heart, thymus, liver and spleen. Ref.1 Ref.3
Sequence similarities	Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WNK subfamily. Contains 1 protein kinase domain.
Caution	Cys-176 is present instead of the conserved Lys which is expected to be an active site residue. Lys-159 appears to fulfill the required catalytic function. UniProtKB Q9JIH7

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase Transferase
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	protein amino acid phosphorylation Inferred from sequence or structural similarity. Source: UniProtKB protein kinase cascade Inferred from sequence or structural similarity. Source: UniProtKB
Molecular function	ATP binding Inferred from sequence or structural similarity. Source: UniProtKB protein binding Inferred from physical interaction. Source: IntAct protein serine/threonine kinase activity Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
CASP3	P42574	2	EBI-1182602,EBI-524064

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9BYP7-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9BYP7-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1247-1247: G → GGGYFGLSFTCPSLKNPISKKSWTRKLKSWAYRLRQSTSFFKRSKVRQ
     1567-1567: D → GKSCLINELEN

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1743	1743	Serine/threonine-protein kinase WNK3		PRO_0000086823
Regions
	Domain	147 – 405	259	Protein kinase
	Nucleotide binding	153 – 161	9	ATP By similarity UniProtKB Q8TDX7
Sites
	Active site	275	1	Proton acceptor By similarity UniProtKB Q8TDX7
	Binding site	159	1	ATP By similarity UniProtKB Q9JIH7
Amino acid modifications
	Modified residue	304	1	Phosphoserine; by autocatalysis By similarity UniProtKB Q9JIH7
	Modified residue	308	1	Phosphoserine; by autocatalysis By similarity UniProtKB Q9JIH7
	Modified residue	734	1	Phosphoserine Ref.6
	Modified residue	1424	1	Phosphoserine Ref.8
Natural variations
	Alternative sequence	1247	1	G → GGGYFGLSFTCPSLKNPISK KSWTRKLKSWAYRLRQSTSF FKRSKVRQ in isoform 2.		VSP_023375
	Alternative sequence	1567	1	D → GKSCLINELEN in isoform 2.		VSP_023376
	Natural variant	704	1	Q → H: dbSNP rs56077971. Ref.9		VAR_041323
	Natural variant	854	1	S → C in a lung squamous cell carcinoma sample; somatic mutation. Ref.9		VAR_041324
	Natural variant	998	1	A → T: dbSNP rs56404148. Ref.9		VAR_041325
	Natural variant	1169	1	K → E: dbSNP rs55903619. Ref.9		VAR_041326
	Natural variant	1328	1	T → I: dbSNP rs55879434. Ref.9		VAR_041327
	Natural variant	1486	1	L → F in a lung large cell carcinoma sample; somatic mutation. Ref.9		VAR_041328
	Natural variant	1577	1	S → P in a renal clear cell carcinoma sample; somatic mutation. Ref.9		VAR_041329
Experimental info
	Sequence conflict	10	1	S → N in AAL99253. Ref.3
	Sequence conflict	431 – 432	2	WV → RD in BAB13392. Ref.5
	Sequence conflict	1211	1	P → S in BAB13392. Ref.5

