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Protein

28S ribosomal protein S26, mitochondrial

Gene

MRPS26

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-5368286 Mitochondrial translation initiation
R-HSA-5389840 Mitochondrial translation elongation
R-HSA-5419276 Mitochondrial translation termination

Names & Taxonomyi

Protein namesi
Recommended name:
28S ribosomal protein S26, mitochondrial
Short name:
MRP-S26
Short name:
S26mt
Alternative name(s):
28S ribosomal protein S13, mitochondrial
Short name:
MRP-S13
Short name:
S13mt
Mitochondrial small ribosomal subunit protein mS261 Publication
Gene namesi
Name:MRPS26
Synonyms:C20orf193, RPMS13
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000125901.5
HGNCiHGNC:14045 MRPS26
MIMi611988 gene
neXtProtiNX_Q9BYN8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000125901
PharmGKBiPA31014

Polymorphism and mutation databases

BioMutaiMRPS26
DMDMi28201886

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 27MitochondrionBy similarityAdd BLAST27
ChainiPRO_000003059128 – 20528S ribosomal protein S26, mitochondrialAdd BLAST178

Proteomic databases

EPDiQ9BYN8
MaxQBiQ9BYN8
PaxDbiQ9BYN8
PeptideAtlasiQ9BYN8
PRIDEiQ9BYN8
TopDownProteomicsiQ9BYN8

PTM databases

iPTMnetiQ9BYN8
PhosphoSitePlusiQ9BYN8

Expressioni

Gene expression databases

BgeeiENSG00000125901
CleanExiHS_MRPS26
GenevisibleiQ9BYN8 HS

Organism-specific databases

HPAiHPA045472
HPA054610

Interactioni

Subunit structurei

Component of the mitochondrial small ribosomal subunit (mt-SSU). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins.1 Publication

Protein-protein interaction databases

BioGridi122356, 69 interactors
CORUMiQ9BYN8
IntActiQ9BYN8, 25 interactors
MINTiQ9BYN8
STRINGi9606.ENSP00000369682

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J9Melectron microscopy3.50AU1-205[»]
ProteinModelPortaliQ9BYN8
SMRiQ9BYN8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG4691 Eukaryota
ENOG4111QCE LUCA
GeneTreeiENSGT00390000008453
HOGENOMiHOG000142246
HOVERGENiHBG036125
InParanoidiQ9BYN8
KOiK17405
OMAiWRRKPRW
OrthoDBiEOG091G0LTE
PhylomeDBiQ9BYN8
TreeFamiTF316309

Family and domain databases

InterProiView protein in InterPro
IPR026140 MRPS26
PANTHERiPTHR21035 PTHR21035, 1 hit
PfamiView protein in Pfam
PF14943 MRP-S26, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9BYN8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRALSRLGA GTPCRPRAPL VLPARGRKTR HDPLAKSKIE RVNMPPAVDP
60 70 80 90 100
AEFFVLMERY QHYRQTVRAL RMEFVSEVQR KVHEARAGVL AERKALKDAA
110 120 130 140 150
EHRELMAWNQ AENRRLHELR IARLRQEERE QEQRQALEQA RKAEEVQAWA
160 170 180 190 200
QRKEREVLQL QEEVKNFITR ENLEARVEAA LDSRKNYNWA ITREGLVVRP

QRRDS
Length:205
Mass (Da):24,212
Last modified:June 1, 2001 - v1
Checksum:iF40EF470813840EF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL121905 Genomic DNA No translation available.
BC013018 mRNA Translation: AAH13018.1
AB051354 Genomic DNA Translation: BAB54943.1
CCDSiCCDS13043.1
RefSeqiNP_110438.1, NM_030811.3
UniGeneiHs.18946

Genome annotation databases

EnsembliENST00000380325; ENSP00000369682; ENSG00000125901
GeneIDi64949
KEGGihsa:64949
UCSCiuc002whs.4 human

Similar proteinsi

Entry informationi

Entry nameiRT26_HUMAN
AccessioniPrimary (citable) accession number: Q9BYN8
Secondary accession number(s): Q96Q58
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2003
Last sequence update: June 1, 2001
Last modified: May 23, 2018
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Ribosomal proteins
    Ribosomal proteins families and list of entries
  5. SIMILARITY comments
    Index of protein domains and families

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