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Protein

28S ribosomal protein S26, mitochondrial

Gene

MRPS26

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • poly(A) RNA binding Source: UniProtKB

GO - Biological processi

  • DNA damage response, detection of DNA damage Source: UniProtKB
  • mitochondrial translational elongation Source: Reactome
  • mitochondrial translational termination Source: Reactome
  • peptide biosynthetic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-5368286. Mitochondrial translation initiation.
R-HSA-5389840. Mitochondrial translation elongation.
R-HSA-5419276. Mitochondrial translation termination.

Names & Taxonomyi

Protein namesi
Recommended name:
28S ribosomal protein S26, mitochondrial
Short name:
MRP-S26
Short name:
S26mt
Alternative name(s):
28S ribosomal protein S13, mitochondrial
Short name:
MRP-S13
Short name:
S13mt
Gene namesi
Name:MRPS26
Synonyms:C20orf193, RPMS13
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:14045. MRPS26.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31014.

Polymorphism and mutation databases

BioMutaiMRPS26.
DMDMi28201886.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2727MitochondrionBy similarityAdd
BLAST
Chaini28 – 20517828S ribosomal protein S26, mitochondrialPRO_0000030591Add
BLAST

Proteomic databases

EPDiQ9BYN8.
MaxQBiQ9BYN8.
PaxDbiQ9BYN8.
PeptideAtlasiQ9BYN8.
PRIDEiQ9BYN8.
TopDownProteomicsiQ9BYN8.

PTM databases

iPTMnetiQ9BYN8.
PhosphoSiteiQ9BYN8.

Expressioni

Gene expression databases

BgeeiQ9BYN8.
CleanExiHS_MRPS26.
GenevisibleiQ9BYN8. HS.

Organism-specific databases

HPAiHPA045472.
HPA054610.

Interactioni

Subunit structurei

Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins.

Protein-protein interaction databases

BioGridi122356. 57 interactions.
IntActiQ9BYN8. 10 interactions.
MINTiMINT-1399494.
STRINGi9606.ENSP00000369682.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3J9Melectron microscopy3.50AU1-205[»]
ProteinModelPortaliQ9BYN8.
SMRiQ9BYN8. Positions 27-203.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG4691. Eukaryota.
ENOG4111QCE. LUCA.
GeneTreeiENSGT00390000008453.
HOGENOMiHOG000142246.
HOVERGENiHBG036125.
InParanoidiQ9BYN8.
KOiK17405.
OMAiWNQAENQ.
OrthoDBiEOG7T7GVZ.
PhylomeDBiQ9BYN8.
TreeFamiTF316309.

Family and domain databases

InterProiIPR026140. MRPS26.
[Graphical view]
PANTHERiPTHR21035. PTHR21035. 1 hit.
PfamiPF14943. MRP-S26. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9BYN8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRALSRLGA GTPCRPRAPL VLPARGRKTR HDPLAKSKIE RVNMPPAVDP
60 70 80 90 100
AEFFVLMERY QHYRQTVRAL RMEFVSEVQR KVHEARAGVL AERKALKDAA
110 120 130 140 150
EHRELMAWNQ AENRRLHELR IARLRQEERE QEQRQALEQA RKAEEVQAWA
160 170 180 190 200
QRKEREVLQL QEEVKNFITR ENLEARVEAA LDSRKNYNWA ITREGLVVRP

QRRDS
Length:205
Mass (Da):24,212
Last modified:June 1, 2001 - v1
Checksum:iF40EF470813840EF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL121905 Genomic DNA. Translation: CAC10339.2.
BC013018 mRNA. Translation: AAH13018.1.
AB051354 Genomic DNA. Translation: BAB54943.1.
CCDSiCCDS13043.1.
RefSeqiNP_110438.1. NM_030811.3.
UniGeneiHs.18946.

Genome annotation databases

EnsembliENST00000380325; ENSP00000369682; ENSG00000125901.
GeneIDi64949.
KEGGihsa:64949.
UCSCiuc002whs.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL121905 Genomic DNA. Translation: CAC10339.2.
BC013018 mRNA. Translation: AAH13018.1.
AB051354 Genomic DNA. Translation: BAB54943.1.
CCDSiCCDS13043.1.
RefSeqiNP_110438.1. NM_030811.3.
UniGeneiHs.18946.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3J9Melectron microscopy3.50AU1-205[»]
ProteinModelPortaliQ9BYN8.
SMRiQ9BYN8. Positions 27-203.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122356. 57 interactions.
IntActiQ9BYN8. 10 interactions.
MINTiMINT-1399494.
STRINGi9606.ENSP00000369682.

PTM databases

iPTMnetiQ9BYN8.
PhosphoSiteiQ9BYN8.

Polymorphism and mutation databases

BioMutaiMRPS26.
DMDMi28201886.

Proteomic databases

EPDiQ9BYN8.
MaxQBiQ9BYN8.
PaxDbiQ9BYN8.
PeptideAtlasiQ9BYN8.
PRIDEiQ9BYN8.
TopDownProteomicsiQ9BYN8.

Protocols and materials databases

DNASUi64949.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000380325; ENSP00000369682; ENSG00000125901.
GeneIDi64949.
KEGGihsa:64949.
UCSCiuc002whs.4. human.

Organism-specific databases

CTDi64949.
GeneCardsiMRPS26.
HGNCiHGNC:14045. MRPS26.
HPAiHPA045472.
HPA054610.
MIMi611988. gene.
neXtProtiNX_Q9BYN8.
PharmGKBiPA31014.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4691. Eukaryota.
ENOG4111QCE. LUCA.
GeneTreeiENSGT00390000008453.
HOGENOMiHOG000142246.
HOVERGENiHBG036125.
InParanoidiQ9BYN8.
KOiK17405.
OMAiWNQAENQ.
OrthoDBiEOG7T7GVZ.
PhylomeDBiQ9BYN8.
TreeFamiTF316309.

Enzyme and pathway databases

ReactomeiR-HSA-5368286. Mitochondrial translation initiation.
R-HSA-5389840. Mitochondrial translation elongation.
R-HSA-5419276. Mitochondrial translation termination.

Miscellaneous databases

ChiTaRSiMRPS26. human.
GeneWikiiMRPS26.
GenomeRNAii64949.
PROiQ9BYN8.
SOURCEiSearch...

Gene expression databases

BgeeiQ9BYN8.
CleanExiHS_MRPS26.
GenevisibleiQ9BYN8. HS.

Family and domain databases

InterProiIPR026140. MRPS26.
[Graphical view]
PANTHERiPTHR21035. PTHR21035. 1 hit.
PfamiPF14943. MRP-S26. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Skin.
  3. "The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders."
    Kenmochi N., Suzuki T., Uechi T., Magoori M., Kuniba M., Higa S., Watanabe K., Tanaka T.
    Genomics 77:65-70(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE OF 162-192.
  4. "The small subunit of the mammalian mitochondrial ribosome: identification of the full complement of ribosomal proteins present."
    Koc E.C., Burkhart W., Blackburn K., Moseley A., Spremulli L.L.
    J. Biol. Chem. 276:19363-19374(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiRT26_HUMAN
AccessioniPrimary (citable) accession number: Q9BYN8
Secondary accession number(s): Q96Q58
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2003
Last sequence update: June 1, 2001
Last modified: June 8, 2016
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.