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified June 1, 2002. Version 2. Checksum: 7B06CC8C7E8E4D67	FASTA	1,743	191,789
	10 20 30 40 50 60 MATDSGDPAS TEDSEKPDGI SFENRVPQVA ATLTVEARLK EKNSTFSASG ETVERKRFFR 70 80 90 100 110 120 KSVEMTEDDK VAESSPKDER IKAAMNIPRV DKLPSNVLRG GQEVKYEQCS KSTSEISKDC 130 140 150 160 170 180 FKEKNEKEME EEAEMKAVAT SPSGRFLKFD IELGRGAFKT VYKGLDTETW VEVAWCELQD 190 200 210 220 230 240 RKLTKAEQQR FKEEAEMLKG LQHPNIVRFY DSWESILKGK KCIVLVTELM TSGTLKTYLK 250 260 270 280 290 300 RFKVMKPKVL RSWCRQILKG LQFLHTRTPP IIHRDLKCDN IFITGPTGSV KIGDLGLATL 310 320 330 340 350 360 MRTSFAKSVI GTPEFMAPEM YEEHYDESVD VYAFGMCMLE MATSEYPYSE CQNAAQIYRK 370 380 390 400 410 420 VTSGIKPASF NKVTDPEVKE IIEGCIRQNK SERLSIRDLL NHAFFAEDTG LRVELAEEDD 430 440 450 460 470 480 CSNSSLALRL WVEDPKKLKG KHKDNEAIEF SFNLETDTPE EVAYEMVKSG FFHESDSKAV 490 500 510 520 530 540 AKSIRDRVTP IKKTREKKPA GCLEERRDSQ CKSMGNVFPQ PQNTTLPLAP AQQTGAECEE 550 560 570 580 590 600 TEVDQHVRQQ LLQRKPQQHC SSVTGDNLSE AGAASVIHSD TSSQPSVAYS SNQTMGSQMV 610 620 630 640 650 660 SNIPQAEVNV PGQIYSSQQL VGHYQQVSGL QKHSKLTQPQ ILPLVQGQST VLPVHVLGPT 670 680 690 700 710 720 VVSQPQVSPL TVQKVPQIKP VSQPVGAEQQ AALLKPDLVR SLNQDVATTK ENVSSPDNPS 730 740 750 760 770 780 GNGKQDRIKQ RRASCPRPEK GTKFQLTVLQ VSTSGDNMVE CQLETHNNKM VTFKFDVDGD 790 800 810 820 830 840 APEDIADYMV EDNFVLESEK EKFVEELRAI VGQAQEILHV HFATERATGV DSITVDSNSS 850 860 870 880 890 900 QTGSSEQVQI NSTSTQTSNE SAPQSSPVGR WRFCINQTIR NRETQSPPSL QHSMSAVPGR 910 920 930 940 950 960 HPLPSPKNTS NKEISRDTLL TIENNPCHRA LFTSKSEHKD VVDGKISECA SVETKQPAIL 970 980 990 1000 1010 1020 YQVEDNRQIM APVTNSSSYS TTSVRAVPAE CEGLTKQASI FIPVYPCHQT ASQADALMSH 1030 1040 1050 1060 1070 1080 PGESTQTSGN SLTTLAFDQK PQTLSVQQPA MDAEFISQEG ETTVNTEASS PKTVIPTQTP 1090 1100 1110 1120 1130 1140 GLEPTTLQPT TVLESDGERP PKLEFADNRI KTLDEKLRNL LYQEHSISSI YPESQKDTQS 1150 1160 1170 1180 1190 1200 IDSPFSSSAE DTLSCPVTEV IAISHCGIKD SPVQSPNFQQ TGSKLLSNVA ASQPANISVF 1210 1220 1230 1240 1250 1260 KRDLNVITSV PSELCLHEMS SDASLPGDPE AYPAAVSSGG AIHLQTGVET EEMRSAIAPD 1270 1280 1290 1300 1310 1320 PIPLTRESTA DTRALNRCKA MSGSFQRGRF QVITIPQQQS AKMTSFGIEH ISVFSETNHS 1330 1340 1350 1360 1370 1380 SEEAFIKTAK SQLVEIEPAT QNPKTSFSYE KLQALQETCK ENKGVPKQGD NFLSFSAACE 1390 1400 1410 1420 1430 1440 TDVSSVTPEK EFEETSATGS SMQSGSELLL KEREILTAGK QPSSDSEFSA SLAGSGKSVA 1450 1460 1470 1480 1490 1500 KTGPESNQCL PHHEEQAYAQ TQSSLFYSPS SPMSSDDESE IEDEDLKVEL QRLREKHIQE 1510 1520 1530 1540 1550 1560 VVNLQTQQNK ELQELYERLR SIKDSKTQST EIPLPPASPR RPRSFKSKLR SRPQSLTHVD 1570 1580 1590 1600 1610 1620 NGIVATDPLC VESNAASCQQ SPASKKGMFT DDLHKLVDDW TKEAVGNSLI KPSLNQLKQS 1630 1640 1650 1660 1670 1680 QHKLETENWN KVSENTPSTM GYTSTWISSL SQIRGAVPTS LPQGLSLPSF PGPLSSYGMP 1690 1700 1710 1720 1730 1740 HVCQYNAVAG AGYPVQWVGI SGTTQQSVVI PAQSGGPFQP GMNMQAFPTS SVQNPATIPP GPK
	Isoform 2. Checksum: 1766D6AC8C7DE864	FASTA	1,800	198,416
	10 20 30 40 50 60 MATDSGDPAS TEDSEKPDGI SFENRVPQVA ATLTVEARLK EKNSTFSASG ETVERKRFFR 70 80 90 100 110 120 KSVEMTEDDK VAESSPKDER IKAAMNIPRV DKLPSNVLRG GQEVKYEQCS KSTSEISKDC 130 140 150 160 170 180 FKEKNEKEME EEAEMKAVAT SPSGRFLKFD IELGRGAFKT VYKGLDTETW VEVAWCELQD 190 200 210 220 230 240 RKLTKAEQQR FKEEAEMLKG LQHPNIVRFY DSWESILKGK KCIVLVTELM TSGTLKTYLK 250 260 270 280 290 300 RFKVMKPKVL RSWCRQILKG LQFLHTRTPP IIHRDLKCDN IFITGPTGSV KIGDLGLATL 310 320 330 340 350 360 MRTSFAKSVI GTPEFMAPEM YEEHYDESVD VYAFGMCMLE MATSEYPYSE CQNAAQIYRK 370 380 390 400 410 420 VTSGIKPASF NKVTDPEVKE IIEGCIRQNK SERLSIRDLL NHAFFAEDTG LRVELAEEDD 430 440 450 460 470 480 CSNSSLALRL WVEDPKKLKG KHKDNEAIEF SFNLETDTPE EVAYEMVKSG FFHESDSKAV 490 500 510 520 530 540 AKSIRDRVTP IKKTREKKPA GCLEERRDSQ CKSMGNVFPQ PQNTTLPLAP AQQTGAECEE 550 560 570 580 590 600 TEVDQHVRQQ LLQRKPQQHC SSVTGDNLSE AGAASVIHSD TSSQPSVAYS SNQTMGSQMV 610 620 630 640 650 660 SNIPQAEVNV PGQIYSSQQL VGHYQQVSGL QKHSKLTQPQ ILPLVQGQST VLPVHVLGPT 670 680 690 700 710 720 VVSQPQVSPL TVQKVPQIKP VSQPVGAEQQ AALLKPDLVR SLNQDVATTK ENVSSPDNPS 730 740 750 760 770 780 GNGKQDRIKQ RRASCPRPEK GTKFQLTVLQ VSTSGDNMVE CQLETHNNKM VTFKFDVDGD 790 800 810 820 830 840 APEDIADYMV EDNFVLESEK EKFVEELRAI VGQAQEILHV HFATERATGV DSITVDSNSS 850 860 870 880 890 900 QTGSSEQVQI NSTSTQTSNE SAPQSSPVGR WRFCINQTIR NRETQSPPSL QHSMSAVPGR 910 920 930 940 950 960 HPLPSPKNTS NKEISRDTLL TIENNPCHRA LFTSKSEHKD VVDGKISECA SVETKQPAIL 970 980 990 1000 1010 1020 YQVEDNRQIM APVTNSSSYS TTSVRAVPAE CEGLTKQASI FIPVYPCHQT ASQADALMSH 1030 1040 1050 1060 1070 1080 PGESTQTSGN SLTTLAFDQK PQTLSVQQPA MDAEFISQEG ETTVNTEASS PKTVIPTQTP 1090 1100 1110 1120 1130 1140 GLEPTTLQPT TVLESDGERP PKLEFADNRI KTLDEKLRNL LYQEHSISSI YPESQKDTQS 1150 1160 1170 1180 1190 1200 IDSPFSSSAE DTLSCPVTEV IAISHCGIKD SPVQSPNFQQ TGSKLLSNVA ASQPANISVF 1210 1220 1230 1240 1250 1260 KRDLNVITSV PSELCLHEMS SDASLPGDPE AYPAAVSSGG AIHLQTGGGY FGLSFTCPSL 1270 1280 1290 1300 1310 1320 KNPISKKSWT RKLKSWAYRL RQSTSFFKRS KVRQVETEEM RSAIAPDPIP LTRESTADTR 1330 1340 1350 1360 1370 1380 ALNRCKAMSG SFQRGRFQVI TIPQQQSAKM TSFGIEHISV FSETNHSSEE AFIKTAKSQL 1390 1400 1410 1420 1430 1440 VEIEPATQNP KTSFSYEKLQ ALQETCKENK GVPKQGDNFL SFSAACETDV SSVTPEKEFE 1450 1460 1470 1480 1490 1500 ETSATGSSMQ SGSELLLKER EILTAGKQPS SDSEFSASLA GSGKSVAKTG PESNQCLPHH 1510 1520 1530 1540 1550 1560 EEQAYAQTQS SLFYSPSSPM SSDDESEIED EDLKVELQRL REKHIQEVVN LQTQQNKELQ 1570 1580 1590 1600 1610 1620 ELYERLRSIK DSKTQSTEIP LPPASPRRPR SFKSKLRSRP QSLTHVDNGI VATGKSCLIN 1630 1640 1650 1660 1670 1680 ELENPLCVES NAASCQQSPA SKKGMFTDDL HKLVDDWTKE AVGNSLIKPS LNQLKQSQHK 1690 1700 1710 1720 1730 1740 LETENWNKVS ENTPSTMGYT STWISSLSQI RGAVPTSLPQ GLSLPSFPGP LSSYGMPHVC 1750 1760 1770 1780 1790 1800 QYNAVAGAGY PVQWVGISGT TQQSVVIPAQ SGGPFQPGMN MQAFPTSSVQ NPATIPPGPK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"WNK kinases, a novel protein kinase subfamily in multi-cellular organisms." Verissimo F., Jordan P. Oncogene 20:5562-5569(2001) [PubMed: 11571656] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, CHROMOSOMAL LOCATION. Tissue: Brain.
[2]	Jordan P. Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases Cited for: SEQUENCE REVISION TO N-TERMINUS.
[3]	"Cloning, genomic organization, alternative splicing and expression analysis of the human gene WNK3 (PRKWNK3)." Holden S., Cox J., Raymond F.L. Gene 335:109-119(2004) [PubMed: 15194194] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY. Tissue: Brain.
[4]	"The DNA sequence of the human X chromosome." Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C. , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R. Nature 434:325-337(2005) [PubMed: 15772651] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Kikuno R., Nakayama M., Hirosawa M., Ohara O. DNA Res. 7:273-281(2000) [PubMed: 10997877] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 431-1743 (ISOFORM 1). Tissue: Brain.
[6]	"Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column." Imami K., Sugiyama N., Kyono Y., Tomita M., Ishihama Y. Anal. Sci. 24:161-166(2008) [PubMed: 18187866] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-734, MASS SPECTROMETRY.
[7]	Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.
[8]	"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach." Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S. Anal. Chem. 81:4493-4501(2009) [PubMed: 19413330] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1424, MASS SPECTROMETRY.
[9]	"Patterns of somatic mutation in human cancer genomes." Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G. , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R. Nature 446:153-158(2007) [PubMed: 17344846] [Abstract] Cited for: VARIANTS [LARGE SCALE ANALYSIS] HIS-704; CYS-854; THR-998; GLU-1169; ILE-1328; PHE-1486 AND PRO-1577.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ409088 mRNA. Translation: CAC32455.2. AY082340 mRNA. Translation: AAL99253.1. AY352048 mRNA. Translation: AAR89465.1. AL591766, AL049793, Z84469 Genomic DNA. Translation: CAI40708.1. Z84469, AL049793, AL591766 Genomic DNA. Translation: CAI42733.1. AL049793, AL591766, Z84469 Genomic DNA. Translation: CAI43129.1. AB046786 mRNA. Translation: BAB13392.1.
IPI	IPI00152474. IPI00387112.
RefSeq	NP_001002838.1. NP_065973.2.
UniGene	Hs.92423
3D structure databases
SMR	Q9BYP7. Positions 137-405.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-46125N.
IntAct	Q9BYP7. 1 interaction.
STRING	Q9BYP7.
PTM databases
PhosphoSite	Q9BYP7.
Proteomic databases
PRIDE	Q9BYP7.
Genome annotation databases
Ensembl	ENST00000375169; ENSP00000364312; ENSG00000196632; Homo sapiens. [Genome view]
GeneID	65267.
KEGG	hsa:65267.
UCSC	uc004dtc.1. human. uc004dtd.1. human.
Organism-specific databases
CTD	65267.
GeneCards	GC0XM054235.
H-InvDB	HIX0016821.
HGNC	HGNC:14543. WNK3.
MIM	300358. gene.
PharmGKB	PA33784.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG06625.
HOVERGEN	Q9BYP7.
OMA	HLQTGGG.
Enzyme and pathway databases
BRENDA	2.7.11.1. 247.
Gene expression databases
ArrayExpress	Q9BYP7.
Bgee	Q9BYP7.
CleanEx	HS_WNK3.
Genevestigator	Q9BYP7.
GermOnline	ENSG00000196632. Homo sapiens.
Family and domain databases
InterPro	IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR017442. Se/Thr_prot_kinase-like_dom. IPR008271. Ser/Thr_prot_kinase_AS. IPR002290. Ser/Thr_prot_kinase_dom. [Graphical view]
Pfam	PF00069. Pkinase. 1 hit. [Graphical view]
SMART	SM00220. S_TKc. 1 hit. [Graphical view]
PROSITE	PS00107. PROTEIN_KINASE_ATP. False negative. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	67402.
SOURCE	Search...

Entry information

Entry name

WNK3_HUMAN

Accession

Primary (citable) accession number: Q9BYP7
Secondary accession number(s): Q5JRC1 , Q6JP76, Q8TCX6, Q9HCK6

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 2, 2004
Last sequence update:	June 1, 2002
Last modified:	February 9, 2010
This is version 80 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.